David Eliezer

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Conformational properties of alpha-synuclein in its free and lipid-associated states
    D Eliezer
    Department of Biochemistry and Program in Structural Biology, Weill Medical College of Cornell University, New York, NY, 10021, USA
    J Mol Biol 307:1061-73. 2001
  2. ncbi request reprint A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins
    Robert Bussell
    Department of Physiology, Biophysics and Molecular Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Mol Biol 329:763-78. 2003
  3. pmc Structural basis for recognition of diubiquitins by NEMO
    Yu Chih Lo
    Department of Biochemistry, Weill Cornell Medical College, New York, NY 10021, USA
    Mol Cell 33:602-15. 2009
  4. ncbi request reprint NMR mapping of copper binding sites in alpha-synuclein
    Yoon Hui Sung
    Department of Biochemistry and Program in Structural Biology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Biochim Biophys Acta 1764:5-12. 2006
  5. pmc Residual structure, backbone dynamics, and interactions within the synuclein family
    Yoon Hui Sung
    Department of Biochemistry and Program in Structural Biology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10021, USA
    J Mol Biol 372:689-707. 2007
  6. pmc Structural transitions in tau k18 on micelle binding suggest a hierarchy in the efficacy of individual microtubule-binding repeats in filament nucleation
    Patrick Barre
    Department of Biochemistry, Program in Structural Biology, Weill Cornell Medical College, New York, 10065, USA
    Protein Sci 22:1037-48. 2013
  7. ncbi request reprint Folding of the repeat domain of tau upon binding to lipid surfaces
    Patrick Barre
    Department of Biochemistry and Program in Structural Biology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Mol Biol 362:312-26. 2006
  8. ncbi request reprint Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein
    Robert Bussell
    Department of Physiology, Biophysics and Molecular Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA
    Biochemistry 43:4810-8. 2004
  9. pmc E46K Parkinson's-linked mutation enhances C-terminal-to-N-terminal contacts in alpha-synuclein
    Carla C Rospigliosi
    Department of Biochemistry and Program in Structural Biology, Weill Cornell Medical College, New York, NY 10065, USA
    J Mol Biol 388:1022-32. 2009
  10. pmc Secondary structure and dynamics of micelle bound beta- and gamma-synuclein
    Yoon Hui Sung
    Department of Biochemistry and Program in Structural Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Protein Sci 15:1162-74. 2006

Collaborators

  • Hao Wu
  • Hilal A Lashuel
  • Haiteng Deng
  • M Lu
  • Trudy F Ramlall
  • Yoon Hui Sung
  • Patrick Barre
  • Carla C Rospigliosi
  • Igor Dikiy
  • Robert Bussell
  • Sebastian McClendon
  • Rachel T Wragg
  • Nicholas W Harbison
  • Bruno Mesmin
  • Valerie L Anderson
  • Yu Chih Lo
  • Ben Gold
  • Gaetano Malgieri
  • Watt W Webb
  • Elizabeth Rhoades
  • Yiqun Deng
  • Indu Menon
  • Jeremy S Dittman
  • David Snead
  • Jihong Bai
  • Yongming Dong
  • Shibani Bhattacharya
  • Nina H Pipalia
  • Frederick R Maxfield
  • Anna Sokolov
  • Frederik W Lund
  • Su Chang Lin
  • Adrian W Schmid
  • Chuan Jin Wu
  • Dietrich B Conze
  • Jonathan D Ashwell
  • Carl Nathan
  • Ruslana Bryk
  • Diana Vargas
  • Julia Roberts
  • Xiuju Jiang
  • Carla Rospigliosi
  • Jie Liu
  • Neville R Kallenbach
  • Qi Zheng
  • Trudy Fiona Ramlall

