A C Leon

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi Prospective study of fluoxetine treatment and suicidal behavior in affectively ill subjects
    A C Leon
    NIMH Collaborative Depression Study, USA
    Am J Psychiatry 156:195-201. 1999
  2. ncbi Can placebo controls reduce the number of nonresponders in clinical trials? A power-analytic perspective
    A C Leon
    Department of Psychiatry, Weill Medical College of Cornell University, New York, New York 10021, USA
    Clin Ther 23:596-603. 2001
  3. ncbi A dynamic adaptation of the propensity score adjustment for effectiveness analyses of ordinal doses of treatment
    A C Leon
    Cornell University Medical College, Department of Psychiatry, Box 140, 525 East 68th Street, New York, NY 10021, USA
    Stat Med 20:1487-98. 2001
  4. ncbi Does incomplete recovery from first lifetime major depressive episode herald a chronic course of illness?
    L L Judd
    Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0603, USA
    Am J Psychiatry 157:1501-4. 2000
  5. ncbi Open trial of psychodynamic psychotherapy for panic disorder: a pilot study
    B Milrod
    Department of Psychiatry, Joan and Sanford I Weill Medical College, Cornell University, New York, NY 10021, USA
    Am J Psychiatry 157:1878-80. 2000
  6. ncbi False positive results: a challenge for psychiatric screening in primary care
    A C Leon
    Department of Psychiatry, Cornell University Medical College, NY 10021, USA
    Am J Psychiatry 154:1462-4. 1997
  7. ncbi Charting patients' course: a comparison of statistics used to summarize patient course in longitudinal and repeated measures studies
    S Arndt
    Department of Psychiatry, University of Iowa, Iowa City, IA 52242 1000, USA
    J Psychiatr Res 34:105-13. 2000
  8. ncbi Violence by patients admitted to a private psychiatric hospital
    K Tardiff
    Department of Psychiatry, Cornell University Medical College, New York, NY 10021, USA
    Am J Psychiatry 154:88-93. 1997
  9. pmc Do risk factors for suicidal behavior differ by affective disorder polarity?
    J G Fiedorowicz
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Psychol Med 39:763-71. 2009
  10. ncbi Correlates of suicidal ideation in dysphoric mania
    J F Goldberg
    Weill Medical College of Cornell University, New York, NY, USA
    J Affect Disord 56:75-81. 1999

Detail Information

Publications80

  1. ncbi Prospective study of fluoxetine treatment and suicidal behavior in affectively ill subjects
    A C Leon
    NIMH Collaborative Depression Study, USA
    Am J Psychiatry 156:195-201. 1999
    ..There has been speculation in the literature about a link between fluoxetine use and suicidal behavior. The authors of this study hypothesized that there is no elevation in risk of suicidal behavior associated with use of fluoxetine...
  2. ncbi Can placebo controls reduce the number of nonresponders in clinical trials? A power-analytic perspective
    A C Leon
    Department of Psychiatry, Weill Medical College of Cornell University, New York, New York 10021, USA
    Clin Ther 23:596-603. 2001
    ..For that reason, substantially fewer subjects need to be enrolled in placebo-controlled trials; consequently, there tend to be far fewer nonresponders in placebo-controlled trials...
  3. ncbi A dynamic adaptation of the propensity score adjustment for effectiveness analyses of ordinal doses of treatment
    A C Leon
    Cornell University Medical College, Department of Psychiatry, Box 140, 525 East 68th Street, New York, NY 10021, USA
    Stat Med 20:1487-98. 2001
    ..The strategy that is applied here to an observational study of affective illness can also be used to evaluate the effectiveness of treatments for other chronic illnesses...
  4. ncbi Does incomplete recovery from first lifetime major depressive episode herald a chronic course of illness?
    L L Judd
    Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0603, USA
    Am J Psychiatry 157:1501-4. 2000
    ..This study investigated the influence of incomplete recovery from first lifetime major depressive episodes on long-term outcome...
  5. ncbi Open trial of psychodynamic psychotherapy for panic disorder: a pilot study
    B Milrod
    Department of Psychiatry, Joan and Sanford I Weill Medical College, Cornell University, New York, NY 10021, USA
    Am J Psychiatry 157:1878-80. 2000
    ..This report contains preliminary data from an open trial of brief psychodynamic psychotherapy for panic disorder...
