Jorge R Kizer

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Clinical practice. Patent foramen ovale in young adults with unexplained stroke
    Jorge R Kizer
    Department of Medicine, Weill Medical College of Cornell University, New York, USA
    N Engl J Med 353:2361-72. 2005
  2. pmc Lipoprotein-associated phospholipase A(2) mass and activity and risk of cardiovascular disease in a population with high prevalences of obesity and diabetes: the Strong Heart Study
    Jorge R Kizer
    Department of Medicine, Weill Cornell Medical Center, New York, New York, USA
    Diabetes Care 35:840-7. 2012
  3. ncbi request reprint Racial differences in the prevalence of cardiac sources of embolism in subjects with unexplained stroke or transient ischemic attack evaluated by transesophageal echocardiography
    Jorge R Kizer
    Division of Cardiology, Department of Medicine, Weill Cornell Medical College, New York, New York, USA
    Am J Cardiol 90:395-400. 2002
  4. ncbi request reprint Left atrial diameter as an independent predictor of first clinical cardiovascular events in middle-aged and elderly adults: the Strong Heart Study (SHS)
    Jorge R Kizer
    Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
    Am Heart J 151:412-8. 2006
  5. pmc Total and high-molecular-weight adiponectin and risk of incident diabetes in older people
    Jorge R Kizer
    Department of Medicine, Weill Cornell Medical College, New York, New York, USA
    Diabetes Care 35:415-23. 2012
  6. pmc Prognostic value of multiple biomarkers in American Indians free of clinically overt cardiovascular disease (from the Strong Heart Study)
    Jorge R Kizer
    Department of Medicine, Weill Cornell Medical Center, New York, NY, USA
    Am J Cardiol 104:247-53. 2009
  7. pmc Longitudinal changes in adiponectin and inflammatory markers and relation to survival in the oldest old: the Cardiovascular Health Study All Stars study
    Jorge R Kizer
    Department of Medicine, Weill Cornell Medical College, New York, New York, USA
    J Gerontol A Biol Sci Med Sci 66:1100-7. 2011
  8. pmc Adiponectin and risk of coronary heart disease in older men and women
    Jorge R Kizer
    Department of Medicine and Public Health, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Clin Endocrinol Metab 93:3357-64. 2008
  9. doi request reprint Evaluation of the patient with unexplained stroke
    Jorge R Kizer
    Department of Medicine, Weill Medical College of Cornell University, New York 10068, USA
    Coron Artery Dis 19:535-40. 2008
  10. pmc Measures of adiposity and future risk of ischemic stroke and coronary heart disease in older men and women
    Jorge R Kizer
    Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
    Am J Epidemiol 173:10-25. 2011

Research Grants

Detail Information

Publications53

  1. ncbi request reprint Clinical practice. Patent foramen ovale in young adults with unexplained stroke
    Jorge R Kizer
    Department of Medicine, Weill Medical College of Cornell University, New York, USA
    N Engl J Med 353:2361-72. 2005
  2. pmc Lipoprotein-associated phospholipase A(2) mass and activity and risk of cardiovascular disease in a population with high prevalences of obesity and diabetes: the Strong Heart Study
    Jorge R Kizer
    Department of Medicine, Weill Cornell Medical Center, New York, New York, USA
    Diabetes Care 35:840-7. 2012
    ....
  3. ncbi request reprint Racial differences in the prevalence of cardiac sources of embolism in subjects with unexplained stroke or transient ischemic attack evaluated by transesophageal echocardiography
    Jorge R Kizer
    Division of Cardiology, Department of Medicine, Weill Cornell Medical College, New York, New York, USA
    Am J Cardiol 90:395-400. 2002
    ....
  4. ncbi request reprint Left atrial diameter as an independent predictor of first clinical cardiovascular events in middle-aged and elderly adults: the Strong Heart Study (SHS)
    Jorge R Kizer
    Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
    Am Heart J 151:412-8. 2006
    ..Less is known about the predictive ability of anteroposterior LA diameter, a simpler measure of LA size obtained routinely during echocardiographic evaluation...
  5. pmc Total and high-molecular-weight adiponectin and risk of incident diabetes in older people
    Jorge R Kizer
    Department of Medicine, Weill Cornell Medical College, New York, New York, USA
    Diabetes Care 35:415-23. 2012
    ..To delineate the associations of total adiponectin, high-molecular-weight (HMW) adiponectin, and the HMW-to-total adiponectin ratio with diabetes in older adults...
