Lorraine Gudas

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. pmc Transcriptional activation of the suppressor of cytokine signaling-3 (SOCS-3) gene via STAT3 is increased in F9 REX1 (ZFP-42) knockout teratocarcinoma stem cells relative to wild-type cells
    Juliana Xu
    Pharmacology Department, Weill Cornell Medical College, 1300 York Avenue, Room E 409, New York, NY 10021, USA
    J Mol Biol 377:28-46. 2008
  2. ncbi request reprint The role of HIF1α in renal cell carcinoma tumorigenesis
    Lorraine J Gudas
    Department of Pharmacology, Weill Cornell Medical College WCMC of Cornell University, New York, NY, 10065, USA
    J Mol Med (Berl) 92:825-36. 2014
  3. pmc Polycomb recruitment attenuates retinoic acid-induced transcription of the bivalent NR2F1 gene
    Kristian B Laursen
    Department of Pharmacology, Weill Cornell Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA
    Nucleic Acids Res 41:6430-43. 2013
  4. pmc Estrogen receptor-β expression and pharmacological targeting in bladder cancer
    Eric C Kauffman
    Department of Urology, Weill Cornell Medical College, New York, NY 10065, USA
    Oncol Rep 30:131-8. 2013
  5. pmc Epigenetic regulation by RARα maintains ligand-independent transcriptional activity
    Kristian B Laursen
    Pharmacology Department of Weill Cornell Medical College of Cornell University, NY 10065, USA
    Nucleic Acids Res 40:102-15. 2012
  6. pmc Retinoids induce stem cell differentiation via epigenetic changes
    Lorraine J Gudas
    Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA Department of Medicine, Weill Medical College of Cornell University, New York, NY 10065, USA Electronic address
    Semin Cell Dev Biol 24:701-5. 2013
  7. pmc Emerging roles for retinoids in regeneration and differentiation in normal and disease states
    Lorraine J Gudas
    PharmacologyDepartment, Weill Cornell Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA
    Biochim Biophys Acta 1821:213-21. 2012
  8. pmc Retinoids regulate stem cell differentiation
    Lorraine J Gudas
    Department of Pharmacology, Weill Cornell Medical College of Cornell University, New York, New York 10065, USA
    J Cell Physiol 226:322-30. 2011
  9. ncbi request reprint Stem cells, differentiation and cancer: mentors, colleagues and academic administration
    Lorraine J Gudas
    Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Cancer Biol Ther 5:1244-6. 2006
  10. doi request reprint The effects of DNA methyltransferase inhibitors and histone deacetylase inhibitors on digit regeneration in mice
    Gang Wang
    Department of Pharmacology, Weill Cornell Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA
    Regen Med 5:201-20. 2010

Research Grants

Collaborators

  • Erik G Lund
  • Dan Su
  • Pierre Chambon
  • Stephen F Badylak
  • Gang Wang
  • Ellen Heber-Katz
  • R Li
  • Daniel C Weinstein
  • K S Zaret
  • Michael Dyer
  • Tina Raman
  • John A Wagner
  • Ker Yu
  • Nigel P Mongan
  • Xiao Han Tang
  • Kristian B Laursen
  • Vasundhra Kashyap
  • Robert F Gillespie
  • Limin Liu
  • Eduardo Martinez-Ceballos
  • Kymora B Scotland
  • Renia Sylvester
  • Juliana Xu
  • Yong Zhuang
  • Michelle A Lane
  • Ann P Tighe
  • Eric C Kauffman
  • Kurt A Reynertson
  • Rui Wang
  • Kevin A David
  • Cristina C Fernandez
  • Theresa Scognamiglio
  • Martin Albert
  • Siming Chen
  • Fadila Derguini
  • Simne Langton
  • David M Nanus
  • Sue Ellen Touma
  • Anne C Chen
  • Deanna Mohn
  • Philippe Costet
  • James R Thompson
  • Douglas S Scherr
  • Mary M Ng
  • Yannick D Benoit
  • Katarzyna Marcinkiewicz
