Andrew J Dannenberg


Affiliation: Cornell University
Country: USA


  1. Zhang N, Subbaramaiah K, Yantiss R, Zhou X, Chin Y, Benezra R, et al. Id1 Deficiency Protects against Tumor Formation in Apc(Min/+) Mice but Not in a Mouse Model of Colitis-Associated Colon Cancer. Cancer Prev Res (Phila). 2015;8:303-11 pubmed publisher
    ..Our findings also highlight the need for different strategies to reduce the risk of colitis-associated colorectal cancer compared with sporadic or hereditary colorectal cancer. ..
  2. Iyengar N, Chen I, Zhou X, Giri D, Falcone D, Winston L, et al. Adiposity, Inflammation, and Breast Cancer Pathogenesis in Asian Women. Cancer Prev Res (Phila). 2018;11:227-236 pubmed publisher
    ..01). A subclinical inflammatory state associated with increased adiposity and metabolic dysfunction could contribute to breast cancer pathogenesis in Asian women. Cancer Prev Res; 11(4); 227-36. ©2017 AACR. ..
  3. Subbaramaiah K, Iyengar N, Morrow M, Elemento O, Zhou X, Dannenberg A. Prostaglandin E2 down-regulates sirtuin 1 (SIRT1), leading to elevated levels of aromatase, providing insights into the obesity-breast cancer connection. J Biol Chem. 2019;294:361-371 pubmed publisher
    ..These findings suggest that reduced SIRT1-mediated deacetylation of HIF-1α contributes to the elevated levels of aromatase in breast tissues of obese women. ..
  4. Quail D, Dannenberg A. The obese adipose tissue microenvironment in cancer development and progression. Nat Rev Endocrinol. 2018;: pubmed publisher
  5. Montrose D, Zhou X, McNally E, Sue E, Wang H, Nishiguchi R, et al. Colonoscopic-Guided Pinch Biopsies in Mice as a Useful Model for Evaluating the Roles of Host and Luminal Factors in Colonic Inflammation. Am J Pathol. 2018;188:2811-2825 pubmed publisher
    ..Taken together, this study demonstrates the utility of the pinch biopsy model of colonic injury to elucidate the molecular underpinnings of colonic inflammation and its treatment. ..
  6. Zhang N, Yantiss R, Nam H, Chin Y, Zhou X, Scherl E, et al. ID1 is a functional marker for intestinal stem and progenitor cells required for normal response to injury. Stem Cell Reports. 2014;3:716-24 pubmed publisher
    ..These experiments identify ID1 as a marker for intestinal stem/progenitor cells and demonstrate a role for ID1 in maintaining the potential for repair in response to colonic injury. ..
  7. Bhardwaj P, Du B, Zhou X, Sue E, Giri D, Harbus M, et al. Estrogen Protects against Obesity-Induced Mammary Gland Inflammation in Mice. Cancer Prev Res (Phila). 2015;8:751-9 pubmed publisher
    ..Taken together, our findings indicate that estrogen via ERα protects against weight gain, WATi and associated increases in proinflammatory mediators and aromatase in the mammary gland. ..
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    Dannenberg A, Subbaramaiah K. Targeting cyclooxygenase-2 in human neoplasia: rationale and promise. Cancer Cell. 2003;4:431-6 pubmed
  9. Iyengar N, Morris P, Zhou X, Gucalp A, Giri D, Harbus M, et al. Menopause is a determinant of breast adipose inflammation. Cancer Prev Res (Phila). 2015;8:349-58 pubmed publisher
    ..Breast WAT inflammation, a process that can potentially be targeted, may help to explain the high incidence of estrogen-dependent tumors in postmenopausal women. ..

More Information


  1. Zhang N, Subbaramaiah K, Yantiss R, Zhou X, Chin Y, Scherl E, et al. Id1 expression in endothelial cells of the colon is required for normal response to injury. Am J Pathol. 2015;185:2983-93 pubmed publisher
    ..These results suggest that endothelial ID1 up-regulation in inflamed colonic mucosa is an adaptive response that modulates the severity of tissue injury. ..
  2. Iyengar N, Zhou X, Gucalp A, Morris P, Howe L, Giri D, et al. Systemic Correlates of White Adipose Tissue Inflammation in Early-Stage Breast Cancer. Clin Cancer Res. 2016;22:2283-9 pubmed publisher
    ..07-3.13) for patients with inflammation. WAT inflammation, a clinically occult process, helps to explain the relationship between metabolic syndrome and worse breast cancer prognosis. Clin Cancer Res; 22(9); 2283-9. ©2015 AACR. ..
  3. Montrose D, Zhou X, McNally E, Sue E, Yantiss R, Gross S, et al. Celecoxib Alters the Intestinal Microbiota and Metabolome in Association with Reducing Polyp Burden. Cancer Prev Res (Phila). 2016;9:721-31 pubmed publisher
    ..We hypothesize that these actions contribute to its chemopreventive activity. Cancer Prev Res; 9(9); 721-31. ©2016 AACR. ..
  4. request reprint
    Dannenberg A, Altorki N, Boyle J, Lin D, Subbaramaiah K. Inhibition of cyclooxygenase-2: an approach to preventing cancer of the upper aerodigestive tract. Ann N Y Acad Sci. 2001;952:109-15 pubmed
    ..Importantly, clinical trials have been initiated to assess the chemopreventive properties of selective COX-2 inhibitors...
  5. Miyazawa M, Subbaramaiah K, Bhardwaj P, Zhou X, Wang H, Falcone D, et al. Pioglitazone Inhibits Periprostatic White Adipose Tissue Inflammation in Obese Mice. Cancer Prev Res (Phila). 2018;11:215-226 pubmed publisher
    ..i>Cancer Prev Res; 11(4); 215-26. ©2017 AACR. ..