Andrew J Dannenberg

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Targeting cyclooxygenase-2 in human neoplasia: rationale and promise
    Andrew J Dannenberg
    Department of Medicine, Weill Medical College of Cornell University and Strang Cancer Prevention Center, New York, NY 10021, USA
    Cancer Cell 4:431-6. 2003
  2. ncbi request reprint AGA 2004 distinguished achievement award to Raymond N. Dubois, M.D., Ph.D
    Andrew J Dannenberg
    Division of Gastroenterology and Hepatology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Gastroenterology 126:1893-6. 2004
  3. ncbi request reprint Cyclo-oxygenase 2: a pharmacological target for the prevention of cancer
    A J Dannenberg
    Department of Medicine, Weill Medical College of Cornell University and Strang Cancer Prevention Center, New York, USA
    Lancet Oncol 2:544-51. 2001
  4. ncbi request reprint Inhibition of cyclooxygenase-2: an approach to preventing cancer of the upper aerodigestive tract
    A J Dannenberg
    Department of Medicine, New York Presbyterian Hospital and Weill Medical College of Cornell University, New York 10021, USA
    Ann N Y Acad Sci 952:109-15. 2001
  5. pmc Pioglitazone, a PPARγ agonist, suppresses CYP19 transcription: evidence for involvement of 15-hydroxyprostaglandin dehydrogenase and BRCA1
    Kotha Subbaramaiah
    Department of Medicine, Weill Cornell Cancer Center, New York, NY 10065, USA
    Cancer Prev Res (Phila) 5:1183-94. 2012
  6. pmc UVR exposure sensitizes keratinocytes to DNA adduct formation
    Sudhir Nair
    Department of Medicine and Weill Cornell Cancer Center, 525 East 68th Street, Room F 206, New York, NY 10065, USA
    Cancer Prev Res (Phila) 2:895-902. 2009
  7. ncbi request reprint Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease. Evidence for involvement of the transcription factor Egr-1
    Kotha Subbaramaiah
    Department of Medicine, New York Presbyterian Hospital, Weill Medical College of Cornell University and Strang Cancer Prevention Center, 1300 York Avenue, Room F 203A, New York, NY 10021, USA
    J Biol Chem 279:12647-58. 2004
  8. pmc Dietary polyphenols suppress elevated levels of proinflammatory mediators and aromatase in the mammary gland of obese mice
    Kotha Subbaramaiah
    Department of Medicine, Weill Cornell Medical College, 525 East 68th St, Room F 206, New York, New York 10065, USA
    Cancer Prev Res (Phila) 6:886-97. 2013
  9. pmc Bile acids inhibit NAD+-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes
    Akira Miyaki
    Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    Am J Physiol Gastrointest Liver Physiol 297:G559-66. 2009
  10. ncbi request reprint Cyclooxygenase-2 and microsomal prostaglandin E synthase-1 are overexpressed in squamous cell carcinoma of the penis
    Dragan Golijanin
    Department of Urology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA
    Clin Cancer Res 10:1024-31. 2004

Detail Information

Publications112 found, 100 shown here

  1. ncbi request reprint Targeting cyclooxygenase-2 in human neoplasia: rationale and promise
    Andrew J Dannenberg
    Department of Medicine, Weill Medical College of Cornell University and Strang Cancer Prevention Center, New York, NY 10021, USA
    Cancer Cell 4:431-6. 2003
  2. ncbi request reprint AGA 2004 distinguished achievement award to Raymond N. Dubois, M.D., Ph.D
    Andrew J Dannenberg
    Division of Gastroenterology and Hepatology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Gastroenterology 126:1893-6. 2004
  3. ncbi request reprint Cyclo-oxygenase 2: a pharmacological target for the prevention of cancer
    A J Dannenberg
    Department of Medicine, Weill Medical College of Cornell University and Strang Cancer Prevention Center, New York, USA
    Lancet Oncol 2:544-51. 2001
    ..Importantly, selective COX 2 inhibitors appear to be safe enough in human beings to allow large-scale clinical testing in healthy people. Several chemoprevention trials using selective COX 2 inhibitors are underway...
  4. ncbi request reprint Inhibition of cyclooxygenase-2: an approach to preventing cancer of the upper aerodigestive tract
    A J Dannenberg
    Department of Medicine, New York Presbyterian Hospital and Weill Medical College of Cornell University, New York 10021, USA
    Ann N Y Acad Sci 952:109-15. 2001
    ..Importantly, clinical trials have been initiated to assess the chemopreventive properties of selective COX-2 inhibitors...
  5. pmc Pioglitazone, a PPARγ agonist, suppresses CYP19 transcription: evidence for involvement of 15-hydroxyprostaglandin dehydrogenase and BRCA1
    Kotha Subbaramaiah
    Department of Medicine, Weill Cornell Cancer Center, New York, NY 10065, USA
    Cancer Prev Res (Phila) 5:1183-94. 2012
    ..PPARγ agonists may have a role in reducing the risk of hormone-dependent breast cancer in obese postmenopausal women...
  6. pmc UVR exposure sensitizes keratinocytes to DNA adduct formation
    Sudhir Nair
    Department of Medicine and Weill Cornell Cancer Center, 525 East 68th Street, Room F 206, New York, NY 10065, USA
    Cancer Prev Res (Phila) 2:895-902. 2009
    ..Collectively, these results suggest that sunlight may activate AhR signaling and thereby sensitize cells to PAH-mediated DNA adduct formation. Antagonists of AhR signaling may have a role in the chemoprevention of photocarcinogenesis...