  6. ncbi False positive results: a challenge for psychiatric screening in primary care
    A C Leon
    Department of Psychiatry, Cornell University Medical College, NY 10021, USA
    Am J Psychiatry 154:1462-4. 1997
    ..The goal of this study was to characterize primary care patients with false positive results on screens for mental disorders...
  7. ncbi Charting patients' course: a comparison of statistics used to summarize patient course in longitudinal and repeated measures studies
    S Arndt
    Department of Psychiatry, University of Iowa, Iowa City, IA 52242 1000, USA
    J Psychiatr Res 34:105-13. 2000
    ..Kendall's tau appears to offer more statistical power to detect change in course, yet its average type I error rate was comparable to the other indices...
  8. ncbi Violence by patients admitted to a private psychiatric hospital
    K Tardiff
    Department of Psychiatry, Cornell University Medical College, New York, NY 10021, USA
    Am J Psychiatry 154:88-93. 1997
    ....
  9. pmc Do risk factors for suicidal behavior differ by affective disorder polarity?
    J G Fiedorowicz
    Department of Psychiatry, Roy J and Lucille A Carver College of Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Psychol Med 39:763-71. 2009
    ..The influence of affective disorder polarity on subsequent suicide attempts or completions and any differential effect of suicide risk factors by polarity were assessed in a prospective cohort...
  10. ncbi Correlates of suicidal ideation in dysphoric mania
    J F Goldberg
    Weill Medical College of Cornell University, New York, NY, USA
    J Affect Disord 56:75-81. 1999
    ..To elucidate the relationship between suicidal ideation and dysphoric mania, we analyzed clinical and demographic features associated with suicidal versus nonsuicidal dysphoric manic inpatients...
  11. ncbi Measuring onset of antidepressant action in clinical trials: an overview of definitions and methodology
    A C Leon
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Clin Psychiatry 62:12-6; discussion 37-40. 2001
    ..Methods for measuring symptom severity changes over time also will be reviewed...
  12. ncbi Suicidal ideation in primary care
    M Olfson
    Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    J Gen Intern Med 11:447-53. 1996
    ..CONCLUSIONS: In these primary care patients, suicidal ideation is strongly associated with mental disorder and mental health-related functional impairment, and can be detected with a single self-report "feeling suicidal" item...
  13. ncbi Lithium and suicidal behavior in major affective disorder: a case-control study
    W Coryell
    Department of Psychiatry, University of Iowa, Iowa City, 52242-1000, USA
    Acta Psychiatr Scand 104:193-7. 2001
    ..Other existing datasets should be explored with this design to establish whether lithium does, or does not, offer special protection against suicide...
  14. ncbi Preliminary evidence of impaired thinking in sick patients
    E J Cassell
    Joan and Sanford I Weill College of Medicine of Cornell University, New York, New York, USA
    Ann Intern Med 134:1120-3. 2001
    ..Earlier anecdotal observations suggested to us that certain aspects of judgment in sick adults approximate the thinking of children...
  15. ncbi Ambient temperature and mortality from unintentional cocaine overdose
    P M Marzuk
    Department of Psychiatry, Cornell University Medical College, New York, NY 10021, USA
    JAMA 279:1795-800. 1998
    ..Hot weather taxes cardiovascular function and is associated with increased deaths from heart disease. Cocaine can cause hypertension, tachycardia, coronary vasospasm, arrhythmias, and increased core temperature...
  16. ncbi Maintenance desipramine for dysthymia: a placebo-controlled study
    N L Miller
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10128, USA
    J Affect Disord 64:231-7. 2001
    ..This study examines the efficacy of maintenance pharmacotherapy in dysthymia without concurrent major depression, i.e. 'pure dysthymia'. No published data exist on this topic...
  17. ncbi An ideal trial to test differential onset of antidepressant effect
    A C Leon
    Department of Biostatistics in Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Clin Psychiatry 62:34-6; discussion 37-40. 2001
    ....
  18. ncbi The development and evaluation of the brief depression screen in medically ill disability claimants
    A C Leon
    Weill Medical College of Cornell University, Department of Psychiatry, New York, NY 10021, USA
    Int J Psychiatry Med 31:389-400. 2001
    ....
