Harold Craighead

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Characterization and optimization of an entropic trap for DNA separation
    Jongyoon Han
    School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
    Anal Chem 74:394-401. 2002
  2. doi request reprint Prion protein detection using nanomechanical resonator arrays and secondary mass labeling
    Madhukar Varshney
    School of Applied and Engineering Physics, Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA
    Anal Chem 80:2141-8. 2008
  3. pmc RAPID-SELEX for RNA Aptamers
    Kylan Szeto
    School of Applied and Engineering Physics, Cornell University, Ithaca, New York, United States of America
    PLoS ONE 8:e82667. 2013
  4. doi request reprint High-throughput binding characterization of RNA aptamer selections using a microplate-based multiplex microcolumn device
    Kylan Szeto
    School of Applied and Engineering Physics, Cornell University, Ithaca, NY, 14853, USA
    Anal Bioanal Chem 406:2727-32. 2014
  5. pmc Multiplexed microcolumn-based process for efficient selection of RNA aptamers
    David R Latulippe
    School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, United States
    Anal Chem 85:3417-24. 2013
  6. ncbi request reprint High, size-dependent quality factor in an array of graphene mechanical resonators
    Robert A Barton
    School of Applied and Engineering Physics, Kavli Institute at Cornell for Nanoscale Science, Cornell University, Ithaca, New York 14853, United States
    Nano Lett 11:1232-6. 2011
  7. doi request reprint Microfluidic extraction, stretching and analysis of human chromosomal DNA from single cells
    Jaime J Benítez
    School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
    Lab Chip 12:4848-54. 2012
  8. doi request reprint Zero-mode waveguides for single-molecule analysis
    Paul Zhu
    Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
    Annu Rev Biophys 41:269-93. 2012
  9. ncbi request reprint Interview: Nanostructures for sensors and analytical systems
    Harold Craighead
    205 Clark Hall, School of Applied and Engineering Physics, Cornell University, Ithaca, NY, USA
    Nanomedicine (Lond) 7:317-9. 2012
  10. ncbi request reprint Future lab-on-a-chip technologies for interrogating individual molecules
    Harold Craighead
    Applied and Engineering Physics, 205 Clark Hall, Cornell University, Ithaca, New York 14853, USA
    Nature 442:387-93. 2006

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Characterization and optimization of an entropic trap for DNA separation
    Jongyoon Han
    School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
    Anal Chem 74:394-401. 2002
    ..The requirement and feasibility of megabase pair DNA separation with the entropic trap array device was discussed...
  2. doi request reprint Prion protein detection using nanomechanical resonator arrays and secondary mass labeling
    Madhukar Varshney
    School of Applied and Engineering Physics, Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA
    Anal Chem 80:2141-8. 2008
    ..In the presence of secondary antibodies the analytical sensitivity was improved to 2 microg/mL. With the use of functionalized nanoparticles, the sensitivity improved an additional 3 orders of magnitude to 2 ng/mL...
  3. pmc RAPID-SELEX for RNA Aptamers
    Kylan Szeto
    School of Applied and Engineering Physics, Cornell University, Ithaca, New York, United States of America
    PLoS ONE 8:e82667. 2013
    ..RAPID provides a generalized approach that can be used with any selection technology to accelerate the rate of aptamer discovery, without compromising selection performance. ..
  4. doi request reprint High-throughput binding characterization of RNA aptamer selections using a microplate-based multiplex microcolumn device
    Kylan Szeto
    School of Applied and Engineering Physics, Cornell University, Ithaca, NY, 14853, USA
    Anal Bioanal Chem 406:2727-32. 2014
    ....
  5. pmc Multiplexed microcolumn-based process for efficient selection of RNA aptamers
    David R Latulippe
    School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, United States
    Anal Chem 85:3417-24. 2013
    ..The combination of our microcolumns with a multiplex approach and high-throughput sequencing enables the selection of aptamers to multiple targets in a high-throughput and efficient manner...
