Lorraine Gudas

..Thus, Rex1, which is highly expressed in stem cells, inhibits signaling via the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway, thereby modulating the differentiation of F9 cells...

..This article is part of a Special Issue entitled Retinoid and Lipid Metabolism...

..Wound-site tissue was collected...

..Mechanistic studies of retinoid signaling continue to suggest novel drug targets and will improve therapeutic strategies for cancer and other diseases, such as immune-mediated inflammatory diseases...

..We hypothesized that upregulation of AKR1B10 expression may be initiated in healthy smokers prior to the development of evidence of lung cancer...

..Collectively, our results show that the combination of a DNA demethylating drug and RA has potential as a strategy to reduce oral cavity cancer in this 4-NQO model...

..Our data indicate that RA-induced inhibition of LIF signaling does not involve Erk1/2-dependent actions...

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..These results indicate that the Rex-1 transcription factor regulates the differentiation of F9 stem cells along several distinct cell lineages found in the early embryo...

..Thus, transcriptional components of the RAR signaling pathway are specifically required for displacement of SUZ12 from RAREs during RA-mediated differentiation of F9 cells...

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..These data suggest that CRABPI functions to regulate the intracellular concentrations of retinoic acid and to maintain high levels of oxidized retinoic acid metabolites such as 4-oxoretinoic acid within cells...

..Finally, we propose a model in which the Hoxa1 protein mediates repression of endodermal differentiation while promoting expression of ectodermal and mesodermal characteristics...

..The more specific RAR activator TTNPB did not induce SREBP-1c in mouse primary macrophages or liver. These studies indicate a direct role of RARgamma/RXR in induction of macrophage ABCA1...

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..These data, taken together, suggest that Rex1 influences differentiation, cell cycle regulation, and cancer progression...

..The maximum tolerated dose (MTD) of both drugs in combination could not be established due to early closure of the trial resulting from a halt in the commercial availability of ATRA-IV...

..Because the lack of RARbeta(2) alters both the control of proliferation and differentiation in F9 cells, the genes that we have characterized may mediate key effects of RA, via RARbeta(2), on these processes...

..We have delineated the complex mechanisms that control RA-mediated transcription in fibroblasts versus stem cells...

..Several phytochemical constituents were isolated; the antioxidant phytochemicals ellagic acid and gallic acid were shown to affect viability of cultured breast carcinoma cells...

..This model will also allow testing of cancer chemopreventive drugs in various transgenic mouse strains...

..05). Taken together, these data show that overexpression of human LRAT specifically in oral basal epithelial cells makes these cells more sensitive to carcinogen induced tumorigenesis...

..However, the F9-399 line exhibits no differences in RA-induced proliferation arrest or endogenous Hoxb1, Pbx1, Hoxa5, Cyp26a1, GATA4, or Meis mRNA levels when compared to F9 wild-type...

..Furthermore, because mutations in the Hoxa1 gene can cause autism spectrum disorder in humans, these data also provide important mechanistic insights into the early developmental processes that may result in this disorder...

..Collectively, our results show that CYP26A1 activity regulates intracellular RA levels, cell proliferation, transcriptional regulation of primary RA target genes, and ES cell differentiation to parietal endoderm...

..These results indicate that ATRA and histone deacetylase inhibitor therapies should be explored for the treatment of advanced RCC...

..Using both genetic and molecular approaches, we have identified some of the molecular mechanisms, such as the large elevation of p27, through which RARbeta(2) mediates these growth inhibitory effects of RA in F9 cells...

..These data suggest that VPA may ultimately be useful in combination therapies in the treatment of human breast cancers...

..These studies provide insight into the dynamics of association of co-regulators with RAREs and demonstrate a novel link between RA signaling and PcG repression...

..Several genes in the Wnt signaling pathway were regulated by RARgamma. Delineation of the receptor-specific actions of RA with respect to cell proliferation and differentiation should result in more effective therapies with this drug...

..The enormous increases in CRABPI and II transcripts ( approximately 60 and 400-fold, respectively) in the absence of LIF may regulate aspects of the ES cell differentiation program in response to retinol...

..The knowledge generated from these studies should allow us to devise better pharmacological strategies to reverse specific gene repression and to restore more normal retinoid signaling in malignant cells. ..

..This knowledge is required to understand complex processes such as pattern formation in development, cell proliferation control, differentiation, teratogenesis, and tumorigenesis. ..

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..This knowledge is required to understand complex processes such as pattern formation in development, cell proliferation control, differentiation, teratogenesis, and tumorigenesis. ..

..The proposed research will focus on the mechanisms by which alcohol increases the incidence of oral cavity cancer. ..

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..This knowledge is required to understand complex processes such as pattern formation in development, cell proliferation control, differentiation, teratogenesis, and tumorigenesis. ..

..The proposed research will focus on the mechanisms by which dietary components and certain drugs can potentially reduce the incidence of oral cavity cancer. ..

..The proposed research will focus on the mechanisms by which dietary components and certain drugs can potentially reduce the incidence of oral cavity cancer. ..

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..Thus, this faculty represents a cohesive, interactive group of individuals who share a common interest in research and training in the area of cancer pharmacology. ..

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..Our proposed studies may lead to the use of 4-oxoretinol or related compounds in the prevention and/or treatment of human breast cancer. ..

..suprabasal cells of the skin) and at specific times during development using the LAP or the tet inducible expression vectors will be delineated. ..

..These studies should lead to advances in the clinical treatment of cancerous and precancerous lesions in the oral cavity...

..All of these lines of experimentation should provide us with important new information about the actions of RA and the binding proteins that mediate RA's effects...

..6 and REX-1 by RA, combined with our investigations of the functions of the Hox 1.6 and REX-1 proteins, should provide us with significantly greater knowledge of the processes of cell differentiation, embryogenesis, and carcinogenesis...