Lorraine J Gudas


Affiliation: Cornell University
Country: USA


  1. Serio R, Laursen K, Urvalek A, Gross S, Gudas L. Ethanol promotes differentiation of embryonic stem cells through retinoic acid receptor-γ. J Biol Chem. 2019;294:5536-5548 pubmed publisher
    ..In stem cells, EtOH may shift cell fate decisions to alter developmental outcomes by increasing endogenous ROL/RA signaling via increased Stra6 expression and ROL oxidation. ..
  2. Quintero C, Laursen K, Mongan N, Luo M, Gudas L. CARM1 (PRMT4) Acts as a Transcriptional Coactivator during Retinoic Acid-Induced Embryonic Stem Cell Differentiation. J Mol Biol. 2018;430:4168-4182 pubmed publisher
  3. Trasino S, Tang X, Shevchuk M, Choi M, Gudas L. Amelioration of Diabetic Nephropathy Using a Retinoic Acid Receptor ?2 Agonist. J Pharmacol Exp Ther. 2018;367:82-94 pubmed publisher
    ..Given the need for novel DN therapies, our results warrant further studies of the therapeutic properties of AC261 in DN. ..
  4. Wang G, Badylak S, Heber Katz E, Braunhut S, Gudas L. The effects of DNA methyltransferase inhibitors and histone deacetylase inhibitors on digit regeneration in mice. Regen Med. 2010;5:201-20 pubmed publisher
    ..5-aza-dC and TSA treatments stimulated cell proliferation at the amputation site, possibly via increased expression of genes involved in digit development and regeneration. ..
  5. Trasino S, Benoit Y, Gudas L. Vitamin A deficiency causes hyperglycemia and loss of pancreatic β-cell mass. J Biol Chem. 2015;290:1456-73 pubmed publisher
    ..Pharmacologic modulation of pancreatic VA signaling should be explored for the preservation and/or restoration of pancreatic β-cell mass and function in individuals with diabetes mellitus. ..
  6. Fu L, Minton D, Zhang T, Nanus D, Gudas L. Genome-Wide Profiling of TRACK Kidneys Shows Similarity to the Human ccRCC Transcriptome. Mol Cancer Res. 2015;13:870-8 pubmed publisher
    ..TRACK (GGT-HIF1αM3) kidney mRNA profiles show similarities to human ccRCC transcriptome and phenotypes associated with the Warburg effect. ..
  7. Laursen K, Gudas L. Combinatorial knockout of RARα, RARβ, and RARγ completely abrogates transcriptional responses to retinoic acid in murine embryonic stem cells. J Biol Chem. 2018;293:11891-11900 pubmed publisher
    ..Our key finding, that in embryonic stem cells the transcriptional effects of RA all depend on RARs, addresses a long-standing topic of discussion in the field of retinoic acid signaling. ..
  8. Orfali N, McKenna S, Cahill M, Gudas L, Mongan N. Retinoid receptor signaling and autophagy in acute promyelocytic leukemia. Exp Cell Res. 2014;324:1-12 pubmed publisher
    ..Here we discuss retinoid signaling in hematopoiesis, leukemogenesis, and APL treatment. We highlight autophagy as a potential important regulator in anti-leukemic strategies. ..
  9. Laursen K, Kashyap V, SCANDURA J, Gudas L. An alternative retinoic acid-responsive Stra6 promoter regulated in response to retinol deficiency. J Biol Chem. 2015;290:4356-66 pubmed publisher
    ..Our data show that kidneys respond to retinol deficiency by differential Stra6 promoter usage, which may play a role in the retention of retinol when vitamin A is low. ..

More Information


  1. Trasino S, Tang X, Jessurun J, Gudas L. A retinoic acid receptor β2 agonist reduces hepatic stellate cell activation in nonalcoholic fatty liver disease. J Mol Med (Berl). 2016;94:1143-1151 pubmed
    ..Retinoids and retinoic acid receptors (RARs) possess favorable metabolic modulating properties. • We show that an agonist for retinoic acid receptor-β2 (RARβ2), but not RARγ, mitigates HSC activation and NAFLD. ..
  2. Gudas L, Wagner J. Retinoids regulate stem cell differentiation. J Cell Physiol. 2011;226:322-30 pubmed publisher
    ..Mechanistic studies of retinoid signaling continue to suggest novel drug targets and will improve therapeutic strategies for cancer and other diseases, such as immune-mediated inflammatory diseases. ..
  3. Gudas L. Retinoids induce stem cell differentiation via epigenetic changes. Semin Cell Dev Biol. 2013;24:701-5 pubmed publisher
    ..A more complete understanding of retinoid-dependent stem cell differentiation should reward us with new insights into the failure to maintain a differentiated state that is an essential part of neoplastic cell transformation and cancer. ..
  4. Urvalek A, Gudas L. Retinoic acid and histone deacetylases regulate epigenetic changes in embryonic stem cells. J Biol Chem. 2014;289:19519-30 pubmed publisher
    ..Overall, we show that HDACs differentially bind to RA-regulated genes to control key epigenetic marks involved in stem cell differentiation. ..
  5. Minton D, Fu L, Mongan N, Shevchuk M, Nanus D, Gudas L. Role of NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex 4-Like 2 in Clear Cell Renal Cell Carcinoma. Clin Cancer Res. 2016;22:2791-801 pubmed publisher
    ..Collectively, our data show that NDUFA4L2 is a novel molecular target for ccRCC treatment. Clin Cancer Res; 22(11); 2791-801. ©2016 AACR. ..