  19. doi Challenges in designing comparative-effectiveness trials for antidepressants
    A C Leon
    Department of Psychiatry, Weill Cornell Medical College, New York, New York, USA
    Clin Pharmacol Ther 91:165-7. 2012
    ..NI hypothesis testing, on the other hand, requires an a priori NI margin and evidence of trial assay sensitivity. Either design demands unusually large samples, which could render such trials infeasible...
  20. ncbi Executive functioning in depressed patients with suicidal ideation
    P M Marzuk
    Department of Psychiatry, Weill Medical College, Cornell University, New York, NY 10021, USA pmmarzuk2med cornell edu
    Acta Psychiatr Scand 112:294-301. 2005
    ....
  21. ncbi Brief screens for mental disorders in primary care
    A C Leon
    Department of Psychiatry, Cornell University Medical College, New York, NY 10021, USA
    J Gen Intern Med 11:426-30. 1996
    ..They detected previously unrecognized cases in this study and may prove to be valuable tools for psychiatric diagnosis in primary care...
  22. pmc A pilot open trial of brief psychodynamic psychotherapy for panic disorder
    B Milrod
    Weill Medical College of Cornell University, Payne Whitney Clinic, New York, NY 10021, USA
    J Psychother Pract Res 10:239-45. 2001
    ..This report was prepared specifically to describe 6-month follow-up on these patients. Psychodynamic psychotherapy appears to be a promising nonpharmacological treatment for panic disorder...
  23. ncbi Psychosocial disability in the course of bipolar I and II disorders: a prospective, comparative, longitudinal study
    Lewis L Judd
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    Arch Gen Psychiatry 62:1322-30. 2005
    ..Evidence of psychosocial disability in bipolar disorder is based primarily on bipolar I disorder (BP-I) and does not relate disability to affective symptom severity and polarity or to bipolar II disorder (BP-II)...
  24. ncbi Antidepressants and youth suicide in New York City, 1999-2002
    Andrew C Leon
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Am Acad Child Adolesc Psychiatry 45:1054-8. 2006
    ..To determine the proportion of youth suicides in New York City from 1999 to 2002 in which antidepressants were detected at autopsy...
  25. ncbi Assessment of outcome in depression
    J Craig Nelson
    Department of Psychiatry, University of California, San Francisco, CA, USA
    J Psychopharmacol 20:47-53. 2006
    ..And we review studies that have identified 'core' symptoms of depression and compare these findings to the magnitude of individual symptom change we found in five studies of selective serotonergic or nonadrenergic antidepressants...
  26. ncbi The naturalistic course of unipolar major depression in the absence of somatic therapy
    Michael A Posternak
    Brown University School of Medicine, Department of Psychiatry and Human Behavior, Providence, Rhode Island, USA
    J Nerv Ment Dis 194:324-9. 2006
    ..Because treatment-seeking behavior is known to be associated with a worse prognosis, 23 weeks probably represents a lower-limit approximation of the median duration of an untreated depressive episode...
  27. ncbi The face behind the mask: a developmental study
    Nim Tottenham
    Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, USA
    Dev Sci 9:288-94. 2006
    ....
  28. ncbi Distinguishing bipolar major depression from unipolar major depression with the screening assessment of depression-polarity (SAD-P)
    David A Solomon
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA
    J Clin Psychiatry 67:434-42. 2006
    ..The goal of this study was to develop and validate a brief instrument to screen for bipolar disorder in patients actively ill with major depression...
  29. ncbi Attrition in randomized controlled clinical trials: methodological issues in psychopharmacology
    Andrew C Leon
    Department of Psychiatry, Weill Medical College, Cornell University, New York, New York 10021, USA
    Biol Psychiatry 59:1001-5. 2006
    ..This information can be used to eliminate some of the very obstacles that lead to attrition, and can be incorporated in data analyses to reduce bias, but it will not eliminate all attrition bias...
  30. ncbi Psychopathology of panic attacks in panic disorder
    E H Uhlenhuth
    Department of Psychiatry, MSC09 5030, 1 University of New Mexico, Albuquerque, 87131 0001, USA
    J Affect Disord 92:55-62. 2006
    ..limited symptom; spontaneous vs. situational) and between these subtypes, panic disorder subtypes, and other characteristics of panic disorder, especially agoraphobia...