  • Brian D Robinson
  • Martin Downes
  • Srinivas Vourganti
  • Pui Mun Wong
  • Mary E Charlson
  • Jacqueline Salit
  • Yael Strulovici-Barel
  • Megan J Ricard
  • Ronald G Crystal
  • Neil R Hackett
  • Christopher Smith
  • Barbara Ferris
  • Jenny Liao Persson
  • Naira C Rezende
  • Sebastian M Shaffer
  • Elana W Wilen
  • Marina Vivero
  • Kisha M Martin
  • Paul Moench
  • Xiaojia Guo
  • Satish K Tickoo
  • Jonathan S Goldberg
  • Beatrice Knudsen
  • Debra Bemis
  • Satish Tickoo
  • Teresa N Faria
  • Margaret H Baron
  • Alan R Tall
  • Kenneth Sahr
  • Siming W Chen
  • Jennifer R Molina
  • Dora Campos Dias
  • Charles E Ducker
  • Gordon Keller
  • Marie C Gerbod-Giannone
  • Florent Lalanne
  • Xuan Fu
  • Elizabeth Zahradka

Detail Information

Publications41

  1. pmc Transcriptional activation of the suppressor of cytokine signaling-3 (SOCS-3) gene via STAT3 is increased in F9 REX1 (ZFP-42) knockout teratocarcinoma stem cells relative to wild-type cells
    Juliana Xu
    Pharmacology Department, Weill Cornell Medical College, 1300 York Avenue, Room E 409, New York, NY 10021, USA
    J Mol Biol 377:28-46. 2008
    ..Thus, Rex1, which is highly expressed in stem cells, inhibits signaling via the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway, thereby modulating the differentiation of F9 cells...
  2. ncbi request reprint The role of HIF1α in renal cell carcinoma tumorigenesis
    Lorraine J Gudas
    Department of Pharmacology, Weill Cornell Medical College WCMC of Cornell University, New York, NY, 10065, USA
    J Mol Med (Berl) 92:825-36. 2014
    ..This indicates that current understanding of the exact roles of HIF1α and HIF2α is incomplete and that further research is required to determine the diverse roles of HIF1α and HIF2α in ccRCC...
  3. pmc Polycomb recruitment attenuates retinoic acid-induced transcription of the bivalent NR2F1 gene
    Kristian B Laursen
    Department of Pharmacology, Weill Cornell Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA
    Nucleic Acids Res 41:6430-43. 2013
    ..We propose that PRC2 recruitment attenuates the RA-associated transcriptional activation of a subset of genes. Such a mechanism would permit the fine-tuning of transcriptional networks during differentiation. ..
  4. pmc Estrogen receptor-β expression and pharmacological targeting in bladder cancer
    Eric C Kauffman
    Department of Urology, Weill Cornell Medical College, New York, NY 10065, USA
    Oncol Rep 30:131-8. 2013
    ..Our study supports a role for ERβ in aggressive UCB. Pharmacological targeting of ERβ warrants further investigation as a therapeutic strategy in UCB...
  5. pmc Epigenetic regulation by RARα maintains ligand-independent transcriptional activity
    Kristian B Laursen
    Pharmacology Department of Weill Cornell Medical College of Cornell University, NY 10065, USA
    Nucleic Acids Res 40:102-15. 2012
    ..We propose that RARα plays an important role in cellular memory and imprinting by regulating the CpG methylation status of specific promoter regions...
  6. pmc Retinoids induce stem cell differentiation via epigenetic changes
    Lorraine J Gudas
    Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA Department of Medicine, Weill Medical College of Cornell University, New York, NY 10065, USA Electronic address
    Semin Cell Dev Biol 24:701-5. 2013
    ..A more complete understanding of retinoid-dependent stem cell differentiation should reward us with new insights into the failure to maintain a differentiated state that is an essential part of neoplastic cell transformation and cancer...