  7. ncbi request reprint Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease. Evidence for involvement of the transcription factor Egr-1
    Kotha Subbaramaiah
    Department of Medicine, New York Presbyterian Hospital, Weill Medical College of Cornell University and Strang Cancer Prevention Center, 1300 York Avenue, Room F 203A, New York, NY 10021, USA
    J Biol Chem 279:12647-58. 2004
    ..Moreover, TNF-alpha induced mPGES-1 by stimulating PC-PLC --> PKC --> NO --> cGMP --> PKG signal transduction pathway...
  8. pmc Dietary polyphenols suppress elevated levels of proinflammatory mediators and aromatase in the mammary gland of obese mice
    Kotha Subbaramaiah
    Department of Medicine, Weill Cornell Medical College, 525 East 68th St, Room F 206, New York, New York 10065, USA
    Cancer Prev Res (Phila) 6:886-97. 2013
    ..Further investigation in obese women is warranted...
  9. pmc Bile acids inhibit NAD+-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes
    Akira Miyaki
    Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    Am J Physiol Gastrointest Liver Physiol 297:G559-66. 2009
    ..These results provide new mechanistic insights into the link between bile acids and gastrointestinal carcinogenesis...
  10. ncbi request reprint Cyclooxygenase-2 and microsomal prostaglandin E synthase-1 are overexpressed in squamous cell carcinoma of the penis
    Dragan Golijanin
    Department of Urology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, USA
    Clin Cancer Res 10:1024-31. 2004
    ..Because human papillomavirus (HPV) has been linked to the development of penile SCC, a secondary objective was to determine whether COX-2 was overexpressed in SCC arising in an HPV16 transgenic mouse...
  11. pmc Effects of cigarette smoke on the human oral mucosal transcriptome
    Jay O Boyle
    Department of Surgery Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cancer Prev Res (Phila) 3:266-78. 2010
    ....
  12. ncbi request reprint Chemotherapy induces the expression of cyclooxygenase-2 in non-small cell lung cancer
    Nasser K Altorki
    Department of Cardiothoracic Surgery and Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    Clin Cancer Res 11:4191-7. 2005
    ..To determine the effect of taxane-based chemotherapy on intratumoral levels of cyclooxygenase-2 (COX-2) and prostaglandin E(2) (PGE(2)) in patients with non-small cell lung cancer (NSCLC)...
  13. pmc Heat shock protein 90 inhibitors suppress aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and DNA adduct formation
    Duncan Hughes
    Departments of 1General Surgery, Weill Cornell Medical College, New York University, New York, New York 10065, USA
    Cancer Prev Res (Phila) 1:485-93. 2008
    ..Inhibitors of HSP90 may have a role in chemoprevention in addition to cancer therapy...
  14. ncbi request reprint Histone deacetylase inhibitors suppress the induction of c-Jun and its target genes including COX-2
    Kentaro Yamaguchi
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 280:32569-77. 2005
    ..This led, in turn, to reduced expression of several activator protein-1-dependent genes (COX-2, cyclin D1, collagenase-1). These findings provide new insights into the mechanisms underlying the antitumor activity of HDAC inhibitors...
  15. pmc Effect of zileuton and celecoxib on urinary LTE4 and PGE-M levels in smokers
    Arash Mohebati
    Department of Surgery Head and Neck Service, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA
    Cancer Prev Res (Phila) 6:646-55. 2013
    ..Combining celecoxib and zileuton was associated with inhibition of both the COX-2 and 5-LO pathways manifested as reduced levels of urinary PGE-M and LTE4...
  16. pmc Combination chemoprevention of HER2/neu-induced breast cancer using a cyclooxygenase-2 inhibitor and a retinoid X receptor-selective retinoid
    Powel H Brown
    Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
    Cancer Prev Res (Phila) 1:208-14. 2008
    ..Our data show that simultaneous blockade of COX/prostaglandin signaling and retinoid X receptor-dependent transcription confers potent anticancer efficacy, suggesting a novel avenue for clinical evaluation...
  17. ncbi request reprint EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells. Evidence of a BRCA1 and p300 exchange
    Kotha Subbaramaiah
    Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    J Biol Chem 283:3433-44. 2008
    ..Reciprocal changes in the interaction between BRCA1, p300, and the aromatase promoter I.3/II contributed to the inductive effects of PGE(2)...
  18. pmc HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling
    Vikram D Kekatpure
    Department of Medicine and the Weill Cornell Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA
    J Biol Chem 284:7436-45. 2009
    ..Given the established link between activation of AhR signaling and xenobiotic metabolism, inhibitors of HDAC6 may alter drug or carcinogen metabolism...
  19. ncbi request reprint Cyclooxygenase-2 transcription is regulated by human papillomavirus 16 E6 and E7 oncoproteins: evidence of a corepressor/coactivator exchange
    Kotha Subbaramaiah
    Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
    Cancer Res 67:3976-85. 2007
    ..To our knowledge, this study also provides the first evidence that NCoR can function as a repressor of COX-2 gene expression...
  20. pmc NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer
    Duncan Hughes
    Department of General Surgery, Weill Cornell Medical College, New York, NY 10065, USA
    Cancer Prev Res (Phila) 1:241-9. 2008
    ..Collectively, these data indicate that 15-PGDH is commonly down-regulated in NSCLC, an effect that contributes to the accumulation of multiple bioactive lipids in NSCLC...
