Research Topics
| K A HalmiSummaryAffiliation: Cornell University Country: USA Publications
Research Grants
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Publications
Eating disorders in females: genetics, pathophysiology, and treatmentKatherine A Halmi
Weill Cornell Medical College, Dept of Psychiatry, White Plains, NY 10605, USA
J Pediatr Endocrinol Metab 15:1379-86. 2002..For bulimia nervosa, the treatment of choice is cognitive-behavioral therapy with directions in a manual for therapists. A second choice for treatment is an antidepressant, beginning with fluoxetine...
An examination of early childhood perfectionism across anorexia nervosa subtypesKatherine A Halmi
Department of Psychiatry, Weill Cornell Medical College, NY, USA
Int J Eat Disord 45:800-7. 2012..To examine childhood perfectionism in anorexia nervosa (AN) restricting (RAN), purging (PAN), and binge eating with or without purging (BAN) subtypes...- Relapse predictors of patients with bulimia nervosa who achieved abstinence through cognitive behavioral therapyKatherine A Halmi
Department of Psychiatry, Weill Medical College of Cornell University, New York Presbyterian Hospital Westchester Division, 21 Bloomingdale Rd, White Plains, NY 10605, USA
Arch Gen Psychiatry 59:1105-9. 2002..Identification of relapse predictors may be useful to design effective early intervention strategies for relapse of susceptible patients with bulimia nervosa... - Perfectionism in anorexia nervosa: variation by clinical subtype, obsessionality, and pathological eating behaviorK A Halmi
Eating Disorders Program, New York Presbyterian Hospital Westchester Division, Weill Medical College of Cornell University, White Plains, NY 10605, USA
Am J Psychiatry 157:1799-805. 2000..The purpose of this study was to examine the role of perfectionism as a phenotypic trait in anorexia nervosa and its relevance across clinical subtypes of this illness... - Predictors of treatment acceptance and completion in anorexia nervosa: implications for future study designsKatherine A Halmi
Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY 10605, USA
Arch Gen Psychiatry 62:776-81. 2005..There have been very few randomized controlled treatment studies of anorexia nervosa... - Obsessions and compulsions in anorexia nervosa subtypesKatherine A Halmi
New York Presbyterian Hospital Westchester Division, Weill Medical College of Cornell University, 21 Bloomingdale Road, White Plains, NY 10605, USA
Int J Eat Disord 33:308-19. 2003..We examined the type and frequency of characteristic OCD obsessions and compulsions in a large sample of AN patients... - Anorexia nervosa: an increasing problem in children and adolescentsKatherine A Halmi
Weill Cornell Medical College, White Plains, New York 10605, USA
Dialogues Clin Neurosci 11:100-3. 2009..There is some indication that anxiety disorders in childhood may be a major risk factor for the development of anorexia nervosa. Early recognition and family treatment for this disorder are essential to prevent chronic impairment... 
Perplexities and provocations of eating disordersKatherine A Halmi
Weill Cornell Medical College, 21 Bloomingdale Rd, White Plains, NY 10605, USA
J Child Psychol Psychiatry 50:163-9. 2009..Etiological hypotheses of eating disorders, anorexia nervosa and bulimia nervosa have not produced informative research for predictably effective treatment...- A 1-year follow-up of a multi-center treatment trial of adults with anorexia nervosaJ Yu
Department of Psychiatry, Stanford University School of Medicine, Stanford, CA 94305 5722, USA
Eat Weight Disord 16:e177-81. 2011..To examine maintenance of recovery following treatment in an adult anorexia nervosa (AN) population... - Alcohol use disorder comorbidity in eating disorders: a multicenter studyCynthia M Bulik
Department of Psychiatry, University of North Carolina at Chapel Hill, 27599 7160, USA
J Clin Psychiatry 65:1000-6. 2004..Our aim was to explore the nature of the co-morbid relation between AUDs and eating disorders in a large and phenotypically well-characterized group of individuals... - Evidence for a susceptibility gene for anorexia nervosa on chromosome 1D E Grice
Department of Psychiatry, University of Pennsylvania, PA 19104, USA
Am J Hum Genet 70:787-92. 2002..03, at marker D1S3721 on chromosome 1p. The genotyping of additional markers in this region led to a peak multipoint NPL score of 3.45, thereby providing suggestive evidence for the presence of an AN-susceptibility locus on chromosome 1p... - Changing patterns of hospitalization in eating disorder patientsC V Wiseman