  7. pmc Emerging roles for retinoids in regeneration and differentiation in normal and disease states
    Lorraine J Gudas
    PharmacologyDepartment, Weill Cornell Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA
    Biochim Biophys Acta 1821:213-21. 2012
    ..This article is part of a Special Issue entitled Retinoid and Lipid Metabolism...
  8. pmc Retinoids regulate stem cell differentiation
    Lorraine J Gudas
    Department of Pharmacology, Weill Cornell Medical College of Cornell University, New York, New York 10065, USA
    J Cell Physiol 226:322-30. 2011
    ..Mechanistic studies of retinoid signaling continue to suggest novel drug targets and will improve therapeutic strategies for cancer and other diseases, such as immune-mediated inflammatory diseases...
  9. ncbi request reprint Stem cells, differentiation and cancer: mentors, colleagues and academic administration
    Lorraine J Gudas
    Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Cancer Biol Ther 5:1244-6. 2006
  10. doi request reprint The effects of DNA methyltransferase inhibitors and histone deacetylase inhibitors on digit regeneration in mice
    Gang Wang
    Department of Pharmacology, Weill Cornell Medical College of Cornell University, 1300 York Avenue, New York, NY 10065, USA
    Regen Med 5:201-20. 2010
    ..Wound-site tissue was collected...
  11. pmc Smoking-induced upregulation of AKR1B10 expression in the airway epithelium of healthy individuals
    Rui Wang
    Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Chest 138:1402-10. 2010
    ..We hypothesized that upregulation of AKR1B10 expression may be initiated in healthy smokers prior to the development of evidence of lung cancer...
  12. ncbi request reprint Diverse actions of retinoid receptors in cancer prevention and treatment
    Nigel P Mongan
    Department of Pharmacology, Weill Cornell Medical College, New York, NY 10021, USA
    Differentiation 75:853-70. 2007
    ....
  13. pmc A DNA methyltransferase inhibitor and all-trans retinoic acid reduce oral cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide
    Xiao Han Tang
    Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA
    Cancer Prev Res (Phila) 2:1100-10. 2009
    ..Collectively, our results show that the combination of a DNA demethylating drug and RA has potential as a strategy to reduce oral cavity cancer in this 4-NQO model...
  14. ncbi request reprint Retinoic acid inhibits leukemia inhibitory factor signaling pathways in mouse embryonic stem cells
    Ann P Tighe
    Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Cell Physiol 198:223-9. 2004
    ..Our data indicate that RA-induced inhibition of LIF signaling does not involve Erk1/2-dependent actions...
  15. ncbi request reprint Retinoic acid induces parietal endoderm but not primitive endoderm and visceral endoderm differentiation in F9 teratocarcinoma stem cells with a targeted deletion of the Rex-1 (Zfp-42) gene
    James R Thompson
    Department of Pharmacology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Mol Cell Endocrinol 195:119-33. 2002
    ..These results indicate that the Rex-1 transcription factor regulates the differentiation of F9 stem cells along several distinct cell lineages found in the early embryo...
  16. ncbi request reprint Retinoic acid receptor isotype specificity in F9 teratocarcinoma stem cells results from the differential recruitment of coregulators to retinoic response elements
    Robert F Gillespie
    Molecular Biology Program, Weill Graduate School of Medical Sciences, Cornell University, New York, New York 10021, USA
    J Biol Chem 282:33421-34. 2007
    ..Thus, transcriptional components of the RAR signaling pathway are specifically required for displacement of SUZ12 from RAREs during RA-mediated differentiation of F9 cells...
  17. ncbi request reprint Overexpression of CRABPI in suprabasal keratinocytes enhances the proliferation of epidermal basal keratinocytes in mouse skin topically treated with all-trans retinoic acid
    Xiao Han Tang
    Department of Pharmacology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10021, USA
    Exp Cell Res 314:38-51. 2008
    ....
