Lotfi Chouchane

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. pmc Protein alterations in infiltrating ductal carcinomas of the breast as detected by nonequilibrium pH gradient electrophoresis and mass spectrometry
    Maria Kabbage
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, 5019 Monastir, Tunisia
    J Biomed Biotechnol 2008:564127. 2008
  2. doi request reprint Breast cancer in Arab populations: molecular characteristics and disease management implications
    Lotfi Chouchane
    Laboratory of Genetic Medicine and Immunology, Weill Cornell Medical College in Qatar, Qatar Foundation, Doha, Qatar
    Lancet Oncol 14:e417-24. 2013
  3. pmc Cancer classification using the Immunoscore: a worldwide task force
    Jerome Galon
    INSERM, U872, Laboratory of Integrative Cancer Immunology, Paris, F 75006, France
    J Transl Med 10:205. 2012
  4. pmc Inferring genome-wide patterns of admixture in Qataris using fifty-five ancestral populations
    Larsson Omberg
    Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853, USA
    BMC Genet 13:49. 2012
  5. pmc Genome scan study of prostate cancer in Arabs: identification of three genomic regions with multiple prostate cancer susceptibility loci in Tunisians
    Jingxuan Shan
    Laboratory of Genetic Medicine and Immunology, Weill Cornell Medical College in Qatar, Qatar Foundation, Doha, Qatar
    J Transl Med 11:121. 2013
  6. pmc The stable traits of melanoma genetics: an alternate approach to target discovery
    Tara L Spivey
    Infectious Disease and Immunogenetics Section IDIS, Department of Transfusion Medicine, Clinical Center and trans NIH Center for Human Immunology CHI, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Genomics 13:156. 2012
  7. pmc Hereditary breast cancer in Middle Eastern and North African (MENA) populations: identification of novel, recurrent and founder BRCA1 mutations in the Tunisian population
    Wijden Mahfoudh
    Department of Molecular Immuno Oncology, Faculty of Medicine, 5019 Monastir, Tunisia
    Mol Biol Rep 39:1037-46. 2012
  8. pmc An immunologic portrait of cancer
    Maria Libera Ascierto
    Infectious Disease and Immunogenetics Section IDIS, Department of Transfusion Medicine, Clinical Center and trans NIH Center for Human Immunology CHI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Transl Med 9:146. 2011
  9. pmc Medical education and research environment in Qatar: a new epoch for translational research in the Middle East
    Lotfi Chouchane
    Weill Cornell Medical College in Qatar, Education City, P, O, Box 24144, Doha, Qatar
    J Transl Med 9:16. 2011
  10. pmc Combined effects of IL-8 and CXCR2 gene polymorphisms on breast cancer susceptibility and aggressiveness
    Kaouther Snoussi
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Universite de Monastir, Monastir 5019, Tunisia
    BMC Cancer 10:283. 2010

Collaborators

Detail Information

Publications49

  1. pmc Protein alterations in infiltrating ductal carcinomas of the breast as detected by nonequilibrium pH gradient electrophoresis and mass spectrometry
    Maria Kabbage
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, 5019 Monastir, Tunisia
    J Biomed Biotechnol 2008:564127. 2008
    ..In contrast, the IGHG1 protein, the complement C3 component C3c, which are two newly identified protein markers, were downregulated in IDCA tissues...
  2. doi request reprint Breast cancer in Arab populations: molecular characteristics and disease management implications
    Lotfi Chouchane
    Laboratory of Genetic Medicine and Immunology, Weill Cornell Medical College in Qatar, Qatar Foundation, Doha, Qatar
    Lancet Oncol 14:e417-24. 2013
    ..These disparities are not only confined to clinicopathological features but also exist at the molecular level, as shown by findings of genome-wide association studies and expression profiling. ..
  3. pmc Cancer classification using the Immunoscore: a worldwide task force
    Jerome Galon
    INSERM, U872, Laboratory of Integrative Cancer Immunology, Paris, F 75006, France
    J Transl Med 10:205. 2012
    ..The results of this international validation may result in the implementation of the Immunoscore as a new component for the classification of cancer, designated TNM-I (TNM-Immune)...
