Lisa A Fortier

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Phenotypic expression of equine articular chondrocytes grown in three-dimensional cultures supplemented with supraphysiologic concentrations of insulin-like growth factor-1
    Lisa A Fortier
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 63:301-5. 2002
  2. ncbi request reprint Systemic therapies for joint disease in horses
    Lisa A Fortier
    Department of Clinical Sciences, Veterinary Medical College, VMC C3 181, Cornell University, Ithaca, NY 14853, USA
    Vet Clin North Am Equine Pract 21:547-57, v. 2005
  3. ncbi request reprint Assessment of the catabolic effects of interleukin-1beta on proteoglycan metabolism in equine cartilage cocultured with synoviocytes
    Abigail J Gregg
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 67:957-62. 2006
  4. ncbi request reprint Hsp90 mediates insulin-like growth factor 1 and interleukin-1beta signaling in an age-dependent manner in equine articular chondrocytes
    Amber K Boehm
    Cornell University, Veterinary Medical Center, Ithaca, New York 14853, USA
    Arthritis Rheum 56:2335-43. 2007
  5. doi request reprint The anti-inflammatory and matrix restorative mechanisms of platelet-rich plasma in osteoarthritis
    Emily A Sundman
    Lisa A Fortier, DVM, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, VMC C3 181, Ithaca, NY 14853
    Am J Sports Med 42:35-41. 2014
  6. doi request reprint Increasing platelet concentrations in leukocyte-reduced platelet-rich plasma decrease collagen gene synthesis in tendons
    Stacie G Boswell
    Lisa A Fortier, Cornell University, VMC C3 181, Ithaca, NY 14853
    Am J Sports Med 42:42-9. 2014
  7. pmc Genetic background affects induced pluripotent stem cell generation
    Lauren V Schnabel
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Stem Cell Res Ther 3:30. 2012
  8. ncbi request reprint Science and animal models of marrow stimulation for cartilage repair
    Lisa A Fortier
    Department of Clinical Science, Cornell University, Ithaca, New York 14853, USA
    J Knee Surg 25:3-8. 2012
  9. pmc Stem cells in veterinary medicine
    Lisa A Fortier
    Department of Clinical Sciences, Cornell University, VMC C3 181, Ithaca, NY 14850, USA
    Stem Cell Res Ther 2:9. 2011
  10. doi request reprint Regenerative medicine for tendinous and ligamentous injuries of sport horses
    Lisa A Fortier
    Department of Clinical Sciences, VMC C3 181, Cornell University, Ithaca, NY 14853, USA
    Vet Clin North Am Equine Pract 24:191-201. 2008

Research Grants

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Phenotypic expression of equine articular chondrocytes grown in three-dimensional cultures supplemented with supraphysiologic concentrations of insulin-like growth factor-1
    Lisa A Fortier
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 63:301-5. 2002
    ..To assess the effects of supraphysiologic concentrations of insulin-like growth factor-1 (IGF-1) on morphologic and phenotypic responses of chondrocytes...
  2. ncbi request reprint Systemic therapies for joint disease in horses
    Lisa A Fortier
    Department of Clinical Sciences, Veterinary Medical College, VMC C3 181, Cornell University, Ithaca, NY 14853, USA
    Vet Clin North Am Equine Pract 21:547-57, v. 2005
    ..When aiming for more of a generalized maintenance or chondro-protective regimen, an alternative medication, such as hyaluronan,polysulfated glycosaminoglycan, or a nutraceutical will commonly be prescribed...
  3. ncbi request reprint Assessment of the catabolic effects of interleukin-1beta on proteoglycan metabolism in equine cartilage cocultured with synoviocytes
    Abigail J Gregg
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 67:957-62. 2006
    ..To evaluate the effects of interleukin (IL)-1beta on proteoglycan metabolism in equine cartilage explants when cultured in the presence of synoviocytes...
  4. ncbi request reprint Hsp90 mediates insulin-like growth factor 1 and interleukin-1beta signaling in an age-dependent manner in equine articular chondrocytes
    Amber K Boehm
    Cornell University, Veterinary Medical Center, Ithaca, New York 14853, USA
    Arthritis Rheum 56:2335-43. 2007
    ..The aim of this study was to investigate the roles of age and Hsp90 in insulin-like growth factor 1 (IGF-1) and interleukin-1beta (IL-1beta) signaling in chondrocytes...
