Research Topics
| R R DietertSummaryAffiliation: Cornell University Country: USA Publications
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Publications
Misregulated inflammation as an outcome of early-life exposure to endocrine-disrupting chemicalsRodney R Dietert
Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
Rev Environ Health 27:117-31. 2012..Additional research into early-life EDC exposure and misregulation of inflammation appears to be a useful avenue for reducing environmental health risks...
Perinatal immunotoxicity: why adult exposure assessment fails to predict riskRodney R Dietert
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, North Tower Road, Ithaca, NY 14853, USA
Environ Health Perspect 114:477-83. 2006..Finally, it stresses the need to replace adult exposure assessment for immune evaluation with protocols that can protect the developing immune system...- Identifying patterns of immune-related disease: use in disease prevention and managementRodney R Dietert
Department of Microbiology and Immunology, Cornell University, Ithaca, NY, 14853, USA
World J Pediatr 6:111-8. 2010..However, no systematic approach has been used to identify life-long patterns of immune-based disease where the primary condition arises in childhood. Such information is useful for both disease prevention and treatment approaches... 
Lead and immune functionRodney R Dietert
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
Crit Rev Toxicol 36:359-85. 2006..Age-based exposure studies also suggest that levels of blood lead previously thought to be safe, that is, below 10 microg/dl, may be associated with later life immune alterations...- Developmental immunotoxicity testing and protection of children's healthRodney R Dietert
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
PLoS Med 3:e296. 2006 - Methodologies for developmental immunotoxicity (DIT) testingRodney R Dietert
Department of Microbiology and Immunology, College of Veterinary Medicine, C 5 135 VMC, N Tower Rd, Cornell University, Ithaca, NY 14853, USA
Methods 41:123-31. 2007..However, multi-cytokine analysis needs to be standardized in terms of optimum source for analysis and protocol... - Early-life immune insult and developmental immunotoxicity (DIT)-associated diseases: potential of herbal- and fungal-derived medicinalsRodney R Dietert
Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853 USA
Curr Med Chem 14:1075-85. 2007..In this review, we consider potential phytotherapeutic candidates among herbal- and fungal-derived medicinals for possible postnatal correction of the most predominant DIT-induced immune problems... - Possible role for early-life immune insult including developmental immunotoxicity in chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME)Rodney R Dietert
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Toxicology 247:61-72. 2008..This review considers the potential role of ELII including DIT as an early-life component of later-life CFS... - The managed immune system: protecting the womb to delay the tombRodney R Dietert
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Hum Exp Toxicol 27:129-34. 2008..Therefore, a more comprehensive and effective approach for the protection of the developing immune system can help to reduce the incidence of later-life chronic diseases... - Developmental immunotoxicology: focus on health risksRodney R Dietert
Department of Microbiology and Immunology, C5 135 VMC, College of Veterinary Medicine, Cornell University, North Tower Road, Ithaca, New York 14853, USA
Chem Res Toxicol 22:17-23. 2009..Because DIT is linked to a majority of the most significant childhood chronic diseases, safety testing for DIT is a pivotal issue in the protection of children's health... - Potential for early-life immune insult including developmental immunotoxicity in autism and autism spectrum disorders: focus on critical windows of immune vulnerabilityRodney R Dietert
Department of Microbiology and Immunology, Cornell University, Ithaca, NY14852, USA
J Toxicol Environ Health B Crit Rev 11:660-80. 2008..This review considers the known features of ELII and DIT and how they may provide important clues to prenatal brain inflammation and the risk of autism and ASDs... - Developmental immunotoxicity (DIT), postnatal immune dysfunction and childhood leukemiaRodney R Dietert
Department of Microbiology and Immunology, College of Veterinary Medicine, C5 135 VMC North Tower Road, Cornell University, Ithaca, NY 14853, USA