  31. ncbi Residual symptoms in depressed patients after treatment with fluoxetine or reboxetine
    J Craig Nelson
    Department of Psychiatry, University of California San Francisco, 401 Parnassus Avenue, PO Box 0984 F, San Francisco, CA 94143, USA
    J Clin Psychiatry 66:1409-14. 2005
    ..We examined the frequency and severity of residual depressive symptoms in 2 studies comparing the selective serotonin reuptake inhibitor (SSRI) fluoxetine with the norepinephrine reuptake inhibitor (NRI) reboxetine...
  32. ncbi Bias reduction in effectiveness analyses of longitudinal ordinal doses with a mixed-effects propensity adjustment
    Andrew C Leon
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Stat Med 26:110-23. 2007
    ..In addition, type I error rate and statistical power are examined. The approach is illustrated by applying it to a longitudinal, observational study of maintenance treatment of major depression...
  33. pmc Assessment of community functioning in people with schizophrenia and other severe mental illnesses: a white paper based on an NIMH-sponsored workshop
    Alan S Bellack
    University of Maryland School of Medicine, 737 West Lombard Street, Suite 551, Baltimore, MD 21201, USA
    Schizophr Bull 33:805-22. 2007
    ..This criterion is problematic because different observers and constituencies often have different opinions about what types of change are clinically important and how much change is significant...
  34. ncbi A comparison of mixed-effects quantile stratification propensity adjustment strategies for longitudinal treatment effectiveness analyses of continuous outcomes
    Andrew C Leon
    Department of Psychiatry, Cornell University, New York, NY, USA
    Stat Med 26:2650-65. 2007
    ..The approach is illustrated in an evaluation of the effectiveness of somatic treatments for major depression in a longitudinal, observational study of affective disorders...
  35. ncbi Statistical power of multiplicity adjustment strategies for correlated binary endpoints
    Andrew C Leon
    Department of Psychiatry, Weill Cornell Medical College, Box 140, 525 East 68th Street, New York, NY 10021, USA
    Stat Med 26:1712-23. 2007
    ..50; whereas the James procedure provides more statistical power with higher rho, the common correlation among the multiple outcomes. A study of gender differences in New York City homicides is used to illustrate the approaches...
  36. ncbi A randomized controlled clinical trial of psychoanalytic psychotherapy for panic disorder
    Barbara Milrod
    Weill Medical College of Cornell University, 525 East 68th St, New York, NY 10021, USA
    Am J Psychiatry 164:265-72. 2007
    ..To the authors' knowledge, this is the first efficacy randomized controlled clinical trial of panic-focused psychodynamic psychotherapy, a manualized psychoanalytical psychotherapy for patients with DSM-IV panic disorder...
  37. pmc Implications of clinical trial design on sample size requirements
    Andrew C Leon
    Weill Medical College of Cornell University, New York, NY 10065, USA
    Schizophr Bull 34:664-9. 2008
    ..The objective of this article is to consider strategies that overcome the problems of unreliability and multiplicity...
  38. doi Residual symptom recovery from major affective episodes in bipolar disorders and rapid episode relapse/recurrence
    Lewis L Judd
    Department of Psychiatry, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0603, USA
    Arch Gen Psychiatry 65:386-94. 2008
    ..Both bipolar disorder type I and type II are characterized by frequent affective episode relapse and/or recurrence. An increasingly important goal of therapy is reducing chronicity by preventing or delaying additional episodes...
  39. ncbi The revised warning for antidepressants and suicidality: unveiling the black box of statistical analyses
    Andrew C Leon
    Department of Psychiatry, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    Am J Psychiatry 164:1786-9. 2007
  40. ncbi Bias reduction with an adjustment for participants' intent to dropout of a randomized controlled clinical trial
    Andrew C Leon
    Weill Medical College of Cornell University, Department of Psychiatry, New York, NY 10021, USA
    Clin Trials 4:540-7. 2007
    ..Although likelihood-based statistical models such as mixed-effects models can accommodate incomplete data, the assumption of ignorable attrition is usually required for valid inferences...
