Richard B Devereux

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. pmc Normal limits in relation to age, body size and gender of two-dimensional echocardiographic aortic root dimensions in persons ≥15 years of age
    Richard B Devereux
    Greenberg Division of Cardiology, Weill Cornell Medical College, New York, New York, USA
    Am J Cardiol 110:1189-94. 2012
  2. pmc Impact of diastolic dysfunction severity on global left ventricular volumetric filling - assessment by automated segmentation of routine cine cardiovascular magnetic resonance
    Dorinna D Mendoza
    Department of Medicine, Weill Cornell Medical College, NY, NY, USA
    J Cardiovasc Magn Reson 12:46. 2010
  3. pmc Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study
    Nathan E Wineinger
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
    BMC Med Genomics 4:4. 2011
  4. pmc Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: the HyperGEN Study
    Donna K Arnett
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham AL 35294 0022, USA
    BMC Med Genet 10:43. 2009
  5. pmc QTLs of factors of the metabolic syndrome and echocardiographic phenotypes: the hypertension genetic epidemiology network study
    Aldi T Kraja
    Division of Statistical Genomics, Washington University School of Medicine, Saint Louis, MO, USA
    BMC Med Genet 9:103. 2008
  6. pmc Identification of a pleiotropic locus on chromosome 7q for a composite left ventricular wall thickness factor and body mass index: the HyperGEN Study
    Weihong Tang
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
    BMC Med Genet 10:40. 2009
  7. ncbi request reprint Regression of hypertensive left ventricular hypertrophy by losartan compared with atenolol: the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) trial
    Richard B Devereux
    Cornell Medical Center, 525 E 68th St, New York, NY 10021, USA
    Circulation 110:1456-62. 2004
  8. ncbi request reprint Blood pressure reduction and antihypertensive medication use in the losartan intervention for endpoint reduction in hypertension (LIFE) study in patients with hypertension and left ventricular hypertrophy
    Richard B Devereux
    Weill Medical College of Cornell University, New York, NY 10021, USA
    Curr Med Res Opin 23:259-70. 2007
  9. ncbi request reprint Congestive heart failure despite normal left ventricular systolic function in a population-based sample: the Strong Heart Study
    R B Devereux
    Department of Medicine, the New York Presbyterian Hospital Weill Cornell Medical Center, New York 10021, USA
    Am J Cardiol 86:1090-6. 2000
  10. ncbi request reprint Potential mechanisms of stroke benefit favoring losartan in the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study
    Richard B Devereux
    Greenberg Division of Cardiology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Curr Med Res Opin 23:443-57. 2007

Research Grants

  1. Cardiovascular Evaluation for the SHS Phase V
    Richard Devereux; Fiscal Year: 2007

Collaborators

Detail Information

Publications190 found, 100 shown here

  1. pmc Normal limits in relation to age, body size and gender of two-dimensional echocardiographic aortic root dimensions in persons ≥15 years of age
    Richard B Devereux
    Greenberg Division of Cardiology, Weill Cornell Medical College, New York, New York, USA
    Am J Cardiol 110:1189-94. 2012
    ..In conclusion, aortic root diameter is larger in men and increases with body size and age. Regression models incorporating body size, age, and gender are applicable to adolescents and adults without limitations of previous nomograms...
  2. pmc Impact of diastolic dysfunction severity on global left ventricular volumetric filling - assessment by automated segmentation of routine cine cardiovascular magnetic resonance
    Dorinna D Mendoza
    Department of Medicine, Weill Cornell Medical College, NY, NY, USA
    J Cardiovasc Magn Reson 12:46. 2010
    ..To examine relationships between severity of echocardiography (echo) -evidenced diastolic dysfunction (DD) and volumetric filling by automated processing of routine cine cardiovascular magnetic resonance (CMR)...
  3. pmc Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study
    Nathan E Wineinger
    Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
    BMC Med Genomics 4:4. 2011
    ..We report a genome-wide association study on aortic root diameter among African Americans enrolled in the HyperGEN study. We invoked a two-stage, mixed model procedure to jointly identify SNP allele and copy number variation effects...
  4. pmc Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: the HyperGEN Study
    Donna K Arnett
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham AL 35294 0022, USA
    BMC Med Genet 10:43. 2009
    ..Eleven of 12 promising (Q < 0.8) single-nucleotide polymorphisms (SNPs) from the genome-wide study were successfully genotyped using quantitative real time PCR in a validation study...
  5. pmc QTLs of factors of the metabolic syndrome and echocardiographic phenotypes: the hypertension genetic epidemiology network study
    Aldi T Kraja
    Division of Statistical Genomics, Washington University School of Medicine, Saint Louis, MO, USA
    BMC Med Genet 9:103. 2008
    ....
  6. pmc Identification of a pleiotropic locus on chromosome 7q for a composite left ventricular wall thickness factor and body mass index: the HyperGEN Study
    Weihong Tang
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
    BMC Med Genet 10:40. 2009
    ....
  7. ncbi request reprint Regression of hypertensive left ventricular hypertrophy by losartan compared with atenolol: the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) trial
    Richard B Devereux
    Cornell Medical Center, 525 E 68th St, New York, NY 10021, USA
    Circulation 110:1456-62. 2004
    ..An echocardiographic substudy of the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) trial was designed to test the ability of losartan to reduce left ventricular (LV) mass more than atenolol...
