Jorge R Kizer

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..Less is known about the predictive ability of anteroposterior LA diameter, a simpler measure of LA size obtained routinely during echocardiographic evaluation...

..Although elevated levels of adiponectin and inflammatory markers each predict mortality in older adults, the implications of their interdependent actions have not been examined...

..Whether these differences translate to better risk prediction will require meta-analytical approaches, as will determination of prognostic cutpoints...

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..Comprehensive and timely evaluation is essential to identify the potential emboligenic substrate, and, pending randomized trial data, to institute appropriate therapy based on best clinical judgment...

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..Risk stratification of these populations with multimarker models could enhance selection for aggressive medical or surgical approaches to prevention...

..Despite established insulin-sensitizing and antiatherogenic preclinical effects, epidemiological investigations of adiponectin have yielded conflicting findings, and its relationship with coronary heart disease (CHD) remains uncertain...

..We evaluated the relationship between MAC, AV sclerosis, and first stroke events in a population-based cohort...

..Whether such differences relate to distinct ambulatory pressure profiles or an ethnic propensity to cardiac hypertrophy requires further investigation...

..To delineate the associations of total adiponectin, high-molecular-weight (HMW) adiponectin, and the HMW-to-total adiponectin ratio with diabetes in older adults...

..Yet the accuracy of these models in contemporary interventional practice--characterized by the widespread use of stents and novel adjuvant pharmacotherapies--has not been sufficiently studied...

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..There are scant data on the correlates and prognostic value of MPI in a population without overt cardiovascular (CV) disease...

..Whether this relates to different proportions of high-molecular-weight (HMW) adiponectin is unknown...

..American Indians have high rates of stroke. Improved risk stratification could enhance prevention, but the ability of biochemical and echocardiographic markers of preclinical disease to improve stroke prediction is not well-defined...

..These findings support the utility of separate assessment of focal atherosclerosis and intimal-medial thickness in epidemiological studies, trials, and risk stratification protocols...

..The presence of LVH detected by these indices predicts increased cardiovascular (CV) events. Whether different indexations of LVH differ in their ability to predict excess risk is unknown...

..09 (95% CI: 0.99-1.21)). In conclusion, a higher WC is associated with an increased risk of HF independent of BMI in community-living older men and women...

..Data regarding the relative impacts of central and brachial pressures on left ventricular hypertrophy and geometry are limited...

..00, 1.76) among never smokers in good health. Greater BMI is associated with PAD in older persons who remain healthy and have never smoked. Normal weight maintenance may decrease PAD incidence and associated comorbidity in older age...

..We sought to confirm the association of fetuin-A with incident diabetes mellitus in older persons and to determine whether the association differs by age, sex, and race and among persons with cardiovascular disease (CVD)...

..We examined the demographic factors associated with RV morphology and function in a population-based multiethnic sample free of clinical cardiovascular disease...

..This study was designed to facilitate clinical use of central pulse pressure (PP). We sought to determine a value that might predict adverse outcome and thereby provide a target for assessment of intervention strategies...

..We have shown that increased cardiac output is related to both fat-free mass and fat mass in obesity...

..These findings support the role of proximal CAA as a direct mediator of the increased stroke risk associated with MAC...

..Although nonesterified fatty acids (NEFA) have been positively associated with coronary heart disease risk factors, limited and inconsistent data are available on the relation between NEFA and sudden cardiac death...

..To examine the relation of fatty acid-binding protein (FABP)4 and nonesterified fatty acids (NEFAs) to diabetes in older adults...

..However, the effect of physical activity on the RV in an older community-based population is unknown. Objectives: We studied the association between levels of physical activity in adults and RV mass and volumes...

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..To examine the association of plasma fatty acid-binding protein 4 (FABP4) with incident heart failure...

..The use of AIABs in those with RV dysfunction warrants further study...

..These findings support prospective examination of use of central blood pressure as a treatment target in future trials...

..Whether the prognostic significance of smaller post-procedural TnT elevations extends beyond the intermediate-term awaits further investigation...

..Sex hormones have effects on the left ventricle, but hormonal influences on the right ventricle (RV) are unknown...

..Further research is necessary to confirm this relationship and to explore the pathologic processes underlying, and potentially linking, these 2 conditions...

..This finding has important implications for evaluation and management in this patient population...

..Hemorrhage is associated with ischemic complications in cardiac patients. The nature of this relationship in surgical patients is unknown...

..One possible exception is patent foramen ovale, for which high-risk features may warrant anticoagulation or mechanical closure. Definitive recommendations for this and other findings await completion of ongoing clinical trials...

..76). No significant difference in outcomes between strategies was detected for a score > or =3. The TIMI risk score provides moderate incremental prognostic information in high-risk patients, during both short- and long-term follow-up...

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..017). In conclusion, MMP-9 and PAI-1 are associated with changes in RV structure and function which could be potentially related to a subclinical increase in pulmonary vascular resistance...

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..33) different from the atenolol group. These data suggest that losartan-based treatment is more effective than an atenolol-based treatment for patients with ISH and a high risk for stroke...

..The efficacy, tolerability, and convenience of losartan/HCTZ combination therapy may increase patient compliance and lower risk for stroke, a devastating outcome in patients with hypertension...

..There are few published data on the incidence of fatal and nonfatal stroke in American Indians. The aims of this observational study were to determine the incidence of stroke and to elucidate stroke risk factors among American Indians...

..Interactions among thrombophilias, thrombophilias and traditional cardiovascular risk factors, and thrombophilias and other potential cardiac sources of embolism will also be investigated. ..