Kathleen Hefferon

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Innovations in siRNA research: a technology comes of age
    Kathleen L Hefferon
    Cornell Research Foundation 395 Pine Tree Rd, Suite 310, Cornell University Ithaca, NY 14850, USA
    Recent Pat Antiinfect Drug Discov 5:226-39. 2010
  2. ncbi request reprint Reconstructing the replication complex of AcMNPV
    Kathleen L Hefferon
    Center for Virology, Department of Botany, University of Toronto, Ontario, Canada
    Eur J Biochem 269:6233-40. 2002
  3. doi request reprint Broadly neutralizing antibodies and the promise of universal vaccines: where are we now?
    Kathleen L Hefferon
    University of Toronto, Toronto, Ontario, Canada and Cornell University, Ithaca, NY, USA
    Immunotherapy 6:51-7. 2014
  4. doi request reprint The mucosal immune response to plant-derived vaccines
    Kathleen Laura Hefferon
    Cornell Research Foundation, Cornell University, 395 Pine Tree Rd Suite 310, Ithaca, NY 14850, USA
    Pharm Res 27:2040-2. 2010
  5. ncbi request reprint Plant biotechnology patents: applications in agriculture and medicine
    Kathleen Hefferon
    Cornell Research Foundation, 395 Pine Tree Road Suite 310, Cornell University, Ithaca, NY 14850, USA
    Recent Pat Biotechnol 4:136-52. 2010
  6. ncbi request reprint Multi-tasking of nonstructural gene products is required for bean yellow dwarf geminivirus transcriptional regulation
    Kathleen L Hefferon
    Cornell University, Cornell Research Foundation, Ithaca, NY, USA
    FEBS J 273:4482-94. 2006
  7. ncbi request reprint Expression of a vaccine protein in a plant cell line using a geminivirus-based replicon system
    Kathleen L Hefferon
    Cornell Research Foundation, Cornell University, 20 Thornwood Dr, Ithaca, NY 14850, USA
    Vaccine 23:404-10. 2004
  8. ncbi request reprint Expression and purification of heterologous proteins in plant tissue using a geminivirus vector system
    K L Hefferon
    Cornell Research Foundation, Plant Sciences Building, Cornell University, Ithaca, NY 14853, USA
    J Mol Microbiol Biotechnol 7:109-14. 2004
  9. ncbi request reprint Baculovirus late expression factors
    Kathleen L Hefferon
    Cornell Research Foundation, Cornell University, Ithaca, NY 14820, USA
    J Mol Microbiol Biotechnol 7:89-101. 2004
  10. ncbi request reprint Characterization of HCF-1, a determinant of Autographa californica multiple nucleopolyhedrovirus host specificity
    K L Hefferon
    Cornell Research Foundation, Cornell University, Ithaca, NY 14850, USA
    Insect Mol Biol 12:651-8. 2003

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Innovations in siRNA research: a technology comes of age
    Kathleen L Hefferon
    Cornell Research Foundation 395 Pine Tree Rd, Suite 310, Cornell University Ithaca, NY 14850, USA
    Recent Pat Antiinfect Drug Discov 5:226-39. 2010
    ..The review also provides detailed lists of the most recent patents that have been issued which cover these areas of siRNA technology, and paves the way for future innovations based on RNA interference in the life sciences...
  2. ncbi request reprint Reconstructing the replication complex of AcMNPV
    Kathleen L Hefferon
    Center for Virology, Department of Botany, University of Toronto, Ontario, Canada
    Eur J Biochem 269:6233-40. 2002
    ..A summary of the interactive properties of the replication LEFs is presented and a model for a putative AcMNPV replication complex is offered...
  3. doi request reprint Broadly neutralizing antibodies and the promise of universal vaccines: where are we now?
    Kathleen L Hefferon
    University of Toronto, Toronto, Ontario, Canada and Cornell University, Ithaca, NY, USA
    Immunotherapy 6:51-7. 2014
    ..The following article describes the most recent innovations in this exciting field. ..
  4. doi request reprint The mucosal immune response to plant-derived vaccines
    Kathleen Laura Hefferon
    Cornell Research Foundation, Cornell University, 395 Pine Tree Rd Suite 310, Ithaca, NY 14850, USA
    Pharm Res 27:2040-2. 2010
    ..Here we discuss the current status of plant-derived vaccines and their potential to champion the battle against infectious diseases in the least developed countries...
