Research Topics
Genomes and Genes | Barbara HempsteadSummaryAffiliation: Cornell University Country: USA Publications
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Publications
The many faces of p75NTRBarbara L Hempstead
Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
Curr Opin Neurobiol 12:260-7. 2002....- Dissecting the diverse actions of pro- and mature neurotrophinsBarbara L Hempstead
Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
Curr Alzheimer Res 3:19-24. 2006.... - Sculpting organ innervationBarbara L Hempstead
Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
J Clin Invest 113:811-3. 2004.... - Commentary: Regulating proNGF action: multiple targets for therapeutic interventionBarbara L Hempstead
Department of Medicine, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA
Neurotox Res 16:255-60. 2009..Multiple strategies that may act to limit proNGF action are considered as potential therapeutic targets for future development... - Coupling neurotrophins to cell migration through selective guanine nucleotide exchange factor activationBarbara L Hempstead
Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 102:5645-6. 2005 - Neurobiology. A glial spin on neurotrophinsBarbara L Hempstead
Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
Science 298:1184-6. 2002 - ProBDNF induces neuronal apoptosis via activation of a receptor complex of p75NTR and sortilinHenry K Teng
Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
J Neurosci 25:5455-63. 2005..Together with our past findings, these data suggest that the neurotrophin family is capable of modulating diverse biological processes via differential processing of the proneurotrophins... - Neuronal release of proBDNFJianmin Yang
Department of Medicine, Weill Cornell Medical College, 1300 York Ave, New York, New York 10065, USA
Nat Neurosci 12:113-5. 2009..Thus, BDNF actions are developmentally regulated by secretion of proBDNF or mature BDNF and by local expression of p75 and TrkB... - Brain-derived neurotrophic factor: a newly described mediator of angiogenesisPouneh Kermani
Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, NY, NY 10021, USA
Trends Cardiovasc Med 17:140-3. 2007.... - TrkB/BDNF signaling regulates photoreceptor progenitor cell fate decisionsBrian A Turner
Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, Room C606, New York, NY 10021, USA
Dev Biol 299:455-65. 2006..These studies suggest that TrkB signaling regulates commitment to and/or differentiation of photoreceptor cells from retinal progenitor cells, identifying a novel role for TrkB/BDNF in regulating cell fate decisions... - Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascinOluwatoyin Shonukan
Department of Medicine, Division of Hematology Oncology, University of Miami School of Medicine, Miami, FL 33136, USA
Oncogene 22:3616-23. 2003..These results suggest a causal role for NGF-mediated dephosphorylation of serine 39 on fascin in mediating actin binding and subsequent melanoma cell migration... - Magnitude of stromal hemangiogenesis correlates with histologic subtype of non-Hodgkin's lymphomaJia Ruan
Center for Lymphoma and Myeloma, Division of Hematology-Oncology, Department of Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
Clin Cancer Res 12:5622-31. 2006.... - Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathwayZhe Yu Chen
Department of Psychiatry, Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
J Neurosci 25:6156-66. 2005.... - A neurotrophin axis in myeloma: TrkB and BDNF promote tumor-cell survivalRoger N Pearse
Division of Hematology, Cornell University Medical College, Rm C 606, 1300 York Ave, New York, NY 10021, USA
Blood 105:4429-36. 2005..Finally, BDNF is expressed by malignant plasma cells isolated from a subset of patients with MM, as well as by most HMCLs, suggesting a potential role for this neurotrophin axis in autocrine as well as paracrine support of MM... - Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discriminationKevin G Bath
Department of Psychiatry, Weill Medical College of Cornell University, New York, New York 10065, USA
J Neurosci 28:2383-93. 2008..Through these observations, we have identified novel links between genetic variant BDNF and adult neurogenesis in vivo, which may contribute to significant impairments in olfactory function... - Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behaviorZhe Yu Chen
Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
Science 314:140-3. 2006..A variant BDNF may thus play a key role in genetic predispositions to anxiety and depressive disorders... - Pro-NGF secreted by astrocytes promotes motor neuron cell deathMarco Domeniconi
Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Mol Cell Neurosci 34:271-9. 2007..These results are consistent with a role for activated astrocytes and pro-NGF in the induction of motor neuron death and suggest a possible therapeutic target for the treatment of motor neuron disease... - Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitorsPouneh Kermani
Division of Hematology, Weill Medical College of Cornell University, New York, New York 10021, USA
J Clin Invest 115:653-63. 2005.... - Understanding proneurotrophin actions: Recent advances and challengesKenneth K Teng
Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA
Dev Neurobiol 70:350-9. 2010..Here, we review emerging evidence for a novel transmembrane mechanism for ligand-specific p75(NTR) activation and several mechanisms by which p75(NTR)-dependent apoptotic and nonapoptotic responses can be selective activated... - A novel p75 neurotrophin receptor-related protein, NRH2, regulates nerve growth factor binding to the TrkA receptorSimon S Murray
Skirball Institute of Bimolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
J Neurosci 24:2742-9. 2004..Coexpression of NRH2 with TrkA receptors resulted in the formation of high-affinity binding sites for NGF. These results indicate that a transmembrane protein related to p75NTR is capable of modulating Trk receptor binding properties... - NRH2 is a trafficking switch to regulate sortilin localization and permit proneurotrophin-induced cell deathTaeho Kim
Graduate Program in Neuroscience, Weill Medical College of Cornell University, New York, NY 10065, USA
EMBO J 28:1612-23. 2009.... - Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neuronsZhe-Yu Chen
Department of Psychiatry and Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
J Neurosci 24:4401-11. 2004.... - Impact of genetic variant BDNF (Val66Met) on brain structure and functionZhe Yu Chen
Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
Novartis Found Symp 289:180-8; discussion 188-95. 2008..A genetic variant BDNF may thus play a key role in genetic predispositions to anxiety and depressive disorders... - Adenovirus vector E4 gene regulates connexin 40 and 43 expression in endothelial cells via PKA and PI3K signal pathwaysFan Zhang
Department of Genetic Medicine, Belfer Gene Therapy Core Facility of Weill Medical of Cornell University, New York, NY 10021, USA
Circ Res 96:950-7. 2005..Taken together, these results suggest that AdE4+ may play an important role in the regulation of Cx expression in ECs, and that these effects are mediated by both the PKA/CREB and PI3K signaling pathways... - Decreased neurotrophin TrkB receptor expression reduces lesion size in the apolipoprotein E-null mutant mouseRosemary Kraemer
Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021, USA
Circulation 112:3644-53. 2005.... - Activation of STAT5-dependent transcription by the neurotrophin receptor TrkMathias Klein
Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
J Neurobiol 63:159-71. 2005..Together these results suggest that neurotrophins may regulate neuronal gene expression via STAT5 in a JAK2 independent manner... - Annexin II regulates fibrin homeostasis and neoangiogenesis in vivoQi Ling
Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
J Clin Invest 113:38-48. 2004..These data establish annexin II as a regulator of cell surface plasmin generation and reveal that impaired endothelial cell fibrinolytic activity constitutes a barrier to effective neoangiogenesis... - Quantitative intact specimen magnetic resonance microscopy at 3.0 TKevin G Bath
Department of Psychiatry, Weill Cornell Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA
Magn Reson Imaging 27:672-80. 2009..The overall methodology was straightforward to implement and provides ready access to basic MRM at field strengths that are widely available in both the laboratory and the clinic... - Cytokine preconditioning promotes codifferentiation of human fetal liver CD133+ stem cells into angiomyogenic tissueSergey V Shmelkov
Weill Medical College of Cornell University, Division of Hematology-Oncology, New York, NY 10021, USA
Circulation 111:1175-83. 2005..Preconditioning of these CD133+ cells with VEGF165 and BDNF enhances the angiomyogenesis. CD133+ fetal liver cells ultimately may be used for therapeutic angiomyogenesis... - Neurotrophins: novel mediators of angiogenesisRosemary Kraemer
Department of Pathology, Weill Medical College of Cornell University, New York, New York, USA
Front Biosci 8:s1181-6. 2003.... - Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injuryPernille Jansen
MIND Center, Department of Medical Biochemistry, Ole Worms Allé 1170, Aarhus University, DK 8000 Aarhus C, Denmark
Nat Neurosci 10:1449-57. 2007..Thus, the sortilin pathway has distinct roles in pro-neurotrophin-induced apoptotic signaling in pathological conditions, but also in specific stages of neuronal development and aging... - Induction of proneurotrophins and activation of p75NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizuresMarta Volosin
Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA
J Neurosci 28:9870-9. 2008..Overall, these studies demonstrate the requirement for NRIF to signal p75(NTR)-mediated apoptosis of hippocampal neurons and that blocking pro-NGF can inhibit neuronal loss after seizures... - The p75 neurotrophin receptor is a central regulator of glioma invasionAngela L M Johnston
Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, Canada
PLoS Biol 5:e212. 2007..These results provide the first evidence for p75(NTR) as a major contributor to the highly invasive nature of malignant gliomas and identify a novel therapeutic target... - Neurotrophins and their receptors stimulate melanoma cell proliferation and migrationFrancesca Truzzi
Department of Dermatology, University of Modena and Reggio Emilia, Modena, Italy
J Invest Dermatol 128:2031-40. 2008..These results indicate that NTs, through their receptors, play a critical role in the progression of melanoma... - Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophinsMarta Volosin
Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA
J Neurosci 26:7756-66. 2006..This study shows that proneurotrophins are produced in the brain under pathological conditions, and can elicit apoptosis of BF neurons even when Trk receptors are activated... - Sortilin is essential for proNGF-induced neuronal cell deathAnders Nykjaer
Department of Medical Biochemistry, Ole Worms Alle 170, Aarhus University, Gustav Wieds Vej 10, DK 8000 Aarhus C, Denmark
Nature 427:843-8. 2004..Here we report that proNGF creates a signalling complex by simultaneously binding to p75NTR and sortilin. Thus sortilin acts as a co-receptor and molecular switch governing the p75NTR-mediated pro-apoptotic signal induced by proNGF... - Paracrine and autocrine functions of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in brain-derived endothelial cellsHyun Kim
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520 8023, USA
J Biol Chem 279:33538-46. 2004..These data support a role for neurotrophins signaling in the dynamic maintenance/differentiation of central nervous system endothelia... - Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticityPetti T Pang
Section on Neural Development and Plasticity, Laboratory of Cellular and Synaptic Neurophysiology, National Institute of Child Health and Human Development NICHD, Bethesda, MD 20892, USA
Science 306:487-91. 2004..Moreover, application of mBDNF is sufficient to rescue L-LTP when protein synthesis is inhibited, which suggests that mBDNF is a key protein synthesis product for L-LTP expression... - Neurotrophin receptor interacting factor (NRIF) is an essential mediator of apoptotic signaling by the p75 neurotrophin receptorMichelle S Linggi
Department of Biochemistry and Center for Molecular Neuroscience, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
J Biol Chem 280:13801-8. 2005..Moreover, we document that NRIF expression is sufficient to induce cell death through a mechanism that requires p53. Taken together, these results establish NRIF as an essential component of the p75 apoptotic pathway... - Activation of p75NTR by proBDNF facilitates hippocampal long-term depressionNewton H Woo
Section on Neural Development and Plasticity, LCSN, NICHD, Porter Neuroscience Research Center, 35 Lincoln Drive, Bethesda, Maryland 20892 3714, USA
Nat Neurosci 8:1069-77. 2005.... - Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neuronsRajappa S Kenchappa
Department of Biochemistry and Center for Molecular Neuroscience, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
Neuron 50:219-32. 2006..These results indicate that p75-mediated apoptosis requires gamma-secretase dependent release of its ICD, which facilitates nuclear translocation of NRIF... - Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced deathStephen M Massa
Department of Neurology, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Neurosci 26:5288-300. 2006..These studies identify a unique range of p75NTR behaviors that can result from isolated receptor liganding and establish several novel therapeutic leads... - ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injuryMichael S Beattie
Department of Neuroscience, The Ohio State University, Columbus, OH 43210, USA
Neuron 36:375-86. 2002..Together, these data suggest that the role of proNGF is to eliminate damaged cells by activating the apoptotic machinery of p75 after injury... - Microglia-derived pronerve growth factor promotes photoreceptor cell death via p75 neurotrophin receptorBhooma Srinivasan
Department of Cell Biology and Genetics, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
J Biol Chem 279:41839-45. 2004..Moreover, our study suggests that defective post-translational processing of NGF might be involved in photoreceptor cell loss in retinal dystrophy...
Research Grants
- RECEPTOR-MEDIATED CONTROL OF CELL DIFFERENTIATIONBarbara Hempstead; Fiscal Year: 2004..3. Define the mechanism and functional consequences of TrkA- and TrkB-mediated activation of the transcription factor STAT5. ..
- Gordon Conference on Neurotrophic Factors (2003,2005)Barbara Hempstead; Fiscal Year: 2005..Hempstead and Y.-A. Barde) to profile new and young investigators as speakers in this Conference and for them to have a leadership role at this meeting. ..
- Regulating BDNF Action in Postnatal Development.Barbara Hempstead; Fiscal Year: 2009....
- RECEPTOR-MEDIATED CONTROL OF CELL DIFFERENTIATIONBarbara Hempstead; Fiscal Year: 2009..abstract_text> ..
- Regulating BDNF Action in Postnatal Development.Barbara L Hempstead; Fiscal Year: 2010....
- Regulating BDNF Action in Postnatal Development.Barbara Hempstead; Fiscal Year: 2009....
- NEUROTROPHINS AND CARDIOGENESISBarbara Hempstead; Fiscal Year: 2002....
- RECEPTOR MEDIATED CONTROL OF CELL DIFFERENTIATIONBarbara Hempstead; Fiscal Year: 2000..Determine the role of native adaptor proteins and v-Crk in linking activated receptor tyrosine kinased to the cytoskeleton. (3.) Characterize the trk A/crk/cytoskeletal interactions which result in enhanced receptor internalization. ..
- RECEPTOR-MEDIATED CONTROL OF CELL DIFFERENTIATIONBarbara L Hempstead; Fiscal Year: 2010..These studies permit us to determine how proBDNF regulates neuronal cell fate, and the regressive events of naturally occurring neuronal death and pruning of dendrites, to establish appropriate neuronal circuitry. ..