Research Topics
Species | Lisa A FortierSummaryAffiliation: Cornell University Country: USA Publications
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Publications
Phenotypic expression of equine articular chondrocytes grown in three-dimensional cultures supplemented with supraphysiologic concentrations of insulin-like growth factor-1Lisa A Fortier
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Am J Vet Res 63:301-5. 2002..These results suggest that application of such composites for in vivo use during cartilage grafting procedures should provide an anabolic effect on the grafted cells...- Systemic therapies for joint disease in horsesLisa A Fortier
Department of Clinical Sciences, Veterinary Medical College, VMC C3 181, Cornell University, Ithaca, NY 14853, USA
Vet Clin North Am Equine Pract 21:547-57, v. 2005..When aiming for more of a generalized maintenance or chondro-protective regimen, an alternative medication, such as hyaluronan,polysulfated glycosaminoglycan, or a nutraceutical will commonly be prescribed... - Hsp90 mediates insulin-like growth factor 1 and interleukin-1beta signaling in an age-dependent manner in equine articular chondrocytesAmber K Boehm
Cornell University, Veterinary Medical Center, Ithaca, New York 14853, USA
Arthritis Rheum 56:2335-43. 2007..The aim of this study was to investigate the roles of age and Hsp90 in insulin-like growth factor 1 (IGF-1) and interleukin-1beta (IL-1beta) signaling in chondrocytes... - Assessment of the catabolic effects of interleukin-1beta on proteoglycan metabolism in equine cartilage cocultured with synoviocytesAbigail J Gregg
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Am J Vet Res 67:957-62. 2006..Further studies involving proteomic and microarray approaches in similar coculture systems may elucidate novel therapeutic targets for the treatment of osteoarthritis... - Science and animal models of marrow stimulation for cartilage repairLisa A Fortier
Department of Clinical Science, Cornell University, Ithaca, New York 14853, USA
J Knee Surg 25:3-8. 2012.... 
The role of growth factors in cartilage repairLisa A Fortier
Department of Clinical Sciences, VMC C3 181, Cornell University, Ithaca, NY 14853, USA
Clin Orthop Relat Res 469:2706-15. 2011..The use of bioactive growth factors is under consideration as a potential therapy to enhance healing of chondral injuries and modify the arthritic disease process...- Stem cells in veterinary medicineLisa A Fortier
Department of Clinical Sciences, Cornell University, VMC C3 181, Ithaca, NY 14850, USA
Stem Cell Res Ther 2:9. 2011..Therefore, in this review, animal model research will be reviewed only in the context of supporting the current clinical application of stem cells in veterinary medicine... 
Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in the equine modelLisa A Fortier
Departments of Clinical Sciences, VMC C3 181, Cornell University, Ithaca, NY 14853, USA
J Bone Joint Surg Am 92:1927-37. 2010....- Synoviocytes are more sensitive than cartilage to the effects of minocycline and doxycycline on IL-1alpha and MMP-13-induced catabolic gene responsesLisa A Fortier
Department of Clinical Sciences, Cornell University, VMC C3 181, Ithaca, New York 14853, USA
J Orthop Res 28:522-8. 2010..Studies to determine the molecular mechanism of action of the tetracyclines in synoviocytes might lead to the design of targeted therapeutics for the treatment of OA or RA... - Regenerative medicine for tendinous and ligamentous injuries of sport horsesLisa A Fortier
Department of Clinical Sciences, VMC C3 181, Cornell University, Ithaca, NY 14853, USA
Vet Clin North Am Equine Pract 24:191-201. 2008..Successful restoration processes for any tissue are thought to recapitulate those of development, in which there are spatial and temporal interactions between scaffold, growth factors, and cell populations... - Signaling through the small G-protein Cdc42 is involved in insulin-like growth factor-I resistance in aging articular chondrocytesLisa A Fortier
Department of Clinical Sciences, VMC C3 181, Cornell University, Ithaca, New York 14853, USA
J Orthop Res 24:1765-72. 2006..Continued studies will identify the upstream regulators of Cdc42, which will further elucidate the molecular mechanism of IGF-I resistance during aging thereby providing insight into targeted strategies for age-related osteoarthritis... - New surgical treatments for osteochondritis dissecans and subchondral bone cystsLisa A Fortier