Detail Information

Publications28

  1. ncbi request reprint Conformational properties of alpha-synuclein in its free and lipid-associated states
    D Eliezer
    Department of Biochemistry and Program in Structural Biology, Weill Medical College of Cornell University, New York, NY, 10021, USA
    J Mol Biol 307:1061-73. 2001
    ..These results suggest that one function of alphaS may be to tether as of yet unidentified partners to lipid surfaces via interactions with its C-terminal tail...
  2. ncbi request reprint A structural and functional role for 11-mer repeats in alpha-synuclein and other exchangeable lipid binding proteins
    Robert Bussell
    Department of Physiology, Biophysics and Molecular Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Mol Biol 329:763-78. 2003
    ..A search of protein sequence databases confirms that synuclein-like 11-mer repeats are present in other proteins that bind lipids reversibly and predicts such a role for a number of hypothetical proteins of unknown function...
  3. pmc Structural basis for recognition of diubiquitins by NEMO
    Yu Chih Lo
    Department of Biochemistry, Weill Cornell Medical College, New York, NY 10021, USA
    Mol Cell 33:602-15. 2009
    ..These studies uncover the energetics and geometry for mutual recognition of NEMO and diubiquitins...
  4. ncbi request reprint NMR mapping of copper binding sites in alpha-synuclein
    Yoon Hui Sung
    Department of Biochemistry and Program in Structural Biology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Biochim Biophys Acta 1764:5-12. 2006
    ..There is no evidence for the formation of any sites requiring long-range order in the protein...
  5. pmc Residual structure, backbone dynamics, and interactions within the synuclein family
    Yoon Hui Sung
    Department of Biochemistry and Program in Structural Biology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10021, USA
    J Mol Biol 372:689-707. 2007
    ..These results raise questions regarding the role of secondary structure propensities and transient long-range contacts in directing synuclein aggregation reactions...
  6. pmc Structural transitions in tau k18 on micelle binding suggest a hierarchy in the efficacy of individual microtubule-binding repeats in filament nucleation
    Patrick Barre
    Department of Biochemistry, Program in Structural Biology, Weill Cornell Medical College, New York, 10065, USA
    Protein Sci 22:1037-48. 2013
    ....
  7. ncbi request reprint Folding of the repeat domain of tau upon binding to lipid surfaces
    Patrick Barre
    Department of Biochemistry and Program in Structural Biology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Mol Biol 362:312-26. 2006
    ..In addition to providing the first structural insights into a folded state of tau, our results support a role for lipid membranes in mediating tau function and tau pathology...
  8. ncbi request reprint Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein
    Robert Bussell
    Department of Physiology, Biophysics and Molecular Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA
    Biochemistry 43:4810-8. 2004
    ..The potential implications of these results for the role of alphaS in PD are discussed...
  9. pmc E46K Parkinson's-linked mutation enhances C-terminal-to-N-terminal contacts in alpha-synuclein
    Carla C Rospigliosi
    Department of Biochemistry and Program in Structural Biology, Weill Cornell Medical College, New York, NY 10065, USA
    J Mol Biol 388:1022-32. 2009
    ....
  10. pmc Secondary structure and dynamics of micelle bound beta- and gamma-synuclein
    Yoon Hui Sung
    Department of Biochemistry and Program in Structural Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Protein Sci 15:1162-74. 2006
    ....
  11. pmc STARD4 abundance regulates sterol transport and sensing
    Bruno Mesmin
    Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA
    Mol Biol Cell 22:4004-15. 2011
    ..Our results suggest that cholesterol transport mediated by STARD4 is an important component of the cholesterol homeostasis regulatory machinery...
  12. pmc Identification of a helical intermediate in trifluoroethanol-induced alpha-synuclein aggregation
    Valerie L Anderson
    School of Applied and Engineering Physics, Cornell University, Ithaca, NY, USA
    Proc Natl Acad Sci U S A 107:18850-5. 2010
    ..Given that αS is known to populate both highly and partially helical states upon association with membranes, these TFE-induced conformations imply relevant pathways for membrane-induced αS aggregation both in vitro and in vivo...
  13. pmc Charge neutralization and collapse of the C-terminal tail of alpha-synuclein at low pH
    Sebastian McClendon
    Department of Biochemistry and Program in Structural Biology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA
    Protein Sci 18:1531-40. 2009
    ..Thus, the release of long-range contacts does not play a role in the increased aggregation of alphaS at low pH, which we instead attribute to the increased hydrophobicity of the protein...
  14. pmc Structural effects of Parkinson's disease linked DJ-1 mutations
    Gaetano Malgieri
    Department of Biochemistry and Program in Structural Biology, Weill Cornell Medical College, New York, New York 10021, USA
    Protein Sci 17:855-68. 2008
    ..The observed structural and thermodynamic differences are likely to underlie any functional variations between these mutants and the wild type, which in turn are likely responsible for the pathogenicity of these mutations...
  15. pmc Helix periodicity, topology, and dynamics of membrane-associated alpha-synuclein
    Robert Bussell
    Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Protein Sci 14:862-72. 2005
