Anna Di Gregorio

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Ciona intestinalis: chordate development made simple
    Yale J Passamaneck
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Dev Dyn 233:1-19. 2005
  2. pmc Tbx2/3 is an essential mediator within the Brachyury gene network during Ciona notochord development
    Diana S José-Edwards
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, Box 60, New York, NY 10065, USA
    Development 140:2422-33. 2013
  3. pmc The identification of transcription factors expressed in the notochord of Ciona intestinalis adds new potential players to the brachyury gene regulatory network
    Diana S José-Edwards
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York, USA
    Dev Dyn 240:1793-805. 2011
  4. pmc Temporal regulation of the muscle gene cascade by Macho1 and Tbx6 transcription factors in Ciona intestinalis
    Jamie E Kugler
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, Box 60, New York, NY 10065, USA
    J Cell Sci 123:2453-63. 2010
  5. pmc Direct activation of a notochord cis-regulatory module by Brachyury and FoxA in the ascidian Ciona intestinalis
    Yale J Passamaneck
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, Box 60, New York, NY 10065, USA
    Development 136:3679-89. 2009
  6. pmc Conservation of notochord gene expression across chordates: insights from the Leprecan gene family
    Terence D Capellini
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10065, USA
    Genesis 46:683-96. 2008
  7. pmc Evolutionary conservation of vertebrate notochord genes in the ascidian Ciona intestinalis
    Jamie E Kugler
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10065, USA
    Genesis 46:697-710. 2008
  8. pmc Dynamic and polarized muscle cell behaviors accompany tail morphogenesis in the ascidian Ciona intestinalis
    Yale J Passamaneck
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York, United States of America
    PLoS ONE 2:e714. 2007
  9. pmc Evolutionary changes in the notochord genetic toolkit: a comparative analysis of notochord genes in the ascidian Ciona and the larvacean Oikopleura
    Jamie E Kugler
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY 10065, USA
    BMC Evol Biol 11:21. 2011
  10. pmc The evolutionarily conserved leprecan gene: its regulation by Brachyury and its role in the developing Ciona notochord
    Matthew P Dunn
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, Box 60, New York, NY 10065, USA
    Dev Biol 328:561-74. 2009

Research Grants

  1. Brachyury-downstream gene networks in the notochord
    Anna Di Gregorio; Fiscal Year: 2007
  2. Brachyury-downstream gene networks in the notochord
    Anna Di Gregorio; Fiscal Year: 2009
  3. Brachyury-downstream gene networks in the notochord
    Anna Di Gregorio; Fiscal Year: 2010
  4. Brachyury-downstream gene networks in the notochord
    Anna Di Gregorio; Fiscal Year: 2010