  21. pmc Levels of prostaglandin E metabolite and leukotriene E(4) are increased in the urine of smokers: evidence that celecoxib shunts arachidonic acid into the 5-lipoxygenase pathway
    Anna J Duffield-Lillico
    Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, Weill Cornell Medical College, New York, NY 10065, USA
    Cancer Prev Res (Phila) 2:322-9. 2009
    ..Because 5-LO activity and LTE(4) have been suggested to play a role in cardiovascular disease, these results may help to explain the link between use of COX-2 inhibitors and cardiovascular complications...
  22. pmc Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer
    Patrick G Morris
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Cancer Prev Res (Phila) 4:1021-9. 2011
    ..The presence of CLS-B may be a biomarker of increased breast cancer risk or poor prognosis...
  23. ncbi request reprint Epidermal growth factor-induced cyclooxygenase-2 expression is mediated through phosphatidylinositol-3 kinase, not mitogen-activated protein/extracellular signal-regulated kinase kinase, in recurrent respiratory papillomas
    Rong Wu
    Institute for Medical Research, North Shore Long Island Jewish Health System, Manhasset, New York, USA
    Clin Cancer Res 11:6155-61. 2005
    ....
  24. pmc Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors
    Masayuki Fukata
    Inflammatory Bowel Disease Center, Mount Sinai School of Medicine, New York, New York, USA
    Gastroenterology 133:1869-81. 2007
    ..The molecular mechanisms linking inflammation and colon carcinogenesis are incompletely understood. We tested the hypothesis that Toll-like receptor 4 (TLR4) is involved in tumorigenesis in the setting of chronic inflammation...
  25. pmc Elevated levels of urinary prostaglandin e metabolite indicate a poor prognosis in ever smoker head and neck squamous cell carcinoma patients
    Vikram D Kekatpure
    Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    Cancer Prev Res (Phila) 2:957-65. 2009
    ..Possibly, HNSCC patients with high COX-2 activity manifested by elevated urinary PGE-M will benefit from treatment with a COX-2 inhibitor...
  26. ncbi request reprint Levels of cyclooxygenase-2 are increased in the oral mucosa of smokers: evidence for the role of epidermal growth factor receptor and its ligands
    Dimitrios Moraitis
    Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, New York, NY 10021, USA
    Cancer Res 65:664-70. 2005
    ..Moreover, these findings strengthen the rationale for determining whether inhibitors of COX-2 or EGFR tyrosine kinase activity can reduce the risk of tobacco smoke-related malignancies of the aerodigestive tract...
  27. ncbi request reprint Development and use of a gene promoter-based screen to identify novel inhibitors of cyclooxygenase-2 transcription
    K Subbaramaiah
    Department of Medicine, New York Presbyterian Hospital-Cornell, and Anne Fisher Nutrition Center at Strang Cancer Prevention Center, New York, NY
    J Biomol Screen 6:101-10. 2001
    ..Collectively, these results demonstrate the successful development and use of a high throughput reporter gene assay for the identification of a novel inhibitor of COX-2 expression...
  28. pmc Increased levels of urinary PGE-M, a biomarker of inflammation, occur in association with obesity, aging, and lung metastases in patients with breast cancer
    Patrick G Morris
    Department of Medicine, Memorial Sloan Kettering Cancer Center, 300 E 66th St, New York, NY 10065, USA
    Cancer Prev Res (Phila) 6:428-36. 2013
    ....
  29. pmc UV radiation inhibits 15-hydroxyprostaglandin dehydrogenase levels in human skin: evidence of transcriptional suppression
    Benjamin L Judson
    Department of Medicine and Weill Cornell Cancer Center, 525 East 68th Street, Room F 206, New York, NY 10065, USA
    Cancer Prev Res (Phila) 3:1104-11. 2010
    ..Possibly, agents that prevent UVR-mediated downregulation of 15-PGDH will affect the acute or the long-term consequences of UVR exposure, including nonmelanoma skin cancer...
  30. ncbi request reprint Levels of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase are reduced in inflammatory bowel disease: evidence for involvement of TNF-alpha
    Taisuke Otani
    Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
    Am J Physiol Gastrointest Liver Physiol 290:G361-8. 2006
    ..The decrease in amounts of 15-PGDH in inflamed mucosa can be explained at least, in part, by TNF-alpha-mediated suppression of 15-PGDH transcription...
  31. ncbi request reprint Phase II study of celecoxib and trastuzumab in metastatic breast cancer patients who have progressed after prior trastuzumab-based treatments
    Chau T Dang
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Clin Cancer Res 10:4062-7. 2004
    ....
  32. pmc Molecular pathways: adipose inflammation as a mediator of obesity-associated cancer
    Louise R Howe
    Authors Affiliations Departments of Cell and Developmental Biology and Medicine, Weill Cornell Medical College and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
    Clin Cancer Res 19:6074-83. 2013
    ..A key future goal is to identify biomarkers that accurately report adipose inflammation, both for identification of at-risk individuals and to assess the efficacy of interventions. Clin Cancer Res; 19(22); 6074-83. ©2013 AACR. ..
  33. pmc Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland
    Kotha Subbaramaiah
    Department of Medicine and Weill Cornell Cancer Center, New York, NY 10065, USA
    Cancer Prev Res (Phila) 4:329-46. 2011
    ..The presence of CLS may be a biomarker of increased breast cancer risk or poor prognosis...
