Research Topics
| Cynthia L HardenSummaryAffiliation: Cornell University Country: USA Publications
Research Grants
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Detail Information
Publications
The effect of menopause and perimenopause on the course of epilepsyC L Harden
Comprehensive Epilepsy Center, New York Presbyterian Hospital Weill Medical College of Cornell University, New York 10021, USA
Epilepsia 40:1402-7. 1999....- Pregnancy and epilepsyCynthia L Harden
Comprehensive Epilepsy Center, Department of Neurology, Weill Cornell Medical College, New York, New York 10021, USA
Semin Neurol 27:453-9. 2007..The metabolism of both lamotrigine and oxcarbazepine is induced during pregnancy, and careful clinical monitoring and frequent level assessment are emerging as important for these AEDs... 
The current state of postmenopausal hormone therapy: update for neurologists and epileptologistsCynthia L Harden
Weill Medical College of Cornell University, New York Presbyterian Hospital, Comprehensive Epilepsy Center, New York, NY, USA
Epilepsy Curr 7:119-22. 2007..To explore this possibility, more information about the neurophysiologic activity of medroxyprogesterone acetate is needed and alternatives to this specific HRT regimen should be considered for women with epilepsy...
Sexual dysfunction in women with epilepsyCynthia L Harden
Comprehensive Epilepsy Center, Department of Neurology, Room k 615, 525 East 68th Street, Weill Cornell Medical College, New York, NY, United States
Seizure 17:131-5. 2008..Strategies for modifying the contributors to sexual dysfunction in WWE will be discussed as well as the role of the neurologist in initiating management of this challenging comorbidity...- Hormone replacement therapy: will it affect seizure control and AED levels?Cynthia L Harden
Comprehensive Epilepsy Center, Department of Neurology, Weill Cornell Medical College, New York, NY, United States
Seizure 17:176-80. 2008..Strategies for managing HRT in symptomatic postmenopausal WWE using estrogenic and progestogenic compounds that may be less likely to promote seizures are discussed... - Optimizing therapy of seizures in women who use oral contraceptivesCynthia L Harden
Comprehensive Epilepsy Center, Weill Cornell Medical Center, New York, NY 10021, USA
Neurology 67:S56-8. 2006..The placebo or pill-free week of the OC regimen may also be a period when clinical toxicity can occur. Even with the considerations discussed in this review, OCs are a reasonable contraceptive option for women with epilepsy taking AEDs... - Hormone replacement therapy in women with epilepsy: a randomized, double-blind, placebo-controlled studyCynthia L Harden
Comprehensive Epilepsy Center, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA
Epilepsia 47:1447-51. 2006..We sought to determine whether adding HRT to the medication regimen of postmenopausal women with epilepsy was associated with an increase in seizure frequency... - Sexuality in men and women with epilepsyCynthia L Harden
Department of Neurology and Neuroscience, Comprehensive Epilepsy Center, Weill Medical College of Cornell University, New York, NY, USA
CNS Spectr 11:13-8. 2006..Psychosocial factors, including sexual anxiety and stigma associated with epilepsy, can also affect the sexual life of patients with epilepsy... - Sexuality in women with epilepsyCynthia L Harden
Comprehensive Epilepsy Center, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY, USA
Epilepsy Behav 7:S2-6. 2005..This review focuses on potential sexual problems that are faced by women with epilepsy, with the suggestion that proper treatment may alleviate these problems... - Aromatase inhibitors as add-on treatment for men with epilepsyCynthia Harden
Weill Medical College of Cornell University, Comprehensive Epilepsy Center, 525 East 68th Street, Room k 615, NY 10021, USA
Expert Rev Neurother 5:123-7. 2005.... - Reaction to epilepsy in the workplaceCynthia L Harden
Comprehensive Epilepsy Center, Weill Medical College of Cornell University, New York, New York 10021, USA
Epilepsia 45:1134-40. 2004..The purpose of this study was to determine the characteristics of epilepsy that produce avoidant behavior in the workplace and therefore contribute to the actual stigma that persons with epilepsy are subjected to on the job... - Aromatase inhibition, testosterone, and seizuresCynthia Harden
Department of Neurology and Neuroscience, Comprehensive Epilepsy Center, Weill Medical College of Cornell University, New York, NY, USA
Epilepsy Behav 5:260-3. 2004..This experience suggests that aromatase inhibitors should be further investigated as a beneficial treatment modality for male patients with epilepsy... - Seizure frequency is associated with age at menopause in women with epilepsyC L Harden
Comprehensive Epilepsy Center, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA
Neurology 61:451-5. 2003..To determine whether the age at menopause in women with epilepsy is associated with seizure frequency... - The diagnostic significance of video-EEG monitoring findings on pseudoseizure patients differs between neurologists and psychiatristsCynthia L Harden
Comprehensive Epilepsy Center, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York, USA
Epilepsia 44:453-6. 2003..In an attempt to elucidate factors contributing to this poor outcome, we hypothesized that neurologists and psychiatrists differ in their views of the diagnosis and management of psychogenic pseudoseizure patients... - Treatment considerations during pregnancy for women with epilepsyCynthia L Harden
Comprehensive Epilepsy Center, Weill Cornell Medical Center, New York, NY, USA
Womens Health (Lond Engl) 2:415-23. 2006.... - Mood disorders in patients with epilepsy: epidemiology and managementCynthia L Harden
Comprehensive Epilepsy Center, Weill Medical College of Cornell University, New York, New York 10021, USA
CNS Drugs 16:291-302. 2002..Bupropion, clomipramine and maprotiline are associated with a greater risk of seizures compared with other antidepressants and consequently should be used with caution in the treatment of depression in patients with epilepsy... - Laterality and location influence catamenial seizure expression in women with partial epilepsyM Quigg
