Research Topics
| David EricksonSummaryAffiliation: Cornell University Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Continuous operation of a hybrid solid-liquid state reconfigurable photonic system without resupply of liquidsErica Eunjung Jung
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York 14853, USA
Lab Chip 12:2575-9. 2012..We believe that our system represents an important step towards the development of practical optofluidically enabled photonic systems...- Optically induced microfluidic reconfigurationMekala Krishnan
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York 14853, USA
Lab Chip 12:613-21. 2012..In addition to characterizing the effect, we also apply this technique to create dynamic traps for biomolecules, and demonstrate trapping of λ-DNA molecules and nanoparticles, with a 25 fold suppression of diffusion... 
Enhanced on-chip SERS based biomolecular detection using electrokinetically active microwellsYun Suk Huh
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA
Lab Chip 9:433-9. 2009..We report a limit of detection for Dengue sequences of 30 pM and show excellent specificity against other serotypes...
Nanomanipulation using near field photonicsDavid Erickson
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, USA
Lab Chip 11:995-1009. 2011..In addition we highlight three application areas where these techniques namely could be of interest to the lab-on-a-chip community, namely: single molecule analysis, nanoassembly, and optical chromatography...- DNA transport and delivery in thermal gradients near optofluidic resonatorsXavier Serey
School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
Phys Rev Lett 108:048102. 2012..Specifically, the region around the electromagnetic hot spot is depleted in biomolecules because of a high free energy barrier... - Nanomanipulation using silicon photonic crystal resonatorsSudeep Mandal
School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
Nano Lett 10:99-104. 2010..Our approach lays the groundwork for a new class of optical trapping platforms that could eventually enable complex all-optical single molecule manipulation and directed assembly of nanoscale material... - A method for nanofluidic device prototyping using elastomeric collapseSeung Min Park
School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
Proc Natl Acad Sci U S A 106:15549-54. 2009..The applicability of the technique to biomolecular analysis is demonstrated by showing DNA elongation in a nanochannel and a technique for optofluidic surface enhanced Raman detection of nucleic acids... - Controlled photonic manipulation of proteins and other nanomaterialsYih Fan Chen
Kavli Institute at Cornell for Nanoscale Science, Cornell University, Ithaca, New York 14853, USA
Nano Lett 12:1633-7. 2012..3 K, which is below the point where unwanted fluid mechanical effects will prevent trapping or damage biological targets... - Nanoporous polymer ring resonators for biosensingMatthew Mancuso
Department of Biomedical Engineering, Cornell University, Ithaca, NY 14850, USA
Opt Express 20:245-55. 2012..We report a 40% increase in polymer device sensitivity attributed to the addition of core energy- bioanalyte interactions... - Forces and transport velocities for a particle in a slot waveguideAllen H J Yang
School of Chemical and Biomolecular Engineering, and Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York, USA
Nano Lett 9:1182-8. 2009..Our results indicate that stable trapping and transport can be achieved for objects as small as 10 or 20 nm in diameter with as much as a 100 fold enhancement in trapping stiffness over the state of the art... - Multiplex single nucleotide polymorphism genotyping utilizing ligase detection reaction coupled surface enhanced Raman spectroscopyAdam J Lowe
Graduate Field of Microbiology, Cornell University, Ithaca, New York 14853, USA
Anal Chem 82:5810-4. 2010..These advances are significant as we have further developed our new SNP genotyping platform and have demonstrated the ability to correlate genotype ratios directly to diagnostic Raman peak signal intensity... - Rapid prototyping of nanofluidic systems using size-reduced electrospun nanofibers for biomolecular analysisSeung Min Park
School of Applied and Engineering Physics, Cornell University, 205 Clark Hall, Ithaca, NY 14853, USA
Small 6:2420-6. 2010.... - Optofluidic waveguides for reconfigurable photonic systemsAram J Chung
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York 14853, USA
Opt Express 19:8602-9. 2011..1-10.7 dB, operability over a broad bandwidth spanning the range of wavelengths from visible to telecommunication, and a 1x2 sub-second switching system with a cross-talk as low as 20 dB and maximum coupling efficiency of 3.87 dB... - Aptamer based surface enhanced Raman scattering detection of vasopressin using multilayer nanotube arraysYun Suk Huh
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA
Biosens Bioelectron 25:1240-3. 2010..This low limit of detection is obtained with device containing the multilayer SERS substrate which we show exhibits a stronger Raman enhancement while maintaining biocompatibility and ease or surface reactivity with the capture probe... - Large area flexible SERS active substrates using engineered nanostructuresAram J Chung
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA
Nanoscale 3:2903-8. 2011..In addition, we present experimental results showing how a hybrid structure comprising of gold nanospheres embedded in a silver nano-pillar structure can be used to obtain a 50× SERS enhancement over the raw nanoparticles themselves... - Optical manipulation of nanoparticles and biomolecules in sub-wavelength slot waveguidesAllen H J Yang
School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York 14853, USA
Nature 457:71-5. 2009..We also carry out a detailed numerical analysis that relates the near-field optical forces to release kinetics. We believe that the architecture demonstrated here will help to bridge the gap between optical manipulation and nanofluidics... - Electroactive micro and nanowells for optofluidic storageBernardo Cordovez
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA
Opt Express 17:21134-48. 2009..We envision that this technique could find eventual application in fluidic memory or display devices... - A multiplexed optofluidic biomolecular sensor for low mass detectionSudeep Mandal
School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
Lab Chip 9:2924-32. 2009..The multiplexing capabilities of our sensor are demonstrated by the individual and concurrent detection of interleukins 4, 6 and 8 using a sandwich assay... - Analysis of liquid-to-solid coupling and other performance parameters for microfluidically reconfigurable photonic systemsErica E Jung
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853 USA
