Huai Hu Chuang

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. pmc Oxidative challenges sensitize the capsaicin receptor by covalent cysteine modification
    Huai Hu Chuang
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 106:20097-102. 2009
  2. doi request reprint RGS proteins maintain robustness of GPCR-GIRK coupling by selective stimulation of the G protein subunit Gαo
    Huai Hu Chuang
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
    Sci Signal 5:ra15. 2012
  3. pmc Mechanism of AMPA receptor activation by partial agonists: disulfide trapping of closed lobe conformations
    Ahmed H Ahmed
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 286:35257-66. 2011
  4. pmc C-terminal dimerization activates the nociceptive transduction channel transient receptor potential vanilloid 1
    Shu Wang
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 286:40601-7. 2011
  5. pmc Induction of TRPV1 desensitization by a biased receptor agonist
    Elaine E Wang
    Cornell University, Ithaca, NY, USA
    Channels (Austin) 5:464-7. 2011
  6. pmc Activity-dependent targeting of TRPV1 with a pore-permeating capsaicin analog
    Hui Li
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 108:8497-502. 2011
  7. pmc Distinct modulations of human capsaicin receptor by protons and magnesium through different domains
    Shu Wang
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 285:11547-56. 2010

Collaborators

  • Hui Li
  • Bruce E Cohen
  • Shu Wang
  • Elaine E Wang
  • Ahmed H Ahmed
  • Robert E Oswald
  • Alexander Y Chuang
  • Kinning Poon

Detail Information

Publications7

  1. pmc Oxidative challenges sensitize the capsaicin receptor by covalent cysteine modification
    Huai Hu Chuang
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 106:20097-102. 2009
    ..Thus, oxidative modulation is a robust mechanism tuning TRPV1 activity via covalent modification of evolutionarily conserved cysteines and may play a role in pain sensing processes during inflammation, infection, or tissue injury...
  2. doi request reprint RGS proteins maintain robustness of GPCR-GIRK coupling by selective stimulation of the G protein subunit Gαo
    Huai Hu Chuang
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
    Sci Signal 5:ra15. 2012
    ....
  3. pmc Mechanism of AMPA receptor activation by partial agonists: disulfide trapping of closed lobe conformations
    Ahmed H Ahmed
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 286:35257-66. 2011
    ..The results are consistent the hypothesis that the efficacy is determined at least in part by the stability of the state in which the lobes are fully closed...
  4. pmc C-terminal dimerization activates the nociceptive transduction channel transient receptor potential vanilloid 1
    Shu Wang
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 286:40601-7. 2011
    ....
  5. pmc Induction of TRPV1 desensitization by a biased receptor agonist
    Elaine E Wang
    Cornell University, Ithaca, NY, USA
    Channels (Austin) 5:464-7. 2011
    ....
  6. pmc Activity-dependent targeting of TRPV1 with a pore-permeating capsaicin analog
    Hui Li
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 108:8497-502. 2011
    ..These results implicate therapeutic potential of these unique TRPV1 agonists exhibiting activity-dependent ion transport but of minimal pain-producing risks...
  7. pmc Distinct modulations of human capsaicin receptor by protons and magnesium through different domains
    Shu Wang
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 285:11547-56. 2010
    ..Our results demonstrate that capsaicin efficacy of hTRPV1 correlates with the extracellular ion milieu and unravel the relevant structural basis of modulation by protons and magnesium...