  4. pmc Inferring genome-wide patterns of admixture in Qataris using fifty-five ancestral populations
    Larsson Omberg
    Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14853, USA
    BMC Genet 13:49. 2012
    ....
  5. pmc Genome scan study of prostate cancer in Arabs: identification of three genomic regions with multiple prostate cancer susceptibility loci in Tunisians
    Jingxuan Shan
    Laboratory of Genetic Medicine and Immunology, Weill Cornell Medical College in Qatar, Qatar Foundation, Doha, Qatar
    J Transl Med 11:121. 2013
    ..Large databases focused on genetic susceptibility to prostate cancer have been accumulated from population studies of different ancestries, including Europeans and African-Americans. Arab populations, however, have been only rarely studied...
  6. pmc The stable traits of melanoma genetics: an alternate approach to target discovery
    Tara L Spivey
    Infectious Disease and Immunogenetics Section IDIS, Department of Transfusion Medicine, Clinical Center and trans NIH Center for Human Immunology CHI, National Institutes of Health, Bethesda, MD 20892, USA
    BMC Genomics 13:156. 2012
    ..We hypothesized that genes steadily expressed by 15 melanoma cell lines (CMs) and their parental tissues (TMs) should be critical for oncogenesis and their expression most frequently influenced by their respective copy number...
  7. pmc Hereditary breast cancer in Middle Eastern and North African (MENA) populations: identification of novel, recurrent and founder BRCA1 mutations in the Tunisian population
    Wijden Mahfoudh
    Department of Molecular Immuno Oncology, Faculty of Medicine, 5019 Monastir, Tunisia
    Mol Biol Rep 39:1037-46. 2012
    ..This suggests that the c.798_799delTT mutation is a Tunisian founder mutation. Our findings indicate that the Tunisian population has a spectrum of prevalent BRCA1 mutations, some of which appear as recurrent and founding mutations...
  8. pmc An immunologic portrait of cancer
    Maria Libera Ascierto
    Infectious Disease and Immunogenetics Section IDIS, Department of Transfusion Medicine, Clinical Center and trans NIH Center for Human Immunology CHI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Transl Med 9:146. 2011
    ..Here we reflect on commonalities and discrepancies among studies and on the genetic or somatic conditions that may cause this schism in cancer behavior...
  9. pmc Medical education and research environment in Qatar: a new epoch for translational research in the Middle East
    Lotfi Chouchane
    Weill Cornell Medical College in Qatar, Education City, P, O, Box 24144, Doha, Qatar
    J Transl Med 9:16. 2011
    ....
  10. pmc Combined effects of IL-8 and CXCR2 gene polymorphisms on breast cancer susceptibility and aggressiveness
    Kaouther Snoussi
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Universite de Monastir, Monastir 5019, Tunisia
    BMC Cancer 10:283. 2010
    ..We also confirmed the implication of IL-8 (-251) T/A polymorphism in a larger cohort. Finally, we combined the IL-8 and CXCR2 variant alleles and analyzed their effects in breast cancer risk and prognosis...
  11. doi request reprint Functional vascular endothelial growth factor -2578 C/A polymorphism in relation to nasopharyngeal carcinoma risk and tumor progression
    Hela Ben Nasr
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, 5019 Monastir, Tunisia
    Clin Chim Acta 395:124-9. 2008
    ..In the current report, we designed a case-controlled study to evaluate whether a genetically predetermined variation in the VEGF expression may affect susceptibility and prognosis...
  12. ncbi request reprint Combined effects of the angiogenic genes polymorphisms on prostate cancer susceptibility and aggressiveness
    Sana Sfar
    Department of Molecular Immuno Oncology, Faculty of Medicine, 5019, Monastir, Tunisia
    Mol Biol Rep 36:37-45. 2009
    ..75, P = 0.002). These results suggest that the gene-gene interaction of angiogenic gene polymorphisms' increased risk of prostate cancer onset and aggressiveness...
