Kirk Deitsch

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Gene silencing and antigenic variation in malaria parasites
    K W Deitsch
    Joan and Sanford I Weill Medical College of Cornell University, New York, NY 10021, USA
    ScientificWorldJournal 1:650-2. 2001
  2. pmc An upstream open reading frame controls translation of var2csa, a gene implicated in placental malaria
    Borko Amulic
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA
    PLoS Pathog 5:e1000256. 2009
  3. pmc Recruitment of PfSET2 by RNA polymerase II to variant antigen encoding loci contributes to antigenic variation in P. falciparum
    Uchechi E Ukaegbu
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America
    PLoS Pathog 10:e1003854. 2014
  4. pmc Malaria parasites utilize both homologous recombination and alternative end joining pathways to maintain genome integrity
    Laura A Kirkman
    Department of Internal Medicine, Division of Infectious Diseases and Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA
    Nucleic Acids Res 42:370-9. 2014
  5. pmc Horizontal gene transfer of epigenetic machinery and evolution of parasitism in the malaria parasite Plasmodium falciparum and other apicomplexans
    Sandeep P Kishore
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA
    BMC Evol Biol 13:37. 2013
  6. pmc A regulatable transgene expression system for cultured Plasmodium falciparum parasites
    Christian Epp
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, W 704, Box 62, New York, NY 10021, USA
    Malar J 7:86. 2008
  7. pmc Common strategies for antigenic variation by bacterial, fungal and protozoan pathogens
    Kirk W Deitsch
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Nat Rev Microbiol 7:493-503. 2009
  8. doi request reprint A mark of silence in malaria parasites
    Kirk W Deitsch
    Department of Microbiology and Immunology, Weill Medical College, Cornell University, New York, NY 10021, USA
    Cell Host Microbe 5:112-3. 2009
  9. pmc Variable switching rates of malaria virulence genes are associated with chromosomal position
    Matthias Frank
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, Box 62, New York, NY 10021, USA
    Mol Microbiol 64:1486-98. 2007
  10. ncbi request reprint Activation, silencing and mutually exclusive expression within the var gene family of Plasmodium falciparum
    Matthias Frank
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Int J Parasitol 36:975-85. 2006

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Gene silencing and antigenic variation in malaria parasites
    K W Deitsch
    Joan and Sanford I Weill Medical College of Cornell University, New York, NY 10021, USA
    ScientificWorldJournal 1:650-2. 2001
    ..This process promotes a long term, persistent infection that is difficult to clear...
  2. pmc An upstream open reading frame controls translation of var2csa, a gene implicated in placental malaria
    Borko Amulic
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA
    PLoS Pathog 5:e1000256. 2009
    ....
  3. pmc Recruitment of PfSET2 by RNA polymerase II to variant antigen encoding loci contributes to antigenic variation in P. falciparum
    Uchechi E Ukaegbu
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America
    PLoS Pathog 10:e1003854. 2014
    ..This work unifies previous reports of histone modifications, the production of ncRNAs, and the promoter activity of var introns into a mechanism that contributes to antigenic variation by malaria parasites. ..
  4. pmc Malaria parasites utilize both homologous recombination and alternative end joining pathways to maintain genome integrity
    Laura A Kirkman
    Department of Internal Medicine, Division of Infectious Diseases and Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA
    Nucleic Acids Res 42:370-9. 2014
    ..We propose that an alternative end-joining pathway rather than C-NHEJ, serves as a primary method for repairing DSBs in malaria parasites. ..
  5. pmc Horizontal gene transfer of epigenetic machinery and evolution of parasitism in the malaria parasite Plasmodium falciparum and other apicomplexans
    Sandeep P Kishore
    Department of Microbiology and Immunology, Weill Cornell Medical College, New York, NY 10065, USA
    BMC Evol Biol 13:37. 2013
    ..How these abilities were acquired remains an outstanding question in protistan biology...
  6. pmc A regulatable transgene expression system for cultured Plasmodium falciparum parasites
    Christian Epp
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, W 704, Box 62, New York, NY 10021, USA
    Malar J 7:86. 2008
    ..In addition, transgene expression levels are usually not regulatable, making it difficult to assess phenotypes that are sensitive to the amount of protein expressed...
  7. pmc Common strategies for antigenic variation by bacterial, fungal and protozoan pathogens
    Kirk W Deitsch
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Nat Rev Microbiol 7:493-503. 2009
    ....
  8. doi request reprint A mark of silence in malaria parasites
    Kirk W Deitsch
    Department of Microbiology and Immunology, Weill Medical College, Cornell University, New York, NY 10021, USA
    Cell Host Microbe 5:112-3. 2009
    ..In this issue, Lopez-Rubio et al. (2009) show that the histone mark H3K9me3 is specifically associated with regulation of expression of these gene families within repressive centers located at the nuclear periphery...