  6. pmc Prognostic value of multiple biomarkers in American Indians free of clinically overt cardiovascular disease (from the Strong Heart Study)
    Jorge R Kizer
    Department of Medicine, Weill Cornell Medical Center, New York, NY, USA
    Am J Cardiol 104:247-53. 2009
    ..Risk stratification of these populations with multimarker models could enhance selection for aggressive medical or surgical approaches to prevention...
  7. pmc Longitudinal changes in adiponectin and inflammatory markers and relation to survival in the oldest old: the Cardiovascular Health Study All Stars study
    Jorge R Kizer
    Department of Medicine, Weill Cornell Medical College, New York, New York, USA
    J Gerontol A Biol Sci Med Sci 66:1100-7. 2011
    ..Although elevated levels of adiponectin and inflammatory markers each predict mortality in older adults, the implications of their interdependent actions have not been examined...
  8. pmc Adiponectin and risk of coronary heart disease in older men and women
    Jorge R Kizer
    Department of Medicine and Public Health, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Clin Endocrinol Metab 93:3357-64. 2008
    ..Despite established insulin-sensitizing and antiatherogenic preclinical effects, epidemiological investigations of adiponectin have yielded conflicting findings, and its relationship with coronary heart disease (CHD) remains uncertain...
  9. doi request reprint Evaluation of the patient with unexplained stroke
    Jorge R Kizer
    Department of Medicine, Weill Medical College of Cornell University, New York 10068, USA
    Coron Artery Dis 19:535-40. 2008
    ..Comprehensive and timely evaluation is essential to identify the potential emboligenic substrate, and, pending randomized trial data, to institute appropriate therapy based on best clinical judgment...
  10. pmc Measures of adiposity and future risk of ischemic stroke and coronary heart disease in older men and women
    Jorge R Kizer
    Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
    Am J Epidemiol 173:10-25. 2011
    ..Whether these differences translate to better risk prediction will require meta-analytical approaches, as will determination of prognostic cutpoints...
  11. pmc Relation of different measures of low-density lipoprotein cholesterol to risk of coronary artery disease and death in a meta-regression analysis of large-scale trials of statin therapy
    Jorge R Kizer
    Department of Medicine, Weill Cornell Medical College, New York, NY, USA
    Am J Cardiol 105:1289-96. 2010
    ....
  12. ncbi request reprint Mitral annular calcification, aortic valve sclerosis, and incident stroke in adults free of clinical cardiovascular disease: the Strong Heart Study
    Jorge R Kizer
    Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
    Stroke 36:2533-7. 2005
    ..We evaluated the relationship between MAC, AV sclerosis, and first stroke events in a population-based cohort...
  13. pmc Change in circulating adiponectin in advanced old age: determinants and impact on physical function and mortality. The Cardiovascular Health Study All Stars Study
    Jorge R Kizer
    Department of Medicine, Weill Cornell Medical College, New York, USA
    J Gerontol A Biol Sci Med Sci 65:1208-14. 2010
    ....
  14. ncbi request reprint Limitations of current risk-adjustment models in the era of coronary stenting
    Jorge R Kizer
    Division of Cardiology, Department of Medicine, Weill Medical College, Cornell University, New York, NY, USA
    Am Heart J 145:683-92. 2003
    ..Yet the accuracy of these models in contemporary interventional practice--characterized by the widespread use of stents and novel adjuvant pharmacotherapies--has not been sufficiently studied...
  15. ncbi request reprint Differences in left ventricular structure between black and white hypertensive adults: the Hypertension Genetic Epidemiology Network study
    Jorge R Kizer
    Division of Cardiology, Weill Medical College of Cornell University, New York, USA
    Hypertension 43:1182-8. 2004
    ..Whether such differences relate to distinct ambulatory pressure profiles or an ethnic propensity to cardiac hypertrophy requires further investigation...
  16. ncbi request reprint Stroke reduction in hypertensive adults with cardiac hypertrophy randomized to losartan versus atenolol: the Losartan Intervention For Endpoint reduction in hypertension study
    Jorge R Kizer
    Weill Medical College of Cornell University, New York, NY, USA
    Hypertension 45:46-52. 2005
    ....
  17. ncbi request reprint Utility of the myocardial performance index in a population with high prevalences of obesity, diabetes, and hypertension: the strong heart study
    Rakesh K Mishra
    Weill Medical College of Cornell University, New York, New York, USA
    Echocardiography 24:340-7. 2007
    ..There are scant data on the correlates and prognostic value of MPI in a population without overt cardiovascular (CV) disease...