Department of Clinical Sciences, Veterinary Medical College, C3 181, Cornell University, Ithaca, NY 14853, USA
Vet Clin North Am Equine Pract 21:673-90, vii. 2005..Methods for improving cartilage repair (ie, restoration of damaged cartilage)or regeneration (ie, reformation or recreation of new articular cartilage) in select cases of OCD and SBCs are discussed... - Caprine obstructive urolithiasis: requirement for 2nd surgical intervention and mortality after percutaneous tube cystostomy, surgical tube cystostomy, or urinary bladder marsupializationLisa A Fortier
Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA
Vet Surg 33:661-7. 2004.... - Insulin-like growth factor-I diminishes the activation status and expression of the small GTPase Cdc42 in articular chondrocytesLisa A Fortier
Department of Clinical Sciences, Cornell University, Ithaca, NY 14853, USA
J Orthop Res 22:436-45. 2004..Further, an additional mechanism for the regulation of chondrocyte phenotype is defined through the IGF-I induced down-regulation of Cdc42 activation... - Stem cells: classifications, controversies, and clinical applicationsLisa A Fortier
Department of Clinical Sciences, Cornell University, Ithaca, NY 14853, USA
Vet Surg 34:415-23. 2005..The goals of this review article are to define embryonic and adult stem cells, compare differences between them, and summarize their potential clinical applications... - Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendonsLauren V Schnabel
Department of Clinical Sciences, VMC C3 181, Cornell University, Ithaca, New York 14853, USA
J Orthop Res 25:230-40. 2007..These findings support in vivo investigation of PRP as an autogenous, patient-side treatment for tendonitis... - A comparison of epidural buprenorphine plus detomidine with morphine plus detomidine in horses undergoing bilateral stifle arthroscopyBerit L Fischer
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
Vet Anaesth Analg 36:67-76. 2009..To compare the analgesic efficacy of buprenorphine plus detomidine with that of morphine plus detomidine when administered epidurally in horses undergoing bilateral stifle arthroscopy... - Assessment of cartilage degradation effects of matrix metalloproteinase-13 in equine cartilage cocultured with synoviocytesLisa A Fortier
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Am J Vet Res 68:379-84. 2007..To determine the effects of matrix metalloproteinase (MMP)-13, compared with interleukin (IL)-1alpha, on cartilage matrix molecule gene expression in a coculture system of equine cartilage explants and synoviocytes... - Comparison of gene-specific DNA methylation patterns in equine induced pluripotent stem cell lines with cells derived from equine adult and fetal tissuesCATHERINE H HACKETT
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Stem Cells Dev 21:1803-11. 2012..Results do not support previous reports that NANOG, SOX2, and POU5F1 are poised for increased activity in MPCs compared with other adult cells... - A technique for laser-facilitated equine pastern arthrodesis using parallel screws inserted in lag fashionAshlee E Watts
Cornell University Hospital for Animals, Cornell University, Ithaca, NY 14853, USA
Vet Surg 39:244-53. 2010..To report a technique for laser-facilitated, minimally invasive proximal interphalangeal joint (PIJ) arthrodesis in horses... - Temporal analysis of equine bone marrow aspirate during establishment of putative mesenchymal progenitor cell populationsCatherine H Radcliffe
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York
Stem Cells Dev 19:269-82. 2010..The results of this study demonstrate numerous dynamic changes in cell surface molecule expression during early establishment of MPC populations, which may aid to improve MPC isolation methods for research or therapeutic applications... - Age-related expression of molecular regulators of hypertrophy and maturation in articular cartilageStacy A Semevolos
Department of Clinical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA
J Orthop Res 24:1773-81. 2006..The increased expression of hedgehog receptor and transcription factors during puberty may indicate maturation of the deep articular layer during this time period... - Analysis of CD14 expression levels in putative mesenchymal progenitor cells isolated from equine bone marrowCATHERINE H HACKETT