  9. pmc Variable switching rates of malaria virulence genes are associated with chromosomal position
    Matthias Frank
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, Box 62, New York, NY 10021, USA
    Mol Microbiol 64:1486-98. 2007
    ..Our data show that different var genes have different intrinsic switching rates that correlate with chromosomal location, and that there is no predetermined order of expression...
  10. ncbi request reprint Activation, silencing and mutually exclusive expression within the var gene family of Plasmodium falciparum
    Matthias Frank
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Int J Parasitol 36:975-85. 2006
    ....
  11. pmc Mutually exclusive expression of virulence genes by malaria parasites is regulated independently of antigen production
    Ron Dzikowski
    Department of Microbiology and Immunology, Weill Medical College, Cornell University, New York, New York, USA
    PLoS Pathog 2:e22. 2006
    ..Mutually exclusive expression in P. falciparum is therefore regulated exclusively at the level of transcription, and a functional PfEMP1 protein is not necessary for viability or for proper gene regulation in cultured parasites...
  12. ncbi request reprint Variant antigen gene expression in malaria
    Ron Dzikowski
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cell Microbiol 8:1371-81. 2006
    ..Here we review the amplification and generation of antigenic diversity within the Plasmodium variant gene families, as well as discuss the mechanisms underlying their tightly controlled gene expression and antigenic switching...
  13. pmc Frequent recombination events generate diversity within the multi-copy variant antigen gene families of Plasmodium falciparum
    Matthias Frank
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, Box 62, New York, NY 10021, USA
    Int J Parasitol 38:1099-109. 2008
    ..falciparum...
  14. pmc Plasmodium falciparum var gene silencing is determined by cis DNA elements that form stable and heritable interactions
    Lakshmi Swamy
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Eukaryot Cell 10:530-9. 2011
    ..This study provides insights into the regulation of endogenous var gene clusters...
  15. pmc Strict pairing of var promoters and introns is required for var gene silencing in the malaria parasite Plasmodium falciparum
    Matthias Frank
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Biol Chem 281:9942-52. 2006
    ....
  16. ncbi request reprint Malaria virulence genes controlling expression through chromatin modification
    Kirk W Deitsch
    Department of Microbiology and Immunology, Weill Medical College, Cornell University, 1300 York Avenue, Box 62, New York, New York 10021, USA
    Cell 121:1-2. 2005
    ..provide evidence for the role of Sir2-dependent alterations in chromatin structure and changes in subnuclear chromatin localization in regulating var gene expression (Duraisingh et al., 2005; Freitas-Junior et al., 2005)...
  17. ncbi request reprint Targeting malaria parasite proteins to the erythrocyte
    Thomas J Templeton
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, Box 62, New York, NY 10021, USA
    Trends Parasitol 21:399-402. 2005
    ..These articles greatly aid the annotation of the parasite "secretome" catalog of proteins that are targeted to the erythrocyte cytoplasm or cell membrane...
  18. ncbi request reprint Variant surface antigens, virulence genes and the pathogenesis of malaria
    Kirk W Deitsch
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, W 704, Box 62, New York, NY 10021, USA
    Trends Parasitol 20:562-6. 2004
    ..We contemplate on these statements, following the recent second Molecular Approaches to Malaria meeting, which was held at the same venue on 2-5 February 2004...
  19. pmc Clonally variant gene families in Plasmodium falciparum share a common activation factor
    Cali A Howitt
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY, USA
    Mol Microbiol 73:1171-85. 2009
    ..falciparum...
  20. pmc Chromatin associated sense and antisense noncoding RNAs are transcribed from the var gene family of virulence genes of the malaria parasite Plasmodium falciparum
    Christian Epp
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    RNA 15:116-27. 2009
    ..These sterile transcripts therefore might act in a manner analogous to noncoding RNAs associated with silent, condensed chromatin found in other eukaryotic systems...
  21. ncbi request reprint Deciphering the export pathway of malaria surface proteins
    Christian Epp
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, Box 62, New York, NY 10021, USA
    Trends Parasitol 22:401-4. 2006
    ..This discovery sheds new light on the little-understood mechanisms that regulate protein trafficking in infected cells...
  22. ncbi request reprint Antigenic variation by protozoan parasites: insights from Babesia bovis
    Ron Dzikowski
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Mol Microbiol 59:364-6. 2006
    ..In this issue, Al-Khedery and Allred provide a detailed description of the genes that encode VESA1 and present convincing evidence for progressive, segmental gene conversion in the generation of variant forms of this surface antigen...
  23. pmc Mechanisms underlying mutually exclusive expression of virulence genes by malaria parasites
    Ron Dzikowski
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, 1300 York Avenue, Box 62, New York, New York 10021, USA
    EMBO Rep 8:959-65. 2007
    ....
  24. pmc An unusual recent expansion of the C-terminal domain of RNA polymerase II in primate malaria parasites features a motif otherwise found only in mammalian polymerases
    Sandeep P Kishore
    Department of Microbiology and Immunology, Weill Cornell Medical College, 1300 York Avenue, Box 62, New York, NY 10021, USA
    J Mol Evol 68:706-14. 2009
    ..These observations raise new questions for the radiation of malaria parasites into diverse hosts and for the molecular evolution of RNA polymerase II...