  5. doi request reprint The anti-inflammatory and matrix restorative mechanisms of platelet-rich plasma in osteoarthritis
    Emily A Sundman
    Lisa A Fortier, DVM, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, VMC C3 181, Ithaca, NY 14853
    Am J Sports Med 42:35-41. 2014
    ..Intra-articular (IA) treatment with platelet-rich plasma (PRP) for osteoarthritis (OA) results in improved patient-reported pain and function scores...
  6. doi request reprint Increasing platelet concentrations in leukocyte-reduced platelet-rich plasma decrease collagen gene synthesis in tendons
    Stacie G Boswell
    Lisa A Fortier, Cornell University, VMC C3 181, Ithaca, NY 14853
    Am J Sports Med 42:42-9. 2014
    ..Platelet-rich plasma (PRP) is used for the treatment of tendinopathy. There are numerous PRP preparations, and the optimal combination of platelets and leukocytes is not known...
  7. pmc Genetic background affects induced pluripotent stem cell generation
    Lauren V Schnabel
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Stem Cell Res Ther 3:30. 2012
    ..These findings have important implications both for future iPSC applications as well as for future investigation into determining the genes responsible for reprograming efficiency and stability...
  8. ncbi request reprint Science and animal models of marrow stimulation for cartilage repair
    Lisa A Fortier
    Department of Clinical Science, Cornell University, Ithaca, New York 14853, USA
    J Knee Surg 25:3-8. 2012
    ....
  9. pmc Stem cells in veterinary medicine
    Lisa A Fortier
    Department of Clinical Sciences, Cornell University, VMC C3 181, Ithaca, NY 14850, USA
    Stem Cell Res Ther 2:9. 2011
    ..Therefore, in this review, animal model research will be reviewed only in the context of supporting the current clinical application of stem cells in veterinary medicine...
  10. doi request reprint Regenerative medicine for tendinous and ligamentous injuries of sport horses
    Lisa A Fortier
    Department of Clinical Sciences, VMC C3 181, Cornell University, Ithaca, NY 14853, USA
    Vet Clin North Am Equine Pract 24:191-201. 2008
    ..Successful restoration processes for any tissue are thought to recapitulate those of development, in which there are spatial and temporal interactions between scaffold, growth factors, and cell populations...
  11. doi request reprint Synoviocytes are more sensitive than cartilage to the effects of minocycline and doxycycline on IL-1alpha and MMP-13-induced catabolic gene responses
    Lisa A Fortier
    Department of Clinical Sciences, Cornell University, VMC C3 181, Ithaca, New York 14853, USA
    J Orthop Res 28:522-8. 2010
    ..Studies to determine the molecular mechanism of action of the tetracyclines in synoviocytes might lead to the design of targeted therapeutics for the treatment of OA or RA...
  12. ncbi request reprint Signaling through the small G-protein Cdc42 is involved in insulin-like growth factor-I resistance in aging articular chondrocytes
    Lisa A Fortier
    Department of Clinical Sciences, VMC C3 181, Cornell University, Ithaca, New York 14853, USA
    J Orthop Res 24:1765-72. 2006
    ..Continued studies will identify the upstream regulators of Cdc42, which will further elucidate the molecular mechanism of IGF-I resistance during aging thereby providing insight into targeted strategies for age-related osteoarthritis...
  13. doi request reprint Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in the equine model
    Lisa A Fortier
    Departments of Clinical Sciences, VMC C3 181, Cornell University, Ithaca, NY 14853, USA
    J Bone Joint Surg Am 92:1927-37. 2010
    ....
  14. ncbi request reprint New surgical treatments for osteochondritis dissecans and subchondral bone cysts
    Lisa A Fortier
    Department of Clinical Sciences, Veterinary Medical College, C3 181, Cornell University, Ithaca, NY 14853, USA
    Vet Clin North Am Equine Pract 21:673-90, vii. 2005
    ..Methods for improving cartilage repair (ie, restoration of damaged cartilage)or regeneration (ie, reformation or recreation of new articular cartilage) in select cases of OCD and SBCs are discussed...
  15. ncbi request reprint Stem cells: classifications, controversies, and clinical applications
    Lisa A Fortier
    Department of Clinical Sciences, Cornell University, Ithaca, NY 14853, USA
    Vet Surg 34:415-23. 2005
    ..The goals of this review article are to define embryonic and adult stem cells, compare differences between them, and summarize their potential clinical applications...
  16. ncbi request reprint Caprine obstructive urolithiasis: requirement for 2nd surgical intervention and mortality after percutaneous tube cystostomy, surgical tube cystostomy, or urinary bladder marsupialization
    Lisa A Fortier
    Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA
    Vet Surg 33:661-7. 2004
    ....