  6. ncbi request reprint High, size-dependent quality factor in an array of graphene mechanical resonators
    Robert A Barton
    School of Applied and Engineering Physics, Kavli Institute at Cornell for Nanoscale Science, Cornell University, Ithaca, New York 14853, United States
    Nano Lett 11:1232-6. 2011
    ....
  7. doi request reprint Microfluidic extraction, stretching and analysis of human chromosomal DNA from single cells
    Jaime J Benítez
    School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
    Lab Chip 12:4848-54. 2012
    ..The device described represents a novel platform to perform a variety of analyses on chromosomal DNA at the single cell level...
  8. doi request reprint Zero-mode waveguides for single-molecule analysis
    Paul Zhu
    Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
    Annu Rev Biophys 41:269-93. 2012
    ..We also review the integration of ZMWs in different optical configurations and microfluidic systems...
  9. ncbi request reprint Interview: Nanostructures for sensors and analytical systems
    Harold Craighead
    205 Clark Hall, School of Applied and Engineering Physics, Cornell University, Ithaca, NY, USA
    Nanomedicine (Lond) 7:317-9. 2012
    Professor Harold Craighead attended the University of Maryland (MD, USA) where he received his Bachelor of Science Degree in Physics. He moved to Cornell University (NY, USA) for his PhD in Physics, which he completed in 1980...
  10. ncbi request reprint Future lab-on-a-chip technologies for interrogating individual molecules
    Harold Craighead
    Applied and Engineering Physics, 205 Clark Hall, Cornell University, Ithaca, New York 14853, USA
    Nature 442:387-93. 2006
    ..Adaptation of these approaches to lab-on-a-chip formats is providing a new class of research tools for the investigation of biochemistry and life processes...
  11. ncbi request reprint Continuous separation of biomolecules by the laterally asymmetric diffusion array with out-of-plane sample injection
    Mario Cabodi
    School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
    Electrophoresis 23:3496-503. 2002
    ..We expect this type of device could now be employed for separation of a variety of different biomolecules, ranging from long dsDNA to small proteins...
  12. doi request reprint Free-standing epitaxial graphene
    Shriram Shivaraman
    Cornell Center for Materials Research, Cornell University, Ithaca, New York 14853, USA
    Nano Lett 9:3100-5. 2009
    ..Raman spectroscopy suggests that the graphene is not chemically modified during the release of the devices, demonstrating that the technique is a robust means of fabricating large-area suspended graphene structures...
  13. ncbi request reprint Macroscopic tuning of nanomechanics: substrate bending for reversible control of frequency and quality factor of nanostring resonators
    Scott S Verbridge
    Department of Physics and the Cornell Center for Materials Research, Cornell University, Ithaca, New York 14853, USA
    Nano Lett 7:1728-35. 2007
    ....
  14. doi request reprint Supported lipid bilayer/carbon nanotube hybrids
    Xinjian Zhou
    Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York 14853, USA
    Nat Nanotechnol 2:185-90. 2007
    ....
  15. ncbi request reprint Entropic recoil separation of long DNA molecules
    Mario Cabodi
    School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
    Anal Chem 74:5169-74. 2002
    ..The extracted resolution and running separation time compare favorably with current conventional separation techniques...
  16. doi request reprint Labeling and purification of cellulose-binding proteins for high resolution fluorescence applications
    Jose M Moran-Mirabal
    Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York 14850, USA
    Anal Chem 81:7981-7. 2009
    ..The protocol for the separation of labeled products is applicable to any mixture of labeled proteins, making this an attractive methodology for the production of labeled proteins suitable for single molecule fluorescence spectroscopy...
  17. doi request reprint Prion protein detection in serum using micromechanical resonator arrays
    Madhukar Varshney
    School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
    Talanta 80:593-9. 2009
    ..Our results show that a minimum of 200 pg mL(-1) of PrP(c) in blood serum can be detected using micromechanical resonator arrays...