The Cornell Eating Disorders Program, Department of Psychiatry, Weill College of Medicine at Cornell University, White Plains, New York 10605, USA
Int J Eat Disord 30:69-74. 2001..For some patients, this change has been deleterious and not cost effective... - Relationships between features associated with vomiting in purging-type eating disordersLauren Reba
Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina 27599-7160, USA
Int J Eat Disord 38:287-94. 2005..Specifically targeting treatment to decrease duration of exposure to this dangerous symptom continues to be an important clinical objective... - Symptom fluctuation in eating disorders: correlates of diagnostic crossoverFederica Tozzi
Department of Psychiatry, CB 7160, University of North Carolina at Chapel Hill, Neurosciences Hospital, Chapel Hill, NC 27599-7160l, USA
Am J Psychiatry 162:732-40. 2005..These results indicate that personality and family characteristics may influence the course of eating disorders and may be informative for planning interventions... - Differences in DSM-III-R and DSM-IV diagnoses in eating disorder patientsS R Sunday
New York Presbyterian Hospital-Weill Medical College of Cornell University, White Plains, NY 10605, USA
Compr Psychiatry 42:448-55. 2001..While there are considerable areas of overlap in DSM-IV and DSM-III-R, there are also areas of substantial differences. Clinicians and researchers must be very cautious when attempting to compare data from the different nosologies... - The relation among perfectionism, obsessive-compulsive personality disorder and obsessive-compulsive disorder in individuals with eating disordersKatherine A Halmi
New York Presbyterian Hospital-Westchester Division, Weill Medical College of Cornell University, White Plains, New York, USA
Int J Eat Disord 38:371-4. 2005..The pairing of perfectionism with OCPD may be a relevant core behavioral feature underlying vulnerability to ED... - Substance use disorders in women with anorexia nervosaTammy L Root
Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA
Int J Eat Disord 43:14-21. 2010..Secondary analyses examined SUD related to lifetime purging behavior and lifetime binge eating... - Suicide attempts in anorexia nervosaCynthia M Bulik
Department of Psychiatry, University of North Carolina at Chapel Hill, 101 Manning Drive, CB 7160, Chapel Hill, NC 27599 7160, USA
Psychosom Med 70:378-83. 2008..To explore prevalence and patterns of suicidal attempts in persons with anorexia nervosa (AN)... - A 4-year prospective study of eating disorder NOS compared with full eating disorder syndromesW Stewart Agras
Department of Psychiatry, Stanford University School of Medicine, Stanford, California, USA
Int J Eat Disord 42:565-70. 2009..To examine the course of Eating Disorder NOS (EDNOS) compared with anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED)... - Comparison of the yale-brown-cornell eating disorders scale in recovered eating disorder patients, restrained dieters, and nondieting controlsS R Sunday
Department of Psychiatry, Weill Medical College of Cornell University White Plains, New York 10605, USA
Int J Eat Disord 28:455-9. 2000..Yale-Brown-Cornell Eating Disorder Scale (YBC-EDS) scores were assessed in recovered eating disorder patients, restrained dieters, and unrestrained nondieters... - Neurocognitive evidence favors "top down" over "bottom up" mechanisms in the pathogenesis of body size distortions in anorexia nervosaJ Epstein
Department of Psychiatry, Weill Medical College of Cornell University, New York, USA
Eat Weight Disord 6:140-7. 2001..This, in turn, suggests that their body image distortion may not be secondary to bottom-up perceptual disturbances... - Patterns of menstrual disturbance in eating disordersAndréa Poyastro Pinheiro
Department of Psychiatry, University of North Carolina at Chapel Hill, North Carolina 27599 7160, USA
Int J Eat Disord 40:424-34. 2007..To describe menstrual disturbance in eating disorders (ED)... - Genetic analysis of bulimia nervosa: methods and sample descriptionWalter H Kaye
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Int J Eat Disord 35:556-70. 2004..The current study presents the clinical characteristics of this sample as well as a description of the study methodology... - Use of nutritional supplements to increase the efficacy of fluoxetine in the treatment of anorexia nervosaNicole C Barbarich
Department of Psychiatry, University of Pittsburgh Medical School, Anorexia and Bulimia Nervosa Research Module, Pittsburgh, Pennsylvania 15213, USA
