Cynthia L Harden

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi The effect of menopause and perimenopause on the course of epilepsy
    C L Harden
    Comprehensive Epilepsy Center, New York Presbyterian Hospital Weill Medical College of Cornell University, New York 10021, USA
    Epilepsia 40:1402-7. 1999
  2. ncbi Pregnancy and epilepsy
    Cynthia L Harden
    Comprehensive Epilepsy Center, Department of Neurology, Weill Cornell Medical College, New York, New York 10021, USA
    Semin Neurol 27:453-9. 2007
  3. pmc The current state of postmenopausal hormone therapy: update for neurologists and epileptologists
    Cynthia L Harden
    Weill Medical College of Cornell University, New York Presbyterian Hospital, Comprehensive Epilepsy Center, New York, NY, USA
    Epilepsy Curr 7:119-22. 2007
  4. doi Sexual dysfunction in women with epilepsy
    Cynthia L Harden
    Comprehensive Epilepsy Center, Department of Neurology, Room k 615, 525 East 68th Street, Weill Cornell Medical College, New York, NY, United States
    Seizure 17:131-5. 2008
  5. pmc Hormone replacement therapy: will it affect seizure control and AED levels?
    Cynthia L Harden
    Comprehensive Epilepsy Center, Department of Neurology, Weill Cornell Medical College, New York, NY, United States
    Seizure 17:176-80. 2008
  6. ncbi Optimizing therapy of seizures in women who use oral contraceptives
    Cynthia L Harden
    Comprehensive Epilepsy Center, Weill Cornell Medical Center, New York, NY 10021, USA
    Neurology 67:S56-8. 2006
  7. ncbi Hormone replacement therapy in women with epilepsy: a randomized, double-blind, placebo-controlled study
    Cynthia L Harden
    Comprehensive Epilepsy Center, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA
    Epilepsia 47:1447-51. 2006
  8. ncbi Sexuality in men and women with epilepsy
    Cynthia L Harden
    Department of Neurology and Neuroscience, Comprehensive Epilepsy Center, Weill Medical College of Cornell University, New York, NY, USA
    CNS Spectr 11:13-8. 2006
  9. ncbi Sexuality in women with epilepsy
    Cynthia L Harden
    Comprehensive Epilepsy Center, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY, USA
    Epilepsy Behav 7:S2-6. 2005
  10. ncbi Aromatase inhibitors as add-on treatment for men with epilepsy
    Cynthia Harden
    Weill Medical College of Cornell University, Comprehensive Epilepsy Center, 525 East 68th Street, Room k 615, NY 10021, USA
    Expert Rev Neurother 5:123-7. 2005