  18. pmc Total and high-molecular-weight adiponectin and risk of coronary heart disease and ischemic stroke in older adults
    Jorge R Kizer
    Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    J Clin Endocrinol Metab 98:255-63. 2013
    ..Whether this relates to different proportions of high-molecular-weight (HMW) adiponectin is unknown...
  19. pmc Incremental value of biochemical and echocardiographic measures in prediction of ischemic stroke: the Strong Heart Study
    Maria G Karas
    Weill Cornell Medical College, New York, NY, USA
    Stroke 43:720-6. 2012
    ..American Indians have high rates of stroke. Improved risk stratification could enhance prevention, but the ability of biochemical and echocardiographic markers of preclinical disease to improve stroke prediction is not well-defined...
  20. pmc Vascular biomarkers in the prediction of clinical cardiovascular disease: the Strong Heart Study
    Mary J Roman
    Division of Cardiology, Weill Cornell Medical College, 525 East 68th Street, New York, NY 10021, USA
    Hypertension 59:29-35. 2012
    ..These findings support the utility of separate assessment of focal atherosclerosis and intimal-medial thickness in epidemiological studies, trials, and risk stratification protocols...
  21. ncbi request reprint Normalization for body size and population-attributable risk of left ventricular hypertrophy: the Strong Heart Study
    Giovanni de Simone
    Division of Cardiology, The New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
    Am J Hypertens 18:191-6. 2005
    ..The presence of LVH detected by these indices predicts increased cardiovascular (CV) events. Whether different indexations of LVH differ in their ability to predict excess risk is unknown...
  22. pmc Adiposity and incident heart failure in older adults: the cardiovascular health study
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 20:1936-41. 2012
    ..09 (95% CI: 0.99-1.21)). In conclusion, a higher WC is associated with an increased risk of HF independent of BMI in community-living older men and women...
  23. doi request reprint Relations of central and brachial blood pressure to left ventricular hypertrophy and geometry: the Strong Heart Study
    Mary J Roman
    Division of Cardiology, Weill Cornell Medical College, New York 10021, USA
    J Hypertens 28:384-8. 2010
    ..Data regarding the relative impacts of central and brachial pressures on left ventricular hypertrophy and geometry are limited...
  24. pmc Association of body mass index with peripheral arterial disease in older adults: the Cardiovascular Health Study
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego and San Diego VA HealthCare System, San Diego, CA 92161, USA
    Am J Epidemiol 174:1036-43. 2011
    ..00, 1.76) among never smokers in good health. Greater BMI is associated with PAD in older persons who remain healthy and have never smoked. Normal weight maintenance may decrease PAD incidence and associated comorbidity in older age...
  25. pmc Association of fetuin-a with incident diabetes mellitus in community-living older adults: the cardiovascular health study
    Joachim H Ix
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego VA Healthcare System, San Diego, CA 92161, USA
    Circulation 125:2316-22. 2012
    ..We sought to confirm the association of fetuin-A with incident diabetes mellitus in older persons and to determine whether the association differs by age, sex, and race and among persons with cardiovascular disease (CVD)...
  26. pmc Sex and race differences in right ventricular structure and function: the multi-ethnic study of atherosclerosis-right ventricle study
    Steven M Kawut
    Penn Cardiovascular Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Circulation 123:2542-51. 2011
    ..We examined the demographic factors associated with RV morphology and function in a population-based multiethnic sample free of clinical cardiovascular disease...
  27. pmc High central pulse pressure is independently associated with adverse cardiovascular outcome the strong heart study
    Mary J Roman
    Weill Cornell Medical College, New York, New York 10021, USA
    J Am Coll Cardiol 54:1730-4. 2009
    ..This study was designed to facilitate clinical use of central pulse pressure (PP). We sought to determine a value that might predict adverse outcome and thereby provide a target for assessment of intervention strategies...
  28. pmc Fatty acid-binding protein 4 and incident heart failure: the Cardiovascular Health Study
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, and Boston Veterans Affairs Healthcare System, Boston, MA 02120, USA
    Eur J Heart Fail 15:394-9. 2013
    ..To examine the association of plasma fatty acid-binding protein 4 (FABP4) with incident heart failure...
  29. pmc Relation between mitral annular calcium and complex aortic atheroma in patients with cerebral ischemia referred for transesophageal echocardiography
    Maria G Karas
    Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
    Am J Cardiol 99:1306-11. 2007
    ..These findings support the role of proximal CAA as a direct mediator of the increased stroke risk associated with MAC...