  8. ncbi request reprint Blood pressure reduction and antihypertensive medication use in the losartan intervention for endpoint reduction in hypertension (LIFE) study in patients with hypertension and left ventricular hypertrophy
    Richard B Devereux
    Weill Medical College of Cornell University, New York, NY 10021, USA
    Curr Med Res Opin 23:259-70. 2007
    ..To compare blood pressure response and antihypertensive medication use visit-by-visit from baseline in patients receiving losartan-based or atenolol-based therapy in the LIFE study...
  9. ncbi request reprint Congestive heart failure despite normal left ventricular systolic function in a population-based sample: the Strong Heart Study
    R B Devereux
    Department of Medicine, the New York Presbyterian Hospital Weill Cornell Medical Center, New York 10021, USA
    Am J Cardiol 86:1090-6. 2000
    ....
  10. ncbi request reprint Potential mechanisms of stroke benefit favoring losartan in the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study
    Richard B Devereux
    Greenberg Division of Cardiology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Curr Med Res Opin 23:443-57. 2007
    ....
  11. ncbi request reprint Losartan for the treatment of hypertension and left ventricular hypertrophy: the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study
    Richard B Devereux
    Weill Medical College of Cornell University, Division of Cardiology, Box 222, 525 East 68th Street, New York, NY 10021, USA
    Expert Opin Pharmacother 5:2311-20. 2004
    ..The focus of this review is the LIFE study...
  12. ncbi request reprint Left ventricular wall stresses and wall stress-mass-heart rate products in hypertensive patients with electrocardiographic left ventricular hypertrophy: the LIFE study. Losartan Intervention For Endpoint reduction in hypertension
    R B Devereux
    Department of Medicine, The New York Presbyterian Hospital Weill Medical College of Cornell University, New York, USA
    J Hypertens 18:1129-38. 2000
    ..Left ventricular (LV) hypertrophy on echocardiogram (ECG) strongly predicts coronary heart disease events, but the mechanisms linking increased LV mass to ischemic vascular events is uncertain...
  13. ncbi request reprint Relations of stroke volume and cardiac output to body composition: the strong heart study
    T Collis
    Cornell Medical Center, New York, NY, USA
    Circulation 103:820-5. 2001
    ..Although cardiac output (CO) plays the vital role of delivering nutrients to body tissues, few data are available concerning the relations of stroke volume (SV) and CO to body composition in large population samples...
  14. ncbi request reprint Prognostic implications of ejection fraction from linear echocardiographic dimensions: the Strong Heart Study
    Richard B Devereux
    Cornell Medical Center, New York, NY, USA
    Am Heart J 146:527-34. 2003
    ....
  15. ncbi request reprint Effects of losartan or atenolol in hypertensive patients without clinically evident vascular disease: a substudy of the LIFE randomized trial
    Richard B Devereux
    Weill Medical College of Cornell University, New York, New York, USA
    Ann Intern Med 139:169-77. 2003
    ....
  16. ncbi request reprint Left ventricular systolic dysfunction in a biracial sample of hypertensive adults: The Hypertension Genetic Epidemiology Network (HyperGEN) Study
    R B Devereux
    Weill Medical College of Cornell University, New York, NY, USA
    Hypertension 38:417-23. 2001
    ....
  17. ncbi request reprint Prognostic significance of left ventricular mass change during treatment of hypertension
    Richard B Devereux
    Department of Medicine, New York Presbyterian Hospital, Cornell Medical Center, New York, NY 10021, USA
    JAMA 292:2350-6. 2004
    ..Increased baseline left ventricular (LV) mass predicts cardiovascular (CV) complications of hypertension, but the relation between lower LV mass and outcome during treatment for hypertension is uncertain...
  18. ncbi request reprint Relation of insulin to left ventricular geometry and function in African American and white hypertensive adults: the HyperGEN study
    Richard B Devereux
    Division of Cardiology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Am J Hypertens 15:1029-35. 2002
    ....
  19. ncbi request reprint Progressive hypertrophy regression with sustained pressure reduction in hypertension: the Losartan Intervention For Endpoint Reduction study
    Richard B Devereux
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Hypertens 20:1445-50. 2002
    ..To examine the time course of left ventricular (LV) geometric response to blood pressure (BP) control during 2 years of systematic antihypertensive treatment...
  20. ncbi request reprint An appraisal of echocardiography as an epidemiological tool. The Strong Heart Study
    Richard B Devereux
    The New York Hospital Cornell Medical Center, New York, NY 10021, USA
    Ann Epidemiol 13:238-44. 2003
    ....
  21. doi request reprint Cardiac chamber volumes, function, and mass as determined by 64-multidetector row computed tomography: mean values among healthy adults free of hypertension and obesity
    Fay Y Lin
    Weill Cornell Medical College, New York, New York 10021, USA
    JACC Cardiovasc Imaging 1:782-6. 2008
    ..We derived mean values for cardiac dimensions, volumes, function, and mass in a normotensive nonobese population free of cardiovascular disease...
  22. doi request reprint Renal outcomes in hypertensive Black patients at high cardiovascular risk
    Matthew R Weir
    Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Kidney Int 81:568-76. 2012
    ..Blacks have a modestly higher increased risk for more advanced increases in serum creatinine than non-Blacks...
  23. doi request reprint Incidence of atrial fibrillation in relation to changing heart rate over time in hypertensive patients: the LIFE study
    Peter M Okin
    Greenberg Division of Cardiology, Weill Cornell Medical College, New York, NY 10065, USA
    Circ Arrhythm Electrophysiol 1:337-43. 2008
    ..Although losartan therapy and decreasing ECG left ventricular hypertrophy are associated with decreased AF incidence, the relationship of HR changes over time to development of AF has not been examined...