  13. doi request reprint Calreticulin expression in infiltrating ductal breast carcinomas: relationships with disease progression and humoral immune responses
    Maria Kabbage
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Monastir, Tunisia
    Tumour Biol 34:1177-88. 2013
    ..Our findings also support a link between calreticulin expression and estrogen transduction pathways. Our results do not, however, support the involvement of calreticulin in the development of a humoral immune response in IDCAs...
  14. doi request reprint Synergistic effect and VEGF/HSP70-hom haplotype analysis: relationship to prostate cancer risk and clinical outcome
    Sana Sfar
    Department of Molecular Immuno Oncology, Faculty of Medicine, Monastir, Tunisia
    Hum Immunol 71:377-82. 2010
    ..28; p = 0.006). Our findings confirm the role of at-risk haplotype across the HSP70-hom/VEGF gene cluster in determining susceptibility to PCa...
  15. ncbi request reprint TSP1 and MMP9 genetic variants in sporadic prostate cancer
    Sana Sfar
    Department of Molecular Immuno Oncology, Faculty of Medicine, University of Monastir, Rue Avicenne 5019 Monastir, Tunisia
    Cancer Genet Cytogenet 172:38-44. 2007
    ..These findings suggest that MMP9 polymorphism is an independent risk factor of PCa development and aggressiveness...
  16. ncbi request reprint Association of IL-8 (-251)T/A polymorphism with susceptibility to and aggressiveness of nasopharyngeal carcinoma
    Hela Ben Nasr
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Monastir, Tunisia
    Hum Immunol 68:761-9. 2007
    ..Our findings suggest that the IL-8 promoter polymorphism is associated with increased nasopharyngeal carcinoma risk, particularly in males, as well as disease progress, supporting our hypothesis for IL-8 involvement in NPC pathogenesis...
  17. ncbi request reprint Tumor necrosis factor promoter gene polymorphism associated with increased susceptibility to non-Hodgkin's lymphomas
    Besma Bel Hadj Jrad
    Laboratoire d Immuno Oncologie Moleculaire, Université du Centre, Monastir, Tunisia
    Eur J Haematol 78:117-22. 2007
    ..Other epidemiologic studies carried out in both the Tunisian population and elsewhere are needed to confirm this finding...
  18. doi request reprint Expression of the molecular chaperone αB-crystallin in infiltrating ductal breast carcinomas and the significance thereof: an immunohistochemical and proteomics-based strategy
    Maria Kabbage
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Monastir, Tunisia
    Tumour Biol 33:2279-88. 2012
    ..Our findings do not, however, support the involvement of this molecular chaperone in the progression of this disease...
  19. ncbi request reprint Genetic variation in pro-inflammatory cytokines (interleukin-1beta, interleukin-1alpha and interleukin-6) associated with the aggressive forms, survival, and relapse prediction of breast carcinoma
    Kaouther Snoussi
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Universite de Monastir, 5019 Monastir, Tunisia
    Eur Cytokine Netw 16:253-60. 2005
    ..We designed a broad study to investigate the susceptibility and prognostic implications of the genetic variation in IL-1alpha, IL-1beta and IL-6 in breast carcinoma...
  20. ncbi request reprint PTGS2 (COX-2) -765 G > C functional promoter polymorphism and its association with risk and lymph node metastasis in nasopharyngeal carcinoma
    Hela Ben Nasr
    Faculte de medecine de Monastir, Universite de Monastir, Monastir, 5019, Tunisia
    Mol Biol Rep 36:193-200. 2009
    ....
  21. ncbi request reprint TAP1 gene polymorphisms and nasopharyngeal carcinoma risk in a Tunisian population
    Elham Hassen
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, 5019 Monastir, Tunisia
    Cancer Genet Cytogenet 175:41-6. 2007
    ..These results back up the fact that the etiology of NPC in intermediate-risk countries is completely different in each peak of age prevalence and that each peak may possess its own particular oncogenic mechanism...