Int J Eat Disord 35:10-5. 2004..DISCUSSION: The results of this study suggest that supplement strategies are not a substitute for adequate nutrition and are ineffective in increasing the efficacy of fluoxetine in underweight AN subjects... - Influence of overanxious disorder of childhood on the expression of anorexia nervosaT J Raney
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7160, USA
Int J Eat Disord 41:326-32. 2008..This study investigates the prevalence of overanxious disorder (OAD) among women with AN and explores how OAD impacts AN symptoms and personality traits... - Association study of 182 candidate genes in anorexia nervosaAndrea Poyastro Pinheiro
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7160, USA
Am J Med Genet B Neuropsychiatr Genet 153:1070-80. 2010.... - An adolescent with anorexia nervosa and gastrointestinal stromal tumorsGladys J Frankel
Department of Psychiatry, Weill Medical College of Cornell University, New York 10605, USA
Am J Psychiatry 160:1056-9. 2003 - Sexual functioning in women with eating disordersAndrea Poyastro Pinheiro
Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA
Int J Eat Disord 43:123-9. 2010..To describe sexual functioning in women with eating disorders... - An eating disorder curriculum for primary care providersV W Gurney
Weill Medical College of Cornell University Westchester Division, White Plains, New York 10605, USA
Int J Eat Disord 30:209-12. 2001.... - Linkage analysis of anorexia nervosa incorporating behavioral covariatesBernie Devlin
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213 2593, USA
Hum Mol Genet 11:689-96. 2002..50, P = 0.00035). By comparing our results to those implemented using more standard linkage methods, we find the covariates convey substantial information for the linkage analysis... - Report of the National Institutes of Health workshop on overcoming barriers to treatment research in anorexia nervosaW Stewart Agras
Department of Psychiatry, Stanford University School of Medicine, Stanford, California, USA
Int J Eat Disord 35:509-21. 2004..DISCUSSION: It is crucial that treatment research in this area be prioritized... - Smoking in eating disordersDoris Anzengruber
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7160, USA
Eat Behav 7:291-9. 2006..Given the high prevalence, the impact of ongoing smoking on maintenance of eating disorders symptoms is worthy of both clinical and research attention... - Temporal patterns of recovery across eating disorder subtypesAnn Von Holle
Department of Psychiatry, University of North Carolina at Chapel Hill, North Carolina 27599 7160, USA
Aust N Z J Psychiatry 42:108-17. 2008..To compare patterns of recovery in individuals with index episodes of anorexia nervosa (AN) and bulimia nervosa (BN)... - Linkage analysis of anorexia and bulimia nervosa cohorts using selected behavioral phenotypes as quantitative traits or covariatesSilviu-Alin Bacanu
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213-2593, USA
Am J Med Genet B Neuropsychiatr Genet 139:61-8. 2005..3); for covariate-based linkage analysis, five suggestive signals (for BMI at 4q13.1, for CM at 11p11.2 and 17q25.1, and for OBF at 17q25.1 and 15q26.2). Overlap between the two cohorts was minimal for substantial linkage signals... - Selection of eating-disorder phenotypes for linkage analysisCynthia M Bulik
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Am J Med Genet B Neuropsychiatr Genet 139:81-7. 2005..Linkage results appear in a subsequent report. Our report lays out a systematic roadmap for utilizing a rich set of phenotypes for genetic analyses, including the selection of linkage methods paired to those phenotypes... - Features associated with excessive exercise in women with eating disordersHemal Shroff
Department of Psychiatry, University of North Carolina, Chapel Hill, NC 27599-7160, and Center for Eating Disorders at Sheppard and Enoch Pratt Hospital, Towson, MD, USA
Int J Eat Disord 39:454-61. 2006..CONCLUSION: Excessive exercise may be associated particularly with the purging subtype of AN as well as with a constellation of anxious/obsessional temperament and personality characteristics among women with eating disorders... - Childhood anxiety associated with low BMI in women with anorexia nervosaJocilyn E Dellava
Department of Psychiatry, University of North Carolina at Chapel Hill, 101 Manning Drive, CB 7160, Chapel Hill, NC 27599 7160, USA
Behav Res Ther 48:60-7. 2010..The present study explores childhood personality characteristics that could be associated with the ability to attain an extremely low BMI... - Energy intake and body composition in anorexia and bulimia nervosaSuzanne R Sunday
Department of Psychiatry, North Shore University Hospital, 400 Community Drive, Manhasset, NY 11030, USA
