G K Gouras

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Increased apolipoprotein E epsilon 4 in epilepsy with senile plaques
    G K Gouras
    Department of Neurology and Neuroscience, Cornell University Medical College, New York, NY 10021, USA
    Ann Neurol 41:402-4. 1997
  2. pmc Intraneuronal Abeta42 accumulation in human brain
    G K Gouras
    Laboratory of Molecular and Cellular Neuroscience and Fisher Center for Research on Alzheimer s Disease, The Rockefeller University New York, New York 10021, USA
    Am J Pathol 156:15-20. 2000
  3. pmc Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides
    J P Greenfield
    Laboratory of Molecular and Cellular Neuroscience, and Fisher Center for Research on Alzheimer Disease, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 96:742-7. 1999
  4. ncbi request reprint Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling
    L Gasparini
    Laboratory of Molecular and Cellular Neuroscience, Fisher Center for Research on Alzheimer Disease, and Laboratory for Mass Spectrometry, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 21:2561-70. 2001
  5. ncbi request reprint Metal chelator decreases Alzheimer beta-amyloid plaques
    G K Gouras
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA
    Neuron 30:641-2. 2001
  6. ncbi request reprint Alzheimer beta-amyloid peptides: normal and abnormal localization
    R H Takahashi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA
    Histol Histopathol 17:239-46. 2002

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Increased apolipoprotein E epsilon 4 in epilepsy with senile plaques
    G K Gouras
    Department of Neurology and Neuroscience, Cornell University Medical College, New York, NY 10021, USA
    Ann Neurol 41:402-4. 1997
    ....
  2. pmc Intraneuronal Abeta42 accumulation in human brain
    G K Gouras
    Laboratory of Molecular and Cellular Neuroscience and Fisher Center for Research on Alzheimer s Disease, The Rockefeller University New York, New York 10021, USA
    Am J Pathol 156:15-20. 2000
    ..This study suggests that intracellular Abeta42 accumulation is an early event in neuronal dysfunction and that preventing intraneuronal Abeta42 aggregation may be an important therapeutic direction for the treatment of AD...
  3. pmc Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides
    J P Greenfield
    Laboratory of Molecular and Cellular Neuroscience, and Fisher Center for Research on Alzheimer Disease, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 96:742-7. 1999
    ..The identification of the organelles in which distinct forms of Abeta are generated and from which they are secreted should facilitate the identification of the proteolytic enzymes responsible for their formation...
  4. ncbi request reprint Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling
    L Gasparini
    Laboratory of Molecular and Cellular Neuroscience, Fisher Center for Research on Alzheimer Disease, and Laboratory for Mass Spectrometry, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 21:2561-70. 2001
    ..The results suggest cell biological and signal transduction mechanisms by which insulin modulates betaAPP and Abeta trafficking in neuronal cultures...
  5. ncbi request reprint Metal chelator decreases Alzheimer beta-amyloid plaques
    G K Gouras
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA
    Neuron 30:641-2. 2001
    ..The metal chelator, clioquinol, is reported by Cherny et al. (2001) to reduce Abeta plaques, presumably by chelation of Abeta-associated zinc and copper. This and other recent Abeta-modulating treatment approaches are discussed...
  6. ncbi request reprint Alzheimer beta-amyloid peptides: normal and abnormal localization
    R H Takahashi
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA
    Histol Histopathol 17:239-46. 2002
    ..In this review we will outline current knowledge of the localization of both intracellular and extracellular A beta...