  5. ncbi request reprint Plant biotechnology patents: applications in agriculture and medicine
    Kathleen Hefferon
    Cornell Research Foundation, 395 Pine Tree Road Suite 310, Cornell University, Ithaca, NY 14850, USA
    Recent Pat Biotechnol 4:136-52. 2010
    ....
  6. ncbi request reprint Multi-tasking of nonstructural gene products is required for bean yellow dwarf geminivirus transcriptional regulation
    Kathleen L Hefferon
    Cornell University, Cornell Research Foundation, Ithaca, NY, USA
    FEBS J 273:4482-94. 2006
    ..The study concludes with an investigation into the expression strategies of the BeYDV capsid protein...
  7. ncbi request reprint Expression of a vaccine protein in a plant cell line using a geminivirus-based replicon system
    Kathleen L Hefferon
    Cornell Research Foundation, Cornell University, 20 Thornwood Dr, Ithaca, NY 14850, USA
    Vaccine 23:404-10. 2004
    ..Construction of an expression cassette encoding a synthetic vaccine gene and analysis of expression levels of a vaccine protein in a plant cell line system are described...
  8. ncbi request reprint Expression and purification of heterologous proteins in plant tissue using a geminivirus vector system
    K L Hefferon
    Cornell Research Foundation, Plant Sciences Building, Cornell University, Ithaca, NY 14853, USA
    J Mol Microbiol Biotechnol 7:109-14. 2004
    ..Using this expression system, the rapid accumulation of a novel Arabidopsis-derived mitogen-activated protein kinase to levels sufficient for standard biochemical analysis is demonstrated...
  9. ncbi request reprint Baculovirus late expression factors
    Kathleen L Hefferon
    Cornell Research Foundation, Cornell University, Ithaca, NY 14820, USA
    J Mol Microbiol Biotechnol 7:89-101. 2004
    ..The role of LEFs in determining baculovirus host range is described. Finally, we compare baculovirus replication and transcription machinery with other viral systems...
  10. ncbi request reprint Characterization of HCF-1, a determinant of Autographa californica multiple nucleopolyhedrovirus host specificity
    K L Hefferon
    Cornell Research Foundation, Cornell University, Ithaca, NY 14850, USA
    Insect Mol Biol 12:651-8. 2003
    ..HCF-1 mutants were constructed and utilized to search for the domains involved in HCF-1 biological function and oligomerization. Possible roles of HCF-1 in determining host specificity are discussed...
  11. ncbi request reprint Independent expression of Rep and RepA and their roles in regulating bean yellow dwarf virus replication
    Kathleen L Hefferon
    Cornell Research Foundation, Cornell University, 20 Thornwood Drive, Ithaca, NY 14850, USA
    J Gen Virol 84:3465-72. 2003
    ..Addition of coat protein increased accumulation of single-stranded DNA and had a detrimental effect on reporter gene expression...
  12. ncbi request reprint Identification of a repressor of late gene expression within the AcMNPV genome
    K L Hefferon
    Department of Entomology, University of Georgia, USA
    Arch Virol 148:1413-8. 2003
    ..We were unable to link repressor activity to a single open reading frame, suggesting that a cis-acting element rather than a trans-acting factor is responsible for this phenomenon...
  13. ncbi request reprint ORF98 of Autographa californica nucleopolyhedrosisvirus is an auxiliary factor in late gene expression
    Kathleen L Hefferon
    Cornell Research Foundation, Cornell University, 20 Thornwood Drive, Ithaca, NY 14850, USA
    Can J Microbiol 49:157-63. 2003
    ..Furthermore, tagged versions of ORF98 were localized to the nuclei of transfected cells and were shown to interact with each other as homo-oligomers. Potential roles of ORF98 in baculovirus infection are discussed...
  14. pmc Expression and mutational analysis of Autographa californica nucleopolyhedrovirus HCF-1: functional requirements for cysteine residues
    Joyce A Wilson
    Departments of Entomology, University of Georgia, Athens, Georgia 30602, USA
    J Virol 79:13900-14. 2005
    ..We propose that HCF-1 is a RING finger-containing protein whose activity requires HCF-1 self-association and gene repression activity...
  15. doi request reprint Plant-derived pharmaceuticals for the developing world
    Kathleen Hefferon
    Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada Cornell University, Ithaca, NY, USA
    Biotechnol J 8:1193-202. 2013
    ..The review concludes by outlining the next steps for plant-produced vaccines to achieve their goal of providing safe, efficacious and inexpensive vaccines to the developing world. ..