Research Grants

Detail Information

Publications36

  1. ncbi The effect of menopause and perimenopause on the course of epilepsy
    C L Harden
    Comprehensive Epilepsy Center, New York Presbyterian Hospital Weill Medical College of Cornell University, New York 10021, USA
    Epilepsia 40:1402-7. 1999
    ....
  2. ncbi Pregnancy and epilepsy
    Cynthia L Harden
    Comprehensive Epilepsy Center, Department of Neurology, Weill Cornell Medical College, New York, New York 10021, USA
    Semin Neurol 27:453-9. 2007
    ..The metabolism of both lamotrigine and oxcarbazepine is induced during pregnancy, and careful clinical monitoring and frequent level assessment are emerging as important for these AEDs...
  3. pmc The current state of postmenopausal hormone therapy: update for neurologists and epileptologists
    Cynthia L Harden
    Weill Medical College of Cornell University, New York Presbyterian Hospital, Comprehensive Epilepsy Center, New York, NY, USA
    Epilepsy Curr 7:119-22. 2007
    ..To explore this possibility, more information about the neurophysiologic activity of medroxyprogesterone acetate is needed and alternatives to this specific HRT regimen should be considered for women with epilepsy...
  4. doi Sexual dysfunction in women with epilepsy
    Cynthia L Harden
    Comprehensive Epilepsy Center, Department of Neurology, Room k 615, 525 East 68th Street, Weill Cornell Medical College, New York, NY, United States
    Seizure 17:131-5. 2008
    ..Strategies for modifying the contributors to sexual dysfunction in WWE will be discussed as well as the role of the neurologist in initiating management of this challenging comorbidity...
  5. pmc Hormone replacement therapy: will it affect seizure control and AED levels?
    Cynthia L Harden
    Comprehensive Epilepsy Center, Department of Neurology, Weill Cornell Medical College, New York, NY, United States
    Seizure 17:176-80. 2008
    ..Strategies for managing HRT in symptomatic postmenopausal WWE using estrogenic and progestogenic compounds that may be less likely to promote seizures are discussed...
  6. ncbi Optimizing therapy of seizures in women who use oral contraceptives
    Cynthia L Harden
    Comprehensive Epilepsy Center, Weill Cornell Medical Center, New York, NY 10021, USA
    Neurology 67:S56-8. 2006
    ..The placebo or pill-free week of the OC regimen may also be a period when clinical toxicity can occur. Even with the considerations discussed in this review, OCs are a reasonable contraceptive option for women with epilepsy taking AEDs...
  7. ncbi Hormone replacement therapy in women with epilepsy: a randomized, double-blind, placebo-controlled study
    Cynthia L Harden
    Comprehensive Epilepsy Center, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA
    Epilepsia 47:1447-51. 2006
    ..We sought to determine whether adding HRT to the medication regimen of postmenopausal women with epilepsy was associated with an increase in seizure frequency...
  8. ncbi Sexuality in men and women with epilepsy
    Cynthia L Harden
    Department of Neurology and Neuroscience, Comprehensive Epilepsy Center, Weill Medical College of Cornell University, New York, NY, USA
    CNS Spectr 11:13-8. 2006
    ..Psychosocial factors, including sexual anxiety and stigma associated with epilepsy, can also affect the sexual life of patients with epilepsy...
  9. ncbi Sexuality in women with epilepsy
    Cynthia L Harden
    Comprehensive Epilepsy Center, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY, USA
    Epilepsy Behav 7:S2-6. 2005
    ..This review focuses on potential sexual problems that are faced by women with epilepsy, with the suggestion that proper treatment may alleviate these problems...
  10. ncbi Aromatase inhibitors as add-on treatment for men with epilepsy
    Cynthia Harden
    Weill Medical College of Cornell University, Comprehensive Epilepsy Center, 525 East 68th Street, Room k 615, NY 10021, USA
    Expert Rev Neurother 5:123-7. 2005
    ....
  11. ncbi Reaction to epilepsy in the workplace
    Cynthia L Harden
    Comprehensive Epilepsy Center, Weill Medical College of Cornell University, New York, New York 10021, USA
    Epilepsia 45:1134-40. 2004
    ..The purpose of this study was to determine the characteristics of epilepsy that produce avoidant behavior in the workplace and therefore contribute to the actual stigma that persons with epilepsy are subjected to on the job...
  12. ncbi Aromatase inhibition, testosterone, and seizures
    Cynthia Harden
    Department of Neurology and Neuroscience, Comprehensive Epilepsy Center, Weill Medical College of Cornell University, New York, NY, USA