  25. ncbi request reprint Nuclear non-coding RNAs are transcribed from the centromeres of Plasmodium falciparum and are associated with centromeric chromatin
    Felomena Li
    Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 283:5692-8. 2008
    ..falciparum, perhaps compensating for a lack of both regulatory transcription factors and RNA interference machinery...
  26. pmc Active transcription is required for maintenance of epigenetic memory in the malaria parasite Plasmodium falciparum
    Ron Dzikowski
    Department of Parasitology, The Kuvin Center for the Study of Infectious and Tropical Diseases, The Institute for Medical Research, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    J Mol Biol 382:288-97. 2008
    ....
  27. ncbi request reprint Malaria: a peek at the var variorum
    Thanat Chookajorn
    Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok 10400, Thailand
    Trends Parasitol 23:563-5. 2007
    ..suggests that only the tip of the var diversity iceberg is currently in view. In this article, we discuss these recent results and provide an overview of current understanding of var diversity...
  28. pmc Pregnancy-associated malaria and the prospects for syndrome-specific antimalaria vaccines
    Joseph D Smith
    Seattle Biomedical Research Institute, 307 Westlake Ave N, Ste 500, Seattle, WA 98109 5219, USA
    J Exp Med 200:1093-7. 2004
    ..Here, we discuss the latest advances in the development of a vaccine that specifically targets pregnancy-associated malaria (PAM)...
  29. pmc A silenced Plasmodium falciparum var promoter can be activated in vivo through spontaneous deletion of a silencing element in the intron
    Laila Gannoun-Zaki
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 8132, USA
    Eukaryot Cell 4:490-2. 2005
    ..The resulting promoter activation does not affect the transcription of chromosomal var genes...
  30. pmc Epigenetic memory at malaria virulence genes
    Thanat Chookajorn
    Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 104:899-902. 2007
    ..We also discuss how gene transcription memory may affect the mechanism of pathogenesis and immune evasion...
  31. ncbi request reprint Plasmodium falciparum var genes are regulated by two regions with separate promoters, one upstream of the coding region and a second within the intron
    Michael S Calderwood
    Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:34125-32. 2003
    ..These findings suggest that interactions between the regions of these two promoters and the generation of the sterile transcripts play a significant role in regulating var gene expression...

Research Grants10

  1. Var gene regulation and antigenic variation in malaria
    Kirk W Deitsch; Fiscal Year: 2010
    ..A better understanding of these processes will lead to new, novel forms of treatment that will help to relieve the enormous public health burden that malaria inflicts on the developing world. ..
  2. Var gene regulation and antigenic variation in malaria
    Kirk Deitsch; Fiscal Year: 2002
    ..In addition, the specific DNA elements necessary for var gene silencing and activation will be identified, and the sequence requirements for DNA elements to functions as silencers or activators elucidated. ..
  3. Var gene regulation and antigenic variation in malaria
    Kirk Deitsch; Fiscal Year: 2009
    ..A better understanding of these processes will lead to new, novel forms of treatment that will help to relieve the enormous public health burden that malaria inflicts on the developing world. ..
  4. Var gene regulation and antigenic variation in malaria
    Kirk Deitsch; Fiscal Year: 2007
    ..In addition, the specific DNA elements necessary for var gene silencing and activation will be identified, and the sequence requirements for DNA elements to functions as silencers or activators elucidated. ..
  5. Var gene regulation and antigenic variation in malaria
    Kirk Deitsch; Fiscal Year: 2006
    ..In addition, the specific DNA elements necessary for var gene silencing and activation will be identified, and the sequence requirements for DNA elements to functions as silencers or activators elucidated. ..
  6. Var gene regulation and antigenic variation in malaria
    Kirk Deitsch; Fiscal Year: 2005
    ..In addition, the specific DNA elements necessary for var gene silencing and activation will be identified, and the sequence requirements for DNA elements to functions as silencers or activators elucidated. ..
  7. Var gene regulation and antigenic variation in malaria
    Kirk Deitsch; Fiscal Year: 2004
    ..In addition, the specific DNA elements necessary for var gene silencing and activation will be identified, and the sequence requirements for DNA elements to functions as silencers or activators elucidated. ..
  8. Var gene regulation and antigenic variation in malaria
    Kirk Deitsch; Fiscal Year: 2003
    ..In addition, the specific DNA elements necessary for var gene silencing and activation will be identified, and the sequence requirements for DNA elements to functions as silencers or activators elucidated. ..
  9. Var gene regulation and antigenic variation in malaria
    Kirk W Deitsch; Fiscal Year: 2010
    ..A better understanding of these processes will lead to new, novel forms of treatment that will help to relieve the enormous public health burden that malaria inflicts on the developing world. ..