  24. ncbi request reprint Utility of the myocardial performance index in a population with high prevalences of obesity, diabetes, and hypertension: the strong heart study
    Rakesh K Mishra
    Weill Medical College of Cornell University, New York, New York, USA
    Echocardiography 24:340-7. 2007
    ..There are scant data on the correlates and prognostic value of MPI in a population without overt cardiovascular (CV) disease...
  25. ncbi request reprint Stroke reduction in hypertensive adults with cardiac hypertrophy randomized to losartan versus atenolol: the Losartan Intervention For Endpoint reduction in hypertension study
    Jorge R Kizer
    Weill Medical College of Cornell University, New York, NY, USA
    Hypertension 45:46-52. 2005
    ....
  26. ncbi request reprint Left atrial systolic force and cardiac markers of preclinical disease in hypertensive patients: the Hypertension Genetic Epidemiology Network (HyperGEN) Study
    Marcello Chinali
    Department of Medicine, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
    Am J Hypertens 18:899-905. 2005
    ..This study analyzes the association of increased LASF to LV geometry and function in hypertensive patients from a population study...
  27. ncbi request reprint Regression of electrocardiographic left ventricular hypertrophy and decreased incidence of new-onset atrial fibrillation in patients with hypertension
    Peter M Okin
    Greenberg Division of Cardiology, Weill Medical College of Cornell University, New York, NY 10021, USA
    JAMA 296:1242-8. 2006
    ..Although the presence and severity of electrocardiographic left ventricular hypertrophy (LVH) appear to predict development of AF, whether regression of electrocardiographic LVH is associated with a decreased incidence of AF is unclear...
  28. doi request reprint Combination of the electrocardiographic strain pattern and albuminuria for the prediction of new-onset heart failure in hypertensive patients: the LIFE study
    Peter M Okin
    Greenberg Division of Cardiology, Weill Medical College of Cornell University, New York, New York, USA
    Am J Hypertens 21:273-9. 2008
    ..Although albuminuria and the electrocardiographic (ECG) strain pattern each predict development of heart failure (HF), whether combining albuminuria and strain improves prediction of new HF is unclear...
  29. ncbi request reprint Left atrial systolic force and cardiovascular outcome. The Strong Heart Study
    Marcello Chinali
    Department of Medicine, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
    Am J Hypertens 18:1570-6; discussion 1577. 2005
    ..The goal of this study was to determine whether LASF adds to prognostic prediction of other markers of preclinical cardiovascular disease in a population with a high prevalence of hypertension and diabetes...
  30. ncbi request reprint Association of albuminuria with systolic and diastolic left ventricular dysfunction in type 2 diabetes: the Strong Heart Study
    Jennifer E Liu
    Division of Cardiology, Box 222, New York Presbyterian Hospital Cornell Medical Center, 525 East 68th Street, New York, NY 10021, USA
    J Am Coll Cardiol 41:2022-8. 2003
    ..We sought to compare systolic and diastolic function in American Indians with diabetes mellitus (DM) based on albuminuria status...
  31. pmc Cardiovascular and metabolic predictors of progression of prehypertension into hypertension: the Strong Heart Study
    Marina De Marco
    Department of Medicine, Weill Cornell Medical College, New York, NY, USA
    Hypertension 54:974-80. 2009
    ..10). Thus, progression to HTN in 38% of Strong Heart Study prehypertensive participants could be predicted by higher left ventricular mass and stroke volume in addition to baseline systolic blood pressure and prevalent diabetes mellitus...
  32. ncbi request reprint Electrocardiographic strain pattern and prediction of cardiovascular morbidity and mortality in hypertensive patients
    Peter M Okin
    Greenberg Division of Cardiology, Weill Medical College of Cornell University, 525 East 68th St, New York, NY 10021, USA
    Hypertension 44:48-54. 2004
    ..33, 95% CI 1.11 to 1.59). Thus, ECG strain is a marker of increased CV risk in hypertensive patients in the setting of aggressive blood pressure lowering, independent of baseline severity of ECG LVH...
  33. ncbi request reprint Normalization for body size and population-attributable risk of left ventricular hypertrophy: the Strong Heart Study
    Giovanni de Simone
    Division of Cardiology, The New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
    Am J Hypertens 18:191-6. 2005
    ..The presence of LVH detected by these indices predicts increased cardiovascular (CV) events. Whether different indexations of LVH differ in their ability to predict excess risk is unknown...
  34. ncbi request reprint Regression of electrocardiographic left ventricular hypertrophy during antihypertensive treatment and the prediction of major cardiovascular events
    Peter M Okin
    Department of Medicine, Division of Cardiology, Cornell University Medical Center, New York, NY 10021, USA
    JAMA 292:2343-9. 2004
    ..However, the predictive value of changes in the magnitude of electrocardiographic LVH criteria during antihypertensive therapy remains unclear...
  35. ncbi request reprint Prognostic implications of relations of left ventricular systolic dysfunction with body composition and myocardial energy expenditure: the Strong Heart Study
    Vittorio Palmieri
    Weill Medical College of Cornell University, New York, New York 10021, USA
    J Am Soc Echocardiogr 21:66-71. 2008
    ....