  30. ncbi request reprint Body composition and fat distribution influence systemic hemodynamics in the absence of obesity: the HyperGEN Study
    Giovanni de Simone
    Department of Medicine, The New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, NY, USA
    Am J Clin Nutr 81:757-61. 2005
    ..We have shown that increased cardiac output is related to both fat-free mass and fat mass in obesity...
  31. pmc Nonesterified fatty acids and risk of sudden cardiac death in older adults
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School and Boston Veterans Affairs Healthcare System, Boston, MA 02120, USA
    Circ Arrhythm Electrophysiol 5:273-8. 2012
    ..Although nonesterified fatty acids (NEFA) have been positively associated with coronary heart disease risk factors, limited and inconsistent data are available on the relation between NEFA and sudden cardiac death...
  32. doi request reprint Relations of Plasma Total and High-Molecular-Weight Adiponectin to New-Onset Heart Failure in Adults ≥65 Years of Age (from the Cardiovascular Health Study)
    Maria G Karas
    Department of Medicine, Weill Cornell Medical College, New York, New York
    Am J Cardiol 113:328-34. 2014
    ..High levels of adiponectin may mark or mediate age-related processes that lead to HF in older adults. ..
  33. pmc Plasma fatty acid-binding protein 4, nonesterified fatty acids, and incident diabetes in older adults
    Luc Djousse
    Division of Aging, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 35:1701-7. 2012
    ..To examine the relation of fatty acid-binding protein (FABP)4 and nonesterified fatty acids (NEFAs) to diabetes in older adults...
  34. pmc Physical activity and right ventricular structure and function. The MESA-Right Ventricle Study
    Carrie P Aaron
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Am J Respir Crit Care Med 183:396-404. 2011
    ..However, the effect of physical activity on the RV in an older community-based population is unknown. Objectives: We studied the association between levels of physical activity in adults and RV mass and volumes...
  35. ncbi request reprint Phage display identification of age-associated TNFalpha-mediated cardiac oxidative induction
    Jay M Edelberg
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    Physiol Genomics 18:255-60. 2004
    ....
  36. pmc The renin-angiotensin system and right ventricular structure and function: The MESA-Right Ventricle Study
    Corey E Ventetuolo
    Department of Medicine, and Health Services Policy and Practice, Alpert Medical School of Brown University, Providence, Rhode Island, USA
    Pulm Circ 2:379-86. 2012
    ..The use of AIABs in those with RV dysfunction warrants further study...
  37. ncbi request reprint Central pressure more strongly relates to vascular disease and outcome than does brachial pressure: the Strong Heart Study
    Mary J Roman
    Division of Cardiology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Hypertension 50:197-203. 2007
    ..These findings support prospective examination of use of central blood pressure as a treatment target in future trials...
  38. ncbi request reprint Role of cardiac troponin T in the long-term risk stratification of patients undergoing percutaneous coronary intervention
    Jorge R Kizer
    Division of Cardiology, Department of Medicine and Public Health, Weill Medical College of Cornell University, New York, NY, USA
    Eur Heart J 24:1314-22. 2003
    ..To investigate the long-term prognostic significance of pre- and post-procedure troponin T (TnT) elevations in patients undergoing percutaneous coronary intervention (PCI)...
  39. pmc Sex hormones are associated with right ventricular structure and function: The MESA-right ventricle study
    Corey E Ventetuolo
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Am J Respir Crit Care Med 183:659-67. 2011
    ..Sex hormones have effects on the left ventricle, but hormonal influences on the right ventricle (RV) are unknown...
  40. ncbi request reprint Association between pulmonary fibrosis and coronary artery disease
    Jorge R Kizer
    Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
    Arch Intern Med 164:551-6. 2004
    ..Moreover, fibrotic lung diseases exhibit systemic effects and have the potential to affect the vasculature beyond the lung. The existence of a relationship between the two, however, has not been studied...
  41. ncbi request reprint Yield of transesophageal echocardiography for nonbacterial thrombotic endocarditis and other cardiac sources of embolism in cancer patients with cerebral ischemia
    Tanya Dutta
    Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
    Am J Cardiol 97:894-8. 2006
    ..This finding has important implications for evaluation and management in this patient population...
