Barbara Hempstead

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. pmc Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction
    Agustín Anastasía
    Department of Medicine, Weill Cornell Medical College of Cornell University, 1300 York Avenue, New York, New York 10065, USA
    Nat Commun 4:2490. 2013
  2. pmc ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation
    Chia Jen Siao
    Division of Hematology Medical Oncology, Weill Cornell Medical College, New York, NY 10065, USA
    J Exp Med 209:2291-305. 2012
  3. ncbi request reprint Deciphering proneurotrophin actions
    B L Hempstead
    Department of Medicine, Weill Cornell Medical College, Room C610, 1300 York Ave, New York, NY, 10065, USA
    Handb Exp Pharmacol 220:17-32. 2014
  4. pmc Coupling neurotrophins to cell migration through selective guanine nucleotide exchange factor activation
    Barbara L Hempstead
    Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:5645-6. 2005
  5. ncbi request reprint The many faces of p75NTR
    Barbara L Hempstead
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    Curr Opin Neurobiol 12:260-7. 2002
  6. pmc Sculpting organ innervation
    Barbara L Hempstead
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 113:811-3. 2004
  7. pmc Commentary: Regulating proNGF action: multiple targets for therapeutic intervention
    Barbara L Hempstead
    Department of Medicine, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA
    Neurotox Res 16:255-60. 2009
  8. ncbi request reprint Dissecting the diverse actions of pro- and mature neurotrophins
    Barbara L Hempstead
    Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Curr Alzheimer Res 3:19-24. 2006
  9. ncbi request reprint Neurobiology. A glial spin on neurotrophins
    Barbara L Hempstead
    Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Science 298:1184-6. 2002
  10. ncbi request reprint ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin
    Henry K Teng
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 25:5455-63. 2005

Research Grants

  1. RECEPTOR-MEDIATED CONTROL OF CELL DIFFERENTIATION
    Barbara Hempstead; Fiscal Year: 2004
  2. Gordon Conference on Neurotrophic Factors (2003,2005)
    Barbara Hempstead; Fiscal Year: 2005
  3. RECEPTOR-MEDIATED CONTROL OF CELL DIFFERENTIATION
    Barbara Hempstead; Fiscal Year: 2005
  4. RECEPTOR-MEDIATED CONTROL OF CELL DIFFERENTIATION
    Barbara Hempstead; Fiscal Year: 2006
  5. RECEPTOR-MEDIATED CONTROL OF CELL DIFFERENTIATION
    Barbara Hempstead; Fiscal Year: 2007
  6. Regulating BDNF Action in Postnatal Development.
    Barbara Hempstead; Fiscal Year: 2009
  7. RECEPTOR-MEDIATED CONTROL OF CELL DIFFERENTIATION
    Barbara Hempstead; Fiscal Year: 2009
  8. Regulating BDNF Action in Postnatal Development.
    Barbara L Hempstead; Fiscal Year: 2010
  9. Regulating BDNF Action in Postnatal Development.
    Barbara Hempstead; Fiscal Year: 2009
  10. RECEPTOR-MEDIATED CONTROL OF CELL DIFFERENTIATION
    Barbara Hempstead; Fiscal Year: 2003