Department of Neurology, University of Virginia, Charlottesville, VA 22908, USA
Neurology 73:223-7. 2009..The location and laterality of the epileptic lesion as well as patient age may affect periodicity... - Effect of levetiracetam on testosterone levels in male patientsCynthia L Harden
Epilepsy Division, Department of Neurology, Miller School of Medicine of the University of Miami, Miami, Florida 33136, USA
Epilepsia 51:2348-51. 2010..038, r = 0.734). These results suggest that levetiracetam increases testosterone levels and that an initial testosterone level may predict the magnitude of increase... - The effect of seizure severity on quality of life in epilepsyCynthia L Harden
Comprehensive Epilepsy Center, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, NY 10021, USA
Epilepsy Behav 11:208-11. 2007..037, R(2)=0.30). These findings indicate that severe and potentially injurious seizure behaviors contribute to anxiety and socially avoidant behavior for persons with intractable epilepsy... - Menopause and bone density issues for women with epilepsyCynthia L Harden
Comprehensive Epilepsy Center, New York-Presbyterian Hospital-Weill Medical College of Cornell University, New York, NY 10021, USA
Neurology 61:S16-22. 2003..This is probably related to an effect of seizures on hypothalamic function, although primary ovarian dysfunction may also be operative in this setting... - Epilepsy in older womenNitin K Sethi
Comprehensive Epilepsy Center, Weill Cornell Medical College, New York, NY 10021, USA
Menopause Int 14:85-7. 2008..Altered antiepileptic drug pharmacokinetics with increasing age and the management of this vulnerable population is also discussed... - Pregnancy and epilepsy--when you're managing bothNitin K Sethi
Department of Neurology, New York Presbyterian Hospital, Weill Cornell Medical Center, 525 East 68th Street, New York, NY 10021, USA
J Fam Pract 59:675-9. 2010..When a patient with epilepsy is pregnant or planning for pregnancy, you face the challenge of balancing the benefits and teratogenic risks of her antiseizure medication. Here's help... - Screening for bone health in epilepsyRaj D Sheth
Department of Neurology, University of Wisconsin Madison, Wisconsin, USA
Epilepsia 48:39-41. 2007.... - Issues for mature women with epilepsyCynthia L Harden
Department of Neurology, Leonard M Miller School of Medicine, University of Miami, Miami, Florida, USA
Int Rev Neurobiol 83:385-95. 2008..Information about gender differences for AED use in the mature population is scant... - A comparison of personality disorder characteristics of patients with nonepileptic psychogenic pseudoseizures with those of patients with epilepsyCynthia L Harden
Comprehensive Epilepsy Center, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Epilepsy Behav 14:481-3. 2009.... - The co-morbidity of depression and epilepsy: epidemiology, etiology, and treatmentCynthia L Harden
Comprehensive Epilepsy Center, Weill Medical College of Cornell University, 525 E 68th Street, Room K-615, New York, NY 10021, USA
Neurology 59:S48-55. 2002..Electroconvulsive therapy is not contraindicated for treatment-resistant or psychotic depression. Depression must be recognized, diagnosed, and adequately treated in patients with epilepsy... - Circalunar and ultralunar periodicities in women with partial seizuresMark Quigg
Department of Neurology, University of Virginia, Charlottesville, Virginia 22908, USA
Epilepsia 49:1081-5. 2008..In the present study, we determined seizure periodicity according to a "menstrual clock" provided by a common phase marker of the onset of menses... - Antiepileptic drug teratogenesis: what are the risks for congenital malformations and adverse cognitive outcomes?Cynthia L Harden
Department of Neurology, Leonard M Miller School of Medicine, University of Miami, Miami, Florida, USA
Int Rev Neurobiol 83:205-13. 2008.... - Pregnancy registries in epilepsy: a consensus statement on health outcomesK J Meador
Department of Neurology, Emory University, Atlanta, GA 30322, USA
Neurology 71:1109-17. 2008..There is a critical need for investigations to delineate the underlying mechanisms and explain the variance seen in outcomes across AEDs and within a single AED... - An analysis of lifetime fractures in women with epilepsyB S Koppel
Department of Neurology, Metropolitan Hospital, New York Medical College, New York, NY 10029, USA
Acta Neurol Scand 111:225-8. 2005..To clarify the relationship between fractures and antiepileptic drug (AED) use... - Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy SocietyJacqueline A French
Neurological Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Epilepsia 45:401-9. 2004..S. Food and Drug Administration] in the treatment of children and adults with newly diagnosed partial and generalized epilepsies... - Efficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy SocietyJacqueline A French
Neurological Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Epilepsia 45:410-23. 2004.... - Consensus statement: the evaluation and treatment of people with epilepsy and affective disordersJohn J Barry
Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA, USA
Epilepsy Behav 13:S1-29. 2008..Recommendations are based on the general depression literature as well as epilepsy-specific studies. It is hoped that this document will improve the overall detection and subsequent treatment of affective illnesses in PWE... - Frequency of catamenial seizure exacerbation in women with localization-related epilepsyAndrew G Herzog
Harvard Neuroendocrine Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215
Ann Neurol 56:431-4. 2004..Among anovulatory cycles, average daily seizure frequency was substantially less during the midfollicular phase than during the remainder of the cycle. Overall, 39.1% of the women had catamenial epilepsy...
Research Grants
- HORMONE REPLACEMENT IN MENOPAUSAL WOMEN WITH EPILEPSYCynthia Harden; Fiscal Year: 2002..The outcome of this study will be determined by comparing seizure frequency in the baseline phase with the treated phase between placebo and hormone treated groups. ..