  18. pmc Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs
    Vasundhra Kashyap
    Department of Pharmacology, Graduate Programs in Pharmacology, Weill Cornell Medical College, New York, New York 10065, USA
    Stem Cells Dev 18:1093-108. 2009
    ....
  19. ncbi request reprint Homozygous deletion of the CRABPI gene in AB1 embryonic stem cells results in increased CRABPII gene expression and decreased intracellular retinoic acid concentration
    Anne C Chen
    Department of Pharmacology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Arch Biochem Biophys 411:159-73. 2003
    ..These data suggest that CRABPI functions to regulate the intracellular concentrations of retinoic acid and to maintain high levels of oxidized retinoic acid metabolites such as 4-oxoretinoic acid within cells...
  20. pmc Retinoic acid receptor-mediated induction of ABCA1 in macrophages
    Philippe Costet
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    Mol Cell Biol 23:7756-66. 2003
    ..The more specific RAR activator TTNPB did not induce SREBP-1c in mouse primary macrophages or liver. These studies indicate a direct role of RARgamma/RXR in induction of macrophage ABCA1...
  21. ncbi request reprint Differences in gene expression between wild type and Hoxa1 knockout embryonic stem cells after retinoic acid treatment or leukemia inhibitory factor (LIF) removal
    Eduardo Martinez-Ceballos
    Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 280:16484-98. 2005
    ..Finally, we propose a model in which the Hoxa1 protein mediates repression of endodermal differentiation while promoting expression of ectodermal and mesodermal characteristics...
  22. ncbi request reprint Mouse Mix gene is activated early during differentiation of ES and F9 stem cells and induces endoderm in frog embryos
    Deanna Mohn
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10128, USA
    Dev Dyn 226:446-59. 2003
    ....
  23. ncbi request reprint Disruption of the lecithin:retinol acyltransferase gene makes mice more susceptible to vitamin A deficiency
    Limin Liu
    Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 280:40226-34. 2005
    ....
  24. doi request reprint CYP26A1 knockout embryonic stem cells exhibit reduced differentiation and growth arrest in response to retinoic acid
    Simne Langton
    Department of Pharmacology, Weill Cornell Medical College, 1300 York Avenue, Rm E 409, New York, NY 10021, USA
    Dev Biol 315:331-54. 2008
    ..Collectively, our results show that CYP26A1 activity regulates intracellular RA levels, cell proliferation, transcriptional regulation of primary RA target genes, and ES cell differentiation to parietal endoderm...
  25. ncbi request reprint The putative human stem cell marker, Rex-1 (Zfp42): structural classification and expression in normal human epithelial and carcinoma cell cultures
    Nigel P Mongan
    Department of Pharmacology, Weill Medical College, Cornell University, New York, New York 10021, USA
    Mol Carcinog 45:887-900. 2006
    ....
  26. ncbi request reprint Identification and characterization of retinoic acid receptor beta2 target genes in F9 teratocarcinoma cells
    Yong Zhuang
    Pharmacology Department, Weill Medical College of Cornell University, New York, NY, USA
    Mol Cancer Res 1:619-30. 2003
    ..Because the lack of RARbeta(2) alters both the control of proliferation and differentiation in F9 cells, the genes that we have characterized may mediate key effects of RA, via RARbeta(2), on these processes...
  27. ncbi request reprint Oral cavity and esophageal carcinogenesis modeled in carcinogen-treated mice
    Xiao Han Tang
    Departments of Pharmacology and Pathology, Weill Medical College of Cornell University, New York, New York
    Clin Cancer Res 10:301-13. 2004
    ..We have developed a mouse model using the carcinogen 4-nitroquinoline 1-oxide (4-NQO) in the drinking water to induce tumorigenesis in the mouse oral cavity...