  34. doi request reprint The prostaglandin transporter regulates adipogenesis and aromatase transcription
    Kotha Subbaramaiah
    Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Cancer Prev Res (Phila) 4:194-206. 2011
    ..Collectively, these results suggest that PGT modulates adipogenesis and thereby PGE(2)-mediated activation of the cAMP → PKA → CREB pathway leading to altered CYP19 transcription and aromatase activity...
  35. ncbi request reprint HER-2/neu status is a determinant of mammary aromatase activity in vivo: evidence for a cyclooxygenase-2-dependent mechanism
    Kotha Subbaramaiah
    Department of Medicine, Weill Medical College of Cornell University, New York, NY, USA
    Cancer Res 66:5504-11. 2006
    ..Collectively, our data indicate that COX-2 is the functional intermediate linking HER-2/neu and aromatase and suggest that inhibitors of PGE(2) synthesis will suppress estrogen biosynthesis in breast tissue...
  36. ncbi request reprint Celecoxib inhibits prostate cancer growth: evidence of a cyclooxygenase-2-independent mechanism
    Manish I Patel
    Department of Medicine, Weill Medical College of Cornell University, 525 East 68th Street, New York, NY 10021, USA
    Clin Cancer Res 11:1999-2007. 2005
    ..The primary purpose of this study was to evaluate whether celecoxib or rofecoxib, two widely used selective COX-2 inhibitors, possess COX-2-independent antitumor activity...
  37. ncbi request reprint Prostaglandin E2 inhibits transforming growth factor beta 1-mediated induction of collagen alpha 1(I) in hepatic stellate cells
    Alex Y Hui
    Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA
    J Hepatol 41:251-8. 2004
    ..We assessed the impact of COX-2 inhibition and PGE(2) on the regulation of TGF-beta 1-stimulated matrix synthesis in an immortalized human HSC line, LX-1 and corroborated these findings in primary stellate cells...
  38. ncbi request reprint COX-2 inhibition in upper aerodigestive tract tumors
    Nasser K Altorki
    New York Presbyterian Medical Center, 525 East 168th Street, Box 110, New York, NY 10021, USA
    Semin Oncol 31:30-6. 2004
    ....
  39. ncbi request reprint Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract
    Taghreed Almahmeed
    Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Carcinogenesis 25:793-9. 2004
  40. pmc Caloric restriction reverses obesity-induced mammary gland inflammation in mice
    Priya Bhardwaj
    Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Cancer Prev Res (Phila) 6:282-9. 2013
    ..Our results provide a rationale for determining whether weight loss can reverse breast inflammation associated with obesity in women...
  41. ncbi request reprint Targeting prostaglandin E2 receptors as an alternative strategy to block cyclooxygenase-2-dependent extracellular matrix-induced matrix metalloproteinase-9 expression by macrophages
    Svetlana Pavlovic
    Department of Pathology and Laboratory Medicine, Vascular Biology Center, Joan and Sanford I Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 281:3321-8. 2006
    ..Thus, COX-2-dependent ECM-induced proteinase expression is effectively blocked by selective inhibition of EP4, a member of the PGE2 family of receptors...
  42. pmc Metabolic profiling, a noninvasive approach for the detection of experimental colorectal neoplasia
    David C Montrose
    Department of Medicine, Weill Cornell Medical College, New York, USA
    Cancer Prev Res (Phila) 5:1358-67. 2012
    ..Collectively, these results provide evidence that metabolomics can be used to detect changes in feces and plasma during azoxymethane-induced colorectal carcinogenesis and thus provide a strong rationale for future studies in humans...
  43. pmc Carnosol, a constituent of Zyflamend, inhibits aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and mutagenesis
    Arash Mohebati
    Department of Surgery Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Cancer Prev Res (Phila) 5:593-602. 2012
    ..Carnosol-mediated inhibition of Hsp90 ATPase activity can help explain the chemopreventive activity of herbs such as Rosemary, which contain this phenolic antioxidant...
  44. pmc Cyclooxygenase-2-derived prostaglandin E2 stimulates Id-1 transcription
    Kotha Subbaramaiah
    Department of Medicine and the Weill Cornell Cancer Center, Weill Cornell Medical College, NY, NY 10065, USA
    J Biol Chem 283:33955-68. 2008
    ..These findings provide new insights into the relationship between COX-2 and Id-1 and their potential role in metastasis...
  45. ncbi request reprint Cyclooxygenase-2: a target for the prevention and treatment of cancers of the upper digestive tract
    Nasser K Altorki
    Department of Cardiothoracic Surgery, Weill Medical College of Cornell University, Stang Cancer Prevention Center, New York, N Y, USA
    Prog Exp Tumor Res 37:107-23. 2003
  46. pmc Levels of prostaglandin E metabolite, the major urinary metabolite of prostaglandin E2, are increased in smokers
    Neil D Gross
    Department of Surgery Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Clin Cancer Res 11:6087-93. 2005
    ..In this study, we investigated whether levels of urinary PGE-M were increased in smokers and in patients with head and neck squamous cell carcinoma (HNSCC)...
  47. ncbi request reprint Tobacco smoke induces urokinase-type plasminogen activator and cell invasiveness: evidence for an epidermal growth factor receptor dependent mechanism
    Baoheng Du
    Department of Medicine, Joan and Sanford I Weill Medical College of Cornell University, New York, New York, USA
    Cancer Res 67:8966-72. 2007
    ..These findings also strengthen the rationale for determining whether inhibitors of EGFR tyrosine kinase reduce the risk of tobacco smoke-related second primary tumors...