  41. pmc Predicting recovery from episodes of major depression
    David A Solomon
    Department of Psychiatry and Human Behavior, The Warren Alpert Medical School of Brown University, Providence, RI 02903 4970, United States
    J Affect Disord 107:285-91. 2008
    ..This study examined psychosocial functioning as a predictor of recovery from episodes of unipolar major depression...
  42. ncbi A randomized trial of depression assessment intervention in home health care
    Martha L Bruce
    Department of Psychiatry, Weill Medical College of Cornell University, White Plains, New York, USA
    J Am Geriatr Soc 55:1793-800. 2007
    ..To determine whether an educational intervention would improve depression assessment and appropriate referral. Secondary analyses tested whether referral led to depression improvement...
  43. ncbi Antidepressants in adult suicides in New York City: 2001-2004
    Andrew C Leon
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Clin Psychiatry 68:1399-403. 2007
    ..Nearly all suicidality in those trials was nonfatal suicide attempts and ideation. Here, we consider whether antidepressants are linked with adult suicide deaths...
  44. ncbi The revised black box warning for antidepressants sets a public health experiment in motion
    Andrew C Leon
    Department of Psychiatry, Weill Cornell Medical College, New York, NY 10021, USA
    J Clin Psychiatry 68:1139-41. 2007
  45. pmc "Gray murder": characteristics of elderly compared with nonelderly homicide victims in New York City
    Robert C Abrams
    Department of Psychiatry, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY 10021, USA
    Am J Public Health 97:1666-70. 2007
    ....
  46. ncbi Do comorbid personality disorders moderate panic-focused psychotherapy? An exploratory examination of the American Psychiatric Association practice guideline
    Barbara L Milrod
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Clin Psychiatry 68:885-91. 2007
    ..No data underlie this recommendation. This exploratory study assessed the moderating effect of personality disorder on psychodynamic and non-psychodynamic psychotherapy outcome...
  47. pmc A placebo-controlled add-on trial of the Ampakine, CX516, for cognitive deficits in schizophrenia
    Donald C Goff
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuropsychopharmacology 33:465-72. 2008
    ..CX516 was not effective for cognition or for symptoms of schizophrenia when added to clozapine, olanzapine, or risperidone...
  48. ncbi Expanding the black box - depression, antidepressants, and the risk of suicide
    Richard A Friedman
    Psychopharmacology Clinic, Weill Cornell Medical College, New York, USA
    N Engl J Med 356:2343-6. 2007
  49. ncbi Antidepressant treatment patterns in a novel methadone maintenance clinic targeting young adults an observational study
    David W Galarneau
    Weill Medical College of Cornell University, New York, NY 10021, USA
    J Addict Dis 25:47-52. 2006
    ..e., general outpatient vs. methadone maintenance)...
  50. ncbi Are two antidepressant mechanisms better than one? Issues in clinical trial design and analysis
    Andrew C Leon
    Department of Psychiatry, Weill Medical College, Cornell University, New York, NY 10021, USA
    J Clin Psychiatry 65:31-6. 2004
    ..equivalence trial), and others are somewhat more discretionary (e.g., assessment tools, statistical procedures). Issues in the design and analysis of clinical trials comparing dual- and single-action antidepressants are discussed...
  51. ncbi The long-term natural history of the weekly symptomatic status of bipolar I disorder
    Lewis L Judd
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0603, USA
    Arch Gen Psychiatry 59:530-7. 2002
    ..To our knowledge, this is the first prospective natural history study of weekly symptomatic status of patients with bipolar I disorder (BP-I) during long-term follow-up...
  52. ncbi Sample-size requirements for comparisons of two groups on repeated observations of a binary outcome
    Andrew C Leon
    Weill Medical College of Cornell University, USA
    Eval Health Prof 27:34-44. 2004
    ....
  53. ncbi The course of depression in elderly patients
    Timothy I Mueller
    Brown University Medical School, Department of Psychiatry and Human Behavior, c o Butler Hospital, 345 Blackstone Blvd, Providence, RI 02906, USA
    Am J Geriatr Psychiatry 12:22-9. 2004
    ..Studies on the course of major depressive disorder (MDD) among elderly persons are limited to short periods of follow-up, seldom provide comparisons with younger cohorts, and raise other methodological concerns...
