Scott D Emr

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. doi request reprint Ubiquitin and membrane protein turnover: from cradle to grave
    Jason A MacGurn
    Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York 14853, USA
    Annu Rev Biochem 81:231-59. 2012
  2. pmc Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase
    Roberto J Botelho
    Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA
    Mol Biol Cell 19:4273-86. 2008
  3. pmc Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway
    Yufeng Shi
    Weill Institute for Cell and Molecular Biology and Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Mol Biol Cell 22:4093-107. 2011
  4. doi request reprint ER-to-plasma membrane tethering proteins regulate cell signaling and ER morphology
    Andrew G Manford
    Weill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Dev Cell 23:1129-40. 2012
  5. doi request reprint Osh proteins regulate phosphoinositide metabolism at ER-plasma membrane contact sites
    Christopher J Stefan
    Weill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Cell 144:389-401. 2011
  6. pmc The dual PH domain protein Opy1 functions as a sensor and modulator of PtdIns(4,5)P₂ synthesis
    Yading Ling
    Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA
    EMBO J 31:2882-94. 2012
  7. pmc Phosphoinositide [PI(3,5)P2] lipid-dependent regulation of the general transcriptional regulator Tup1
    Bong Kwan Han
    Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Genes Dev 25:984-95. 2011
  8. pmc Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3
    Dan Baird
    Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA
    J Cell Biol 183:1061-74. 2008
  9. doi request reprint TORC1 regulates endocytosis via Npr1-mediated phosphoinhibition of a ubiquitin ligase adaptor
    Jason A MacGurn
    Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA
    Cell 147:1104-17. 2011
  10. doi request reprint The Endosomal Sorting Complex ESCRT-II Mediates the Assembly and Architecture of ESCRT-III Helices
    William Mike Henne
    Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Cell 151:356-71. 2012

Collaborators

  • David Teis
  • Anjon Audhya
  • Roberto J Botelho
  • Marcus B Smolka
  • Tian Xia
  • Arthur E Johnson
  • Christopher J Stefan
  • Jason A MacGurn
  • Bong Kwan Han
  • Andrew G Manford
  • Suraj Saksena
  • William Mike Henne
  • Yading Ling
  • Pi Chiang Hsu
  • Yufeng Shi
  • Yuxin Mao
  • Andrew Manford
  • Dan Baird
  • Jem A Efe
  • Helen L Yuan
  • Yingying Zhao
  • Nicholas J Buchkovich
  • Daniel Baird
  • Sarah M Rue
  • Jason Yamada-Hanff
  • Ajay Kumar Saxena
  • Fenghua Hu
  • Christopher Stefan
  • Judit Wahlman
  • Sabine Weys
  • Chris Stefan

