Research Topics
| Harold CraigheadSummaryAffiliation: Cornell University Country: USA Publications
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Detail Information
Publications
Characterization and optimization of an entropic trap for DNA separationJongyoon Han
School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
Anal Chem 74:394-401. 2002..The requirement and feasibility of megabase pair DNA separation with the entropic trap array device was discussed...
Prion protein detection using nanomechanical resonator arrays and secondary mass labelingMadhukar Varshney
School of Applied and Engineering Physics, Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA
Anal Chem 80:2141-8. 2008..In the presence of secondary antibodies the analytical sensitivity was improved to 2 microg/mL. With the use of functionalized nanoparticles, the sensitivity improved an additional 3 orders of magnitude to 2 ng/mL...- High, size-dependent quality factor in an array of graphene mechanical resonatorsRobert A Barton
School of Applied and Engineering Physics, Kavli Institute at Cornell for Nanoscale Science, Cornell University, Ithaca, New York 14853, United States
Nano Lett 11:1232-6. 2011.... - Microfluidic extraction, stretching and analysis of human chromosomal DNA from single cellsJaime J Benítez
School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
Lab Chip 12:4848-54. 2012..The device described represents a novel platform to perform a variety of analyses on chromosomal DNA at the single cell level... - Zero-mode waveguides for single-molecule analysisPaul Zhu
Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
Annu Rev Biophys 41:269-93. 2012..We also review the integration of ZMWs in different optical configurations and microfluidic systems... - Interview: Nanostructures for sensors and analytical systemsHarold Craighead
205 Clark Hall, School of Applied and Engineering Physics, Cornell University, Ithaca, NY, USA
Nanomedicine (Lond) 7:317-9. 2012Professor Harold Craighead attended the University of Maryland (MD, USA) where he received his Bachelor of Science Degree in Physics. He moved to Cornell University (NY, USA) for his PhD in Physics, which he completed in 1980... - Future lab-on-a-chip technologies for interrogating individual moleculesHarold Craighead
Applied and Engineering Physics, 205 Clark Hall, Cornell University, Ithaca, New York 14853, USA
Nature 442:387-93. 2006..Adaptation of these approaches to lab-on-a-chip formats is providing a new class of research tools for the investigation of biochemistry and life processes... - Continuous separation of biomolecules by the laterally asymmetric diffusion array with out-of-plane sample injectionMario Cabodi
School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
Electrophoresis 23:3496-503. 2002..We expect this type of device could now be employed for separation of a variety of different biomolecules, ranging from long dsDNA to small proteins... - Supported lipid bilayer/carbon nanotube hybridsXinjian Zhou
Laboratory of Atomic and Solid State Physics, Cornell University, Ithaca, New York 14853, USA
Nat Nanotechnol 2:185-90. 2007.... - Free-standing epitaxial grapheneShriram Shivaraman
Cornell Center for Materials Research, Cornell University, Ithaca, New York 14853, USA
Nano Lett 9:3100-5. 2009..Raman spectroscopy suggests that the graphene is not chemically modified during the release of the devices, demonstrating that the technique is a robust means of fabricating large-area suspended graphene structures... - Labeling and purification of cellulose-binding proteins for high resolution fluorescence applicationsJose M Moran-Mirabal
Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York 14850, USA
Anal Chem 81:7981-7. 2009..The protocol for the separation of labeled products is applicable to any mixture of labeled proteins, making this an attractive methodology for the production of labeled proteins suitable for single molecule fluorescence spectroscopy... - Prion protein detection in serum using micromechanical resonator arraysMadhukar Varshney
School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
Talanta 80:593-9. 2009..Our results show that a minimum of 200 pg mL(-1) of PrP(c) in blood serum can be detected using micromechanical resonator arrays... - Entropic recoil separation of long DNA moleculesMario Cabodi
School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
Anal Chem 74:5169-74. 2002..The extracted resolution and running separation time compare favorably with current conventional separation techniques... - Macroscopic tuning of nanomechanics: substrate bending for reversible control of frequency and quality factor of nanostring resonatorsScott S Verbridge
Department of Physics and the Cornell Center for Materials Research, Cornell University, Ithaca, New York 14853, USA
Nano Lett 7:1728-35. 2007.... 