  48. pmc Effects of tobacco smoke on gene expression and cellular pathways in a cellular model of oral leukoplakia
    Zeynep H Gümüs
    Department of Physiology and Biophysics, Weill Medical College of Cornell University, Box 75, Room E 509, 1300 York Avenue, New York, NY 10065, USA
    Cancer Prev Res (Phila) 1:100-11. 2008
    ..Moreover, the inductive effects of TS on xenobiotic metabolizing enzymes may help explain the reduced efficacy of chemotherapy, and suggest targets for chemopreventive agents in smokers...
  49. ncbi request reprint COX-2 inhibitors for the prevention of breast cancer
    Louise R Howe
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York, USA
    J Mammary Gland Biol Neoplasia 8:31-43. 2003
    ..Thus, selective COX-2 inhibitors offer considerable promise for the prevention and treatment of human breast cancer...
  50. ncbi request reprint Bryostatin-1 stimulates the transcription of cyclooxygenase-2: evidence for an activator protein-1-dependent mechanism
    Mariana S De Lorenzo
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    Clin Cancer Res 9:5036-43. 2003
    ..Moreover, it will be worthwhile to evaluate whether the addition of a selective COX-2 inhibitor can increase the antitumor activity of bryostatin...
  51. ncbi request reprint Cyclooxygenase-2: a novel molecular target for the prevention and treatment of head and neck cancer
    Derrick T Lin
    Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York
    Head Neck 24:792-9. 2002
    ..In this review, evidence is presented that inhibition of COX-2 represents a promising strategy to prevent or possibly treat human head and neck cancers...
  52. ncbi request reprint Celecoxib, a selective cyclooxygenase 2 inhibitor, protects against human epidermal growth factor receptor 2 (HER-2)/neu-induced breast cancer
    Louise R Howe
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Cancer Res 62:5405-7. 2002
    ..These results strengthen the rationale for developing clinical trials to determine whether selective Cox-2 inhibitors possess anticancer properties in humans at risk for breast cancer...
  53. ncbi request reprint HER2/neu-induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout mice
    Louise R Howe
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, NY, USA
    Cancer Res 65:10113-9. 2005
    ..This finding may help to explain the reduced risk of breast cancer associated with regular use of nonsteroidal anti-inflammatory drugs...
  54. pmc Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women
    Kotha Subbaramaiah
    Department of Medicine, Weill Cornell Medical College, New York, New York 10065, USA
    Cancer Discov 2:356-65. 2012
    ..These findings help to explain the link among obesity, low-grade chronic inflammation, and breast cancer with important clinical implications...
  55. ncbi request reprint Retinoids and carnosol suppress cyclooxygenase-2 transcription by CREB-binding protein/p300-dependent and -independent mechanisms
    Kotha Subbaramaiah
    Department of Medicine, New York Presbyterian Hospital Cornell and Strang Cancer Prevention Center, New York, New York 10021, USA
    Cancer Res 62:2522-30. 2002
    ..Taken together, these results show that small molecules can block the activation of COX-2 transcription by distinct mechanisms...
  56. ncbi request reprint Tobacco smoke induces CYP1B1 in the aerodigestive tract
    Jeffrey L Port
    Department of Cardiothoracic Surgery, Weill Medical College of Cornell University, New York, NY 10021, USA
    Carcinogenesis 25:2275-81. 2004
    ..05). Taken together, these results support a role for CYP1B1 in TS-induced carcinogenesis in the aerodigestive tract...
  57. ncbi request reprint Potentially reduced exposure cigarettes accelerate atherosclerosis: evidence for the role of nicotine
    Daniel F Catanzaro
    Department of Cardiothoracic Surgery, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY, 10021, USA
    Cardiovasc Toxicol 7:192-201. 2007
    ..Taken together, these observations suggest that smoking may accelerate atherosclerosis by increasing oxidative stress mediated at least in part via the actions of nicotine...
  58. pmc Matrix metalloproteinase-dependent microsomal prostaglandin E synthase-1 expression in macrophages: role of TNF-α and the EP4 prostanoid receptor
    K M Faisal Khan
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    J Immunol 188:1970-80. 2012
    ..Thus, in addition to inhibiting macrophage MMP-9 expression, EP4 antagonists emerge as potential therapy to reduce mPGES-1 expression and PGE(2) levels in inflammatory and neoplastic settings...
  59. pmc Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: Role in proliferation and apoptosis in the intestine
    Masayuki Fukata
    Inflammatory Bowel Disease Center, Division of Gastroenterology, New York, New York, USA
    Gastroenterology 131:862-77. 2006
    ..We wished to test the hypothesis that cyclooxygenase 2 (Cox-2)-derived prostaglandin E2 (PGE2) is important in TLR4-related mucosal repair...
  60. pmc 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis
    Seung Jae Myung
    Department of Medicine, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 103:12098-102. 2006
    ....
  61. ncbi request reprint Tobacco smoke stimulates the transcription of amphiregulin in human oral epithelial cells: evidence of a cyclic AMP-responsive element binding protein-dependent mechanism
    Baoheng Du
    Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA
    Cancer Res 65:5982-8. 2005
    ..The ability of tobacco smoke to induce amphiregulin and thereby enhance DNA synthesis is likely to contribute to the procarcinogenic effects of tobacco smoke...
  62. ncbi request reprint Microsomal prostaglandin E synthase-1 is overexpressed in head and neck squamous cell carcinoma
    Erik G Cohen
    Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 9:3425-30. 2003
    ..Additional studies will be needed to determine whether this enzyme is a bona fide target for anticancer therapy...