    Epilepsy Behav 5:260-3. 2004
    ..This experience suggests that aromatase inhibitors should be further investigated as a beneficial treatment modality for male patients with epilepsy...
  13. ncbi Mood disorders in patients with epilepsy: epidemiology and management
    Cynthia L Harden
    Comprehensive Epilepsy Center, Weill Medical College of Cornell University, New York, New York 10021, USA
    CNS Drugs 16:291-302. 2002
    ..Bupropion, clomipramine and maprotiline are associated with a greater risk of seizures compared with other antidepressants and consequently should be used with caution in the treatment of depression in patients with epilepsy...
  14. ncbi The diagnostic significance of video-EEG monitoring findings on pseudoseizure patients differs between neurologists and psychiatrists
    Cynthia L Harden
    Comprehensive Epilepsy Center, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York, USA
    Epilepsia 44:453-6. 2003
    ..In an attempt to elucidate factors contributing to this poor outcome, we hypothesized that neurologists and psychiatrists differ in their views of the diagnosis and management of psychogenic pseudoseizure patients...
  15. ncbi Seizure frequency is associated with age at menopause in women with epilepsy
    C L Harden
    Comprehensive Epilepsy Center, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA
    Neurology 61:451-5. 2003
    ..To determine whether the age at menopause in women with epilepsy is associated with seizure frequency...
  16. ncbi Treatment considerations during pregnancy for women with epilepsy
    Cynthia L Harden
    Comprehensive Epilepsy Center, Weill Cornell Medical Center, New York, NY, USA
    Womens Health (Lond Engl) 2:415-23. 2006
    ....
  17. pmc Laterality and location influence catamenial seizure expression in women with partial epilepsy
    M Quigg
    Department of Neurology, University of Virginia, Charlottesville, VA 22908, USA
    Neurology 73:223-7. 2009
    ..The location and laterality of the epileptic lesion as well as patient age may affect periodicity...
  18. doi Effect of levetiracetam on testosterone levels in male patients
    Cynthia L Harden
    Epilepsy Division, Department of Neurology, Miller School of Medicine of the University of Miami, Miami, Florida 33136, USA
    Epilepsia 51:2348-51. 2010
    ..038, r = 0.734). These results suggest that levetiracetam increases testosterone levels and that an initial testosterone level may predict the magnitude of increase...
  19. ncbi The effect of seizure severity on quality of life in epilepsy
    Cynthia L Harden
    Comprehensive Epilepsy Center, New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, NY 10021, USA
    Epilepsy Behav 11:208-11. 2007
    ..037, R(2)=0.30). These findings indicate that severe and potentially injurious seizure behaviors contribute to anxiety and socially avoidant behavior for persons with intractable epilepsy...
  20. ncbi Menopause and bone density issues for women with epilepsy
    Cynthia L Harden
    Comprehensive Epilepsy Center, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, NY 10021, USA
    Neurology 61:S16-22. 2003
    ..This is probably related to an effect of seizures on hypothalamic function, although primary ovarian dysfunction may also be operative in this setting...
  21. doi Epilepsy in older women
    Nitin K Sethi
    Comprehensive Epilepsy Center, Weill Cornell Medical College, New York, NY 10021, USA
    Menopause Int 14:85-7. 2008
    ..Altered antiepileptic drug pharmacokinetics with increasing age and the management of this vulnerable population is also discussed...
  22. doi Suicidal ideation and behavior screening in intractable focal epilepsy eligible for drug trials
    Dale C Hesdorffer
    GH Sergievsky Center and Department of Epidemiology, Columbia University, New York, New York 10032, USA
    Epilepsia 54:879-87. 2013
    ..This was done to determine which instrument was optimal for use in epilepsy...
  23. ncbi Screening for bone health in epilepsy
    Raj D Sheth
    Department of Neurology, University of Wisconsin Madison, Wisconsin, USA
    Epilepsia 48:39-41. 2007
    ....
  24. ncbi Pregnancy and epilepsy--when you're managing both
    Nitin K Sethi
    Department of Neurology, New York Presbyterian Hospital, Weill Cornell Medical Center, 525 East 68th Street, New York, NY 10021, USA
    J Fam Pract 59:675-9. 2010
    ..When a patient with epilepsy is pregnant or planning for pregnancy, you face the challenge of balancing the benefits and teratogenic risks of her antiseizure medication. Here's help...
  25. doi A comparison of personality disorder characteristics of patients with nonepileptic psychogenic pseudoseizures with those of patients with epilepsy