  36. ncbi request reprint Prevalence and correlates of rheumatic heart disease in American Indians (the Strong Heart Study)
    Wendy L Schaffer
    Cornell Medical Center, New York, NY 10021, USA
    Am J Cardiol 91:1379-82. 2003
  37. doi request reprint Prognostic value of changes in the electrocardiographic strain pattern during antihypertensive treatment: the Losartan Intervention for End-Point Reduction in Hypertension Study (LIFE)
    Peter M Okin
    Greenberg Division of Cardiology, Weill Cornell Medical College, New York, NY 10065, USA
    Circulation 119:1883-91. 2009
    ....
  38. ncbi request reprint Left atrial diameter as an independent predictor of first clinical cardiovascular events in middle-aged and elderly adults: the Strong Heart Study (SHS)
    Jorge R Kizer
    Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
    Am Heart J 151:412-8. 2006
    ..Less is known about the predictive ability of anteroposterior LA diameter, a simpler measure of LA size obtained routinely during echocardiographic evaluation...
  39. ncbi request reprint Four-group classification of left ventricular hypertrophy based on ventricular concentricity and dilatation identifies a low-risk subset of eccentric hypertrophy in hypertensive patients
    Casper N Bang
    From the Department of Medicine, Weill Cornell Medical College, New York, NY C N B, G d S, K W, R B D Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen, Denmark C N B, L K Department of Clinical Science, University of Bergen, Bergen, Norway E G Department of Medicine, Division of Cardiology, University of Massachusetts Medical School, Worcester G P A Department of Medicine, Institution of Public Health and Clinical Medicine, Umea University, Umea, Sweden K B Department of Translational Medical Sciences, Federico II University, Naples, Italy G d S Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden B D and Department of Cardiology, Copenhagen University Hospital Glostrup, Glostrup, Denmark K W
    Circ Cardiovasc Imaging 7:422-9. 2014
    ....
  40. ncbi request reprint QRS duration and QT interval predict mortality in hypertensive patients with left ventricular hypertrophy: the Losartan Intervention for Endpoint Reduction in Hypertension Study
    Lasse Oikarinen
    Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland
    Hypertension 43:1029-34. 2004
    ....
  41. doi request reprint Change in pulse pressure/stroke index in response to sustained blood pressure reduction and its impact on left ventricular mass and geometry changes: the life study
    Vittorio Palmieri
    Division of Cardiology, Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
    Am J Hypertens 21:701-7. 2008
    ..In cross-sectional data in hypertensive subjects, brachial pulse pressure (PP)/Doppler stroke index (SVi), (PP/SVi) correlates weakly but significantly with left ventricular (LV) mass and relative wall thickness (RWT)...
  42. ncbi request reprint Ventricular hypertrophy and hypertension: prognostic elements and implications for management
    Daniel G Krauser
    New York Presbyterian Hospital, Weill Cornell Medical Center, New York, NY, USA
    Herz 31:305-16. 2006
    ..Further studies are required to determine if these agents should become first-line therapy for all patients with hypertension and LVH...
  43. ncbi request reprint Associations of aortic and mitral regurgitation with body composition and myocardial energy expenditure in adults with hypertension: the Hypertension Genetic Epidemiology Network study
    Vittorio Palmieri
    Weill Medical College of Cornell University, New York, NY, USA
    Am Heart J 145:1071-7. 2003
    ..However, the relations of valvular regurgitation to body composition and myocardial bioenergetic expenditure have not been previously investigated in a population-based sample...
  44. ncbi request reprint Left ventricular concentric geometry is associated with impaired relaxation in hypertension: the HyperGEN study
    Giovanni de Simone
    Weill Medical College of Cornell University, New York, NY, USA
    Eur Heart J 26:1039-45. 2005
    ..We tested the hypothesis that abnormal left ventricular (LV) relaxation is associated with concentric LV geometry...
  45. ncbi request reprint Regression of electrocardiographic left ventricular hypertrophy by losartan versus atenolol: The Losartan Intervention for Endpoint reduction in Hypertension (LIFE) Study
    Peter M Okin
    Department of Medicine, Cornell University Medical Center, 525 East 68th St, New York, NY 10021, USA
    Circulation 108:684-90. 2003
    ..However, uncertainty persists as to how best to regress ECG LVH...
  46. ncbi request reprint Combined echocardiographic left ventricular hypertrophy and electrocardiographic ST depression improve prediction of mortality in American Indians: the Strong Heart Study
    Peter M Okin
    Division of Cardiology, Department of Medicine, Cornell Medical Center, 525 East 68th Street, New York, NY 10021, USA
    Hypertension 43:769-74. 2004
    ..These findings support the value of combining Echo-LVH and ECG-STD to improve risk stratification. These findings require verification in other populations...
  47. ncbi request reprint Gender difference in diastolic function in hypertension (the HyperGEN study)
    Jonathan N Bella
    Department of Medicine, Cornell Medical Center, New York, New York 10021, USA
    Am J Cardiol 89:1052-6. 2002
    ..This gender difference in diastolic function may provide insight into gender differences in congestive heart failure and other specific cardiovascular diseases...
  48. ncbi request reprint Systolic left ventricular function according to left ventricular concentricity and dilatation in hypertensive patients: the Losartan Intervention For Endpoint reduction in hypertension study
    Casper N Bang
    aDepartment of Medicine, Weill Cornell Medical College, New York, USA bDepartment of Cardiology, The Heart Center, Rigshospitalet, Copenhagen, Denmark cDepartment of Clinical Science, University of Bergen dDepartment of Heart Disease, Haukeland University Hospital, Bergen, Norway eDivision of Cardiology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA fInstitution of Public Health and Clinical Medicine, Umea University, Medicine Skellefteå, Umeå gDepartment of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden hDepartment of Medicine, Glostrup Hospital, Glostrup, Denmark
    J Hypertens 31:2060-8. 2013
    ..We evaluated left ventricular systolic function in a new four-group LVH classification based on left ventricular dilatation [high left ventricular end-diastolic volume (EDV) index and concentricity (LVM/EDV)] in hypertensive patients...