    ..These results clarify the topological features of aS bound to membrane-mimicking detergent micelles, with implications for aS function and pathology...
  16. pmc Biophysical characterization of intrinsically disordered proteins
    David Eliezer
    Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, United States
    Curr Opin Struct Biol 19:23-30. 2009
    ..This article discusses recent advances in the applications of these methods to intrinsically disordered proteins...
  17. pmc Amyloid ion channels: a porous argument or a thin excuse?
    David Eliezer
    Department of Biochemistry and Program in Structural Biology, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Gen Physiol 128:631-3. 2006
  18. pmc Synaptic vesicles position complexin to block spontaneous fusion
    Rachel T Wragg
    Department of Biochemistry, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA
    Neuron 77:323-34. 2013
    ..We propose that the SV pool serves as a platform to sequester and position complexin where it can intercept the rapidly assembling SNAREs and control the rate of spontaneous fusion...
  19. ncbi request reprint Residual structure in the repeat domain of tau: echoes of microtubule binding and paired helical filament formation
    David Eliezer
    Department of Biochemistry and Program in Structural Biology, Weill Medical College of Cornell University, 1300 York Avenue, New York, New York 10021, USA dae2005 med cornell edu
    Biochemistry 44:1026-36. 2005
    ....
  20. ncbi request reprint Characterizing residual structure in disordered protein States using nuclear magnetic resonance
    David Eliezer
    Department of Biochemistry and Program in Structural Biology, Weill Medical College of Cornell University, New York, NY, USA
    Methods Mol Biol 350:49-67. 2007
    ..Advances in NMR instrumentation and methods have greatly facilitated this task and in principle can now be accomplished by those without extensive prior experience in NMR spectroscopy. This chapter describes how this can be accomplished...
  21. pmc Identification of a copper-binding metallothionein in pathogenic mycobacteria
    Ben Gold
    Department of Microbiology and Immunology, Weill Cornell Medical College, 1300 York Avenue, New York, New York 10065, USA
    Nat Chem Biol 4:609-16. 2008
    ..We propose that the product of the MT0196 gene be named mycobacterial metallothionein (MymT). To our knowledge, MymT is the first metallothionein of a Gram-positive bacterium with a demonstrated function...
  22. pmc ¹H, ¹³C, and ¹⁵N backbone resonance assignments of the L124D mutant of StAR-related lipid transfer domain protein 4 (StARD4)
    Igor Dikiy
    Department of Biochemistry and Program in Structural Biology, Weill Cornell Medical College, New York, NY, USA
    Biomol NMR Assign 7:245-8. 2013
    ..To this end, we report nearly complete (1)H, (15)N, and (13)C backbone resonance assignments of an inactive but well behaved mutant (L124D) of StARD4. ..
  23. pmc Folding and misfolding of alpha-synuclein on membranes
    Igor Dikiy
    Department of Biochemistry and Program in Structural Biology, Weill Cornell Medical College, New York, NY 10065, USA
    Biochim Biophys Acta 1818:1013-8. 2012
    ..This article reviews this area, with a focus on a particular model that has emerged in the past few years. This article is part of a Special Issue entitled: Protein Folding in Membranes...
  24. pmc Assigning backbone NMR resonances for full length tau isoforms: efficient compromise between manual assignments and reduced dimensionality
    Nicholas W Harbison
    Tri Institutional Program in Chemical Biology, Department of Biochemistry, Weill Cornell Medical College, New York, New York, United States of America
    PLoS ONE 7:e34679. 2012
    ..An analysis of the backbone chemical shifts obtained in this fashion indicates several regions in full length tau with a notable propensity for helical or strand-like structure that are in good agreement with previous observations...
  25. doi request reprint Distance information for disordered proteins from NMR and ESR measurements using paramagnetic spin labels
    David Eliezer
    Department of Biochemistry and Program in Structural Biology, Weill Cornell Medical College, New York, NY, USA
    Methods Mol Biol 895:127-38. 2012
    ..This chapter describes the use of paramagnetic spin labeling in combination with paramagnetic relaxation enhancement (PRE) in NMR spectroscopy and pulsed dipolar ESR spectroscopy (PDS) for this purpose...
  26. ncbi request reprint Native chemical ligation in covalent caspase inhibition by p35
    Miao Lu
    Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA
    Chem Biol 13:117-22. 2006
    ..Participation of native chemical ligation in caspase inhibition by p35 illustrates an unusual mechanism of protease inhibition...
  27. ncbi request reprint Antiparallel four-stranded coiled coil specified by a 3-3-1 hydrophobic heptad repeat
    Yiqun Deng
    Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA
    Structure 14:247-55. 2006
    ..The results suggest that the conserved, charged residues at the g positions in the GCN4 leucine zipper can impart a negative design element to disfavor thermodynamically more stable, antiparallel tetramers...
  28. pmc Quantification of alpha-synuclein binding to lipid vesicles using fluorescence correlation spectroscopy
    Elizabeth Rhoades
    School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853 2501, USA
    Biophys J 90:4692-700. 2006
    ..Our results demonstrate that fluorescence correlation spectroscopy provides a powerful tool for the quantitative characterization of alphaS-lipid interactions...