  18. pmc A method for nanofluidic device prototyping using elastomeric collapse
    Seung Min Park
    School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 106:15549-54. 2009
    ..The applicability of the technique to biomolecular analysis is demonstrated by showing DNA elongation in a nanochannel and a technique for optofluidic surface enhanced Raman detection of nucleic acids...
  19. pmc Nanoscale resolution, multicomponent biomolecular arrays generated by aligned printing with parylene peel-off
    Christine P Tan
    Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA
    Nano Lett 10:719-25. 2010
    ..We further patterned combinatorial nanoarrays by performing a second print-run superimposed over the first, thereby extending the multiplexing capability of the technique...
  20. pmc Micrometer-sized supported lipid bilayer arrays for bacterial toxin binding studies through total internal reflection fluorescence microscopy
    Jose M Moran-Mirabal
    Applied and Engineering Physics, Cornell University, Ithaca, New York, 14853, USA
    Biophys J 89:296-305. 2005
    ....
  21. doi request reprint Zero-mode waveguides: sub-wavelength nanostructures for single molecule studies at high concentrations
    Jose M Moran-Mirabal
    School of Applied and Engineering Physics, Cornell University, 212 Clark Hall, Ithaca, NY 14853, USA
    Methods 46:11-7. 2008
    ..In this review, the concept and implementation of ZMWs is outlined, along with their application to the study of freely diffusing, and membrane-bound fluorescent biomolecules...
  22. doi request reprint Immobilization of cellulose fibrils on solid substrates for cellulase-binding studies through quantitative fluorescence microscopy
    Jose M Moran-Mirabal
    Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York 14853, USA
    Biotechnol Bioeng 101:1129-41. 2008
    ..These results validate our method for immobilizing nanoscale cellulose fibrils and fibril aggregates on solid supports and lay the foundation for future studies on cellulase-cellulose interactions...
  23. pmc High spatial resolution observation of single-molecule dynamics in living cell membranes
    Joshua B Edel
    School of Applied and Engineering Physics, Cornell University, Ithaca, New York, USA
    Biophys J 88:L43-5. 2005
    ..We show that optical confinement with ZMWs is a facile way to probe dynamic processes on the membrane surface...
  24. ncbi request reprint Single molecule studies of quantum dot conjugates in a submicrometer fluidic channel
    Samuel M Stavis
    School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
    Lab Chip 5:337-43. 2005
    ..The union of fluidic channels with submicrometer dimensions and quantum dots as fluorescent labels resulted in efficient and rapid multiplexed single molecule detection and analysis...
  25. pmc Single molecule epigenetic analysis in a nanofluidic channel
    Benjamin R Cipriany
    Department of Electrical and Computer Engineering, Cornell University, Ithaca, New York 14853, USA
    Anal Chem 82:2480-7. 2010
    ..This technique will provide the unprecedented opportunity for genome wide, simultaneous analysis of multiple epigenetic states on single molecules...
  26. doi request reprint Selection and elution of aptamers using nanoporous sol-gel arrays with integrated microheaters
    Seung Min Park
    Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
    Lab Chip 9:1206-12. 2009
    ..To our knowledge, this is the first demonstration of a chip-based selection of aptamers using microfluidics, thereby allowing development of a high throughput and efficient SELEX procedures...
  27. pmc Entropic unfolding of DNA molecules in nanofluidic channels
    Stephen L Levy
    School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
    Nano Lett 8:3839-44. 2008
    ..The ratio of this unfolding force to hydrodynamic friction per DNA contour length is measured in nanochannels with two different diameters...
  28. ncbi request reprint Micro- and nanomechanical sensors for environmental, chemical, and biological detection
    Philip S Waggoner
    School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
    Lab Chip 7:1238-55. 2007
    ....
  29. ncbi request reprint DNA fragment sizing by single molecule detection in submicrometer-sized closed fluidic channels
    Mathieu Foquet
    School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
    Anal Chem 74:1415-22. 2002
    ..The amount of sample required for the analysis was approximately 10,000 molecules, or 76 fg. Other potential applications of these submicrometer structures for DNA analysis are discussed...