  17. ncbi request reprint Insulin-like growth factor-I diminishes the activation status and expression of the small GTPase Cdc42 in articular chondrocytes
    Lisa A Fortier
    Department of Clinical Sciences, Cornell University, Ithaca, NY 14853, USA
    J Orthop Res 22:436-45. 2004
    ..Further, an additional mechanism for the regulation of chondrocyte phenotype is defined through the IGF-I induced down-regulation of Cdc42 activation...
  18. pmc The role of growth factors in cartilage repair
    Lisa A Fortier
    Department of Clinical Sciences, VMC C3 181, Cornell University, Ithaca, NY 14853, USA
    Clin Orthop Relat Res 469:2706-15. 2011
    ..The use of bioactive growth factors is under consideration as a potential therapy to enhance healing of chondral injuries and modify the arthritic disease process...
  19. ncbi request reprint Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons
    Lauren V Schnabel
    Department of Clinical Sciences, VMC C3 181, Cornell University, Ithaca, New York 14853, USA
    J Orthop Res 25:230-40. 2007
    ..These findings support in vivo investigation of PRP as an autogenous, patient-side treatment for tendonitis...
  20. doi request reprint A comparison of epidural buprenorphine plus detomidine with morphine plus detomidine in horses undergoing bilateral stifle arthroscopy
    Berit L Fischer
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Vet Anaesth Analg 36:67-76. 2009
    ..To compare the analgesic efficacy of buprenorphine plus detomidine with that of morphine plus detomidine when administered epidurally in horses undergoing bilateral stifle arthroscopy...
  21. ncbi request reprint Assessment of cartilage degradation effects of matrix metalloproteinase-13 in equine cartilage cocultured with synoviocytes
    Lisa A Fortier
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 68:379-84. 2007
    ..To determine the effects of matrix metalloproteinase (MMP)-13, compared with interleukin (IL)-1alpha, on cartilage matrix molecule gene expression in a coculture system of equine cartilage explants and synoviocytes...
  22. pmc Comparison of gene-specific DNA methylation patterns in equine induced pluripotent stem cell lines with cells derived from equine adult and fetal tissues
    CATHERINE H HACKETT
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Stem Cells Dev 21:1803-11. 2012
    ..Results do not support previous reports that NANOG, SOX2, and POU5F1 are poised for increased activity in MPCs compared with other adult cells...
  23. doi request reprint A technique for laser-facilitated equine pastern arthrodesis using parallel screws inserted in lag fashion
    Ashlee E Watts
    Cornell University Hospital for Animals, Cornell University, Ithaca, NY 14853, USA
    Vet Surg 39:244-53. 2010
    ..To report a technique for laser-facilitated, minimally invasive proximal interphalangeal joint (PIJ) arthrodesis in horses...
  24. pmc Temporal analysis of equine bone marrow aspirate during establishment of putative mesenchymal progenitor cell populations
    Catherine H Radcliffe
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York
    Stem Cells Dev 19:269-82. 2010
    ..The results of this study demonstrate numerous dynamic changes in cell surface molecule expression during early establishment of MPC populations, which may aid to improve MPC isolation methods for research or therapeutic applications...
  25. ncbi request reprint Age-related expression of molecular regulators of hypertrophy and maturation in articular cartilage
    Stacy A Semevolos
    Department of Clinical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, USA
    J Orthop Res 24:1773-81. 2006
    ..The increased expression of hedgehog receptor and transcription factors during puberty may indicate maturation of the deep articular layer during this time period...
  26. doi request reprint Platelet-rich plasma: a milieu of bioactive factors
    Stacie G Boswell
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    Arthroscopy 28:429-39. 2012
    ..Depending on the specific constituents of a PRP preparation, the clinical use can theoretically be matched to the pathology being treated in an effort to improve clinical efficacy...
  27. pmc Analysis of CD14 expression levels in putative mesenchymal progenitor cells isolated from equine bone marrow
    CATHERINE H HACKETT
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Stem Cells Dev 20:721-35. 2011
    ..By definition, MPCs are considered nonhematopoietic because they lack expression of molecules such as CD14. Our results challenge this assumption, as equine MPCs appear to represent a descendant of a CD14-positive cell...
  28. doi request reprint Interleukin-1α, -6, and -8 decrease Cdc42 activity resulting in loss of articular chondrocyte phenotype
    Kira D Novakofski
    Department of Clinical Sciences, VMC, Cornell University, C3 181, Ithaca, New York 14853, USA
    J Orthop Res 30:246-51. 2012
    ..These results show that IL-mediated Cdc42 signaling modifies chondrocyte phenotype and morphology. This may lend insight into the altered chondrocyte phenotype in catabolic conditions such as osteoarthritis...