  28. pmc Induction of murine embryonic stem cell differentiation by medicinal plant extracts
    Kurt A Reynertson
    Center for Complementary and Integrative Medicine, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA
    Exp Cell Res 317:82-93. 2011
    ..Several phytochemical constituents were isolated; the antioxidant phytochemicals ellagic acid and gallic acid were shown to affect viability of cultured breast carcinoma cells...
  29. ncbi request reprint Retinoic acid causes cell growth arrest and an increase in p27 in F9 wild type but not in F9 retinoic acid receptor beta2 knockout cells
    Rong Li
    Department of Pharmacology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Exp Cell Res 294:290-300. 2004
    ..Using both genetic and molecular approaches, we have identified some of the molecular mechanisms, such as the large elevation of p27, through which RARbeta(2) mediates these growth inhibitory effects of RA in F9 cells...
  30. pmc Epigenetic regulatory mechanisms distinguish retinoic acid-mediated transcriptional responses in stem cells and fibroblasts
    Vasundhra Kashyap
    Department of Pharmacology, Weill Cornell Medical College of Cornell University, New York, New York 10065, USA
    J Biol Chem 285:14534-48. 2010
    ..We have delineated the complex mechanisms that control RA-mediated transcription in fibroblasts versus stem cells...
  31. ncbi request reprint Valproic acid, in combination with all-trans retinoic acid and 5-aza-2'-deoxycytidine, restores expression of silenced RARbeta2 in breast cancer cells
    Nigel P Mongan
    Department of Pharmacology, Weill Medical College, Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Mol Cancer Ther 4:477-86. 2005
    ..These data suggest that VPA may ultimately be useful in combination therapies in the treatment of human breast cancers...
  32. pmc Phase I trial of ATRA-IV and Depakote in patients with advanced solid tumor malignancies
    Kevin A David
    Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medical College New York Presbyterian Hospital, New York, NY, USA
    Cancer Biol Ther 9:678-84. 2010
    ..The maximum tolerated dose (MTD) of both drugs in combination could not be established due to early closure of the trial resulting from a halt in the commercial availability of ATRA-IV...
  33. doi request reprint Hoxa1 is required for the retinoic acid-induced differentiation of embryonic stem cells into neurons
    Eduardo Martinez-Ceballos
    Department of Pharmacology, Weill Cornell Medical College, New York, New York 10065, USA
    J Neurosci Res 86:2809-19. 2008
    ..Furthermore, because mutations in the Hoxa1 gene can cause autism spectrum disorder in humans, these data also provide important mechanistic insights into the early developmental processes that may result in this disorder...
  34. pmc The truncated Hoxa1 protein interacts with Hoxa1 and Pbx1 in stem cells
    Cristina C Fernandez
    Department of Pharmacology, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA
    J Cell Biochem 106:427-43. 2009
    ..However, the F9-399 line exhibits no differences in RA-induced proliferation arrest or endogenous Hoxb1, Pbx1, Hoxa5, Cyp26a1, GATA4, or Meis mRNA levels when compared to F9 wild-type...
  35. pmc Overexpression of lecithin:retinol acyltransferase in the epithelial basal layer makes mice more sensitive to oral cavity carcinogenesis induced by a carcinogen
    Xiao Han Tang
    Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA
    Cancer Biol Ther 8:1212-3. 2009
    ..05). Taken together, these data show that overexpression of human LRAT specifically in oral basal epithelial cells makes these cells more sensitive to carcinogen induced tumorigenesis...
  36. pmc Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells
    Robert F Gillespie
    Molecular Biology Program of Weill Graduate School of Medical Sciences, Cornell University, New York, NY 10021, USA
    J Mol Biol 372:298-316. 2007
    ..These studies provide insight into the dynamics of association of co-regulators with RAREs and demonstrate a novel link between RA signaling and PcG repression...
  37. pmc Metabolism and regulation of gene expression by 4-oxoretinol versus all-trans retinoic acid in normal human mammary epithelial cells
    Limin Liu
    Department of Pharmacology, Weill Cornell Medical College of Cornell University, New York, New York 10065, USA
    J Cell Physiol 220:771-9. 2009
    ....