  54. ncbi Toward rapproachment in the placebo control debate. A calculated compromise of power
    Andrew C Leon
    Weill Medical College of Cornell University, USA
    Eval Health Prof 26:404-14. 2003
    ....
  55. ncbi Unipolar mania over the course of a 20-year follow-up study
    David A Solomon
    NIMH Collaborative Program on the Psychobiology of Depression Clinical Studies, at Mood Disorders Program, Department of Psychiatry, Rhode Island Hospital, 593 Eddy Street, Providence RI 02903 4970, USA
    Am J Psychiatry 160:2049-51. 2003
    ..Using data from a longitudinal study of the mood disorders, the investigators address the phenomenon of unipolar mania...
  56. ncbi The long-term course of rapid-cycling bipolar disorder
    William Coryell
    National Institute of Mental Health Collaborative Program on the Psychobiology of Depression Clinical Studies, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 60:914-20. 2003
    ..To our knowledge, no prospective study has, as yet, described the course of this phenomenon beyond 5 years...
  57. ncbi Role of antidepressants in murder and suicide
    Kenneth Tardiff
    Am J Psychiatry 159:1248-9. 2002
  58. ncbi Income distribution and risk of fatal drug overdose in New York City neighborhoods
    Sandro Galea
    Center for Urban Epidemiologic Studies, New York Academy of Medicine, New York 10024, USA
    Drug Alcohol Depend 70:139-48. 2003
    ..Disinvestment in social and economic resources in unequal neighborhoods may explain this association. Public health interventions related to overdose risk should pay particular attention to highly unequal neighborhoods...
  59. ncbi A 20-year longitudinal observational study of somatic antidepressant treatment effectiveness
    Andrew C Leon
    NIMH Collaborative Program on the Psychobiology of Depression, USA
    Am J Psychiatry 160:727-33. 2003
    ..This observational study examined the effectiveness of somatic antidepressant treatments as administered in the community...
  60. ncbi A prospective investigation of the natural history of the long-term weekly symptomatic status of bipolar II disorder
    Lewis L Judd
    Department of Psychiatry, University of California, San Diego, La Jolla 92093 0603, USA
    Arch Gen Psychiatry 60:261-9. 2003
    ..This is the first prospective longitudinal study, to our knowledge, of the natural history of the weekly symptomatic status of bipolar II disorder (BP-II)...
  61. ncbi Paroxetine, other antidepressants, and youth suicide in New York City: 1993 through 1998
    Andrew C Leon
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY10021, USA
    J Clin Psychiatry 65:915-8. 2004
    ....
  62. ncbi Psychosocial impairment and recurrence of major depression
    David A Solomon
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA
    Compr Psychiatry 45:423-30. 2004
    ..In patients who have recovered from an episode of major depression, the presence of psychosocial impairment may help identify who is at increased risk of recurrence...
  63. ncbi Multiplicity-adjusted sample size requirements: a strategy to maintain statistical power with Bonferroni adjustments
    Andrew C Leon
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Clin Psychiatry 65:1511-4. 2004
    ..Here, a simple strategy is described that adjusts alpha for multiple primary efficacy measures, yet maintains statistical power for each test...
  64. ncbi A comparison of multiplicity adjustment strategies for correlated binary endpoints
    Andrew C Leon
    Weill Cornell Medical College, Department of Psychiatry, New York 10021, USA
    J Biopharm Stat 15:839-55. 2005
    ..Analyses of data from a randomized controlled clinical trial of treatments for mania in bipolar disorder are used to illustrate the application of the multiplicity adjustments...
  65. ncbi Symptoms of late-life depression: frequency and change during treatment
    J Craig Nelson
    Dept of Psychiatry, University of California at San Francisco, 401 Parnassus Ave, Box 0984 F, San Francisco, CA 94143, USA
    Am J Geriatr Psychiatry 13:520-6. 2005
    ....
  66. ncbi Are there differences in the symptoms that respond to a selective serotonin or norepinephrine reuptake inhibitor?
    J Craig Nelson
    Department of Psychiatry, University of California San Francisco, San Francisco, California 94143, USA
    Biol Psychiatry 57:1535-42. 2005
    ....