  63. pmc Impact of obesity on the survival of patients with early-stage squamous cell carcinoma of the oral tongue
    Neil M Iyengar
    Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York
    Cancer 120:983-91. 2014
    ..Although obesity increases risk and negatively affects survival for many malignancies, the prognostic implications in squamous cell carcinoma (SCC) of the oral tongue, a disease often associated with prediagnosis weight loss, are unknown...
  64. pmc A web-based screening and accrual strategy for a cancer prevention clinical trial in healthy smokers
    Arash Mohebati
    Department of Surgery Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Contemp Clin Trials 33:942-8. 2012
    ..Craigslist is a cost effective and efficient web-based resource that can be utilized in accruing subjects to some chemoprevention trials...
  65. pmc The effect of HIV and HPV coinfection on cervical COX-2 expression and systemic prostaglandin E2 levels
    Daniel W Fitzgerald
    Division of Infectious Diseases, Center for Global Health, Weill Cornell Medical College, 440 East 69 Street, New York, NY, USA
    Cancer Prev Res (Phila) 5:34-40. 2012
    ..Drugs that inhibit the synthesis of PGE(2) may prove useful in reducing the risk of cervical cancer or systemic inflammation in HIV-infected women...
  66. ncbi request reprint A role for cyclooxygenase-2 inhibitors in the prevention and treatment of cancer
    Louise R Howe
    Departments of Cell and Developmental Biology and Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Semin Oncol 29:111-9. 2002
    ..Clinical trials are warranted to define the role of selective COX-2 inhibitors in the prevention and treatment of cancer...
  67. ncbi request reprint Regulation of cyclooxgenase-2 mRNA stability by taxanes: evidence for involvement of p38, MAPKAPK-2, and HuR
    Kotha Subbaramaiah
    Department of Medicine Division of Gastroenterology and Hepatology, New York Presbyterian Hospital, New York, New York 10021, USA
    J Biol Chem 278:37637-47. 2003
    ..To the best of our knowledge, this is the first evidence that taxanes can promote stabilization of mRNA in addition to modulating gene transcription...
  68. ncbi request reprint Cyclooxygenase 2: a molecular target for cancer prevention and treatment
    Kotha Subbaramaiah
    Weill Medical College of Cornell University, Dept of Medicine, New York, NY 10021, USA
    Trends Pharmacol Sci 24:96-102. 2003
    ....
  69. ncbi request reprint The role of COX-2 in breast and cervical cancer
    Andrew J Dannenberg
    Department of Medicine, Weill Medical College of Cornell University, Strang Cancer Research Laboratory, New York, N Y, USA
    Prog Exp Tumor Res 37:90-106. 2003
  70. pmc Macrophages induce COX-2 expression in breast cancer cells: role of IL-1β autoamplification
    Zhe Hou
    Department of Medicine and Weill Cornell Cancer Center, Weill Cornell Medical College, New York, NY 10021, USA
    Carcinogenesis 32:695-702. 2011
    ..IL-1β-dependent induction of COX-2 in breast cancer cells provides a mechanism whereby macrophages contribute to tumor progression and potential therapeutic targets in breast cancer...
  71. ncbi request reprint The overexpression of cyclo-oxygenase-2 in chronic periodontitis
    Fan Zhang
    Department of Genetic Medicine, Weill Medical College of Cornell University, New York City, NY 10021, USA
    J Am Dent Assoc 134:861-7. 2003
    ..The objective of this prospective cross-sectional study was to determine if cyclo-oxygenase-2, or COX-2, is overexpressed in the inflamed gingival tissue of patients diagnosed as having moderate-to-severe chronic periodontitis, or CP...
  72. ncbi request reprint Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancer
    K Yoshimatsu
    Department of Medicine, Weill Medical College of Cornell University and Strang Cancer Prevention Center, New York, New York 10021, USA
    Clin Cancer Res 7:2669-74. 2001
    ..Consistent with prior observations for COX-2, these data suggest that both cellular transformation and cytokines contribute to the up-regulation of mPGES in NSCLC...
  73. ncbi request reprint Inducible microsomal prostaglandin E synthase is overexpressed in colorectal adenomas and cancer
    K Yoshimatsu
    Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Clin Cancer Res 7:3971-6. 2001
    ..The mechanisms controlling the expression of these two enzymes are not identical...
  74. ncbi request reprint COX-2 is expressed in human pulmonary, colonic, and mammary tumors
    R A Soslow
    Department of Pathology, New York Presbyterian Hospital Weill Medical College of Cornell University, New York, New York 10021, USA
    Cancer 89:2637-45. 2000
    ..The inducible form of COX, COX-2, has been shown to be important in carcinogenesis...
  75. ncbi request reprint Cyclooxygenase-2 is overexpressed in HER-2/neu-positive breast cancer: evidence for involvement of AP-1 and PEA3
    Kotha Subbaramaiah
    Department of Medicine, New York Presbyterian Hospital, Weill Medical College of Cornell University, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 277:18649-57. 2002
    ..The clear relationship between HER-2/neu status and COX-2 expression in human breast tumors suggests that this mechanism is likely to be operative in vivo...
  76. doi request reprint Potential carcinogenic effects of cigarette smoke and Swedish moist snuff on pancreas: a study using a transgenic mouse model of chronic pancreatitis
    Zhigang Song
    Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, NY, USA
    Lab Invest 90:426-35. 2010
    ..Collectively, these findings provide new insights into the mechanism by which tobacco products are likely to promote carcinogenesis in the setting of chronic pancreatitis...
