Andrew C Leon

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi A 20-year longitudinal observational study of somatic antidepressant treatment effectiveness
    Andrew C Leon
    NIMH Collaborative Program on the Psychobiology of Depression, USA
    Am J Psychiatry 160:727-33. 2003
  2. pmc Evolution of psychopharmacology trial design and analysis: six decades in the making
    Andrew C Leon
    Weill Cornell Medical College, Department of Psychiatry, Box 140, 525 East 68th St, New York, NY 10065, USA
    J Clin Psychiatry 72:331-40. 2011
  3. ncbi The revised black box warning for antidepressants sets a public health experiment in motion
    Andrew C Leon
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10021, USA
    J Clin Psychiatry 68:1139-41. 2007
  4. pmc "Gray murder": characteristics of elderly compared with nonelderly homicide victims in New York City
    Robert C Abrams
    Department of Psychiatry, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY 10021, USA
    Am J Public Health 97:1666-70. 2007
  5. ncbi Do comorbid personality disorders moderate panic-focused psychotherapy? An exploratory examination of the American Psychiatric Association practice guideline
    Barbara L Milrod
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Clin Psychiatry 68:885-91. 2007
  6. ncbi A randomized controlled clinical trial of psychoanalytic psychotherapy for panic disorder
    Barbara Milrod
    Weill Medical College of Cornell University, 525 East 68th St, New York, NY 10021, USA
    Am J Psychiatry 164:265-72. 2007
  7. ncbi Statistical power of multiplicity adjustment strategies for correlated binary endpoints
    Andrew C Leon
    Department of Psychiatry, Weill Cornell Medical College, Box 140, 525 East 68th Street, New York, NY 10021, USA
    Stat Med 26:1712-23. 2007
  8. ncbi A comparison of mixed-effects quantile stratification propensity adjustment strategies for longitudinal treatment effectiveness analyses of continuous outcomes
    Andrew C Leon
    Department of Psychiatry, Cornell University, New York, NY, USA
    Stat Med 26:2650-65. 2007
  9. ncbi The face behind the mask: a developmental study
    Nim Tottenham
    Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, USA
    Dev Sci 9:288-94. 2006
  10. ncbi Attrition in randomized controlled clinical trials: methodological issues in psychopharmacology
    Andrew C Leon
    Department of Psychiatry, Weill Medical College, Cornell University, New York, New York 10021, USA
    Biol Psychiatry 59:1001-5. 2006

Detail Information

Publications67

  1. ncbi A 20-year longitudinal observational study of somatic antidepressant treatment effectiveness
    Andrew C Leon
    NIMH Collaborative Program on the Psychobiology of Depression, USA
    Am J Psychiatry 160:727-33. 2003
    ..This observational study examined the effectiveness of somatic antidepressant treatments as administered in the community...
  2. pmc Evolution of psychopharmacology trial design and analysis: six decades in the making
    Andrew C Leon
    Weill Cornell Medical College, Department of Psychiatry, Box 140, 525 East 68th St, New York, NY 10065, USA
    J Clin Psychiatry 72:331-40. 2011
    ..The evolution of trial design and analysis during the lifespan of psychopharmacology is examined...
  3. ncbi The revised black box warning for antidepressants sets a public health experiment in motion
    Andrew C Leon
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10021, USA
    J Clin Psychiatry 68:1139-41. 2007
  4. pmc "Gray murder": characteristics of elderly compared with nonelderly homicide victims in New York City
    Robert C Abrams
    Department of Psychiatry, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY 10021, USA
    Am J Public Health 97:1666-70. 2007
    ....
  5. ncbi Do comorbid personality disorders moderate panic-focused psychotherapy? An exploratory examination of the American Psychiatric Association practice guideline
    Barbara L Milrod
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Clin Psychiatry 68:885-91. 2007
    ..No data underlie this recommendation. This exploratory study assessed the moderating effect of personality disorder on psychodynamic and non-psychodynamic psychotherapy outcome...
  6. ncbi A randomized controlled clinical trial of psychoanalytic psychotherapy for panic disorder
    Barbara Milrod
    Weill Medical College of Cornell University, 525 East 68th St, New York, NY 10021, USA
    Am J Psychiatry 164:265-72. 2007
    ..To the authors' knowledge, this is the first efficacy randomized controlled clinical trial of panic-focused psychodynamic psychotherapy, a manualized psychoanalytical psychotherapy for patients with DSM-IV panic disorder...
