Aparna Lakkaraju

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. pmc Itinerant exosomes: emerging roles in cell and tissue polarity
    Aparna Lakkaraju
    Margaret M Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Trends Cell Biol 18:199-209. 2008
  2. pmc It takes two to tango to the melanosome
    Aparna Lakkaraju
    Margaret M Dyson Vision Research Institute, Weill Medical College, Cornell University, New York, NY 10065, USA
    J Cell Biol 187:161-3. 2009
  3. ncbi request reprint Evolving endosomes: how many varieties and why?
    Emilie Perret
    Margaret Dyson Vision Research Institute, LC 300, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Curr Opin Cell Biol 17:423-34. 2005
  4. pmc The lipofuscin fluorophore A2E perturbs cholesterol metabolism in retinal pigment epithelial cells
    Aparna Lakkaraju
    Margaret M Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:11026-31. 2007
  5. pmc In vivo diffusion of lactoferrin in brain extracellular space is regulated by interactions with heparan sulfate
    Robert G Thorne
    Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 105:8416-21. 2008
  6. ncbi request reprint Low-density lipoprotein receptor-related protein mediates the endocytosis of anionic liposomes in neurons
    Aparna Lakkaraju
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 277:15085-92. 2002
  7. ncbi request reprint Cell biology: caught in the traffic
    Aparna Lakkaraju
    Nature 448:266-7. 2007

Research Grants

Collaborators

Detail Information

Publications7

  1. pmc Itinerant exosomes: emerging roles in cell and tissue polarity
    Aparna Lakkaraju
    Margaret M Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Trends Cell Biol 18:199-209. 2008
    ..In this review, we discuss new evidence suggesting that exosomes participate in the transport of morphogens and RNA, and thus influence cell polarity and developmental patterning of tissues...
  2. pmc It takes two to tango to the melanosome
    Aparna Lakkaraju
    Margaret M Dyson Vision Research Institute, Weill Medical College, Cornell University, New York, NY 10065, USA
    J Cell Biol 187:161-3. 2009
    ..1083/jcb.200907122) show that a close interaction between the clathrin adaptor AP-1 and a kinesin motor KIF13A is essential for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes and for organelle biogenesis...
  3. ncbi request reprint Evolving endosomes: how many varieties and why?
    Emilie Perret
    Margaret Dyson Vision Research Institute, LC 300, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Curr Opin Cell Biol 17:423-34. 2005
    ..The emerging picture from these studies is of a highly complex, dynamic and adaptable endosomal system that interacts at various points with the secretory system of the cell...
  4. pmc The lipofuscin fluorophore A2E perturbs cholesterol metabolism in retinal pigment epithelial cells
    Aparna Lakkaraju
    Margaret M Dyson Vision Research Institute, Department of Ophthalmology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 104:11026-31. 2007
    ..Our results provide direct evidence that A2E causes aberrant cholesterol metabolism in RPE cells which could likely contribute to AMD progression...
  5. pmc In vivo diffusion of lactoferrin in brain extracellular space is regulated by interactions with heparan sulfate
    Robert G Thorne
    Department of Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Proc Natl Acad Sci U S A 105:8416-21. 2008
    ..Quantifying ECM effects on diffusion will also aid in the modeling and design of drug delivery strategies for growth factors and viral vectors, some of which are likely to interact with heparan sulfate...
  6. ncbi request reprint Low-density lipoprotein receptor-related protein mediates the endocytosis of anionic liposomes in neurons
    Aparna Lakkaraju
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 277:15085-92. 2002
    ..Thus, constitutive endocytosis of anionic liposomes by LRP utilizes only one component, in contrast to the more involved heparan sulfate proteoglycan-LRP pathway implicated in the pathogenesis of Alzheimer's disease...
  7. ncbi request reprint Cell biology: caught in the traffic
    Aparna Lakkaraju
    Nature 448:266-7. 2007

Research Grants1

  1. Role of Cholesterol Homeostasis in Macular Degeneration
    Aparna Lakkaraju; Fiscal Year: 2006
    ....