A method for nanofluidic device prototyping using elastomeric collapseSeung Min Park
School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
Proc Natl Acad Sci U S A 106:15549-54. 2009..The applicability of the technique to biomolecular analysis is demonstrated by showing DNA elongation in a nanochannel and a technique for optofluidic surface enhanced Raman detection of nucleic acids...- Nanoscale resolution, multicomponent biomolecular arrays generated by aligned printing with parylene peel-offChristine P Tan
Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA
Nano Lett 10:719-25. 2010..We further patterned combinatorial nanoarrays by performing a second print-run superimposed over the first, thereby extending the multiplexing capability of the technique... - Zero-mode waveguides: sub-wavelength nanostructures for single molecule studies at high concentrationsJose M Moran-Mirabal
School of Applied and Engineering Physics, Cornell University, 212 Clark Hall, Ithaca, NY 14853, USA
Methods 46:11-7. 2008..In this review, the concept and implementation of ZMWs is outlined, along with their application to the study of freely diffusing, and membrane-bound fluorescent biomolecules... - Immobilization of cellulose fibrils on solid substrates for cellulase-binding studies through quantitative fluorescence microscopyJose M Moran-Mirabal
Department of Biological and Environmental Engineering, Cornell University, Ithaca, New York 14853, USA
Biotechnol Bioeng 101:1129-41. 2008..These results validate our method for immobilizing nanoscale cellulose fibrils and fibril aggregates on solid supports and lay the foundation for future studies on cellulase-cellulose interactions... - Micrometer-sized supported lipid bilayer arrays for bacterial toxin binding studies through total internal reflection fluorescence microscopyJose M Moran-Mirabal
Applied and Engineering Physics, Cornell University, Ithaca, New York, 14853, USA
Biophys J 89:296-305. 2005.... - Single molecule epigenetic analysis in a nanofluidic channelBenjamin R Cipriany
Department of Electrical and Computer Engineering, Cornell University, Ithaca, New York 14853, USA
Anal Chem 82:2480-7. 2010..This technique will provide the unprecedented opportunity for genome wide, simultaneous analysis of multiple epigenetic states on single molecules... - Single molecule studies of quantum dot conjugates in a submicrometer fluidic channelSamuel M Stavis
School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
Lab Chip 5:337-43. 2005..The union of fluidic channels with submicrometer dimensions and quantum dots as fluorescent labels resulted in efficient and rapid multiplexed single molecule detection and analysis... - High spatial resolution observation of single-molecule dynamics in living cell membranesJoshua B Edel
School of Applied and Engineering Physics, Cornell University, Ithaca, New York, USA
Biophys J 88:L43-5. 2005..We show that optical confinement with ZMWs is a facile way to probe dynamic processes on the membrane surface... - Selection and elution of aptamers using nanoporous sol-gel arrays with integrated microheatersSeung Min Park
Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
Lab Chip 9:1206-12. 2009..To our knowledge, this is the first demonstration of a chip-based selection of aptamers using microfluidics, thereby allowing development of a high throughput and efficient SELEX procedures... - Entropic unfolding of DNA molecules in nanofluidic channelsStephen L Levy
School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
Nano Lett 8:3839-44. 2008..The ratio of this unfolding force to hydrodynamic friction per DNA contour length is measured in nanochannels with two different diameters... - Micro- and nanomechanical sensors for environmental, chemical, and biological detectionPhilip S Waggoner
School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
Lab Chip 7:1238-55. 2007.... - DNA fragment sizing by single molecule detection in submicrometer-sized closed fluidic channelsMathieu Foquet
School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
Anal Chem 74:1415-22. 2002..The amount of sample required for the analysis was approximately 10,000 molecules, or 76 fg. Other potential applications of these submicrometer structures for DNA analysis are discussed... - Focal volume confinement by submicrometer-sized fluidic channelsMathieu Foquet
School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
Anal Chem 76:1618-26. 2004..Applications of these nanofabricated devices for high-throughput, single-molecule detection in drug screening and genomic analysis are discussed... - Controlling microarray spot morphology with polymer liftoff arraysJose M Moran Mirabal
Department of Applied Physics, Cornell University, Ithaca, New York 14853, USA
Anal Chem 79:1109-14. 2007..We envision that these novel substrates can be generalized to produce more uniform arrays of other patterned biomaterials... - Detection of prostate specific antigen with nanomechanical resonatorsPhilip S Waggoner
School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
Lab Chip 9:3095-9. 2009..5 fM, could be detected from the realistic samples. The presence of non-specific proteins in the serum did not significantly affect the sensitivity of our assay... - DNA manipulation, sorting, and mapping in nanofluidic systemsStephen L Levy
School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
Chem Soc Rev 39:1133-52. 2010..In this critical review, recent experiments utilizing fluidic systems comprised of nanochannels, nanoslits, nanopores, and zero-mode waveguides for DNA analysis are reviewed (161 references)... - Electrochemical imaging of fusion pore openings by electrochemical detector arraysIsmail Hafez
School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
Proc Natl Acad Sci U S A 102:13879-84. 2005.... - Visualization of plasma membrane compartmentalization with patterned lipid bilayersMin Wu
Department of Chemistry and Chemical Biology and School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
Proc Natl Acad Sci U S A 101:13798-803. 2004..Cell activation using patterned surfaces provides unique insights into cell membrane structural organization, revealing dynamic, large-scale uncoupling of inner and outer leaflet components of lipid rafts... - Parylene peel-off arrays to probe the role of cell-cell interactions in tumour angiogenesisChristine P Tan
Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA
Integr Biol (Camb) 1:587-94. 2009.... - Extracellular recordings from patterned neuronal networks using planar microelectrode arraysConrad D James
Cornell University, Ithaca, NY 14850 USA
IEEE Trans Biomed Eng 51:1640-8. 2004..Finally, we present here an extracellular recording from a approximately 2 microm bundle of guided neurites... - Impermeable atomic membranes from graphene sheetsJ Scott Bunch
Cornell Center for Materials Research, Cornell University, Ithaca, New York 14853, USA
Nano Lett 8:2458-62. 2008..This pressurized graphene membrane is the world's thinnest balloon and provides a unique separation barrier between 2 distinct regions that is only one atom thick... - Phase separation and fractal domain formation in phospholipid/diacetylene-supported lipid bilayersJose M Moran Mirabal
School of Applied and Engineering Physics, Cornell University, Ithaca, New York 14853, USA
Langmuir 23:10661-71. 2007..Phase separation induced by nanometer-scale perturbations could prove useful in selectively positioning lipid patches with specific compositions... - The NanoBioWorldCarmelina Ruggiero
IEEE Trans Nanobioscience 1:1-3. 2002 - Single molecule correlation spectroscopy in continuous flow mixers with zero-mode waveguidesDavid Liao
Department of Physics, Princeton University, Princeton, NJ 08544, USA
Opt Express 16:10077-90. 2008..Thus zero-mode waveguides make FCS suitable for direct kinetics measurements in rapid continuous flow... - Patterning axonal guidance molecules using a novel strategy for microcontact printingAnthony A Oliva
Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, Oregon 97239, USA
Neurochem Res 28:1639-48. 2003..This method should be broadly applicable to many classes of proteins...