  49. ncbi request reprint Association of left ventricular hypertrophy with metabolic risk factors: the HyperGEN study
    Giovanni de Simone
    Department of Medicine, The New York Presbyterian Hospital, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Hypertens 20:323-31. 2002
    ..To determine whether combinations of metabolic risk factors (obesity, diabetes and hypercholesterolemia) influence the magnitude of left ventricular (LV) mass and prevalence of LV hypertrophy...
  50. pmc Incremental value of biochemical and echocardiographic measures in prediction of ischemic stroke: the Strong Heart Study
    Maria G Karas
    Weill Cornell Medical College, New York, NY, USA
    Stroke 43:720-6. 2012
    ..American Indians have high rates of stroke. Improved risk stratification could enhance prevention, but the ability of biochemical and echocardiographic markers of preclinical disease to improve stroke prediction is not well-defined...
  51. ncbi request reprint Impact of diabetes mellitus on regression of electrocardiographic left ventricular hypertrophy and the prediction of outcome during antihypertensive therapy: the Losartan Intervention For Endpoint (LIFE) Reduction in Hypertension Study
    Peter M Okin
    Division of Cardiology, Department of Medicine, Cornell University Medical Center, New York, NY 10021, USA
    Circulation 113:1588-96. 2006
    ....
  52. ncbi request reprint In-treatment resolution or absence of electrocardiographic left ventricular hypertrophy is associated with decreased incidence of new-onset diabetes mellitus in hypertensive patients: the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE)
    Peter M Okin
    Department of Medicine, Division of Cardiology, Cornell University Medical Center, New York, NY 10021, USA
    Hypertension 50:984-90. 2007
    ....
  53. ncbi request reprint The ratio of mitral deceleration time to E-wave velocity and mitral deceleration slope outperform deceleration time alone in predicting cardiovascular outcomes: the Strong Heart Study
    Rakesh K Mishra
    Weill Medical College of Cornell University, New York, New York, USA
    J Am Soc Echocardiogr 20:1300-6. 2007
    ..It is not known whether deceleration time normalized for E-velocity or its inverse (deceleration slope) better predicts cardiovascular (CV) events compared with deceleration time or E-velocity alone...
  54. doi request reprint Relations of central and brachial blood pressure to left ventricular hypertrophy and geometry: the Strong Heart Study
    Mary J Roman
    Division of Cardiology, Weill Cornell Medical College, New York 10021, USA
    J Hypertens 28:384-8. 2010
    ..Data regarding the relative impacts of central and brachial pressures on left ventricular hypertrophy and geometry are limited...
  55. ncbi request reprint Mitral ratio of peak early to late diastolic filling velocity as a predictor of mortality in middle-aged and elderly adults: the Strong Heart Study
    Jonathan N Bella
    Weill Medical College of Cornell University, New York, NY, USA
    Circulation 105:1928-33. 2002
    ..However, the prognostic significance of low or high E/A in older adults remains to be elucidated in population-based samples...
  56. ncbi request reprint Assessment of the thoracic aorta by multidetector computed tomography: age- and sex-specific reference values in adults without evident cardiovascular disease
    Fay Y Lin
    Department of Medicine, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY 10021 USA
    J Cardiovasc Comput Tomogr 2:298-308. 2008
    ..Reference values for aortic diameters in anatomically correct double-oblique short axis images have not been established with the use of electrocardiogram (ECG)-gated 64-detector row multidetector CT (MDCT)...
  57. ncbi request reprint Impact of obesity on cardiac geometry and function in a population of adolescents: the Strong Heart Study
    Marcello Chinali
    Department of Medicine, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York, USA
    J Am Coll Cardiol 47:2267-73. 2006
    ....
  58. ncbi request reprint Gender differences in regression of electrocardiographic left ventricular hypertrophy during antihypertensive therapy
    Peter M Okin
    Greenberg Division of Cardiology, Weill Cornell Medical College, New York, NY 10021, USA
    Hypertension 52:100-6. 2008
    ....
  59. ncbi request reprint Influence of fat-free mass on detection of appropriateness of left ventricular mass: the HyperGEN Study
    Giovanni de Simone
    Department of Medicine, The New York Presbyterian Hospital Weill Medical College of Cornell University, New York, NY 10021, USA
    J Hypertens 21:1747-52. 2003
    ....
  60. ncbi request reprint Relationship of left atrial enlargement to persistence or development of ECG left ventricular hypertrophy in hypertensive patients: implications for the development of new atrial fibrillation
    Peter M Okin
    Greenberg Division of Cardiology, Weill Cornell Medical College, New York, New York 10065, USA
    J Hypertens 28:1534-40. 2010
    ..We postulated that this association might be in part mediated via greater left atrial enlargement (LAE) in patients with new and persistent ECG LVH...
  61. ncbi request reprint Electrocardiographic strain pattern and left ventricular diastolic function in hypertensive patients with left ventricular hypertrophy: the LIFE study
    Vittorio Palmieri
    Weill Medical College of Cornell University, New York, NY 10021, USA
    J Hypertens 24:2079-84. 2006
    ....