  42. doi request reprint Association between major perioperative hemorrhage and stroke or Q-wave myocardial infarction
    Hooman Kamel
    Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, NY 10065, USA
    Circulation 126:207-12. 2012
    ..Hemorrhage is associated with ischemic complications in cardiac patients. The nature of this relationship in surgical patients is unknown...
  43. ncbi request reprint Usefulness of the TIMI risk score in predicting both short- and long-term outcomes in the Veterans Affairs Non-Q-Wave Myocardial Infarction Strategies In-Hospital (VANQWISH) Trial
    Frederick F Samaha
    Cardiovascular Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Cardiol 90:922-6. 2002
    ..76). No significant difference in outcomes between strategies was detected for a score > or =3. The TIMI risk score provides moderate incremental prognostic information in high-risk patients, during both short- and long-term follow-up...
  44. doi request reprint Cardiogenic and aortogenic brain embolism
    Eleni Doufekias
    Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
    J Am Coll Cardiol 51:1049-59. 2008
    ..One possible exception is patent foramen ovale, for which high-risk features may warrant anticoagulation or mechanical closure. Definitive recommendations for this and other findings await completion of ongoing clinical trials...
  45. doi request reprint Echocardiographic assessment of the right ventricle and associated hemodynamics
    Maria G Karas
    Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Prog Cardiovasc Dis 55:144-60. 2012
    ....
  46. ncbi request reprint Age-associated impairment in TNF-alpha cardioprotection from myocardial infarction
    Dongqing Cai
    Department of Medicine, Weill Medical College of Cornell University, 520 East 70th Street, A352, New York, NY 10021, USA
    Am J Physiol Heart Circ Physiol 285:H463-9. 2003
    ....
  47. pmc Matrix metalloproteinase-9 and plasminogen activator inhibitor-1 are associated with right ventricular structure and function: the MESA-RV Study
    Steven M Kawut
    Penn Cardiovascular Institute, Department of Medicine, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Biomarkers 15:731-8. 2010
    ..017). In conclusion, MMP-9 and PAI-1 are associated with changes in RV structure and function which could be potentially related to a subclinical increase in pulmonary vascular resistance...
  48. doi request reprint Management of the stroke patient with patent foramen ovale: new insights and persistent questions in the wake of recent randomized trials
    Jessica M Peña
    Division of Cardiology, Department of Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, 1825 Eastchester Road, Bronx, NY 10461, USA
    Curr Atheroscler Rep 15:338. 2013
    ..We review epidemiological evidence linking PFO and stroke and recent observational and randomized trial data evaluating different treatment strategies...
  49. pmc Fixed combination of losartan and hydrochlorothiazide and reduction of risk of stroke
    Sverre E Kjeldsen
    Department of Cardiology, Ullevaal University Hospital, N 0407 Oslo, Norway
    Vasc Health Risk Manag 3:299-305. 2007
    ..The efficacy, tolerability, and convenience of losartan/HCTZ combination therapy may increase patient compliance and lower risk for stroke, a devastating outcome in patients with hypertension...
  50. ncbi request reprint Regression of left ventricular hypertrophy: lodestar to stroke prevention in the treatment of hypertension?
    Jorge R Kizer
    Am J Hypertens 19:439-42. 2006
  51. ncbi request reprint The effects of losartan compared to atenolol on stroke in patients with isolated systolic hypertension and left ventricular hypertrophy. The LIFE study
    Sverre E Kjeldsen
    Department of Cardiology, Ullevaal University Hospital, Oslo, Norway
    J Clin Hypertens (Greenwich) 7:152-8. 2005
    ..33) different from the atenolol group. These data suggest that losartan-based treatment is more effective than an atenolol-based treatment for patients with ISH and a high risk for stroke...
  52. pmc Incidence and risk factors for stroke in American Indians: the Strong Heart Study
    Ying Zhang
    Center for American Indian Health Research, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    Circulation 118:1577-84. 2008
    ..There are few published data on the incidence of fatal and nonfatal stroke in American Indians. The aims of this observational study were to determine the incidence of stroke and to elucidate stroke risk factors among American Indians...
  53. ncbi request reprint Patent foramen ovale and cryptogenic stroke
    Jorge R Kizer
    Am J Med 120:e13; author reply e15. 2007

Research Grants1

  1. Thrombophilia In Cryptogenic Stroke (THICK) Study
    JORGE KIZER; Fiscal Year: 2006
    ..Interactions among thrombophilias, thrombophilias and traditional cardiovascular risk factors, and thrombophilias and other potential cardiac sources of embolism will also be investigated. ..