  22. ncbi request reprint Detection of protein alterations in male breast cancer using two dimensional gel electrophoresis and mass spectrometry: the involvement of several pathways in tumorigenesis
    Karim Chahed
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Monastir, Tunisia
    Clin Chim Acta 388:106-14. 2008
    ..Little emphasis has been placed today on the elucidation of protein alterations in male breast carcinogenesis...
  23. doi request reprint TNRC9 downregulates BRCA1 expression and promotes breast cancer aggressiveness
    Jingxuan Shan
    Laboratory of Genetic Medicine and Immunology, Weill Cornell Medical College in Qatar Qatar Foundation, Qatar
    Cancer Res 73:2840-9. 2013
    ..Our studies unveil a function for TNRC9 in breast cancer that highlights a new paradigm in BRCA1 regulation...
  24. ncbi request reprint Matrix metalloproteinase-1 (-1607) 1G/2G and -9 (-1562) C/T promoter polymorphisms: susceptibility and prognostic implications in nasopharyngeal carcinomas
    Hela Ben Nasr
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, 5019 Monastir, Tunisia
    Clin Chim Acta 384:57-63. 2007
    ..The aim of this study was to investigate the susceptibility and prognostic implications of the MMP-1 (-1607) 1G/2G and MMP-9 (-1562) C/T polymorphisms in nasopharyngeal carcinomas...
  25. doi request reprint Expression and clinical significance of latent membrane protein-1, matrix metalloproteinase-1 and Ets-1 transcription factor in tunisian nasopharyngeal carcinoma patients
    Hela Ben Nasr
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Monastir, Tunisia
    Arch Med Res 40:196-203. 2009
    ..The aim of this study was to investigate the prognostic relevance of LMP-1 and its relationship with MMP-1 and Ets-1 expression in NPC biopsies...
  26. doi request reprint FASL-844 T/C polymorphism: a biomarker of good prognosis of breast cancer in the Tunisian population
    Wijden Mahfoudh
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Universite de Monastir, 5019 Monastir, Tunisia
    Hum Immunol 73:932-8. 2012
    ..53, P=0.06; OR=0.73, P=0.07, respectively). Thus, the FASL-844 CC genotype and C allele seem to be associated with a good prognosis in patients with diagnosis age ≤ 50 years...
  27. doi request reprint A single nucleotide polymorphism in the E-cadherin gene promoter -160 C/A is associated with risk of nasopharyngeal cancer
    Hela Ben Nasr
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, 5019 Monastir, Tunisia
    Clin Chim Acta 411:1253-7. 2010
    ..In the current study we investigated the impact of the functional C/A genetic polymorphism at -160 from transcriptional start site of the E-cadherin gene promoter on susceptibility and prognosis in NPC...
  28. doi request reprint Lack of association between human leukocyte antigen-E alleles and nasopharyngeal carcinoma in Tunisians
    Elham Hassen
    Molecular Immuno oncology Laboratory, Faculty of Medicine, Monastir University, Monastir, Tunisia
    DNA Cell Biol 30:603-9. 2011
    ..Our study further supports the dissimilarity of NPC between populations with different NPC incidence...
  29. ncbi request reprint Genetic variation in IL-8 associated with increased risk and poor prognosis of breast carcinoma
    Kaouther Snoussi
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Universite de Monastir, 5019 Monastir, Tunisia
    Hum Immunol 67:13-21. 2006
    ..The polymorphism in the promoter region of the IL-8 gene may not only represent a marker for the increased risk of breast carcinoma but also predict the clinical outcome...
  30. pmc Implication of Xenobiotic Metabolizing Enzyme gene (CYP2E1, CYP2C19, CYP2D6, mEH and NAT2) polymorphisms in breast carcinoma
    Achraf Khedhaier
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Tunisia
    BMC Cancer 8:109. 2008
    ..This study investigated the susceptibility and prognostic implications of the CYP2E1, CYP2C19, CYP2D6, mEH and NAT2 gene polymorphisms in breast carcinoma patients...
  31. doi request reprint Proteomics-based identification of alpha1-antitrypsin and haptoglobin precursors as novel serum markers in infiltrating ductal breast carcinomas
    Bechr Hamrita
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Tunisia
    Clin Chim Acta 404:111-8. 2009
    ..The identification of pathological markers of breast cancer for either diagnosis, treatment response or for survival is of critical importance...