  62. pmc Vascular biomarkers in the prediction of clinical cardiovascular disease: the Strong Heart Study
    Mary J Roman
    Division of Cardiology, Weill Cornell Medical College, 525 East 68th Street, New York, NY 10021, USA
    Hypertension 59:29-35. 2012
    ..These findings support the utility of separate assessment of focal atherosclerosis and intimal-medial thickness in epidemiological studies, trials, and risk stratification protocols...
  63. ncbi request reprint Differences in left ventricular structure between black and white hypertensive adults: the Hypertension Genetic Epidemiology Network study
    Jorge R Kizer
    Division of Cardiology, Weill Medical College of Cornell University, New York, USA
    Hypertension 43:1182-8. 2004
    ..Whether such differences relate to distinct ambulatory pressure profiles or an ethnic propensity to cardiac hypertrophy requires further investigation...
  64. ncbi request reprint Heritability of left ventricular dimensions and mass in American Indians: The Strong Heart Study
    Jonathan N Bella
    Weill Medical College of Cornell University, New York, New York, USA
    J Hypertens 22:281-6. 2004
    ..We sought to determine the heritability of left ventricular dimensions and mass in adult American Indians...
  65. ncbi request reprint Regression of electrocardiographic left ventricular hypertrophy is associated with less hospitalization for heart failure in hypertensive patients
    Peter M Okin
    Weill Medical College of Cornell University, New York, New York 10021, USA
    Ann Intern Med 147:311-9. 2007
    ..However, whether reduction of electrocardiographic LVH is associated with decreased heart failure is unclear...
  66. ncbi request reprint Electrocardiographic characteristics and metabolic risk factors associated with inappropriately high left ventricular mass in patients with electrocardiographic left ventricular hypertrophy: the LIFE Study
    Vittorio Palmieri
    Weill Medical College of Cornell University, New York, NY 10021, USA
    J Hypertens 25:1079-85. 2007
    ....
  67. ncbi request reprint Comparison of cardiac structure and function in American Indians with and without the metabolic syndrome (the Strong Heart Study)
    Marcello Chinali
    Department of Medicine, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
    Am J Cardiol 93:40-4. 2004
    ..Therefore, abnormal LV geometry and function are related to the MS. Increased BP is the component of the MS most strongly associated with cardiac markers of preclinical disease, even in the absence of traditionally defined hypertension...
  68. ncbi request reprint Relation of left ventricular hypertrophy to inflammation and albuminuria in adults with type 2 diabetes: the strong heart study
    Vittorio Palmieri
    Weill Medical College of Cornell University, New York, New York 10021, USA
    Diabetes Care 26:2764-9. 2003
    ....
  69. ncbi request reprint Aortic valve sclerosis is associated with preclinical cardiovascular disease in hypertensive adults: the Hypertension Genetic Epidemiology Network study
    Felizen S Agno
    Weill Medical College of Cornell University, New York, New York, USA
    J Hypertens 23:867-73. 2005
    ..However, whether AVS is associated with preclinical cardiovascular disease among adults at high risk because of hypertension has not been determined in a population-based sample...
  70. ncbi request reprint Metabolic syndrome less strongly associated with target organ damage than syndrome components in a healthy, working population
    Kazuo Eguchi
    Center for Behavioral Cardiovascular Health and Hypertension Program, Columbia University Medical Center, New York, NY 10032, USA
    J Clin Hypertens (Greenwich) 9:337-44. 2007
    ..The data suggest that physicians should evaluate blood pressure and high-density lipoprotein cholesterol as well as other cardiovascular risk factors without regard to whether a patient meets the criteria for the MS...
  71. ncbi request reprint Relation of left ventricular geometry and function to aortic root dilatation in patients with systemic hypertension and left ventricular hypertrophy (the LIFE study)
    Jonathan N Bella
    Cornell Medical Center, New York, New York, USA
    Am J Cardiol 89:337-41. 2002
  72. ncbi request reprint Prevalence and prognostic significance of wall-motion abnormalities in adults without clinically recognized cardiovascular disease: the Strong Heart Study
    Silvana Cicala
    Greenberg Division of Cardiology, Weill Medical College of Cornell University, 525 E 68th St, New York, NY 10021, USA
    Circulation 116:143-50. 2007
    ..Our objective was to determine whether echocardiographic WM abnormalities predict subsequent cardiovascular events in a population-based sample...
  73. ncbi request reprint Electrocardiographic strain pattern and prediction of new-onset congestive heart failure in hypertensive patients: the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) study
    Peter M Okin
    Greenberg Division of Cardiology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Circulation 113:67-73. 2006
    ..However, whether ECG strain is an independent predictor of new-onset congestive heart failure (CHF) in the setting of aggressive antihypertensive therapy in unclear...
  74. ncbi request reprint Myocardial function and geometry in hypertensive subjects with low levels of afterload
    Gerard P Aurigemma
    Division of Cardiology, Department of Medicine, University of Massachusetts Medical Center, Worcester, Mass 01655, USA
    Am Heart J 143:546-51. 2002
    ..It has been hypothesized that the level of end-systolic wall stress (sigma(m)) is a feedback signal that regulates the level of hypertrophy. Thus, low levels of sigma(m) may signify inappropriate hypertrophy...
  75. ncbi request reprint A population-based assessment of left ventricular systolic dysfunction in middle-aged and older adults: the Strong Heart Study
    R B Devereux
    Department of Medicine, Cornell Medical Center, New York, NY, USA
    Am Heart J 141:439-46. 2001
    ....