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Ciona intestinalis: chordate development made simple
    Yale J Passamaneck
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Dev Dyn 233:1-19. 2005
    ..Here, we review the main similarities and differences so far identified, at the molecular level, between ascidian and vertebrate tissues and discuss the evolution of the compact ascidian genome...
  2. pmc Tbx2/3 is an essential mediator within the Brachyury gene network during Ciona notochord development
    Diana S José-Edwards
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, Box 60, New York, NY 10065, USA
    Development 140:2422-33. 2013
    ..This work sheds light on a large section of the notochord regulatory circuitry controlled by T-box factors, and reveals new components of the complement of genes required for the proper formation of this structure...
  3. pmc The identification of transcription factors expressed in the notochord of Ciona intestinalis adds new potential players to the brachyury gene regulatory network
    Diana S José-Edwards
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York, USA
    Dev Dyn 240:1793-805. 2011
    ..We found that Ciona Brachyury regulates the expression of most, although not all, of these genes. These results shed light on the genetic regulatory program underlying notochord formation in Ciona and possibly other chordates...
  4. pmc Temporal regulation of the muscle gene cascade by Macho1 and Tbx6 transcription factors in Ciona intestinalis
    Jamie E Kugler
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, Box 60, New York, NY 10065, USA
    J Cell Sci 123:2453-63. 2010
    ..We use these representative examples to reconstruct how compact CRMs orchestrate the muscle developmental program from pre-localized ooplasmic determinants to differentiated larval muscle in ascidian embryos...
  5. pmc Direct activation of a notochord cis-regulatory module by Brachyury and FoxA in the ascidian Ciona intestinalis
    Yale J Passamaneck
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, Box 60, New York, NY 10065, USA
    Development 136:3679-89. 2009
    ....
  6. pmc Conservation of notochord gene expression across chordates: insights from the Leprecan gene family
    Terence D Capellini
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10065, USA
    Genesis 46:683-96. 2008
    ..These results have interesting implications for the evolution and development of chordates...
  7. pmc Evolutionary conservation of vertebrate notochord genes in the ascidian Ciona intestinalis
    Jamie E Kugler
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10065, USA
    Genesis 46:697-710. 2008
    ..We provide a first description of notochord genes that are not evidently influenced by the ectopic expression of Ci-Bra and we propose alternative regulatory mechanisms that might control their transcription...
  8. pmc Dynamic and polarized muscle cell behaviors accompany tail morphogenesis in the ascidian Ciona intestinalis
    Yale J Passamaneck
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York, United States of America
    PLoS ONE 2:e714. 2007
    ..Investigating the cell behaviors underlying the morphogenesis of muscle in ascidians may therefore reveal the evolutionarily conserved mechanisms operating during this process...
  9. pmc Evolutionary changes in the notochord genetic toolkit: a comparative analysis of notochord genes in the ascidian Ciona and the larvacean Oikopleura
    Jamie E Kugler
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY 10065, USA
    BMC Evol Biol 11:21. 2011
    ....
  10. pmc The evolutionarily conserved leprecan gene: its regulation by Brachyury and its role in the developing Ciona notochord
    Matthew P Dunn
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, Box 60, New York, NY 10065, USA
    Dev Biol 328:561-74. 2009
    ..Together, these observations provide mechanistic insights generally applicable to T-box transcription factors and their target sequences, as well as a first set of clues on the function of Leprecan in early chordate development...
  11. ncbi request reprint The identification of transcription factors expressed in the notochord of Ciona intestinalis adds new potential players to the brachyury gene regulatory network
    Diana S José-Edwards
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York
    Dev Dyn 240:spcone. 2011
    ..Embryos are counterstained with phalloidin (red) and DAPI (blue) to highlight F-actin and nuclei, respectively. From José-Edwards et al., Developmental Dynamics 240:1793-1805, 2011...
  12. ncbi request reprint Live imaging of fluorescent proteins in chordate embryos: from ascidians to mice
    Yale J Passamaneck
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Microsc Res Tech 69:160-7. 2006
    ....
  13. ncbi request reprint Lineage-independent mosaic expression and regulation of the Ciona multidom gene in the ancestral notochord
    Izumi Oda-Ishii
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Dev Dyn 236:1806-19. 2007