Collaborators

Detail Information

Publications48

  1. pmc Val66Met polymorphism of BDNF alters prodomain structure to induce neuronal growth cone retraction
    Agustín Anastasía
    Department of Medicine, Weill Cornell Medical College of Cornell University, 1300 York Avenue, New York, New York 10065, USA
    Nat Commun 4:2490. 2013
    ..Expression of p75(NTR) and differential engagement of the Met66 prodomain to the SorCS2 receptor are required for this effect. These results identify the Met66 prodomain as a new active ligand, which modulates neuronal morphology. ..
  2. pmc ProNGF, a cytokine induced after myocardial infarction in humans, targets pericytes to promote microvascular damage and activation
    Chia Jen Siao
    Division of Hematology Medical Oncology, Weill Cornell Medical College, New York, NY 10065, USA
    J Exp Med 209:2291-305. 2012
    ..Furthermore, deficiency in p75(NTR) limits infarct size after I-R. These studies identify novel, nonneuronal actions for proNGF and suggest that proNGF represents a new target to limit microvascular dysfunction...
  3. ncbi request reprint Deciphering proneurotrophin actions
    B L Hempstead
    Department of Medicine, Weill Cornell Medical College, Room C610, 1300 York Ave, New York, NY, 10065, USA
    Handb Exp Pharmacol 220:17-32. 2014
    ..Here, recent findings on the biological actions, regulation of expression, and pathophysiological effects of proneurotrophins will be reviewed. ..
  4. pmc Coupling neurotrophins to cell migration through selective guanine nucleotide exchange factor activation
    Barbara L Hempstead
    Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:5645-6. 2005
  5. ncbi request reprint The many faces of p75NTR
    Barbara L Hempstead
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    Curr Opin Neurobiol 12:260-7. 2002
    ....
  6. pmc Sculpting organ innervation
    Barbara L Hempstead
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 113:811-3. 2004
    ....
  7. pmc Commentary: Regulating proNGF action: multiple targets for therapeutic intervention
    Barbara L Hempstead
    Department of Medicine, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA
    Neurotox Res 16:255-60. 2009
    ..Multiple strategies that may act to limit proNGF action are considered as potential therapeutic targets for future development...
  8. ncbi request reprint Dissecting the diverse actions of pro- and mature neurotrophins
    Barbara L Hempstead
    Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Curr Alzheimer Res 3:19-24. 2006
    ....
  9. ncbi request reprint Neurobiology. A glial spin on neurotrophins
    Barbara L Hempstead
    Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Science 298:1184-6. 2002
  10. ncbi request reprint ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilin
    Henry K Teng
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 25:5455-63. 2005
    ..Together with our past findings, these data suggest that the neurotrophin family is capable of modulating diverse biological processes via differential processing of the proneurotrophins...
  11. pmc Neuronal release of proBDNF
    Jianmin Yang
    Department of Medicine, Weill Cornell Medical College, 1300 York Ave, New York, New York 10065, USA
    Nat Neurosci 12:113-5. 2009
    ..Thus, BDNF actions are developmentally regulated by secretion of proBDNF or mature BDNF and by local expression of p75 and TrkB...
  12. pmc Brain-derived neurotrophic factor: a newly described mediator of angiogenesis
    Pouneh Kermani
    Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, NY, NY 10021, USA
    Trends Cardiovasc Med 17:140-3. 2007
    ....
  13. pmc TrkB/BDNF signaling regulates photoreceptor progenitor cell fate decisions
    Brian A Turner
    Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, Room C606, New York, NY 10021, USA
    Dev Biol 299:455-65. 2006
    ..These studies suggest that TrkB signaling regulates commitment to and/or differentiation of photoreceptor cells from retinal progenitor cells, identifying a novel role for TrkB/BDNF in regulating cell fate decisions...
  14. ncbi request reprint Magnitude of stromal hemangiogenesis correlates with histologic subtype of non-Hodgkin's lymphoma
    Jia Ruan
    Center for Lymphoma and Myeloma, Division of Hematology Oncology, Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Clin Cancer Res 12:5622-31. 2006
    ..Here, we investigated whether stromal incorporation of CD68(+) hemangiogenic cells and alpha-smooth muscle actin(+) (alpha-SMA(+)) stromal cells correlates with neoangiogenesis and progression in human non-Hodgkin's lymphoma subtypes...
  15. ncbi request reprint Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin
    Oluwatoyin Shonukan
    Department of Medicine, Division of Hematology Oncology, University of Miami School of Medicine, Miami, FL 33136, USA
    Oncogene 22:3616-23. 2003
    ..These results suggest a causal role for NGF-mediated dephosphorylation of serine 39 on fascin in mediating actin binding and subsequent melanoma cell migration...
  16. pmc Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway
    Zhe Yu Chen
    Department of Psychiatry, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 25:6156-66. 2005
    ....
  17. ncbi request reprint A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survival
    Roger N Pearse
    Division of Hematology, Cornell University Medical College, Rm C 606, 1300 York Ave, New York, NY 10021, USA
    Blood 105:4429-36. 2005
    ..Finally, BDNF is expressed by malignant plasma cells isolated from a subset of patients with MM, as well as by most HMCLs, suggesting a potential role for this neurotrophin axis in autocrine as well as paracrine support of MM...