  38. pmc Analysis of Rex1 (zfp42) function in embryonic stem cell differentiation
    Kymora B Scotland
    Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10065, USA
    Dev Dyn 238:1863-77. 2009
    ..These data, taken together, suggest that Rex1 influences differentiation, cell cycle regulation, and cancer progression...
  39. ncbi request reprint Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model
    Sue Ellen Touma
    Department of Pharmacology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Clin Cancer Res 11:3558-66. 2005
    ..Therefore, we tested whether combining histone deacetylase inhibitors with retinoic acid (RA) would restore RARbeta2 receptor expression, leading to increased growth inhibition in RCC cells...
  40. pmc LIF removal increases CRABPI and CRABPII transcripts in embryonic stem cells cultured in retinol or 4-oxoretinol
    Michelle A Lane
    Department of Human Ecology, Division of Nutritional Sciences, The University of Texas at Austin, GEA 117, A2700 Austin, TX 78712, USA
    Mol Cell Endocrinol 280:63-74. 2008
    ..The enormous increases in CRABPI and II transcripts ( approximately 60 and 400-fold, respectively) in the absence of LIF may regulate aspects of the ES cell differentiation program in response to retinol...
  41. pmc Gene expression profiling elucidates a specific role for RARgamma in the retinoic acid-induced differentiation of F9 teratocarcinoma stem cells
    Dan Su
    Department of Pharmacology, Weill Cornell Medical College United States
    Biochem Pharmacol 75:1129-60. 2008
    ..Several genes in the Wnt signaling pathway were regulated by RARgamma. Delineation of the receptor-specific actions of RA with respect to cell proliferation and differentiation should result in more effective therapies with this drug...

Research Grants63

  1. Metabolism of Vitamin A in the Prostate
    Lorraine Gudas; Fiscal Year: 2009
    ..The knowledge generated from these studies should allow us to devise better pharmacological strategies to reverse specific gene repression and to restore more normal retinoid signaling in malignant cells. ..
  2. Retinoic Acid Binding Proteins: Functional Studies
    Lorraine Gudas; Fiscal Year: 2003
    ..This knowledge is required to understand complex processes such as pattern formation in development, cell proliferation control, differentiation, teratogenesis, and tumorigenesis. ..
  3. Metabolism of Vitamin A in the Prostate
    Lorraine Gudas; Fiscal Year: 2005
    ..abstract_text> ..
  4. Retinoic Acid Binding Proteins: Functional Studies
    Lorraine Gudas; Fiscal Year: 2007
    ..This knowledge is required to understand complex processes such as pattern formation in development, cell proliferation control, differentiation, teratogenesis, and tumorigenesis. ..
  5. Diet and Alcohol Induced Epigenetic Changes in an Oral Cavity Carcinogenesis Mode
    Lorraine J Gudas; Fiscal Year: 2010
    ..The proposed research will focus on the mechanisms by which alcohol increases the incidence of oral cavity cancer. ..
  6. SQUAMOUS CELL CARCINOMAS - EFFECTS OF RETINOIDS
    Lorraine Gudas; Fiscal Year: 2006
    ..abstract_text> ..
  7. Cellular Retinoic Acid Binding Proteins: Functional Studies
    Lorraine J Gudas; Fiscal Year: 2010
    ..abstract_text> ..
  8. CELLULAR RETINOIC ACID BINDING PROTEIN--FUNCTIONAL STUDI
    Lorraine Gudas; Fiscal Year: 2002
    ..suprabasal cells of the skin) and at specific times during development using the LAP or the tet inducible expression vectors will be delineated. ..
  9. RETINOIC ACID--ROLE IN DIFFERENTIATION
    Lorraine Gudas; Fiscal Year: 2000
    ....