    ..These results suggest that despite its morphological simplicity and invariant cell-lineage, the ancestral notochord is a mosaic of cells in which the gene cascade downstream of Brachyury is differentially modulated...
  14. ncbi request reprint The multidimensionality of cell behaviors underlying morphogenesis: a case study in ascidians
    Anna Di Gregorio
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Bioessays 28:874-9. 2006
    ..They convincingly illustrated the utility of their approach by applying it to the early ascidian embryo...
  15. pmc Optimization of a method for chromatin immunoprecipitation assays in the marine invertebrate chordate ciona
    Hitoshi Aihara
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, Box 60, New York, NY, 10065, USA
    Mar Biotechnol (NY) 15:520-5. 2013
    ....
  16. ncbi request reprint Live imaging and morphometric analysis of embryonic development in the ascidian Ciona intestinalis
    Jerry M Rhee
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Genesis 43:136-47. 2005
    ..The approach we describe can be used to document morphogenetic cell and tissue rearrangements in living embryos and paves the way for a live digitized anatomical atlas of Ciona...
  17. pmc From notochord formation to hereditary chordoma: the many roles of Brachyury
    Yutaka Nibu
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY 10065, USA
    Biomed Res Int 2013:826435. 2013
    ..In particular, we report on the current knowledge of the role of Brachyury and of its possible mechanisms of action in both notochord formation and chordoma etiogenesis...
  18. doi request reprint Pbx1/Pbx2 govern axial skeletal development by controlling Polycomb and Hox in mesoderm and Pax1/Pax9 in sclerotome
    Terence D Capellini
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Dev Biol 321:500-14. 2008
    ....
  19. ncbi request reprint The draft genome of Ciona intestinalis: insights into chordate and vertebrate origins
    Paramvir Dehal
    U S Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA
    Science 298:2157-67. 2002
    ..The ascidian genome has also acquired a number of lineage-specific innovations, including a group of genes engaged in cellulose metabolism that are related to those in bacteria and fungi...
  20. doi request reprint Simple chordates exhibit a proton-independent function of acid-sensing ion channels
    Tatjana Coric
    Department of Cellular and Molecular Physiology, Yale University, 333 Cedar St, New Haven, CT 06520, USA
    FASEB J 22:1914-23. 2008
    ..Together the data identify ASIC as a highly conserved channel distinctive of chordate nervous systems and show that protons are not essential for ASIC function...
  21. pmc A saturation screen for cis-acting regulatory DNA in the Hox genes of Ciona intestinalis
    David N Keys
    U S Department of Energy Joint Genome Institute, Walnut Creek, CA 94598, USA
    Proc Natl Acad Sci U S A 102:679-83. 2005
    ..In addition to vertebrate-like CNS regulation, the discovery of cis-regulatory domains that drive epidermal transcription suggests that C. intestinalis has arthropod-like Hox patterning in the epidermis...
  22. ncbi request reprint Unusual number and genomic organization of Hox genes in the tunicate Ciona intestinalis
    Antonietta Spagnuolo
    Laboratory of Biochemistry and Molecular Biology, Stazione Zoologica Anton Dohrn, Villa Comunale, 80121, Naples, Italy
    Gene 309:71-9. 2003
    ..We speculate that such an arrangement of Hox genes does not correspond to the chordate primordial cluster but occurred independently in the ascidian lineage...
  23. ncbi request reprint A genomewide survey of developmentally relevant genes in Ciona intestinalis. II. Genes for homeobox transcription factors
    Shuichi Wada
    Department of Zoology, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Dev Genes Evol 213:222-34. 2003
    ..The present data thus reveal the repertoire of homeodomain-containing transcription factors in the Ciona genome, which will be useful for future research on the development and evolution of chordates...
  24. ncbi request reprint Tail morphogenesis in the ascidian, Ciona intestinalis, requires cooperation between notochord and muscle
    Anna Di Gregorio
    Department of Molecular and Cell Biology, University of California, 401 Barker Hall, Berkeley, California 94720 3204, USA
    Dev Biol 244:385-95. 2002
    ..Taken together, these observations suggest that tail formation in ascidian larvae requires not only signaling from notochord to muscle cells, but also a "retrograde" signal from muscle cells to notochord...

Research Grants6

  1. Brachyury-downstream gene networks in the notochord
    Anna Di Gregorio; Fiscal Year: 2007
    ....
  2. Brachyury-downstream gene networks in the notochord
    Anna Di Gregorio; Fiscal Year: 2009
    ....
  3. Brachyury-downstream gene networks in the notochord
    Anna Di Gregorio; Fiscal Year: 2010
    ....
  4. Brachyury-downstream gene networks in the notochord
    Anna Di Gregorio; Fiscal Year: 2010
    ....