  7. ncbi Statistical power of multiplicity adjustment strategies for correlated binary endpoints
    Andrew C Leon
    Department of Psychiatry, Weill Cornell Medical College, Box 140, 525 East 68th Street, New York, NY 10021, USA
    Stat Med 26:1712-23. 2007
    ..50; whereas the James procedure provides more statistical power with higher rho, the common correlation among the multiple outcomes. A study of gender differences in New York City homicides is used to illustrate the approaches...
  8. ncbi A comparison of mixed-effects quantile stratification propensity adjustment strategies for longitudinal treatment effectiveness analyses of continuous outcomes
    Andrew C Leon
    Department of Psychiatry, Cornell University, New York, NY, USA
    Stat Med 26:2650-65. 2007
    ..The approach is illustrated in an evaluation of the effectiveness of somatic treatments for major depression in a longitudinal, observational study of affective disorders...
  9. ncbi The face behind the mask: a developmental study
    Nim Tottenham
    Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, USA
    Dev Sci 9:288-94. 2006
    ....
  10. ncbi Attrition in randomized controlled clinical trials: methodological issues in psychopharmacology
    Andrew C Leon
    Department of Psychiatry, Weill Medical College, Cornell University, New York, New York 10021, USA
    Biol Psychiatry 59:1001-5. 2006
    ..This information can be used to eliminate some of the very obstacles that lead to attrition, and can be incorporated in data analyses to reduce bias, but it will not eliminate all attrition bias...
  11. ncbi Antidepressants and youth suicide in New York City, 1999-2002
    Andrew C Leon
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Am Acad Child Adolesc Psychiatry 45:1054-8. 2006
    ..To determine the proportion of youth suicides in New York City from 1999 to 2002 in which antidepressants were detected at autopsy...
  12. ncbi Bias reduction in effectiveness analyses of longitudinal ordinal doses with a mixed-effects propensity adjustment
    Andrew C Leon
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Stat Med 26:110-23. 2007
    ..In addition, type I error rate and statistical power are examined. The approach is illustrated by applying it to a longitudinal, observational study of maintenance treatment of major depression...
  13. ncbi Antidepressants in adult suicides in New York City: 2001-2004
    Andrew C Leon
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Clin Psychiatry 68:1399-403. 2007
    ..Nearly all suicidality in those trials was nonfatal suicide attempts and ideation. Here, we consider whether antidepressants are linked with adult suicide deaths...
  14. ncbi A randomized trial of depression assessment intervention in home health care
    Martha L Bruce
    Department of Psychiatry, Weill Medical College of Cornell University, White Plains, New York, USA
    J Am Geriatr Soc 55:1793-800. 2007
    ..To determine whether an educational intervention would improve depression assessment and appropriate referral. Secondary analyses tested whether referral led to depression improvement...
  15. doi A new scale for assessing the quality of randomized clinical trials of psychotherapy
    James H Kocsis
    Weill Cornell Medical College, New York, NY 10065, USA
    Compr Psychiatry 51:319-24. 2010
    ..In 2004, the American Psychiatric Association's Committee on Research on Psychiatric Treatments appointed a subcommittee to investigate the status of empirical evidence with regard to psychodynamic psychotherapy...
  16. pmc Enhancing clinical trial design of interventions for posttraumatic stress disorder
    Andrew C Leon
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10065, USA
    J Trauma Stress 22:603-11. 2009
    ..Fundamental goals of RCT design are described. Strategies in design and analysis that contribute to the goals of an RCT and thereby enhance the likelihood of signal detection are considered...
  17. pmc Cognitive behavioral analysis system of psychotherapy and brief supportive psychotherapy for augmentation of antidepressant nonresponse in chronic depression: the REVAMP Trial
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA
    Arch Gen Psychiatry 66:1178-88. 2009
    ..Previous studies have found that few chronically depressed patients remit with antidepressant medications alone...