  10. VITAMIN A (RETINOL) AND 4 OXORETINOL IN BREAST CANCER
    Lorraine Gudas; Fiscal Year: 2001
    ..Our proposed studies may lead to the use of 4-oxoretinol or related compounds in the prevention and/or treatment of human breast cancer. ..
  11. SQUAMOUS CELL CARCINOMAS--EFFECT OF RETINOIDS
    Lorraine Gudas; Fiscal Year: 2001
    ..abstract_text> ..
  12. SQUAMOUS CELL CARCINOMAS--EFFECT OF RETINOIDS
    Lorraine Gudas; Fiscal Year: 2000
    ..abstract_text> ..
  13. VITAMIN A (RETINOL) AND 4 OXORETINOL IN BREAST CANCER
    Lorraine Gudas; Fiscal Year: 2002
    ..Our proposed studies may lead to the use of 4-oxoretinol or related compounds in the prevention and/or treatment of human breast cancer. ..
  14. Metabolism of Vitamin A in the Prostate
    Lorraine Gudas; Fiscal Year: 2006
    ..The knowledge generated from these studies should allow us to devise better pharmacological strategies to reverse specific gene repression and to restore more normal retinoid signaling in malignant cells. ..
  15. SQUAMOUS CELL CARCINOMAS - EFFECTS OF RETINOIDS
    Lorraine J Gudas; Fiscal Year: 2010
    ..The proposed research will focus on the mechanisms by which dietary components and certain drugs can potentially reduce the incidence of oral cavity cancer. ..
  16. SQUAMOUS CELL CARCINOMAS - EFFECTS OF RETINOIDS
    Lorraine J Gudas; Fiscal Year: 2010
    ..The proposed research will focus on the mechanisms by which dietary components and certain drugs can potentially reduce the incidence of oral cavity cancer. ..
  17. Cellular Retinoic Acid Binding Proteins: Functional Studies
    Lorraine J Gudas; Fiscal Year: 2010
    ....
  18. CANCER PHARMACOLOGY
    Lorraine Gudas; Fiscal Year: 2007
    ..Thus, this faculty represents a cohesive, interactive group of individuals who share a common interest in research and training in the area of cancer pharmacology. ..
  19. SQUAMOUS CELL CARCINOMAS - EFFECTS OF RETINOIDS
    Lorraine Gudas; Fiscal Year: 2007
    ..abstract_text> ..
  20. Retinoic Acid Binding Proteins: Functional Studies
    Lorraine Gudas; Fiscal Year: 2006
    ..This knowledge is required to understand complex processes such as pattern formation in development, cell proliferation control, differentiation, teratogenesis, and tumorigenesis. ..
  21. Retinoic Acid Binding Proteins: Functional Studies
    Lorraine Gudas; Fiscal Year: 2007
    ..This knowledge is required to understand complex processes such as pattern formation in development, cell proliferation control, differentiation, teratogenesis, and tumorigenesis. ..
  22. CELLULAR RETINOIC ACID BINDING PROTEIN--FUNCTIONAL STUDI
    Lorraine Gudas; Fiscal Year: 2000
    ..suprabasal cells of the skin) and at specific times during development using the LAP or the tet inducible expression vectors will be delineated. ..
  23. EFFECTS OF RETINOIDS ON SQUAMOUS CELL CARCONOMAS
    Lorraine Gudas; Fiscal Year: 1993
    ..These studies should lead to advances in the clinical treatment of cancerous and precancerous lesions in the oral cavity...
  24. RETINOIC ACID--ROLE IN DIFFERENTIATION
    Lorraine Gudas; Fiscal Year: 1999
    ....
  25. CELLULAR RETINOIC ACID BINDING PROTEIN--FUNCTIONAL STUDI
    Lorraine Gudas; Fiscal Year: 1999
    ..suprabasal cells of the skin) and at specific times during development using the LAP or the tet inducible expression vectors will be delineated. ..