    Cynthia L Harden
    Comprehensive Epilepsy Center, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Epilepsy Behav 14:481-3. 2009
    ....
  26. doi Issues for mature women with epilepsy
    Cynthia L Harden
    Department of Neurology, Leonard M Miller School of Medicine, University of Miami, Miami, Florida, USA
    Int Rev Neurobiol 83:385-95. 2008
    ..Information about gender differences for AED use in the mature population is scant...
  27. ncbi The co-morbidity of depression and epilepsy: epidemiology, etiology, and treatment
    Cynthia L Harden
    Comprehensive Epilepsy Center, Weill Medical College of Cornell University, 525 E 68th Street, Room k 615, New York, NY 10021, USA
    Neurology 59:S48-55. 2002
    ..Electroconvulsive therapy is not contraindicated for treatment-resistant or psychotic depression. Depression must be recognized, diagnosed, and adequately treated in patients with epilepsy...
  28. doi Neuroendocrine considerations in the treatment of men and women with epilepsy
    Cynthia L Harden
    Division of Epilepsy and Electroencephalography, Hofstra North Shore LIJ School of Medicine at Hofstra University, Hempstead, NY, USA
    Lancet Neurol 12:72-83. 2013
    ..Knowledge of these complex interactions has increased and can now be incorporated in meaningful treatment approaches for men and women with epilepsy...
  29. doi Circalunar and ultralunar periodicities in women with partial seizures
    Mark Quigg
    Department of Neurology, University of Virginia, Charlottesville, Virginia 22908, USA
    Epilepsia 49:1081-5. 2008
    ..In the present study, we determined seizure periodicity according to a "menstrual clock" provided by a common phase marker of the onset of menses...
  30. doi Antiepileptic drug teratogenesis: what are the risks for congenital malformations and adverse cognitive outcomes?
    Cynthia L Harden
    Department of Neurology, Leonard M Miller School of Medicine, University of Miami, Miami, Florida, USA
    Int Rev Neurobiol 83:205-13. 2008
    ....
  31. doi Pregnancy registries in epilepsy: a consensus statement on health outcomes
    K J Meador
    Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Neurology 71:1109-17. 2008
    ..There is a critical need for investigations to delineate the underlying mechanisms and explain the variance seen in outcomes across AEDs and within a single AED...
  32. ncbi An analysis of lifetime fractures in women with epilepsy
    B S Koppel
    Department of Neurology, Metropolitan Hospital, New York Medical College, New York, NY 10029, USA
    Acta Neurol Scand 111:225-8. 2005
    ..To clarify the relationship between fractures and antiepileptic drug (AED) use...
  33. ncbi Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society
    Jacqueline A French
    Neurological Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 45:401-9. 2004
    ..S. Food and Drug Administration] in the treatment of children and adults with newly diagnosed partial and generalized epilepsies...
  34. ncbi Efficacy and tolerability of the new antiepileptic drugs, II: Treatment of refractory epilepsy: report of the TTA and QSS Subcommittees of the American Academy of Neurology and the American Epilepsy Society
    Jacqueline A French
    Neurological Institute, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Epilepsia 45:410-23. 2004
    ....
  35. doi Consensus statement: the evaluation and treatment of people with epilepsy and affective disorders
    John J Barry
    Department of Psychiatry and Behavioral Sciences, Stanford University Medical Center, Stanford, CA, USA
    Epilepsy Behav 13:S1-29. 2008
    ..Recommendations are based on the general depression literature as well as epilepsy-specific studies. It is hoped that this document will improve the overall detection and subsequent treatment of affective illnesses in PWE...
  36. ncbi Frequency of catamenial seizure exacerbation in women with localization-related epilepsy
    Andrew G Herzog
    Harvard Neuroendocrine Unit, Beth Israel Deaconess Medical Center, Boston, MA 02215
    Ann Neurol 56:431-4. 2004
    ..Among anovulatory cycles, average daily seizure frequency was substantially less during the midfollicular phase than during the remainder of the cycle. Overall, 39.1% of the women had catamenial epilepsy...

Research Grants3

  1. HORMONE REPLACEMENT IN MENOPAUSAL WOMEN WITH EPILEPSY
    Cynthia Harden; Fiscal Year: 2002
    ..The outcome of this study will be determined by comparing seizure frequency in the baseline phase with the treated phase between placebo and hormone treated groups. ..