  29. doi request reprint Trochlear block recession in an alpaca with traumatic lateral patellar luxation
    Stephanie M Furman
    Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vet Surg 38:421-5. 2009
    ..To report surgical treatment of traumatic lateral patellar luxation using trochlear block recession in an alpaca...
  30. doi request reprint A technique for internal fixation of scapulohumeral luxation using scapulohumeral tension sutures in three alpacas and one miniature steer
    Ashlee E Watts
    Cornell University Hospital for Animals, Cornell University, Ithaca, NY 14853, USA
    Vet Surg 37:161-5. 2008
    ..To report a technique for open reduction and internal fixation of scapulohumeral joint luxation in large animals, and outcome...
  31. ncbi request reprint Epidural morphine and detomidine decreases postoperative hindlimb lameness in horses after bilateral stifle arthroscopy
    Laurie R Goodrich
    Cornell University, College of Veterinary Medicine, Ithaca, NY 14853, USA
    Vet Surg 31:232-9. 2002
    ..To determine whether preoperative epidural administration of morphine and detomidine would decrease postoperative lameness after bilateral stifle arthroscopy in horses...
  32. ncbi request reprint Tenoscopic release of the equine carpal canal
    Jamie A Textor
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vet Surg 32:278-84. 2003
    ..To develop a tenoscopic method to divide the carpal flexor retinaculum and decompress the carpal canal...
  33. doi request reprint Growth factor and catabolic cytokine concentrations are influenced by the cellular composition of platelet-rich plasma
    Emily A Sundman
    Department of Clinical Sciences, Cornell University, Ithaca, NY 14853, USA
    Am J Sports Med 39:2135-40. 2011
    ..Previous studies of bioactive molecules in platelet-rich plasma (PRP) have documented growth factor concentrations that promote tissue healing. However, the effects of leukocytes and inflammatory molecules in PRP have not been defined...
  34. pmc Embryonic stem cells and iPS cells: sources and characteristics
    CATHERINE H HACKETT
    Department of Clinical Sciences, Box 32, Veterinary Medical Center, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vet Clin North Am Equine Pract 27:233-42. 2011
    ....
  35. doi request reprint Effect of a tart cherry juice blend on exercise-induced muscle damage in horses
    Normand G Ducharme
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 70:758-63. 2009
    ..To evaluate whether administering a tart cherry juice blend (TCJB) prior to exercise would reduce skeletal and cardiac muscle damage by decreasing the inflammatory and oxidative stress response to exercise in horses...
  36. doi request reprint Therapeutic use of stem cells in horses: which type, how, and when?
    Lauren V Schnabel
    Department of Clinical Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA Electronic address
    Vet J 197:570-7. 2013
    ..Clinicians must also be aware of the limitation in current knowledge regarding stem cells, and the impending regulatory laws that may limit the use of equine stem cells in clinical patients. ..
  37. doi request reprint Doxycycline concentration over time after storage in a compounded veterinary preparation
    Mark G Papich
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA
    J Am Vet Med Assoc 242:1674-8. 2013
    ..To determine the concentration of doxycycline compounded from doxycycline hyclate tablets into liquid formulations for oral administration in veterinary species and stored for 28 days...
  38. doi request reprint Platelet-rich plasma for articular cartilage repair
    Geoffrey D Abrams
    Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL College of Veterinary Medicine, Cornell University, Ithaca, NY
    Sports Med Arthrosc 21:213-9. 2013
    ..Human trials, mostly conducted in the form of injection into knees with osteoarthritis, have shown promise in a number of investigations for achieving symptomatic relief of pain and improving function. ..
  39. ncbi request reprint Biomechanical assessment of tissue retrieved after in vivo cartilage defect repair: tensile modulus of repair tissue and integration with host cartilage
    Kenneth R Gratz
    Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, Mail Code 0412, La Jolla, CA 92093 0412, USA
    J Biomech 39:138-46. 2006
    ..This represents the first quantitative biomechanical investigation of the tensile properties of repair tissue and its integration strength in an in vivo joint defect environment...

Research Grants1

  1. GTPase Activating Proteins in Aging and Osteoarthritis
    Lisa Fortier; Fiscal Year: 2007
    ..We anticipate that these findings will facilitate identification of target molecules for development of therapeutics modalities for OA. ..