  18. pmc A double-blind randomized controlled trial of olanzapine plus sertraline vs olanzapine plus placebo for psychotic depression: the study of pharmacotherapy of psychotic depression (STOP-PD)
    Barnett S Meyers
    Department of Psychiatry, Weill Medical College of Cornell University and New York Presbyterian Hospital, Westchester Division, White Plains, New York 10605, USA
    Arch Gen Psychiatry 66:838-47. 2009
    ..Evidence for the efficacy of combination pharmacotherapy has been limited and without positive trials in geriatric patients with major depression (MD) with psychotic features...
  19. pmc The NimStim set of facial expressions: judgments from untrained research participants
    Nim Tottenham
    Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College, New York, NY 10021, USA
    Psychiatry Res 168:242-9. 2009
    ..The results lend empirical support for the validity and reliability of this set of facial expressions as determined by accurate identification of expressions and high intra-participant agreement across two testing sessions, respectively...
  20. ncbi Antidepressant use in elderly suicide victims in New York city: an analysis of 255 cases
    Robert C Abrams
    Department of Psychiatry, Weill Cornell Medical College, New York, N Y 10021, USA
    J Clin Psychiatry 70:312-7. 2009
    ..We examined postmortem evidence of antidepressant, analgesic, and anxiolytic-hypnotic drugs in suicide victims aged 65 years and older...
  21. ncbi Patient preference as a moderator of outcome for chronic forms of major depressive disorder treated with nefazodone, cognitive behavioral analysis system of psychotherapy, or their combination
    James H Kocsis
    Department of Psychiatry, Weill Cornell Medical College, New York, N Y, USA
    J Clin Psychiatry 70:354-61. 2009
    ..We hypothesized that patient preference at baseline would interact with treatment group to differentially affect treatment outcome...
  22. doi Statistical power and sample size requirements for three level hierarchical cluster randomized trials
    Moonseong Heo
    Department of Psychiatry, Weill Medical College of Cornell University, White Plains, New York 10605, USA
    Biometrics 64:1256-62. 2008
    ..Recommendations at the design stage of a cluster-RCT are discussed...
  23. ncbi The revised warning for antidepressants and suicidality: unveiling the black box of statistical analyses
    Andrew C Leon
    Department of Psychiatry, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    Am J Psychiatry 164:1786-9. 2007
  24. ncbi Bias reduction with an adjustment for participants' intent to dropout of a randomized controlled clinical trial
    Andrew C Leon
    Weill Medical College of Cornell University, Department of Psychiatry, New York, NY 10021, USA
    Clin Trials 4:540-7. 2007
    ..Although likelihood-based statistical models such as mixed-effects models can accommodate incomplete data, the assumption of ignorable attrition is usually required for valid inferences...
  25. ncbi A comparison of multiplicity adjustment strategies for correlated binary endpoints
    Andrew C Leon
    Weill Cornell Medical College, Department of Psychiatry, New York 10021, USA
    J Biopharm Stat 15:839-55. 2005
    ..Analyses of data from a randomized controlled clinical trial of treatments for mania in bipolar disorder are used to illustrate the application of the multiplicity adjustments...
  26. ncbi Performance of a mixed effects logistic regression model for binary outcomes with unequal cluster size
    Moonseong Heo
    Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY 10605, USA
    J Biopharm Stat 15:513-26. 2005
    ..This is illustrated using data from the Prevention Of Suicide in Primary care Elderly: Collaborative Trial (PROSPECT) study...
  27. pmc Implications of clinical trial design on sample size requirements
    Andrew C Leon
    Weill Medical College of Cornell University, New York, NY 10065, USA
    Schizophr Bull 34:664-9. 2008
    ..The objective of this article is to consider strategies that overcome the problems of unreliability and multiplicity...
  28. ncbi Paroxetine, other antidepressants, and youth suicide in New York City: 1993 through 1998
    Andrew C Leon
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY10021, USA
    J Clin Psychiatry 65:915-8. 2004
    ....
  29. pmc Preference for fall from height as a method of suicide by elderly residents of New York City
    Robert C Abrams
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY, USA
    Am J Public Health 95:1000-2. 2005
    ..Among persons who died by fall from height, those 65 or older were more likely than others to have fallen from buildings where they lived...