  77. ncbi request reprint Association of frequency and duration of aspirin use and hormone receptor status with breast cancer risk
    Mary Beth Terry
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    JAMA 291:2433-40. 2004
    ..Given the importance of estrogen in the pathogenesis of breast cancer, the ability of aspirin and other NSAIDs to protect against breast cancer could vary according to hormone receptor status...
  78. doi request reprint Individuals' willingness to talk to their doctors about clinical trial enrollment
    Katherine A McComas
    Department of Communication, Cornell University, 313 Kennedy Hall, Ithaca, NY 14853, USA
    J Health Commun 15:189-204. 2010
    ..Fairness of interactions and trust in doctors were less relevant to respondents who were less willing to talk to their doctors; however, these respondents also were more likely to express intentions to enroll in future clinical trials...
  79. ncbi request reprint Cyclooxygenase-2: a target for the prevention and treatment of breast cancer
    L R Howe
    Strang Cancer Research Laboratory, Rockefeller University, Box 231, 1230 York Avenue, New York, New York 10021, USA
    Endocr Relat Cancer 8:97-114. 2001
    ..Clinical trials will be needed to determine whether COX-2 inhibition represents a useful approach to preventing or treating human breast cancer...
  80. ncbi request reprint Peroxisome proliferator-activated receptor gamma ligands suppress the transcriptional activation of cyclooxygenase-2. Evidence for involvement of activator protein-1 and CREB-binding protein/p300
    K Subbaramaiah
    Department of Medicine, Division of Gastroenterology, New York Presbyterian Hospital and Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 276:12440-8. 2001
    ..Taken together, these findings are likely to be important for understanding the anti-inflammatory and anti-cancer properties of PPARgamma ligands...
  81. ncbi request reprint PEA3 is up-regulated in response to Wnt1 and activates the expression of cyclooxygenase-2
    L R Howe
    Department of Cell Biology and Anatomy, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Biol Chem 276:20108-15. 2001
    ..Therefore, we speculate that PEA3 factors may contribute to the up-regulation of COX-2 expression resulting from both APC mutation and Wnt1 expression...
  82. ncbi request reprint Resveratrol inhibits cyclooxygenase-2 transcription in human mammary epithelial cells
    K Subbaramaiah
    Department of Medicine, New York Presbyterian Hospital Cornell, New York 10021, USA
    Ann N Y Acad Sci 889:214-23. 1999
    ..Phorbol ester-mediated induction of AP-1 activity was blocked by resveratrol. These data are likely to be important for understanding the anticancer and anti-inflammatory properties of resveratrol...
  83. ncbi request reprint Transcriptional activation of cyclooxygenase-2 in Wnt-1-transformed mouse mammary epithelial cells
    L R Howe
    Strang Cancer Research Laboratory, The Rockefeller University, New York, New York 10021, USA
    Cancer Res 59:1572-7. 1999
    ..In view of the critical role of cyclooxygenase-2 in intestinal tumorigenesis, cyclooxygenase-2 up-regulation in response to Wnt signaling may contribute to Wnt-induced mammary carcinogenesis...
  84. ncbi request reprint Celecoxib, a selective cyclo-oxygenase-2 inhibitor, enhances the response to preoperative paclitaxel and carboplatin in early-stage non-small-cell lung cancer
    N K Altorki
    Department of Cardiothoracic Surgery, Strang Cancer Prevention Center and Weill Medical College of Cornell University, New York, NY 10021, USA
    J Clin Oncol 21:2645-50. 2003
    ..End points were toxicity, response rates, and measurement of intratumoral levels of prostaglandin E2 (PGE2)...
  85. ncbi request reprint Microtubule-interfering agents stimulate the transcription of cyclooxygenase-2. Evidence for involvement of ERK1/2 AND p38 mitogen-activated protein kinase pathways
    K Subbaramaiah
    Department of Medicine, New York Presbyterian Hospital Cornell and Strang Cancer Prevention Center, New York, New York 10021, USA
    J Biol Chem 275:14838-45. 2000
    ..Thus, microtubule- or actin-interfering agents stimulated MAPK signaling and activator protein-1 activity. This led, in turn, to induction of COX-2 gene expression via the cyclic AMP response element site in the COX-2 promoter...
  86. ncbi request reprint Induction of cyclooxygenase-2 by tumor promoters in transformed and cytochrome P450 2E1-expressing hepatocytes
    Victor de Ledinghen
    Department of Medicine, Strang Cancer Prevention Center, Weill Medical College of Cornell University, New York, NY 10021, USA
    Carcinogenesis 23:73-9. 2002
    ..However, these conditions do render hepatocytes susceptible to COX-2 induction from tumor promoters by post-transcriptional mechanisms...
  87. ncbi request reprint Bile acids induce cyclooxygenase-2 expression in human pancreatic cancer cell lines
    Olga N Tucker
    Department of Surgery, New York Presbyterian Hospital and Weill Medical College of Cornell University, New York, NY 10021, USA
    Carcinogenesis 25:419-23. 2004
    ..Unconjugated and conjugated bile acids caused 7- and 4-fold increases in PGE2 production, respectively. Taken together, these findings suggest a possible role for bile acids in the pathogenesis of pancreatic cancer...