  32. pmc Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma
    Kaouther Snoussi
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Universite de Monastir, Tunisia
    BMC Cancer 6:38. 2006
    ..Leptin exerts its physiological action through its specific receptor (LEPR). We have investigated whether genetic variations in LEP and LEPR have implications for susceptibility to and prognosis in breast carcinoma...
  33. doi request reprint Apolipoprotein A1 -75 G/A and +83 C/T polymorphisms: susceptibility and prognostic implications in breast cancer
    Bechr Hamrita
    Faculte de medecine de Monastir, Laboratoire d Immuno Oncologie Moleculaire, 5019 Monastir, Tunisia
    Mol Biol Rep 38:1637-43. 2011
    ..02). This is the first report on the studies of ApoA1 single nucleotide polymorphisms (SNPs) in breast carcinomas. Our data suggest that these genetic variations of ApoA1 may represent a marker for the increased risk of breast cancer...
  34. pmc Genome-Wide Association Studies (GWAS) breast cancer susceptibility loci in Arabs: susceptibility and prognostic implications in Tunisians
    Jingxuan Shan
    Genetic Medicine and Immunology Laboratory, Weill Cornell Medical College in Qatar, Qatar Foundation, Education City, P O Box 24144, Doha, Qatar
    Breast Cancer Res Treat 135:715-24. 2012
    ..In conclusion, GWAS breast cancer FGFR2, TNRC9, MAP3K1, and 8q24 loci are associated with an increased risk of breast cancer and genetic variation in FGFR2 gene may predict the aggressiveness of breast cancer in Tunisians...
  35. ncbi request reprint A polymorphism in FAS gene promoter associated with increased risk of nasopharyngeal carcinoma and correlated with anti-nuclear autoantibodies induction
    Besma Bel Hadj Jrad
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Université du Centre, 5019 Monastir, Tunisia
    Cancer Lett 233:21-7. 2006
    ..The FAS promoter polymorphism associated not only with the increased risk of nasopharyngeal carcinoma in Tunisians but also with immune response deregulation observed in this cancer...
  36. doi request reprint A novel CASR mutation in a Tunisian FHH/NSHPT family associated with a mental retardation
    Sana Sfar
    Research Unit 01 UR 08 14, Faculty of Medicine of Monastir, 5019 Monastir, Tunisia
    Mol Biol Rep 39:2395-400. 2012
    ..Our findings provide additional support for the implication of CASR gene in the FHH/NSHPT pathogenesis...
  37. ncbi request reprint Association of HSP70-hom genetic variant with prostate cancer risk
    Sana Sfar
    Department of Molecular Immuno Oncology, Faculty of Medicine, Monastir, Tunisia
    Mol Biol Rep 35:459-64. 2008
    ..This is the first report on the studies of HSP70 SNPs in PCa and our data suggest that this genetic variant may be a genetic marker for PCa susceptibility in Tunisians...
  38. ncbi request reprint Association of VEGF genetic polymorphisms with prostate carcinoma risk and clinical outcome
    Sana Sfar
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Universite de Monastir, Tunisia
    Cytokine 35:21-8. 2006
    ..We evaluated the role of the functional VEGF polymorphisms as genetic markers for PCa susceptibility and prognosis...
  39. doi request reprint Identification of tumor antigens that elicit a humoral immune response in breast cancer patients' sera by serological proteome analysis (SERPA)
    Bechr Hamrita
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Tunisia
    Clin Chim Acta 393:95-102. 2008
    ..In this study we applied a serological proteomics-based approach (SERPA) to identify tumor antigens that commonly induce a humoral immune response in patients with infiltrating ductal breast carcinomas...
  40. ncbi request reprint Expression of fibrinogen E-fragment and fibrin E-fragment is inhibited in the human infiltrating ductal carcinoma of the breast: the two-dimensional electrophoresis and MALDI-TOF-mass spectrometry analyses
    Karim Chahed
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Tunisia
    Int J Oncol 27:1425-31. 2005
    ..The identification of these differentially expressed proteins could lead to a better understanding of the molecular events linked to breast cancer progression...