  30. ncbi Are two antidepressant mechanisms better than one? Issues in clinical trial design and analysis
    Andrew C Leon
    Department of Psychiatry, Weill Medical College, Cornell University, New York, NY 10021, USA
    J Clin Psychiatry 65:31-6. 2004
    ..equivalence trial), and others are somewhat more discretionary (e.g., assessment tools, statistical procedures). Issues in the design and analysis of clinical trials comparing dual- and single-action antidepressants are discussed...
  31. ncbi Multiplicity-adjusted sample size requirements: a strategy to maintain statistical power with Bonferroni adjustments
    Andrew C Leon
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Clin Psychiatry 65:1511-4. 2004
    ..Here, a simple strategy is described that adjusts alpha for multiple primary efficacy measures, yet maintains statistical power for each test...
  32. ncbi Comparison of statistical methods for analysis of clustered binary observations
    Moonseong Heo
    Department of Psychiatry, Weill Medical College of Cornell University, Westchester Division, White Plains, NY 10605, USA
    Stat Med 24:911-23. 2005
    ....
  33. ncbi Suicide among New York City police officers, 1977-1996
    Peter M Marzuk
    Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Am J Psychiatry 159:2069-71. 2002
    ..The authors assessed the suicide rates of New York City police officers during a recent period...
  34. ncbi A mixed-effects quintile-stratified propensity adjustment for effectiveness analyses of ordered categorical doses
    Andrew C Leon
    Weill Medical College of Cornell University, Department of Psychiatry, New York, NY 10021, USA
    Stat Med 24:647-58. 2005
    ..This approach is a useful strategy for observational studies of treatment effectiveness. It is capable of adjusting for selection bias, incorporating multiple observations per subject, and comparing effectiveness of ordinal doses...
  35. ncbi Toward rapproachment in the placebo control debate. A calculated compromise of power
    Andrew C Leon
    Weill Medical College of Cornell University, USA
    Eval Health Prof 26:404-14. 2003
    ....
  36. ncbi The course of depression in elderly patients
    Timothy I Mueller
    Brown University Medical School, Department of Psychiatry and Human Behavior, c o Butler Hospital, 345 Blackstone Blvd, Providence, RI 02906, USA
    Am J Geriatr Psychiatry 12:22-9. 2004
    ..Studies on the course of major depressive disorder (MDD) among elderly persons are limited to short periods of follow-up, seldom provide comparisons with younger cohorts, and raise other methodological concerns...
  37. pmc Drugs and firearm deaths in New York City, 1990-1998
    Sandro Galea
    Center for Urban Epidemiologic Studies, New York Academy of Medicine, New York, New York 10029, USA
    J Urban Health 79:70-86. 2002
    ..These results suggest a complex role of drugs in firearm-related deaths...
  38. ncbi Sample-size requirements for comparisons of two groups on repeated observations of a binary outcome
    Andrew C Leon
    Weill Medical College of Cornell University, USA
    Eval Health Prof 27:34-44. 2004
    ....
  39. pmc Predicting recovery from episodes of major depression
    David A Solomon
    Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, RI 02903 4970, United States
    J Affect Disord 107:285-91. 2008
    ..This study examined psychosocial functioning as a predictor of recovery from episodes of unipolar major depression...
  40. ncbi Unipolar mania over the course of a 20-year follow-up study
    David A Solomon
    NIMH Collaborative Program on the Psychobiology of Depression Clinical Studies, at Mood Disorders Program, Department of Psychiatry, Rhode Island Hospital, 593 Eddy Street, Providence RI 02903 4970, USA
    Am J Psychiatry 160:2049-51. 2003
    ..Using data from a longitudinal study of the mood disorders, the investigators address the phenomenon of unipolar mania...
  41. ncbi The long-term course of rapid-cycling bipolar disorder
    William Coryell
    National Institute of Mental Health Collaborative Program on the Psychobiology of Depression Clinical Studies, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 60:914-20. 2003
    ..To our knowledge, no prospective study has, as yet, described the course of this phenomenon beyond 5 years...
  42. doi Residual symptom recovery from major affective episodes in bipolar disorders and rapid episode relapse/recurrence
    Lewis L Judd
    Department of Psychiatry, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0603, USA
    Arch Gen Psychiatry 65:386-94. 2008
    ..Both bipolar disorder type I and type II are characterized by frequent affective episode relapse and/or recurrence. An increasingly important goal of therapy is reducing chronicity by preventing or delaying additional episodes...