  88. ncbi request reprint Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis
    S K Boolbol
    Strang Cancer Prevention Center, New York, 10021, USA
    Cancer Res 56:2556-60. 1996
    ..These data suggest that overexpression of Cox-2 is associated with tumorigenesis in the gastrointestinal epithelium, and that both are inhibited by sulindac administration...
  89. ncbi request reprint Elevated expression of cyclooxygenase-2 contributes to immune dysfunction in a murine model of trauma
    P J Mackrell
    Departments of Surgery, New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, NY10021, USA
    Surgery 130:826-33. 2001
    ..CONCLUSIONS: These experiments link trauma-induced increases in Cox-2 expression and PGE2 production to reduced immune function. Cox-2 represents a potential pharmacologic target to prevent or reverse trauma-induced immunosuppression...
  90. ncbi request reprint Duodenal reflux induces cyclooxygenase-2 in the esophageal mucosa of rats: evidence for involvement of bile acids
    F Zhang
    Department of Cardiothoracic Surgery, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Gastroenterology 121:1391-9. 2001
    ..CONCLUSIONS: Reflux of duodenal contents into the esophagus led to increased COX-2 expression and mucosal thickening. Bile acids are likely to contribute to these effects...
  91. ncbi request reprint Phenotypic abnormalities in macrophages from leptin-deficient, obese mice
    F Y Lee
    Department of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Am J Physiol 276:C386-94. 1999
    ..Given the importance of macrophages in the general regulation of inflammation and immunity, these alterations in macrophage function may contribute to obesity-related pathophysiology...
  92. ncbi request reprint Cyclooxygenase-2 is overexpressed in human cervical cancer
    S Kulkarni
    Department of Medicine, New York Presbyterian Hospital-Cornell, New York 10021, USA
    Clin Cancer Res 7:429-34. 2001
    ..Taken together, these findings suggest that deregulation of the EGF receptor signaling pathway may lead to enhanced COX-2 expression in cervical cancer...
  93. ncbi request reprint (+)-Catechin inhibits intestinal tumor formation and suppresses focal adhesion kinase activation in the min/+ mouse
    M J Weyant
    Department of Surgery, The New York Presbyterian Hospital and Weill Cornell Medical College, New York, New York 10021, USA
    Cancer Res 61:118-25. 2001
    ..Thus, the natural abundance and favorable bioavailability of (+)-catechin make it a promising addition to the list of potential colorectal cancer chemopreventive agents...
  94. ncbi request reprint Thalidomide and its analogues inhibit lipopolysaccharide-mediated Iinduction of cyclooxygenase-2
    J Fujita
    Department of Surgery, New York Presbyterian Hospital and Weill Medical College of Cornell University, New York, NY 10021, USA
    Clin Cancer Res 7:3349-55. 2001
    ..A series of structural analogues of thalidomide also inhibited LPS-mediated induction of Cox-2 and PGE(2) synthesis. Taken together, these data provide new insights into the antineoplastic and anti-inflammatory properties of thalidomide...
  95. ncbi request reprint The sulfide metabolite of sulindac prevents tumors and restores enterocyte apoptosis in a murine model of familial adenomatous polyposis
    N N Mahmoud
    The New York Hospital Cornell University Medical Center, NY 10021, USA
    Carcinogenesis 19:87-91. 1998
    ..001). These data suggest that the anti-tumor effect of sulindac in Apc-deficient animals is mediated by the sulfide metabolite and correlates with suppression of tissue prostaglandin synthesis...
  96. ncbi request reprint Aspirin prevents tumors in a murine model of familial adenomatous polyposis
    N N Mahmoud
    New York Hospital Cornell University Medical Center, NY 10021, USA
    Surgery 124:225-31. 1998
    ..Both human and murine studies suggest that anti-inflammatory drugs prevent intestinal neoplasia. The purpose of this study was to investigate the role of aspirin as a chemopreventive agent for colorectal cancer...
  97. ncbi request reprint Combined targeting of the epidermal growth factor receptor and cyclooxygenase-2 pathways
    Scott M Lippman
    Clin Cancer Res 11:6097-9. 2005
  98. ncbi request reprint Alcoholic liver injury in the rat is associated with reduced expression of peroxisome proliferator-alpha (PPARalpha)-regulated genes and is ameliorated by PPARalpha activation
    Amin A Nanji
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 4283, USA
    J Pharmacol Exp Ther 310:417-24. 2004
    ....
  99. ncbi request reprint The retinoid X receptor-selective retinoid, LGD1069, down-regulates cyclooxygenase-2 expression in human breast cells through transcription factor crosstalk: implications for molecular-based chemoprevention
    Gu Kong
    Breast Center, Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 65:3462-9. 2005
    ..Furthermore, such RXR-selective retinoids may be most useful in combination with antiestrogens for more effective prevention of breast cancer in women at high risk of this disease...
  100. doi request reprint Pilot randomized phase II study of celecoxib in oral premalignant lesions
    Vassiliki A Papadimitrakopoulou
    Department of Thoracic Head, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:2095-101. 2008
    ..In this pilot randomized phase II study, we evaluated the efficacy and safety of the COX-2 inhibitor celecoxib in patients with oral premalignant lesions (OPL)...
  101. ncbi request reprint Desmethyl derivatives of indomethacin and sulindac as probes for cyclooxygenase-dependent biology
    Andrew S Felts
    ACS Chem Biol 2:479-83. 2007
    ..These compounds serve as useful probes of COX-dependent biology and may represent leads for antidiabetic and anticancer drugs...