  26. VITAMIN A (RETINOL) AND 4 OXORETINOL IN BREAST CANCER
    Lorraine Gudas; Fiscal Year: 1999
    ..Our proposed studies may lead to the use of 4-oxoretinol or related compounds in the prevention and/or treatment of human breast cancer. ..
  27. Metabolism of Vitamin A in the Prostate
    Lorraine Gudas; Fiscal Year: 2006
    ..The knowledge generated from these studies should allow us to devise better pharmacological strategies to reverse specific gene repression and to restore more normal retinoid signaling in malignant cells. ..
  28. RETINOIC ACID IN DIFFERENTIATION AND CARCINOGENESIS
    Lorraine Gudas; Fiscal Year: 1993
    ..6 and REX-1 by RA, combined with our investigations of the functions of the Hox 1.6 and REX-1 proteins, should provide us with significantly greater knowledge of the processes of cell differentiation, embryogenesis, and carcinogenesis...
  29. Metabolism of Vitamin A in the Prostate
    Lorraine Gudas; Fiscal Year: 2007
    ..The knowledge generated from these studies should allow us to devise better pharmacological strategies to reverse specific gene repression and to restore more normal retinoid signaling in malignant cells. ..
  30. Cellular Retinoic Acid Binding Proteins: Functional Studies
    Lorraine Gudas; Fiscal Year: 2009
    ....
  31. CELLULAR RETINOIC ACID BINDING PROTEIN
    Lorraine Gudas; Fiscal Year: 1993
    ..All of these lines of experimentation should provide us with important new information about the actions of RA and the binding proteins that mediate RA's effects...
  32. CELLULAR RETINOIC ACID BINDING PROTEIN--FUNCTIONAL STUDI
    Lorraine Gudas; Fiscal Year: 2001
    ..suprabasal cells of the skin) and at specific times during development using the LAP or the tet inducible expression vectors will be delineated. ..
  33. EFFECTS OF RETINOIDS ON SQUAMOUS CELL CARCONOMAS
    Lorraine Gudas; Fiscal Year: 1992
    ..These studies should lead to advances in the clinical treatment of cancerous and precancerous lesions in the oral cavity...
  34. RETINOIC ACID--ROLE IN DIFFERENTIATION
    Lorraine Gudas; Fiscal Year: 2001
    ....
  35. SQUAMOUS CELL CARCINOMAS--EFFECT OF RETINOIDS
    Lorraine Gudas; Fiscal Year: 1999
    ..abstract_text> ..
  36. RETINOIC ACID--ROLE IN DIFFERENTIATION
    Lorraine Gudas; Fiscal Year: 2002
    ....
  37. SQUAMOUS CELL CARCINOMAS--EFFECT OF RETINOIDS
    Lorraine Gudas; Fiscal Year: 2002
    ..abstract_text> ..
  38. SQUAMOUS CELL CARCINOMAS--EFFECT OF RETINOIDS
    Lorraine Gudas; Fiscal Year: 2003
    ..abstract_text> ..
  39. SQUAMOUS CELL CARCINOMAS - EFFECTS OF RETINOIDS
    Lorraine Gudas; Fiscal Year: 2004
    ..abstract_text> ..
  40. Retinoic Acid Binding Proteins: Functional Studies
    Lorraine Gudas; Fiscal Year: 2006
    ..This knowledge is required to understand complex processes such as pattern formation in development, cell proliferation control, differentiation, teratogenesis, and tumorigenesis. ..
  41. VITAMIN A (RETINOL) AND 4 OXORETINOL IN BREAST CANCER
    Lorraine Gudas; Fiscal Year: 2000
    ..Our proposed studies may lead to the use of 4-oxoretinol or related compounds in the prevention and/or treatment of human breast cancer. ..
  42. SQUAMOUS CELL CARCINOMAS - EFFECTS OF RETINOIDS
    Lorraine Gudas; Fiscal Year: 2005
    ..abstract_text> ..