Blood Cells Mol Dis 42:108-12. 2009..This review details the range of disease susceptibilities impacted by DIT and discusses the importance of effective DIT safety testing for drugs and chemicals as a preventative measure... - Early-life environment, developmental immunotoxicology, and the risk of pediatric allergic disease including asthmaRodney R Dietert
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Birth Defects Res B Dev Reprod Toxicol 83:547-60. 2008.... - Developmental immunotoxicology (DIT): windows of vulnerability, immune dysfunction and safety assessmentRodney R Dietert
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Immunotoxicol 5:401-12. 2008..A multifunctional DIT protocol using influenza challenge is presented as one example of an approach that permits dysfunction and misregulation to be evaluated... - Role of developmental immunotoxicity and immune dysfunction in chronic disease and cancerRodney R Dietert
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Reprod Toxicol 31:319-26. 2011..For this reason, mandatory and relevant DIT testing is needed for all drugs and chemicals where pregnant women and children are at risk... - Commentary on hormetic dose-response relationships in immunology: occurrence, quantitative features of the dose response, mechanistic foundations, and clinical implicationsRodney R Dietert
Department of Microbiology, and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
Crit Rev Toxicol 35:305-6. 2005 - Breaking patterns of environmentally influenced disease for health risk reduction: immune perspectivesRodney R Dietert
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
Environ Health Perspect 118:1091-9. 2010.... - Fractal immunology and immune patterning: potential tools for immune protection and optimizationRodney R Dietert
Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA
J Immunotoxicol 8:101-10. 2011.... - Developmental immunotoxicology of leadRodney R Dietert
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Toxicol Appl Pharmacol 198:86-94. 2004..The existence of and probable basis for developmental windows of immune hyper-susceptibility are presented. Finally, the potential for lead to serve as a perinatal risk factor for childhood asthma as well as other diseases is considered... - Avian macrophage metabolismR R Dietert
Department of Microbiology and Immunology, College of Veterinary Medicine, and Institute for Comparative and Environmental Toxicology, Cornell University, Ithaca, New York 14850, USA
Poult Sci 77:990-7. 1998..The present review considers prior and recent information on the production of the metabolites by avian macrophages. Additionally, the potential ramifications of metabolite production and regulation are discussed... - Developmental immunotoxicity of dexamethasone: comparison of fetal versus adult exposuresRodney R Dietert
Department of Microbiology and Immunology, College of Veterinary Medicine, Veterinary Medical Center, C5 135 VMC, Tower Rd, Cornell University, Ithaca, NY 14853, USA
Toxicology 194:163-76. 2003..Furthermore, there was no apparent advantage in delaying immune assessment until the offspring reached adulthood... - Developmental immunotoxicology: emerging issuesR R Dietert
Department of Microbiology and Immunology, Institute for Comparative and Environmental Toxicology, Cornell University, Ithaca, New York 14853, USA
Hum Exp Toxicol 21:479-85. 2002..Recent research results involving early exposure to lead (Pb) and other chemicals are discussed to highlight the nature of the decisions that are available and the potential cost-benefit associated with various approaches to evaluation... - Exposure to lead during critical windows of embryonic development: differential immunotoxic outcome based on stage of exposure and genderT L Bunn
Department of Microbiology and Immunology, College of Veterinary Medicine, and Institute for Comparative and Environmental Toxicology, Cornell University, Ithaca, New York 14853-6401, USA
Toxicol Sci 64:57-66. 2001..Therefore, additional developmental immunotoxicity studies are needed to examine critical windows of immune development for immunotoxicity and differential susceptibility based on gender... - Developmental windows of differential lead-induced immunotoxicity in chickensJ E Lee
Department of Microbiology and Immunology, Institute for Comparative and Environmental Toxicology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Toxicology 156:161-70. 2001..Based on these results, it is hypothesized that lead exposure during different windows of embryonic development is likely to result in different immunotoxic outcomes in the juvenile... - Gender-based profiles of developmental immunotoxicity to lead in the rat: assessment in juveniles and adultsT L Bunn