  76. ncbi request reprint Effects of once-daily angiotensin-converting enzyme inhibition and calcium channel blockade-based antihypertensive treatment regimens on left ventricular hypertrophy and diastolic filling in hypertension: the prospective randomized enalapril study evaluat
    R B Devereux
    Cornell Medical Center, New York, NY, 10021, USA
    Circulation 104:1248-54. 2001
    ....
  77. ncbi request reprint Stroke volume/pulse pressure ratio and cardiovascular risk in arterial hypertension
    G De Simone
    Division of Cardiology, The New York Presbyterian Hospital Weill Medical College of Cornell University, New York, NY 10021, USA
    Hypertension 33:800-5. 1999
    ....
  78. ncbi request reprint Reference values for echocardiographic measurements in urban and rural populations of differing ethnicity: the Strong Heart Study
    A Ilercil
    Department of Medicine, New York Presbyterian Hospital-Weill Medical College of Cornell University, USA
    J Am Soc Echocardiogr 14:601-11. 2001
    ....
  79. ncbi request reprint Relation of QT interval and QT dispersion to regression of echocardiographic and electrocardiographic left ventricular hypertrophy in hypertensive patients: the Losartan Intervention For Endpoint Reduction (LIFE) study
    Lasse Oikarinen
    Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
    Am Heart J 145:919-25. 2003
    ..Experimentally, regression of LVH normalizes ventricular electrophysiology...
  80. pmc Heritability and genetic linkage of left ventricular mass, systolic and diastolic function in hypertensive African Americans (From the GENOA Study)
    Ervin R Fox
    Department of Medicine, University of Mississippi School of Medicine, Jackson, USA
    Am J Hypertens 23:870-5. 2010
    ..We used pedigree information from 454 tandem markers across the genome to estimate the heritability and linkage of various echocardiographic measures of LV structure and function in a cohort of African-American hypertensive siblings...
  81. pmc Marked regional left ventricular heterogeneity in hypertensive left ventricular hypertrophy patients: a losartan intervention for endpoint reduction in hypertension (LIFE) cardiovascular magnetic resonance and echocardiographic substudy
    Robert W W Biederman
    Division of Cardiology, Department of Cardiovascular MRI, Gerald McGuiness Center, Allegheny General Hospital, 320 E North Ave, Pittsburgh, PA 15212, USA
    Hypertension 52:279-86. 2008
    ....
  82. ncbi request reprint Reduction of development of left ventricular hypertrophy in salt-loaded Dahl salt-sensitive rats by angiotensin II receptor inhibition
    G De Simone
    Department of Medicine, New York Hospital-Cornell Medical Center, New York 10021, USA
    Am J Hypertens 9:216-22. 1996
    ..Inhibition of angiotensin II AT1 receptors reduces the development of LV hypertrophy in Dahl-S rats despite lack of efficient control of blood pressure...
  83. ncbi request reprint Relation of age to left ventricular function and systemic hemodynamics in uncomplicated mild hypertension
    D J Slotwiner
    Department of Medicine and Hypertension Center, The New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, New York 10021, USA
    Hypertension 37:1404-9. 2001
    ..Vascular stiffness progressively increases with age, independent of change in mean pressure or resistance, possibly contributing to increased rates of cardiovascular events in older individuals...
  84. doi request reprint Automated segmentation of routine clinical cardiac magnetic resonance imaging for assessment of left ventricular diastolic dysfunction
    Keigo Kawaji
    Department of Radiology and the Division of Cardiology, Weill Cornell Medical College, New York, NY 10021, USA
    Circ Cardiovasc Imaging 2:476-84. 2009
    ..This study tested performance of a novel CMR segmentation algorithm (LV-METRIC) for automated assessment of diastolic function...
  85. ncbi request reprint Prognostic impact of metabolic syndrome by different definitions in a population with high prevalence of obesity and diabetes: the Strong Heart Study
    Giovanni de Simone
    Division of Cardiology, Weill Medical College of Cornell University, New York, New York, USA
    Diabetes Care 30:1851-6. 2007
    ..This study analyzed which definition of the metabolic syndrome is more predictive of cardiovascular events in both diabetic and nondiabetic members of a population-based sample...
  86. ncbi request reprint Assessment of the interaction of heritability of volume load and left ventricular mass: the HyperGEN offspring study
    Giovanni de Simone
    Weill Medical College of Cornell University, New York, NY, USA
    J Hypertens 25:1397-402. 2007
    ..Left ventricular mass (LVM) is more closely associated with volume load than pressure load. We assessed whether part of the genetic heritability of LVM can be explained by stroke volume (SV) inheritance...
  87. pmc Left ventricular mass and incident hypertension in individuals with initial optimal blood pressure: the Strong Heart Study
    Giovanni de Simone
    Weill Cornell Medical College, New York, NY, USA
    J Hypertens 26:1868-74. 2008
    ....
  88. ncbi request reprint Genetic influences on aortic root size in American Indians: the Strong Heart Study
    Jonathan N Bella
    Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
    Arterioscler Thromb Vasc Biol 22:1008-11. 2002
    ..Echocardiographic screening of family members with aortic root dilatation may identify other individuals predisposed to aortic dissection or rupture...