  43. ncbi A prospective investigation of the natural history of the long-term weekly symptomatic status of bipolar II disorder
    Lewis L Judd
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0603, USA
    Arch Gen Psychiatry 60:261-9. 2003
    ..This is the first prospective longitudinal study, to our knowledge, of the natural history of the weekly symptomatic status of bipolar II disorder (BP-II)...
  44. ncbi Income distribution and risk of fatal drug overdose in New York City neighborhoods
    Sandro Galea
    Center for Urban Epidemiologic Studies, New York Academy of Medicine, New York 10024, USA
    Drug Alcohol Depend 70:139-48. 2003
    ..Disinvestment in social and economic resources in unequal neighborhoods may explain this association. Public health interventions related to overdose risk should pay particular attention to highly unequal neighborhoods...
  45. ncbi Role of antidepressants in murder and suicide
    Kenneth Tardiff
    Am J Psychiatry 159:1248-9. 2002
  46. ncbi The long-term natural history of the weekly symptomatic status of bipolar I disorder
    Lewis L Judd
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0603, USA
    Arch Gen Psychiatry 59:530-7. 2002
    ..To our knowledge, this is the first prospective natural history study of weekly symptomatic status of patients with bipolar I disorder (BP-I) during long-term follow-up...
  47. pmc A placebo-controlled add-on trial of the Ampakine, CX516, for cognitive deficits in schizophrenia
    Donald C Goff
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuropsychopharmacology 33:465-72. 2008
    ..CX516 was not effective for cognition or for symptoms of schizophrenia when added to clozapine, olanzapine, or risperidone...
  48. ncbi Expanding the black box - depression, antidepressants, and the risk of suicide
    Richard A Friedman
    Psychopharmacology Clinic, Weill Cornell Medical College, New York, USA
    N Engl J Med 356:2343-6. 2007
  49. ncbi Are there differences in the symptoms that respond to a selective serotonin or norepinephrine reuptake inhibitor?
    J Craig Nelson
    Department of Psychiatry, University of California San Francisco, San Francisco, California 94143, USA
    Biol Psychiatry 57:1535-42. 2005
    ....
  50. ncbi Symptoms of late-life depression: frequency and change during treatment
    J Craig Nelson
    Dept of Psychiatry, University of California at San Francisco, 401 Parnassus Ave, Box 0984 F, San Francisco, CA 94143, USA
    Am J Geriatr Psychiatry 13:520-6. 2005
    ....
  51. ncbi Psychosocial disability in the course of bipolar I and II disorders: a prospective, comparative, longitudinal study
    Lewis L Judd
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    Arch Gen Psychiatry 62:1322-30. 2005
    ..Evidence of psychosocial disability in bipolar disorder is based primarily on bipolar I disorder (BP-I) and does not relate disability to affective symptom severity and polarity or to bipolar II disorder (BP-II)...
  52. ncbi A summary of the FDA-NIMH-MATRICS workshop on clinical trial design for neurocognitive drugs for schizophrenia
    Robert W Buchanan
    Maryland Psychiatric Research Center, P O Box 21247, Baltimore, MD 21228, USA
    Schizophr Bull 31:5-19. 2005
    ....
  53. ncbi Residual symptoms in depressed patients after treatment with fluoxetine or reboxetine
    J Craig Nelson
    Department of Psychiatry, University of California San Francisco, 401 Parnassus Avenue, PO Box 0984 F, San Francisco, CA 94143, USA
    J Clin Psychiatry 66:1409-14. 2005
    ..We examined the frequency and severity of residual depressive symptoms in 2 studies comparing the selective serotonin reuptake inhibitor (SSRI) fluoxetine with the norepinephrine reuptake inhibitor (NRI) reboxetine...
  54. ncbi Tachyphylaxis in unipolar major depressive disorder
    David A Solomon
    Department of Psychiatry and Human Behavior, Brown University, 593 Eddy Street, Providence, RI 02903, USA
    J Clin Psychiatry 66:283-90. 2005
    ..This study describes recurrence of major depression despite maintenance pharmacotherapy, termed tachyphylaxis...