  41. pmc Prevalence of the apolipoprotein E Arg145Cys dyslipidemia at-risk polymorphism in African-derived populations
    Maen D Abou Ziki
    Department of Genetic Medicine, Weill Cornell Medical College, New York, New York Department of Genetic Medicine, Weill Cornell Medical College Qatar, Doha, Qatar
    Am J Cardiol 113:302-8. 2014
    ..In conclusion, although larger epidemiologic studies are necessary to determine the long-term consequences of this polymorphism, the available evidence suggests it is a common cause of a mild triglyceride dyslipidemia. ..
  42. doi request reprint Combined analysis of interferon-gamma and interleukin-10 gene polymorphisms and chronic hepatitis C severity
    Nadia Bouzgarrou
    Molecular Immuno oncology Laboratory, Faculty of Medicine, Monastir, Tunisia
    Hum Immunol 70:230-6. 2009
    ..015). In conclusion, our findings suggest that the imbalance between the pro-inflammatory and anti-inflammatory responses mediated by polymorphisms in the IFNgamma and IL-10 genes may influence the outcome of chronic HCV infection...
  43. pmc Combined effect of pro- and anti-inflammatory cytokine gene polymorphisms on susceptibility to liver cirrhosis in Tunisian HCV-infected patients
    Nadia Bouzgarrou
    Molecular Immuno oncology Laboratory, Faculty of Medicine, Monastir, Tunisia
    Hepatol Int 5:681-7. 2011
    ..Interestingly, it has been demonstrated that a combination of specific genotypes may be a more significant and powerful approach for predicting disease risk...
  44. doi request reprint Epstein-Barr virus DNA quantification and follow-up in Tunisian nasopharyngeal carcinoma patients
    Elham Hassen
    Molecular Immuno oncology Laboratory, Faculty of Medicine, Monastir University, Monastir, Tunisia
    Biomarkers 16:274-80. 2011
    ..These results suggest that the EBV DNA load quantification after treatment may be a useful predictor of disease progression and survival...
  45. ncbi request reprint Genetic analysis of hereditary multiple exostoses in Tunisian families: a novel frame-shift mutation in the EXT1 gene
    Sana Sfar
    Department of Molecular Immuno Oncology, Faculty of Medicine, University of Monastir, Monastir, Tunisia
    Mol Biol Rep 36:661-7. 2009
    ..These findings provide additional support for the involvement of EXT1 gene in the HME disease...
  46. ncbi request reprint A functional polymorphism of the tumor necrosis factor receptor-II gene associated with the survival and relapse prediction of breast carcinoma
    Souhir Mestiri
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Université du Centre, Monastir, Tunisia
    Cytokine 30:182-7. 2005
    ..We investigated the susceptibility and prognostic implications of the genetic variation in the TNFRII in breast carcinoma...
  47. ncbi request reprint Polymorphism of the stress protein HSP70-2 gene is associated with the susceptibility to the nasopharyngeal carcinoma
    Majida Jalbout
    Laboratoire d Immuno Oncologie Moleculaire, Faculte de medecine de Monastir, Monastir 5019, Tunisia
    Cancer Lett 193:75-81. 2003
    ..In contrast, a significant relative risk of NPC was found associated with the HSP70-2 homozygous genotype (P2/P2) (OR=2.309; P=0.006). The P2/P2 genotype of the HSP70-2 gene may be a marker of increased risk of NPC in Tunisians...
  48. doi request reprint Genetic linkage study of an autosomal recessive form of juvenile myoclonic epilepsy in a consanguineous Tunisian family
    Samia Layouni
    Department of Physiology, Faculty of Medicine, Monastir, Tunisia
    Epilepsy Res 90:33-8. 2010
    ..3 and on 2q24.1. We decided to sequence the exons of the two genes coding for such proteins located in 2q23.3, CACNB4 and 2q24.1, KCNJ3. No nucleotide variation--comprising the previously reported mutations--was detected...