  89. ncbi request reprint Separate and joint effects of systemic hypertension and diabetes mellitus on left ventricular structure and function in American Indians (the Strong Heart Study)
    J N Bella
    Department of Medicine, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, New York 10021, USA
    Am J Cardiol 87:1260-5. 2001
    ..001). In conclusion, DM and SH each have adverse effects on LV geometry and function, and the combination of SH and DM results in the greatest degree of LV hypertrophy, myocardial dysfunction, and arterial stiffness...
  90. ncbi request reprint Prognostic implications of the compensatory nature of left ventricular mass in arterial hypertension
    G De Simone
    Division of Cardiology, The New York Presbyterian Hospital Weill Medical College of Cornell University, New York 10021, USA
    J Hypertens 19:119-25. 2001
    ..e. higher than predicted by individual body size, sex and cardiac load [delta%LVM]) is associated with an increased rate of cardiovascular events, and whether values of LV mass lower than appropriate confer protection...
  91. ncbi request reprint Relationship between left ventricular diastolic relaxation and systolic function in hypertension: The Hypertension Genetic Epidemiology Network (HyperGEN) Study
    J N Bella
    New York Presbyterian Hospital-Weill Cornell Medical Center, New York, NY 10021, USA
    Hypertension 38:424-8. 2001
    ..Whether combined diastolic and systolic dysfunction identifies hypertensive patients at especially high risk of cardiovascular events requires further study...
  92. ncbi request reprint Sex-related difference in regression of left ventricular hypertrophy with antihypertensive treatment: the LIFE study
    J N Bella
    Weill Medical College of Cornell University, New York, NY, USA
    J Hum Hypertens 18:411-6. 2004
    ..Further studies are needed to identify the mechanisms and prognostic implications of this sex-related difference...
  93. ncbi request reprint Comparison of left ventricular mass and geometry in black and white patients with essential hypertension
    M J Koren
    Department of Medicine, New York Hospital-Cornell Medical Center, NY 10021
    Am J Hypertens 6:815-23. 1993
    ..Cholesterol level was not independently associated with increased LV mass but was weakly associated with increased relative wall thickness.(ABSTRACT TRUNCATED AT 250 WORDS)..
  94. ncbi request reprint Association of pulse pressure with cardiovascular outcome is independent of left ventricular hypertrophy and systolic dysfunction: the Strong Heart Study
    Vittorio Palmieri
    Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    Am J Hypertens 19:601-7. 2006
    ..Whether increased pulse pressure (PP) predicts cardiovascular (CV) events independent of left ventricular hypertrophy (LVH) and systolic dysfunction is unclear...
  95. ncbi request reprint Risk factors for arterial hypertension in adults with initial optimal blood pressure: the Strong Heart Study
    Giovanni de Simone
    Weill Medical College, Cornell University, New York, NY 10021, USA
    Hypertension 47:162-7. 2006
    ..Possible implications of these findings for primary cardiovascular prevention should be tested in prospective studies...
  96. doi request reprint Clinical impact of 'in-treatment' wall motion abnormalities in hypertensive patients with left ventricular hypertrophy: the LIFE study
    Silvana Cicala
    Division of Cardiology, Weill Cornell Medical College, New York, New York 10021, USA
    J Hypertens 26:806-12. 2008
    ..We examined whether 'in-treatment' wall motion abnormalities predicted outcome in the Losartan Intervention For Endpoint (LIFE) reduction in hypertension echocardiographic substudy...
  97. pmc Diabetes and incident heart failure in hypertensive and normotensive participants of the Strong Heart Study
    Giovanni de Simone
    Weill Cornell Medical College, New York, USA
    J Hypertens 28:353-60. 2010
    ..We tested the hypothesis that diabetes predisposes to heart failure independently of hypertension and intercurrent MI...
  98. pmc Relation between mitral annular calcium and complex aortic atheroma in patients with cerebral ischemia referred for transesophageal echocardiography
    Maria G Karas
    Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
    Am J Cardiol 99:1306-11. 2007
    ..These findings support the role of proximal CAA as a direct mediator of the increased stroke risk associated with MAC...
  99. ncbi request reprint Association of blood pressure with blood viscosity in american indians: the Strong Heart Study
    Giovanni de Simone
    Weill Medical College of Cornell University, New York, NY, USA
    Hypertension 45:625-30. 2005
    ..42; P<0.0001). Thus, under normal physiological conditions, in vivo WBV is negatively related pulse pressure. In contrast, the presence of arterial hypertension makes this relation less evident...
  100. ncbi request reprint Echocardiographic insights into the pathophysiology and prognostic significance of hypertensive cardiac hypertrophy
    R B Devereux
    Department of Medicine, New York Hospital-Cornell Medical Center, NY 10021
    Am J Hypertens 2:186S-195S. 1989
    ..The possible relationship of this heterogeneity of cardiac patterns in hypertension to differences in the etiology, pathogenesis, and prognosis of hypertension is a fruitful area for further investigation...
  101. ncbi request reprint Relation of left ventricular geometry and function to systemic hemodynamics in hypertension: the LIFE Study. Losartan Intervention For Endpoint Reduction in Hypertension Study
    J N Bella
    Cornell Medical Center, New York, USA
    J Hypertens 19:127-34. 2001
    ..CONCLUSION: In patients with moderate hypertension and ECG LV hypertrophy, the levels of SV and pulse pressure/ SV, are associated with, and may be stimuli to different LV geometric phenotypes...

Research Grants2

  1. Cardiovascular Evaluation for the SHS Phase V
    Richard Devereux; Fiscal Year: 2007
    ..End of Abstract) ..