Affiliation: Cornell University
Formenti S, Rudqvist N, Golden E, Cooper B, Wennerberg E, Lhuillier C, et al
. Radiotherapy induces responses of lung cancer to CTLA-4 blockade. Nat Med. 2018;24:1845-1851 pubmed publisher
Diamond J, Vanpouille Box C, Spada S, Rudqvist N, Chapman J, Ueberheide B, et al
. Exosomes Shuttle TREX1-Sensitive IFN-Stimulatory dsDNA from Irradiated Cancer Cells to DCs. Cancer Immunol Res. 2018;6:910-920 pubmed publisher
..We have previously shown that the expression of TREX1 is dependent on the RT dose size. Thus, these data have important implications for the use of RT with immunotherapy. Cancer Immunol Res; 6(8); 910-20. ©2018 AACR. ..
Rodriguez Ruiz M, Vanpouille Box C, Melero I, FORMENTI S, Demaria S. Immunological Mechanisms Responsible for Radiation-Induced Abscopal Effect. Trends Immunol. 2018;39:644-655 pubmed publisher
..Here, we review the immunological mechanisms that are responsible for the ability of focal radiation to promote antitumor T cell responses that mediate tumor rejection and, in some cases, result in systemic effects. ..
Ascierto P, Atkins M, Bifulco C, Botti G, COCHRAN A, Davies M, et al
. Future perspectives in melanoma research: meeting report from the "Melanoma Bridge": Napoli, December 3rd-6th 2014. J Transl Med. 2015;13:374 pubmed publisher
..Translation of the knowledge gained from the biology of tumor microenvironment across different tumors represents a bridge to impact on prognosis and response to therapy in melanoma. ..
Vanpouille Box C, Formenti S, Demaria S. Toward Precision Radiotherapy for Use with Immune Checkpoint Blockers. Clin Cancer Res. 2018;24:259-265 pubmed publisher
..Here, we discuss the rationale for an optimized use of radiotherapy as well as candidate biomarkers that may predict clinical responses to radiotherapy combined with ICBs. Clin Cancer Res; 24(2); 259-65. ©2017 AACR. ..
Rudqvist N, Pilones K, Lhuillier C, Wennerberg E, Sidhom J, Emerson R, et al
. Radiotherapy and CTLA-4 Blockade Shape the TCR Repertoire of Tumor-Infiltrating T Cells. Cancer Immunol Res. 2018;6:139-150 pubmed publisher
..Overall, data support a model whereby a diverse TCR repertoire is required to achieve tumor rejection and may underlie the synergy between RT and CTLA-4 blockade. Cancer Immunol Res; 6(2); 139-50. ©2017 AACR. ..
Lhuillier C, Vanpouille Box C, Galluzzi L, FORMENTI S, Demaria S. Emerging biomarkers for the combination of radiotherapy and immune checkpoint blockers. Semin Cancer Biol. 2018;52:125-134 pubmed publisher
..Here, we discuss emerging biomarkers that may potentially predict the response of cancer patients to RT plus ICBs. ..