Detail Information

Publications17

  1. doi request reprint Ubiquitin and membrane protein turnover: from cradle to grave
    Jason A MacGurn
    Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York 14853, USA
    Annu Rev Biochem 81:231-59. 2012
    ..This review summarizes our current understanding of how ubiquitin modification influences cargo trafficking, with a special emphasis on mechanisms of quality control and quality maintenance in the secretory and endocytic pathways...
  2. pmc Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase
    Roberto J Botelho
    Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA
    Mol Biol Cell 19:4273-86. 2008
    ..We propose a model explaining the dual roles of Vac14 and Fig4 in the synthesis and turnover of PtdIns(3,5)P(2)...
  3. pmc Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway
    Yufeng Shi
    Weill Institute for Cell and Molecular Biology and Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Mol Biol Cell 22:4093-107. 2011
    ..Moreover, a complex containing the two novel proteins Ere1 and Ere2 mediates cargo-specific recognition by the retromer pathway...
  4. doi request reprint ER-to-plasma membrane tethering proteins regulate cell signaling and ER morphology
    Andrew G Manford
    Weill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Dev Cell 23:1129-40. 2012
    ..These results reveal critical roles for ER-PM contacts in cell signaling, organelle morphology, and ER function...
  5. doi request reprint Osh proteins regulate phosphoinositide metabolism at ER-plasma membrane contact sites
    Christopher J Stefan
    Weill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Cell 144:389-401. 2011
    ..Our findings further suggest that the conserved Osh proteins control PI metabolism at additional membrane contact sites...
  6. pmc The dual PH domain protein Opy1 functions as a sensor and modulator of PtdIns(4,5)P₂ synthesis
    Yading Ling
    Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY, USA
    EMBO J 31:2882-94. 2012
    ..Our results also suggest that additional conserved tandem PH domain-containing proteins may play important roles in regulating phosphoinositide signalling...
  7. pmc Phosphoinositide [PI(3,5)P2] lipid-dependent regulation of the general transcriptional regulator Tup1
    Bong Kwan Han
    Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Genes Dev 25:984-95. 2011
    ..Our findings provide important insights toward understanding how the chromatin architecture and epigenetic status of a gene are regulated by cytoplasmic components...
  8. pmc Assembly of the PtdIns 4-kinase Stt4 complex at the plasma membrane requires Ypp1 and Efr3
    Dan Baird
    Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA
    J Cell Biol 183:1061-74. 2008
    ..Efr3 is essential for assembly of both Ypp1 and Stt4 at PIK patches. We conclude that Ypp1 and Efr3 are required for the formation and architecture of Stt4 PIK patches and ultimately PM-based PtdIns4P signaling...
  9. doi request reprint TORC1 regulates endocytosis via Npr1-mediated phosphoinhibition of a ubiquitin ligase adaptor
    Jason A MacGurn
    Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA
    Cell 147:1104-17. 2011
    ....
  10. doi request reprint The Endosomal Sorting Complex ESCRT-II Mediates the Assembly and Architecture of ESCRT-III Helices
    William Mike Henne
    Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Cell 151:356-71. 2012
    ..We propose that ESCRT-III has distinct architectural stages that are modulated by ESCRT-II to mediate cargo capture and vesicle formation by ordered assembly...
  11. doi request reprint Functional reconstitution of ESCRT-III assembly and disassembly
    Suraj Saksena
    Weill Institute for Cell and Molecular Biology and Department of Molecular Biology and Genetics, Weill Hall, Cornell University, Ithaca, NY 14853, USA
    Cell 136:97-109. 2009
    ..Furthermore, using an in vitro disassembly assay, we directly demonstrate that Vps24 and Vps2 function as adaptors in the ATP-dependent membrane disassembly of the ESCRT-III complex by recruiting the AAA ATPase Vps4...
  12. pmc Crystal structure of the yeast Sac1: implications for its phosphoinositide phosphatase function
    Andrew Manford
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA
    EMBO J 29:1489-98. 2010
    ..Homology structural modeling of human Fig4/Sac3 allows the mapping of several disease-related mutations and provides a framework for the understanding of the molecular mechanisms of human diseases...
  13. doi request reprint ESCRTs and human disease
    Suraj Saksena
    Weill Institute for Cell and Molecular Biology and Department of Molecular Biology and Genetics, 441 Weill Hall, Cornell University, Ithaca, NY 14853, USA
    Biochem Soc Trans 37:167-72. 2009
    ..This review summarizes the growing number of links identified between ESCRT-mediated protein sorting in the MVB (multivesicular body) pathway and various human diseases...
  14. doi request reprint Ordered assembly of the ESCRT-III complex on endosomes is required to sequester cargo during MVB formation
    David Teis
    Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA
    Dev Cell 15:578-89. 2008
    ..We propose that the ordered assembly and disassembly of ESCRT-III delineates an MVB sorting domain to sequester cargo and complete the last steps of MVB sorting...
  15. doi request reprint ER-PM connections: sites of information transfer and inter-organelle communication
    Christopher J Stefan
    Weill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, United States Electronic address
    Curr Opin Cell Biol 25:434-42. 2013
    ..Recent discoveries have revealed additional exciting roles for ER-PM junctions in the regulation of cell signaling, ER shape and architecture, and PM domain organization. ..
  16. pmc The phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2)-dependent Tup1 conversion (PIPTC) regulates metabolic reprogramming from glycolysis to gluconeogenesis
    Bong Kwan Han
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 288:20633-45. 2013
    ....
  17. pmc Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate
    Jem A Efe
    Department of Cellular and Molecular Medicine, Cornell Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA
    Mol Biol Cell 18:4232-44. 2007
    ..Atg18p is likely a PtdIns(3,5)P(2)"sensor," acting as an effector to remodel membranes as well as regulating its synthesis via feedback that might involve Vac7p...