  18. pmc Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination
    Kevin G Bath
    Department of Psychiatry, Weill Medical College of Cornell University, New York, New York 10065, USA
    J Neurosci 28:2383-93. 2008
    ..Through these observations, we have identified novel links between genetic variant BDNF and adult neurogenesis in vivo, which may contribute to significant impairments in olfactory function...
  19. pmc Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior
    Zhe Yu Chen
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Science 314:140-3. 2006
    ..A variant BDNF may thus play a key role in genetic predispositions to anxiety and depressive disorders...
  20. pmc NRH2 is a trafficking switch to regulate sortilin localization and permit proneurotrophin-induced cell death
    Taeho Kim
    Graduate Program in Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
    EMBO J 28:1612-23. 2009
    ....
  21. pmc Understanding proneurotrophin actions: Recent advances and challenges
    Kenneth K Teng
    Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    Dev Neurobiol 70:350-9. 2010
    ..Here, we review emerging evidence for a novel transmembrane mechanism for ligand-specific p75(NTR) activation and several mechanisms by which p75(NTR)-dependent apoptotic and nonapoptotic responses can be selective activated...
  22. pmc Pro-NGF secreted by astrocytes promotes motor neuron cell death
    Marco Domeniconi
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Mol Cell Neurosci 34:271-9. 2007
    ..These results are consistent with a role for activated astrocytes and pro-NGF in the induction of motor neuron death and suggest a possible therapeutic target for the treatment of motor neuron disease...
  23. ncbi request reprint Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons
    Zhe Yu Chen
    Department of Psychiatry and Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 24:4401-11. 2004
    ....
  24. ncbi request reprint A novel p75 neurotrophin receptor-related protein, NRH2, regulates nerve growth factor binding to the TrkA receptor
    Simon S Murray
    Skirball Institute of Bimolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 24:2742-9. 2004
    ..Coexpression of NRH2 with TrkA receptors resulted in the formation of high-affinity binding sites for NGF. These results indicate that a transmembrane protein related to p75NTR is capable of modulating Trk receptor binding properties...
  25. pmc Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors
    Pouneh Kermani
    Division of Hematology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 115:653-63. 2005
    ....
  26. doi request reprint Formation of microvascular networks in vitro
    John P Morgan
    School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, USA
    Nat Protoc 8:1820-36. 2013
    ..After one-time microfabrication steps, the system can be assembled in less than 1 d and experiments can run for weeks. ..
  27. pmc Impact of genetic variant BDNF (Val66Met) on brain structure and function
    Zhe Yu Chen
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Novartis Found Symp 289:180-8; discussion 188-95. 2008
    ..A genetic variant BDNF may thus play a key role in genetic predispositions to anxiety and depressive disorders...
  28. ncbi request reprint Decreased neurotrophin TrkB receptor expression reduces lesion size in the apolipoprotein E-null mutant mouse
    Rosemary Kraemer
    Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Circulation 112:3644-53. 2005
    ....
  29. pmc Adenovirus vector E4 gene regulates connexin 40 and 43 expression in endothelial cells via PKA and PI3K signal pathways
    Fan Zhang
    Department of Genetic Medicine, Belfer Gene Therapy Core Facility of Weill Medical of Cornell University, New York, NY 10021, USA
    Circ Res 96:950-7. 2005
    ..Taken together, these results suggest that AdE4+ may play an important role in the regulation of Cx expression in ECs, and that these effects are mediated by both the PKA/CREB and PI3K signaling pathways...
  30. ncbi request reprint Activation of STAT5-dependent transcription by the neurotrophin receptor Trk
    Mathias Klein
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurobiol 63:159-71. 2005
    ..Together these results suggest that neurotrophins may regulate neuronal gene expression via STAT5 in a JAK2 independent manner...
  31. pmc Annexin II regulates fibrin homeostasis and neoangiogenesis in vivo
    Qi Ling
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Clin Invest 113:38-48. 2004
    ..These data establish annexin II as a regulator of cell surface plasmin generation and reveal that impaired endothelial cell fibrinolytic activity constitutes a barrier to effective neoangiogenesis...
  32. pmc Quantitative intact specimen magnetic resonance microscopy at 3.0 T
    Kevin G Bath
    Department of Psychiatry, Weill Cornell Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA
    Magn Reson Imaging 27:672-80. 2009
    ..The overall methodology was straightforward to implement and provides ready access to basic MRM at field strengths that are widely available in both the laboratory and the clinic...
  33. ncbi request reprint Cytokine preconditioning promotes codifferentiation of human fetal liver CD133+ stem cells into angiomyogenic tissue
    Sergey V Shmelkov
    Weill Medical College of Cornell University, Division of Hematology Oncology, New York, NY 10021, USA
    Circulation 111:1175-83. 2005
    ..Because human fetal liver is a rich source of CD133+ cells, we sought to identify the growth factors that promote codifferentiation of these cells into angiogenic and myogenic cells...
  34. ncbi request reprint Neurotrophins: novel mediators of angiogenesis