Physiol Behav 78:11-7. 2003..Other than BMI at hospital admission, bulimics' energy intakes were unrelated to all demographic and eating disorder-related variables, including body composition... - Significant linkage on chromosome 10p in families with bulimia nervosaCynthia M Bulik
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298 0126, USA
Am J Hum Genet 72:200-7. 2003..92 and 3.39, meet the widely accepted criterion for genomewide significance. Another region on 14q meets the criterion for genomewide suggestive linkage, with MLSs of 1.97 (full sample) and 1.75 (subset) at 62 centimorgans from p-ter... - The perplexities of conducting randomized, double-blind, placebo-controlled treatment trials in anorexia nervosa patientsKatherine A Halmi
Am J Psychiatry 165:1227-8. 2008 - A placebo-controlled study of fluoxetine in continued treatment of bulimia nervosa after successful acute fluoxetine treatmentSteven J Romano
Pfizer Inc. New York, USA
Am J Psychiatry 159:96-102. 2002..CONCLUSIONS: Continued treatment with fluoxetine in patients with bulimia nervosa who responded to acute treatment with fluoxetine improved outcome and decreased the likelihood of relapse... - A comparison of cognitive and behavioral symptoms between Mexican and American eating disorder patientsAlejandro R Caballero
, Mexico City,
Int J Eat Disord 34:136-41. 2003..DISCUSSION: Cultural factors may influence characteristics of eating disorders. The previous treatment experiences of the U.S. patients seemed to positively influence their motivation for further treatment... - Personality in men with eating disordersD Blake Woodside
Program for Eating Disorders, University Health Network, Toronto General Hospital, Toronto, Ontario, Canada
J Psychosom Res 57:273-8. 2004..This study compares personality variables of men with eating disorders to women with eating disorders... - Personality characteristics of women before and after recovery from an eating disorderKelly L Klump
Department of Psychology, Michigan State University, East Lansing, MI 48824 1116, USA
Psychol Med 34:1407-18. 2004..This study compares personality characteristics among women who are ill with eating disorders, recovered from eating disorders, and those without eating or other Axis I disorder pathology... - Association of multiple DRD2 polymorphisms with anorexia nervosaAndrew W Bergen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7236, USA
Neuropsychopharmacology 30:1703-10. 2005..Genetically transmitted variation in D2 dopamine receptor expression mediated by functional polymorphisms affecting transcription and translation efficiency may play a role in vulnerability to AN... - From Giacometti to Botero: images of eating disorders under investigationKatherine A Halmi
Am J Psychiatry 160:205-7. 2003 - Symptom profile of major depressive disorder in women with eating disordersFernando Fernandez Aranda
Department of Psychiatry, University Hospital of Bellvitge, Barcelona, Spain
Aust N Z J Psychiatry 41:24-31. 2007..The temporal relation between EDs and MDD onset was analyzed to determine differences in the course and nature of MDD when experienced prior to versus after the onset of the ED... - Application of a latent class analysis to empirically define eating disorder phenotypesPamela K Keel
Department of Psychology, Harvard University, Cambridge, MA, USA
Arch Gen Psychiatry 61:192-200. 2004..Diagnostic criteria for eating disorders influence how we recognize, research, and treat eating disorders, and empirically valid phenotypes are required for revealing their genetic bases... - Features associated with diet pill use in individuals with eating disordersLauren Reba-Harrelson
Department of Psychiatry, University of North Carolina at Chapel Hill, NC, United States
Eat Behav 9:73-81. 2008..In the eating disorder population, vigilant screening for diet pill use should be routine clinical practice...
Research Grants
- Family Therapy and Fluoxetine in the Treatment of AdolescentsKatherine Halmi; Fiscal Year: 2007..From the public health perspective, development of effective treatments for adolescents will reduce the morbidity, mortality, and high costs associated with chronic AN. ..
- The Genetics of Anorexia NervosaKatherine Halmi; Fiscal Year: 2005..The diagnostic and genetic data and lymphoblastoid cell lines (derived from blood samples) will become part of a national archival resource for genetic studies of AN through the NIMH Genetics Initiative. ..
- STEPPED CARE VS. BEST AVAILABLE CARE FOR BULIMIA NERVOSAKatherine Halmi; Fiscal Year: 2004..abstract_text> ..