  30. doi request reprint DNA manipulation, sorting, and mapping in nanofluidic systems
    Stephen L Levy
    School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
    Chem Soc Rev 39:1133-52. 2010
    ..In this critical review, recent experiments utilizing fluidic systems comprised of nanochannels, nanoslits, nanopores, and zero-mode waveguides for DNA analysis are reviewed (161 references)...
  31. ncbi request reprint Focal volume confinement by submicrometer-sized fluidic channels
    Mathieu Foquet
    School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
    Anal Chem 76:1618-26. 2004
    ..Applications of these nanofabricated devices for high-throughput, single-molecule detection in drug screening and genomic analysis are discussed...
  32. doi request reprint Detection of prostate specific antigen with nanomechanical resonators
    Philip S Waggoner
    School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
    Lab Chip 9:3095-9. 2009
    ..5 fM, could be detected from the realistic samples. The presence of non-specific proteins in the serum did not significantly affect the sensitivity of our assay...
  33. pmc Controlling microarray spot morphology with polymer liftoff arrays
    Jose M Moran-Mirabal
    Department of Applied Physics, Cornell University, Ithaca, New York 14853, USA
    Anal Chem 79:1109-14. 2007
    ..We envision that these novel substrates can be generalized to produce more uniform arrays of other patterned biomaterials...
  34. doi request reprint Impermeable atomic membranes from graphene sheets
    J Scott Bunch
    Cornell Center for Materials Research, Cornell University, Ithaca, New York 14853, USA
    Nano Lett 8:2458-62. 2008
    ..This pressurized graphene membrane is the world's thinnest balloon and provides a unique separation barrier between 2 distinct regions that is only one atom thick...
  35. pmc Visualization of plasma membrane compartmentalization with patterned lipid bilayers
    Min Wu
    Department of Chemistry and Chemical Biology and School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 101:13798-803. 2004
    ..Cell activation using patterned surfaces provides unique insights into cell membrane structural organization, revealing dynamic, large-scale uncoupling of inner and outer leaflet components of lipid rafts...
  36. ncbi request reprint Phase separation and fractal domain formation in phospholipid/diacetylene-supported lipid bilayers
    Jose M Moran-Mirabal
    School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
    Langmuir 23:10661-71. 2007
    ..Phase separation induced by nanometer-scale perturbations could prove useful in selectively positioning lipid patches with specific compositions...
  37. ncbi request reprint Extracellular recordings from patterned neuronal networks using planar microelectrode arrays
    Conrad D James
    Cornell University, Ithaca, NY 14850 USA
    IEEE Trans Biomed Eng 51:1640-8. 2004
    ..Finally, we present here an extracellular recording from a approximately 2 microm bundle of guided neurites...
  38. pmc Electrochemical imaging of fusion pore openings by electrochemical detector arrays
    Ismail Hafez
    School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 102:13879-84. 2005
    ....
  39. doi request reprint Parylene peel-off arrays to probe the role of cell-cell interactions in tumour angiogenesis
    Christine P Tan
    Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA
    Integr Biol (Camb) 1:587-94. 2009
    ....
  40. ncbi request reprint Single molecule correlation spectroscopy in continuous flow mixers with zero-mode waveguides
    David Liao
    Department of Physics, Princeton University, Princeton, NJ 08544, USA
    Opt Express 16:10077-90. 2008
    ..Thus zero-mode waveguides make FCS suitable for direct kinetics measurements in rapid continuous flow...
  41. ncbi request reprint Patterning axonal guidance molecules using a novel strategy for microcontact printing
    Anthony A Oliva
    Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Neurochem Res 28:1639-48. 2003
    ..This method should be broadly applicable to many classes of proteins...
  42. ncbi request reprint The NanoBioWorld
    Carmelina Ruggiero
    IEEE Trans Nanobioscience 1:1-3. 2002