  67. ncbi Performance of a mixed effects logistic regression model for binary outcomes with unequal cluster size
    Moonseong Heo
    Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY 10605, USA
    J Biopharm Stat 15:513-26. 2005
    ..This is illustrated using data from the Prevention Of Suicide in Primary care Elderly: Collaborative Trial (PROSPECT) study...
  68. pmc Preference for fall from height as a method of suicide by elderly residents of New York City
    Robert C Abrams
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY, USA
    Am J Public Health 95:1000-2. 2005
    ..Among persons who died by fall from height, those 65 or older were more likely than others to have fallen from buildings where they lived...
  69. pmc Drugs and firearm deaths in New York City, 1990-1998
    Sandro Galea
    Center for Urban Epidemiologic Studies, New York Academy of Medicine, New York, New York 10029, USA
    J Urban Health 79:70-86. 2002
    ..These results suggest a complex role of drugs in firearm-related deaths...
  70. ncbi A summary of the FDA-NIMH-MATRICS workshop on clinical trial design for neurocognitive drugs for schizophrenia
    Robert W Buchanan
    Maryland Psychiatric Research Center, P O Box 21247, Baltimore, MD 21228, USA
    Schizophr Bull 31:5-19. 2005
    ....
  71. ncbi Tachyphylaxis in unipolar major depressive disorder
    David A Solomon
    Department of Psychiatry and Human Behavior, Brown University, 593 Eddy Street, Providence, RI 02903, USA
    J Clin Psychiatry 66:283-90. 2005
    ..This study describes recurrence of major depression despite maintenance pharmacotherapy, termed tachyphylaxis...
  72. ncbi A mixed-effects quintile-stratified propensity adjustment for effectiveness analyses of ordered categorical doses
    Andrew C Leon
    Weill Medical College of Cornell University, Department of Psychiatry, New York, NY 10021, USA
    Stat Med 24:647-58. 2005
    ..This approach is a useful strategy for observational studies of treatment effectiveness. It is capable of adjusting for selection bias, incorporating multiple observations per subject, and comparing effectiveness of ordinal doses...
  73. ncbi Comparison of statistical methods for analysis of clustered binary observations
    Moonseong Heo
    Department of Psychiatry, Weill Medical College of Cornell University, Westchester Division, White Plains, NY 10605, USA
    Stat Med 24:911-23. 2005
    ....
  74. ncbi Suicide among New York City police officers, 1977-1996
    Peter M Marzuk
    Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Am J Psychiatry 159:2069-71. 2002
    ..The authors assessed the suicide rates of New York City police officers during a recent period...
  75. ncbi The prospectively observed course of illness among depressed patients who commit suicide
    William Coryell
    Department of Psychiatry, University of Iowa, Iowa City 52242 1000, USA
    Acta Psychiatr Scand 105:218-23. 2002
    ..These analyses were conducted to describe the course of illness among patients with major affective disorders who commit suicide...
  76. ncbi Opiates, cocaine and alcohol combinations in accidental drug overdose deaths in New York City, 1990-98
    Phillip O Coffin
    Center for Urban Epidemiologic Studies, New York Academy of Medicine, New York 10029, USA
    Addiction 98:739-47. 2003
    ..Multi-drug use has been documented as a key risk factor in overdose and overdose mortality in several studies. This study investigated the contribution of multiple drug combinations to overdose mortality trends...
  77. ncbi ACNP Task Force report on SSRIs and suicidal behavior in youth
    J John Mann
    Columbia University New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 31:473-92. 2006
    ....
  78. ncbi Can interpersonal loss precipitate panic disorder?
    Barbara Milrod
    Am J Psychiatry 161:758-9. 2004
  79. ncbi Prevention of missing data in clinical research studies
    Stephen R Wisniewski
    Epidemiology Data Center, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Biol Psychiatry 59:997-1000. 2006
    ..Despite efforts devoted to areas, no study is without missing data. Once the study is completed, it is essential to assess the pattern of missing data and apply the appropriate statistical analysis...
  80. ncbi Assessment and treatment of depression in disability claimants: a cost-benefit simulation study
    Andrew C Leon
    Weill Medical College of Cornell University, Department of Psychiatry, New York, New York 10021, USA
    J Nerv Ment Dis 190:3-9. 2002
    ..The economic and public health benefits both point toward the value of such an intervention for disability claimants...