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
J Toxicol Environ Health A 64:223-40. 2001..Additionally, while most effects were evident at both juvenile and adult ages, some changes were not fully evident until measured in the adult. Most changes were persistent with only one exception (male nitrite levels at 100 ppm)... - Workshop to identify critical windows of exposure for children's health: immune and respiratory systems work group summaryR R Dietert
Department of Microbiology and Immunology and Institute of Comparative and Environmental Toxicology, Cornell University, Ithaca, New York, USA
Environ Health Perspect 108:483-90. 2000..We also provide a template for comparative research. Finally, we discuss the application of these data to risk assessment... - Embryonic exposure to lead: comparison of immune and cellular responses in unchallenged and virally stressed chickensJi-Eun Lee
Institute for Comparative and Environmental Toxicology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Arch Toxicol 75:717-24. 2002..It appears that lead exposure during different stages of embryonic development is likely to result in different immunotoxic outcomes in juveniles... - Developmental immunotoxicity of cyclosporin-A in rats: age-associated differential effectsIrshad Hussain
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853-6401, USA
Toxicology 206:273-84. 2005..However, embryonic exposure appears to produce a series of immune perturbations including functional impairment during postnatal maturation... - Developmental immunotoxicity (DIT) in drug safety testing: matching DIT testing to adverse outcomes and childhood disease riskRodney R Dietert
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Curr Drug Saf 3:216-26. 2008..A longer-term goal is to help narrow the difference between current guideline expectations and the known sensitivity of the developing immune system for potential adverse outcomes... - Developmental immunotoxicity of lead: impact on thymic functionJi-Eun Lee
Institute for Comparative and Environmental Toxicology, Cornell University, Ithaca, New York 14853, USA
Birth Defects Res A Clin Mol Teratol 67:861-7. 2003..Lead exposure appears to alter thymic functions directly; however, indirect effects via endocrine factors are not precluded... - Dietary arginine intake alters avian leukocyte population distribution during infectious bronchitis challengeJ E Lee
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
Poult Sci 81:793-8. 2002..These results show that dietary arginine influences the character of the chicken cellular response to IBV and the distribution of responding leukocyte subpopulations in a target tissue for the infection... - Effect of dietary vitamin E and selenium deficiency on chicken splenocyte proliferation and cell surface marker expressionW P Chang
Department of Microbiology, Immunology, and Parasitology, Cornell University, Ithaca, NY 14853
Immunopharmacol Immunotoxicol 16:203-23. 1994..These results support the conclusion that vitamin E and Se deficiencies may affect both the maturation of specific lymphocyte subpopulations and the functional and proliferative capabilities of the peripheral lymphocytes... - 3-Methylcholanthrene-induced immunosuppression in mice to Trichinella spiralis antigensB E Johnson
Institute for Comparative and Environmental Toxicology, Cornell University, Ithaca, New York 14853
Immunopharmacol Immunotoxicol 12:237-56. 1990..These results suggest that MC treatment has a similar suppressive effect on the immune responses of both B6 and D2 mice that involves the quality of accessory cell-T-cell interactions... - Impact of in ovo-administered lead and testosterone on developing female thymocytesIrshad Hussain
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
J Toxicol Environ Health A 68:1309-19. 2005..Therefore, sex hormonal balance in early life appears to influence the manner in which the developing thymus responds to the heavy metal lead... - Symposium summary: children's health risk--what's so special about the developing immune system?Michael P Holsapple
ILSI Health and Environmental Sciences Institute, Washington, DC 20005 5802, USA
Toxicol Appl Pharmacol 199:61-70. 2004.... - Induction of asthma and the environment: what we know and need to knowMaryJane K Selgrade
National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Environ Health Perspect 114:615-9. 2006..Research to address these questions could have a significant public health and economic impact that would be well worth the investment...