Opt Express 18:10973-84. 2010..g. unchangeable structure and properties) and liquid waveguide systems (e.g. diversion and attenuation) yielding a new paradigm for reconfigurable photonics... - Slab waveguide photobioreactors for microalgae based biofuel productionErica Eunjung Jung
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA
Lab Chip 12:3740-5. 2012..We also show that the stackable nature of the slab waveguide approach could yield a 12-fold improvement in the volumetric productivity... - Size-selective concentration and label-free characterization of protein aggregates using a Raman active nanofluidic deviceInhee Choi
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA
Lab Chip 11:632-8. 2011..We expect that our method could facilitate definitive diagnosis and possible therapeutics of diseases at early stages... - Gel-based optical waveguides with live cell encapsulation and integrated microfluidicsAadhar Jain
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York 14853, USA
Opt Lett 37:1472-4. 2012..We characterize the optical properties of the waveguide and further incorporate a microfluidic channel over the optical structure, thus developing an integrated optofluidic system fabricated entirely from agarose gel... - Nanoscale optofluidic sensor arraysSudeep Mandal
School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
Opt Express 16:1623-31. 2008..While other techniques such as SPR possess a equivalent RI detection limit, the advantage of this architecture lies in its potential for low mass limit of detection which is enabled by confining the size of the probed surface area... - A robust, electrochemically driven microwell drug delivery system for controlled vasopressin releaseAram J Chung
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA
Biomed Microdevices 11:861-7. 2009..The concentration profile vs. time, the power consumption, and ejection efficiency are also investigated. To demonstrate the medical utility of the device we also characterize the in-vitro release of vasopressin... - Engineering insect flight metabolics using immature stage implanted microfluidicsAram J Chung
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA
Lab Chip 9:669-76. 2009..Behavior ranging from retarded motion to complete, reversible paralysis, over timescales ranging from minutes to hours is demonstrated... - Biopatterning for label-free detectionJulie M Goddard
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA
Colloids Surf B Biointerfaces 76:375-80. 2010.... - Angular orientation of nanorods using nanophotonic tweezersPilgyu Kang
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York 14853, United States
Nano Lett 12:6400-7. 2012..8 pN·nm/rad(2)·mW is measured for the nanotubes. We expect that this new capability will facilitate the development of high precision nanoassembly schemes and biophysical studies of bending strains of biomolecules... - Elucidating mechanical transition effects of invading cancer cells with a subnucleus-scaled microfluidic serial dimensional modulation deviceMichael Mak
Biomedical Engineering Department, Cornell University, Ithaca, NY, United States
Lab Chip 13:340-8. 2013..These results illustrate that subnucleus-scaled confinement modulation can play a distinctive role in inducing behavioral responses in invading cells and can help reveal the mechanical elements of non-proteolytic invasion... - Hydrodynamic optical alignment for microflow cytometryMatthew J Kennedy
Department of Electrical and Computer Engineering, Cornell University, Ithaca, NY 14853, USA
Lab Chip 11:1138-43. 2011..The device exhibited a linear response to fluorescence intensity calibration microparticles as shown by comparison with a commercial cytometer instrument... - Bioconjugation techniques for microfluidic biosensorsJulie M Goddard
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA
Anal Bioanal Chem 394:469-79. 2009.... - Surface-enhanced Raman scattering based ligase detection reactionYun Suk Huh
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York 14853, USA
J Am Chem Soc 131:2208-13. 2009..We report a limit of detection of 20 pM of target DNA with the anticipated specificity engendered by the LDR platform... - Label-free electrochemical monitoring of vasopressin in aptamer-based microfluidic biosensorsPeng He
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, United States
Anal Chim Acta 759:74-80. 2013..Ultimately such a system could serve as a point-of-care diagnostics tool for patients with excessive bleeding when standard medical infrastructure is not available... - Stability analysis of optofluidic transport on solid-core waveguiding structuresAllen H J Yang
School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14850, USA
Nanotechnology 19:045704. 2008.... - Microfabricated physical spatial gradients for investigating cell migration and invasion dynamicsMichael Mak
Department of Biomedical Engineering, Cornell University, Ithaca, New York, United States of America
PLoS ONE 6:e20825. 2011..Incorporation of micro-architectures in confined channels enables the probing of migration behaviors specific to defined geometries that mimic in vivo microenvironments... - Optofluidic ring resonator switch for optical particle transportAllen H J Yang
Cornell University, Ithaca, USA
Lab Chip 10:769-74. 2010..The optofluidic switch we present here demonstrates the versatility in exploiting planar optical devices for integrated particle manipulation applications... - Hydrodynamically tunable affinities for fluidic assemblyMekala Krishnan
Sibley School of Mechanical and Aerospace Engineering and Computing and Information Science, Cornell University, Ithaca, New York 14853, USA
Langmuir 25:3769-74. 2009..Although this technique is demonstrated here for a small number of passive mobile components around a fixed structure, it has the potential to overcome some of the limitations of current static affinity based self-assembly... - Optothermorheological flow manipulationMekala Krishnan
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA
Opt Lett 34:1976-8. 2009..In our approach a laser beam incident on an absorbing substrate is used to locally heat a thermorheological fluid flowing in a microfluidic channel. The resulting gelation in the heated region creates a reversible fluid valve... - Electrokinetic microfluidic devices for rapid, low power drug delivery in autonomous microsystemsAram J Chung
Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA
Lab Chip 8:330-8. 2008..This paper focuses on presenting the design and characterizing the electrokinetic transport mechanics which govern the release time and dispersal pattern of the well contents using a series of experimental and numerical techniques...
Research Grants
- Nanoscale Optofluidic Pathogen DetectionDavid Erickson; Fiscal Year: 2007..The near term major application will be as an early stage detection platform. ..