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Stem Cells Dev 20:721-35. 2011..By definition, MPCs are considered nonhematopoietic because they lack expression of molecules such as CD14. Our results challenge this assumption, as equine MPCs appear to represent a descendant of a CD14-positive cell... - Interleukin-1α, -6, and -8 decrease Cdc42 activity resulting in loss of articular chondrocyte phenotypeKira D Novakofski
Department of Clinical Sciences, VMC, Cornell University, C3 181, Ithaca, New York 14853, USA
J Orthop Res 30:246-51. 2012..These results show that IL-mediated Cdc42 signaling modifies chondrocyte phenotype and morphology. This may lend insight into the altered chondrocyte phenotype in catabolic conditions such as osteoarthritis... - Epidural morphine and detomidine decreases postoperative hindlimb lameness in horses after bilateral stifle arthroscopyLaurie R Goodrich
Cornell University, College of Veterinary Medicine, Ithaca, NY 14853, USA
Vet Surg 31:232-9. 2002.... - Tenoscopic release of the equine carpal canalJamie A Textor
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Surg 32:278-84. 2003..CLINICAL RELEVANCE: Tensocopic release of the carpal flexor retinaculum is a safe alternative to open division of the retinaculum to decompress the carpal canal in horses with carpal canal syndrome... - A technique for internal fixation of scapulohumeral luxation using scapulohumeral tension sutures in three alpacas and one miniature steerAshlee E Watts
Cornell University Hospital for Animals, Cornell University, Ithaca, NY 14853, USA
Vet Surg 37:161-5. 2008..To report a technique for open reduction and internal fixation of scapulohumeral joint luxation in large animals, and outcome... - Trochlear block recession in an alpaca with traumatic lateral patellar luxationStephanie M Furman
Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Surg 38:421-5. 2009..To report surgical treatment of traumatic lateral patellar luxation using trochlear block recession in an alpaca... - Platelet-rich plasma: a milieu of bioactive factorsStacie G Boswell
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
Arthroscopy 28:429-39. 2012..Depending on the specific constituents of a PRP preparation, the clinical use can theoretically be matched to the pathology being treated in an effort to improve clinical efficacy... - Embryonic stem cells and iPS cells: sources and characteristicsCATHERINE H HACKETT
Department of Clinical Sciences, Box 32, Veterinary Medical Center, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Clin North Am Equine Pract 27:233-42. 2011.... - Effect of a tart cherry juice blend on exercise-induced muscle damage in horsesNormand G Ducharme
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Am J Vet Res 70:758-63. 2009..To evaluate whether administering a tart cherry juice blend (TCJB) prior to exercise would reduce skeletal and cardiac muscle damage by decreasing the inflammatory and oxidative stress response to exercise in horses... - Growth factor and catabolic cytokine concentrations are influenced by the cellular composition of platelet-rich plasmaEmily A Sundman
Department of Clinical Sciences, Cornell University, Ithaca, NY 14853, USA
Am J Sports Med 39:2135-40. 2011..Previous studies of bioactive molecules in platelet-rich plasma (PRP) have documented growth factor concentrations that promote tissue healing. However, the effects of leukocytes and inflammatory molecules in PRP have not been defined... - Biomechanical assessment of tissue retrieved after in vivo cartilage defect repair: tensile modulus of repair tissue and integration with host cartilageKenneth R Gratz
Department of Bioengineering, University of California-San Diego, 9500 Gilman Drive, Mail Code 0412, La Jolla, CA 92093-0412, USA
J Biomech 39:138-46. 2006..This represents the first quantitative biomechanical investigation of the tensile properties of repair tissue and its integration strength in an in vivo joint defect environment...
Research Grants
- GTPase Activating Proteins in Aging and OsteoarthritisLisa Fortier; Fiscal Year: 2007..We anticipate that these findings will facilitate identification of target molecules for development of therapeutics modalities for OA. ..