Laurie H Glimcher
Affiliation: Cornell University
Greenblatt M, Shin D, Oh H, Lee K, Zhai B, Gygi S, et al
. MEKK2 mediates an alternative Î²-catenin pathway that promotes bone formation. Proc Natl Acad Sci U S A. 2016;113:E1226-35 pubmed publisher
..Thus, an FGF2/MEKK2 pathway mediates an alternative nonclassical pathway for Î²-catenin activation, and this pathway is a key regulator of bone formation by osteoblasts. ..
Ermann J, Staton T, Glickman J, de Waal Malefyt R, Glimcher L. Nod/Ripk2 signaling in dendritic cells activates IL-17A-secreting innate lymphoid cells and drives colitis in T-bet-/-.Rag2-/- (TRUC) mice. Proc Natl Acad Sci U S A. 2014;111:E2559-66 pubmed publisher
..Our data provide insight into the complex network of interactions between IL-17A-secreting ILCs and other components of the innate immune system in the development of colitis. ..
Cameron T, Gresshoff I, Bell K, PirÃ³g K, Sampurno L, Hartley C, et al
. Cartilage-specific ablation of XBP1 signaling in mouse results in a chondrodysplasia characterized by reduced chondrocyte proliferation and delayed cartilage maturation and mineralization. Osteoarthritis Cartilage. 2015;23:661-70 pubmed publisher
..Our work suggests roles for XBP1 in regulating chondrocyte proliferation and the timing of mineralization during endochondral ossification, findings which have implications for both skeletal development and disease. ..
Cubillos Ruiz J, Silberman P, Rutkowski M, Chopra S, Perales Puchalt A, Song M, et al
. ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis. Cell. 2015;161:1527-38 pubmed publisher
..Targeting the ER stress response should concomitantly inhibit tumor growth and enhance anti-cancer immunity, thus offering a unique approach to cancer immunotherapy. ..
MartÃnez G, Vidal R, Mardones P, Serrano F, Ardiles A, Wirth C, et al
. Regulation of Memory Formation by the Transcription Factor XBP1. Cell Rep. 2016;14:1382-1394 pubmed publisher
..Overexpression of BDNF in the hippocampus reversed the XBP1-deficient phenotype. Our study revealed an unanticipated function of XBP1 in cognitive processes that is apparently unrelated to its role in ER stress. ..