P A Karplus

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. pmc Experimentally observed conformation-dependent geometry and hidden strain in proteins
    P A Karplus
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Protein Sci 5:1406-20. 1996
  2. pmc Hydrophobicity regained
    P A Karplus
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Protein Sci 6:1302-7. 1997
  3. pmc The insect immune protein scolexin is a novel serine proteinase homolog
    C M Finnerty
    Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, New York 14853, USA
    Protein Sci 8:242-8. 1999
  4. ncbi request reprint Crystal structure of the catalytic domain of a thermophilic endocellulase
    M Spezio
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853
    Biochemistry 32:9906-16. 1993
  5. ncbi request reprint Structures of the Klebsiella aerogenes urease apoenzyme and two active-site mutants
    E Jabri
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Biochemistry 35:10616-26. 1996
  6. ncbi request reprint Crystal structure of thermostable family 5 endocellulase E1 from Acidothermus cellulolyticus in complex with cellotetraose
    J Sakon
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Biochemistry 35:10648-60. 1996
  7. ncbi request reprint Structure and mechanism of endo/exocellulase E4 from Thermomonospora fusca
    J Sakon
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Nat Struct Biol 4:810-8. 1997
  8. ncbi request reprint Novel fold and putative receptor binding site of granulocyte-macrophage colony-stimulating factor
    K Diederichs
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853
    Science 254:1779-82. 1991
  9. ncbi request reprint The crystal structure of urease from Klebsiella aerogenes
    E Jabri
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853, USA
    Science 268:998-1004. 1995
  10. ncbi request reprint Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain
    M A Pearson
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Cell 101:259-70. 2000

Collaborators

  • A Bretscher
  • C M Finnerty
  • J Sakon
  • E Jabri
  • M A Pearson
  • D Reczek
  • D B Wilson
  • D Irwin
  • M E Himmel
  • S R Thomas
  • M Spezio
  • W S Adney
  • M B Carr
  • R P Hausinger
  • K Diederichs
  • T Boone

Detail Information

Publications10

  1. pmc Experimentally observed conformation-dependent geometry and hidden strain in proteins
    P A Karplus
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Protein Sci 5:1406-20. 1996
    ....
  2. pmc Hydrophobicity regained
    P A Karplus
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Protein Sci 6:1302-7. 1997
    ....
  3. pmc The insect immune protein scolexin is a novel serine proteinase homolog
    C M Finnerty
    Boyce Thompson Institute for Plant Research, Cornell University, Ithaca, New York 14853, USA
    Protein Sci 8:242-8. 1999
    ..Most remarkable is the absence of a canonical activation peptide cleavage site. This suggests that the regulation of scolexin activity will involve a novel activation mechanism...
  4. ncbi request reprint Crystal structure of the catalytic domain of a thermophilic endocellulase
    M Spezio
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853
    Biochemistry 32:9906-16. 1993
    ....
  5. ncbi request reprint Structures of the Klebsiella aerogenes urease apoenzyme and two active-site mutants
    E Jabri
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Biochemistry 35:10616-26. 1996
    ....
  6. ncbi request reprint Crystal structure of thermostable family 5 endocellulase E1 from Acidothermus cellulolyticus in complex with cellotetraose
    J Sakon
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Biochemistry 35:10648-60. 1996
    ....
  7. ncbi request reprint Structure and mechanism of endo/exocellulase E4 from Thermomonospora fusca
    J Sakon
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Nat Struct Biol 4:810-8. 1997
    ..We also provide evidence that E4 has two novel characteristics: first it combines exo- and endo-activities and second, when it functions as an exo-cellulase, it cleaves off cellotetraose units...
  8. ncbi request reprint Novel fold and putative receptor binding site of granulocyte-macrophage colony-stimulating factor
    K Diederichs
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853
    Science 254:1779-82. 1991
    ..Residues implicated in receptor recognition, which are distant in the primary sequence, are on adjacent alpha helices in the folded protein. A working model for the receptor binding site is presented...
  9. ncbi request reprint The crystal structure of urease from Klebsiella aerogenes
    E Jabri
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853, USA
    Science 268:998-1004. 1995
    ..A surprisingly high structural similarity between the urease catalytic domain and that of the zinc-dependent adenosine deaminase reveals a remarkable example of active site divergence...
  10. ncbi request reprint Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain
    M A Pearson
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Cell 101:259-70. 2000
    ..This extended binding mode suggests a novel mechanism for how different signals could produce varying levels of activation. Sequence conservation suggests a similar regulation of the tumor suppressor merlin...