  55. ncbi Distinguishing bipolar major depression from unipolar major depression with the screening assessment of depression-polarity (SAD-P)
    David A Solomon
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA
    J Clin Psychiatry 67:434-42. 2006
    ..The goal of this study was to develop and validate a brief instrument to screen for bipolar disorder in patients actively ill with major depression...
  56. ncbi The naturalistic course of unipolar major depression in the absence of somatic therapy
    Michael A Posternak
    Brown University School of Medicine, Department of Psychiatry and Human Behavior, Providence, Rhode Island, USA
    J Nerv Ment Dis 194:324-9. 2006
    ..Because treatment-seeking behavior is known to be associated with a worse prognosis, 23 weeks probably represents a lower-limit approximation of the median duration of an untreated depressive episode...
  57. ncbi Psychosocial impairment and recurrence of major depression
    David A Solomon
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA
    Compr Psychiatry 45:423-30. 2004
    ..In patients who have recovered from an episode of major depression, the presence of psychosocial impairment may help identify who is at increased risk of recurrence...
  58. pmc Assessment of community functioning in people with schizophrenia and other severe mental illnesses: a white paper based on an NIMH-sponsored workshop
    Alan S Bellack
    University of Maryland School of Medicine, 737 West Lombard Street, Suite 551, Baltimore, MD 21201, USA
    Schizophr Bull 33:805-22. 2007
    ..This criterion is problematic because different observers and constituencies often have different opinions about what types of change are clinically important and how much change is significant...
  59. ncbi Psychopathology of panic attacks in panic disorder
    E H Uhlenhuth
    Department of Psychiatry, MSC09 5030, 1 University of New Mexico, Albuquerque, 87131 0001, USA
    J Affect Disord 92:55-62. 2006
    ..limited symptom; spontaneous vs. situational) and between these subtypes, panic disorder subtypes, and other characteristics of panic disorder, especially agoraphobia...
  60. ncbi Assessment of outcome in depression
    J Craig Nelson
    Department of Psychiatry, University of California, San Francisco, CA, USA
    J Psychopharmacol 20:47-53. 2006
    ..And we review studies that have identified 'core' symptoms of depression and compare these findings to the magnitude of individual symptom change we found in five studies of selective serotonergic or nonadrenergic antidepressants...
  61. ncbi Antidepressant treatment patterns in a novel methadone maintenance clinic targeting young adults an observational study
    David W Galarneau
    Weill Medical College of Cornell University, New York, NY 10021, USA
    J Addict Dis 25:47-52. 2006
    ..e., general outpatient vs. methadone maintenance)...
  62. ncbi Assessment and treatment of depression in disability claimants: a cost-benefit simulation study
    Andrew C Leon
    Weill Medical College of Cornell University, Department of Psychiatry, New York, New York 10021, USA
    J Nerv Ment Dis 190:3-9. 2002
    ..The economic and public health benefits both point toward the value of such an intervention for disability claimants...
  63. ncbi ACNP Task Force report on SSRIs and suicidal behavior in youth
    J John Mann
    Columbia University New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 31:473-92. 2006
    ....
  64. ncbi Prevention of missing data in clinical research studies
    Stephen R Wisniewski
    Epidemiology Data Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Biol Psychiatry 59:997-1000. 2006
    ..Despite efforts devoted to areas, no study is without missing data. Once the study is completed, it is essential to assess the pattern of missing data and apply the appropriate statistical analysis...
  65. ncbi The prospectively observed course of illness among depressed patients who commit suicide
    William Coryell
    Department of Psychiatry, University of Iowa, Iowa City 52242 1000, USA
    Acta Psychiatr Scand 105:218-23. 2002
    ..These analyses were conducted to describe the course of illness among patients with major affective disorders who commit suicide...
  66. ncbi Can interpersonal loss precipitate panic disorder?
    Barbara Milrod
    Am J Psychiatry 161:758-9. 2004
  67. ncbi Opiates, cocaine and alcohol combinations in accidental drug overdose deaths in New York City, 1990-98
    Phillip O Coffin
    Center for Urban Epidemiologic Studies, New York Academy of Medicine, New York 10029, USA
    Addiction 98:739-47. 2003
    ..Multi-drug use has been documented as a key risk factor in overdose and overdose mortality in several studies. This study investigated the contribution of multiple drug combinations to overdose mortality trends...