    Rosemary Kraemer
    Department of Pathology, Weill Medical College of Cornell University, New York, New York, USA
    Front Biosci 8:s1181-6. 2003
    ....
  35. ncbi request reprint Sortilin is essential for proNGF-induced neuronal cell death
    Anders Nykjaer
    Department of Medical Biochemistry, Ole Worms Alle 170, Aarhus University, Gustav Wieds Vej 10, DK 8000 Aarhus C, Denmark
    Nature 427:843-8. 2004
    ..Here we report that proNGF creates a signalling complex by simultaneously binding to p75NTR and sortilin. Thus sortilin acts as a co-receptor and molecular switch governing the p75NTR-mediated pro-apoptotic signal induced by proNGF...
  36. pmc ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury
    Michael S Beattie
    Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
    Neuron 36:375-86. 2002
    ..Together, these data suggest that the role of proNGF is to eliminate damaged cells by activating the apoptotic machinery of p75 after injury...
  37. pmc Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures
    Marta Volosin
    Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 28:9870-9. 2008
    ..Overall, these studies demonstrate the requirement for NRIF to signal p75(NTR)-mediated apoptosis of hippocampal neurons and that blocking pro-NGF can inhibit neuronal loss after seizures...
  38. ncbi request reprint Activation of p75NTR by proBDNF facilitates hippocampal long-term depression
    Newton H Woo
    Section on Neural Development and Plasticity, LCSN, NICHD, Porter Neuroscience Research Center, 35 Lincoln Drive, Bethesda, Maryland 20892 3714, USA
    Nat Neurosci 8:1069-77. 2005
    ....
  39. ncbi request reprint Paracrine and autocrine functions of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in brain-derived endothelial cells
    Hyun Kim
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
    J Biol Chem 279:33538-46. 2004
    ..These data support a role for neurotrophins signaling in the dynamic maintenance/differentiation of central nervous system endothelia...
  40. ncbi request reprint Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons
    Rajappa S Kenchappa
    Department of Biochemistry and Center for Molecular Neuroscience, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    Neuron 50:219-32. 2006
    ..These results indicate that p75-mediated apoptosis requires gamma-secretase dependent release of its ICD, which facilitates nuclear translocation of NRIF...
  41. ncbi request reprint Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death
    Stephen M Massa
    Department of Neurology, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Neurosci 26:5288-300. 2006
    ..These studies identify a unique range of p75NTR behaviors that can result from isolated receptor liganding and establish several novel therapeutic leads...
  42. ncbi request reprint Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins
    Marta Volosin
    Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 26:7756-66. 2006
    ..This study shows that proneurotrophins are produced in the brain under pathological conditions, and can elicit apoptosis of BF neurons even when Trk receptors are activated...
  43. ncbi request reprint Neurotrophin receptor interacting factor (NRIF) is an essential mediator of apoptotic signaling by the p75 neurotrophin receptor
    Michelle S Linggi
    Department of Biochemistry and Center for Molecular Neuroscience, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    J Biol Chem 280:13801-8. 2005
    ..Moreover, we document that NRIF expression is sufficient to induce cell death through a mechanism that requires p53. Taken together, these results establish NRIF as an essential component of the p75 apoptotic pathway...
  44. ncbi request reprint Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity
    Petti T Pang
    Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development NICHD, Bethesda, MD 20892, USA
    Science 306:487-91. 2004
    ..Moreover, application of mBDNF is sufficient to rescue L-LTP when protein synthesis is inhibited, which suggests that mBDNF is a key protein synthesis product for L-LTP expression...
  45. pmc The p75 neurotrophin receptor is a central regulator of glioma invasion
    Angela L M Johnston
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada
    PLoS Biol 5:e212. 2007
    ..These results provide the first evidence for p75(NTR) as a major contributor to the highly invasive nature of malignant gliomas and identify a novel therapeutic target...
  46. ncbi request reprint Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury
    Pernille Jansen
    MIND Center, Department of Medical Biochemistry, Ole Worms Allé 1170, Aarhus University, DK 8000 Aarhus C, Denmark
    Nat Neurosci 10:1449-57. 2007
    ..Thus, the sortilin pathway has distinct roles in pro-neurotrophin-induced apoptotic signaling in pathological conditions, but also in specific stages of neuronal development and aging...
  47. doi request reprint Neurotrophins and their receptors stimulate melanoma cell proliferation and migration
    Francesca Truzzi
    Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy
    J Invest Dermatol 128:2031-40. 2008
    ..These results indicate that NTs, through their receptors, play a critical role in the progression of melanoma...
  48. ncbi request reprint Microglia-derived pronerve growth factor promotes photoreceptor cell death via p75 neurotrophin receptor
    Bhooma Srinivasan
    Department of Cell Biology and Genetics, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    J Biol Chem 279:41839-45. 2004
    ..Moreover, our study suggests that defective post-translational processing of NGF might be involved in photoreceptor cell loss in retinal dystrophy...

Research Grants27

  1. RECEPTOR-MEDIATED CONTROL OF CELL DIFFERENTIATION
    Barbara Hempstead; Fiscal Year: 2004
    ..3. Define the mechanism and functional consequences of TrkA- and TrkB-mediated activation of the transcription factor STAT5. ..
  2. Gordon Conference on Neurotrophic Factors (2003,2005)
    Barbara Hempstead; Fiscal Year: 2005
    ..Hempstead and Y.-A. Barde) to profile new and young investigators as speakers in this Conference and for them to have a leadership role at this meeting. ..
  3. RECEPTOR-MEDIATED CONTROL OF CELL DIFFERENTIATION
    Barbara Hempstead; Fiscal Year: 2005
    ..abstract_text> ..
  4. RECEPTOR-MEDIATED CONTROL OF CELL DIFFERENTIATION
    Barbara Hempstead; Fiscal Year: 2006
    ..abstract_text> ..
  5. RECEPTOR-MEDIATED CONTROL OF CELL DIFFERENTIATION
    Barbara Hempstead; Fiscal Year: 2007
    ..abstract_text> ..
  6. Regulating BDNF Action in Postnatal Development.
    Barbara Hempstead; Fiscal Year: 2009
    ....
  7. RECEPTOR-MEDIATED CONTROL OF CELL DIFFERENTIATION
    Barbara Hempstead; Fiscal Year: 2009
    ..abstract_text> ..
  8. Regulating BDNF Action in Postnatal Development.
    Barbara L Hempstead; Fiscal Year: 2010
    ....
  9. Regulating BDNF Action in Postnatal Development.
    Barbara Hempstead; Fiscal Year: 2009
    ....
  10. RECEPTOR-MEDIATED CONTROL OF CELL DIFFERENTIATION
    Barbara Hempstead; Fiscal Year: 2003
    ..3. Define the mechanism and functional consequences of TrkA- and TrkB-mediated activation of the transcription factor STAT5. ..
  11. RECEPTOR-MEDIATED CONTROL OF CELL DIFFERENTIATION
    Barbara Hempstead; Fiscal Year: 2002
    ..3. Define the mechanism and functional consequences of TrkA- and TrkB-mediated activation of the transcription factor STAT5. ..
  12. NEUROTROPHINS AND CARDIOGENESIS
    Barbara Hempstead; Fiscal Year: 2002
    ....
  13. NEUROTROPHINS AND CARDIOGENESIS
    Barbara Hempstead; Fiscal Year: 1999
    ....
  14. RECEPTOR MEDIATED CONTROL OF CELL DIFFERENTIATION
    Barbara Hempstead; Fiscal Year: 1999
    ..Determine the role of native adaptor proteins and v-Crk in linking activated receptor tyrosine kinased to the cytoskeleton. (3.) Characterize the trk A/crk/cytoskeletal interactions which result in enhanced receptor internalization. ..
  15. NEUROTROPHINS AND CARDIOGENESIS
    Barbara Hempstead; Fiscal Year: 2000
    ....
  16. RECEPTOR MEDIATED CONTROL OF CELL DIFFERENTIATION
    Barbara Hempstead; Fiscal Year: 2000
    ..Determine the role of native adaptor proteins and v-Crk in linking activated receptor tyrosine kinased to the cytoskeleton. (3.) Characterize the trk A/crk/cytoskeletal interactions which result in enhanced receptor internalization. ..
  17. NEUROTROPHINS AND CARDIOGENESIS
    Barbara Hempstead; Fiscal Year: 2001
    ....
  18. Role of Neurotrophins and Receptors in Neurogenesis
    Barbara Hempstead; Fiscal Year: 2001
    ..3. Define the mechanism and functional consequences of TrkA- and TrkB-mediated activation of the transcription factor STAT5. ..
  19. RECEPTOR-MEDIATED CONTROL OF CELL DIFFERENTIATION
    Barbara L Hempstead; Fiscal Year: 2010
    ..These studies permit us to determine how proBDNF regulates neuronal cell fate, and the regressive events of naturally occurring neuronal death and pruning of dendrites, to establish appropriate neuronal circuitry. ..