Yao Tseng Chen

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. pmc Chromosome X-encoded Cancer/Testis antigens are less frequently expressed in non-seminomatous germ cell tumors than in seminomas
    Yao Tseng Chen
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA
    Cancer Immun 13:10. 2013
  2. doi request reprint Chromosome X-encoded cancer/testis antigens show distinctive expression patterns in developing gonads and in testicular seminoma
    Yao Tseng Chen
    Weill Cornell Medical College, 1300 York Avenue, New York, NY 10021, USA
    Hum Reprod 26:3232-43. 2011
  3. doi request reprint MicroRNA analysis as a potential diagnostic tool for papillary thyroid carcinoma
    Yao Tseng Chen
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Mod Pathol 21:1139-46. 2008
  4. pmc Multiple cancer/testis antigens are preferentially expressed in hormone-receptor negative and high-grade breast cancers
    Yao Tseng Chen
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York, United States of America
    PLoS ONE 6:e17876. 2011
  5. ncbi request reprint Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome
    Yao Tseng Chen
    Weill Medical College of Cornell University, New York, New York 10021, USA
    Genes Chromosomes Cancer 45:392-400. 2006
  6. doi request reprint Cancer/testis antigen CT45: analysis of mRNA and protein expression in human cancer
    Yao Tseng Chen
    Departments of Pathology and Surgery, Weill Cornell Medical College, New York, NY 10065, USA
    Int J Cancer 124:2893-8. 2009
  7. ncbi request reprint Messenger RNA expression ratios among four genes predict subtypes of renal cell carcinoma and distinguish oncocytoma from carcinoma
    Yao Tseng Chen
    Department of Pathology and Laboratory Medicine, Weill Medical College, Cornell University, New York, NY 10021, USA
    Clin Cancer Res 11:6558-66. 2005
  8. pmc Identification of cancer/testis-antigen genes by massively parallel signature sequencing
    Yao Tseng Chen
    Weill Medical College of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:7940-5. 2005
  9. ncbi request reprint Vaccine-induced CD4+ T cell responses to MAGE-3 protein in lung cancer patients
    Djordje Atanackovic
    Ludwig Institute for Cancer Research, and Department of Human Immunogenetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 172:3289-96. 2004
  10. pmc Survey of naturally occurring CD4+ T cell responses against NY-ESO-1 in cancer patients: correlation with antibody responses
    Sacha Gnjatic
    Ludwig Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:8862-7. 2003

Detail Information

Publications82

  1. pmc Chromosome X-encoded Cancer/Testis antigens are less frequently expressed in non-seminomatous germ cell tumors than in seminomas
    Yao Tseng Chen
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA
    Cancer Immun 13:10. 2013
    ....
  2. doi request reprint Chromosome X-encoded cancer/testis antigens show distinctive expression patterns in developing gonads and in testicular seminoma
    Yao Tseng Chen
    Weill Cornell Medical College, 1300 York Avenue, New York, NY 10021, USA
    Hum Reprod 26:3232-43. 2011
    ..Cancer/testis (CT) antigens are cancer antigens normally expressed in adult testicular germ cells. The expression of chromosome X-encoded CT antigens (CT-X antigens) in human fetal gonads and in testicular seminomas was examined...
  3. doi request reprint MicroRNA analysis as a potential diagnostic tool for papillary thyroid carcinoma
    Yao Tseng Chen
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Mod Pathol 21:1139-46. 2008
    ..We concluded that miRNAs, particularly miR-146b, might potentially be adjunct markers for diagnosing papillary thyroid carcinoma in both FNA and surgical pathology specimens...
  4. pmc Multiple cancer/testis antigens are preferentially expressed in hormone-receptor negative and high-grade breast cancers
    Yao Tseng Chen
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York, United States of America
    PLoS ONE 6:e17876. 2011
    ..Although some previous studies found breast cancer to be "CT-poor", our recent analysis identified increased CT mRNA transcripts in the ER-negative subset of breast cancer...
  5. ncbi request reprint Identification of a new cancer/testis gene family, CT47, among expressed multicopy genes on the human X chromosome
    Yao Tseng Chen
    Weill Medical College of Cornell University, New York, New York 10021, USA
    Genes Chromosomes Cancer 45:392-400. 2006
    ..The only species other than human in which a gene homologous to CT47 has been detected is the chimpanzee, with the predicted protein showing approximately 80% identity in its carboxy terminal region...
  6. doi request reprint Cancer/testis antigen CT45: analysis of mRNA and protein expression in human cancer
    Yao Tseng Chen
    Departments of Pathology and Surgery, Weill Cornell Medical College, New York, NY 10065, USA
    Int J Cancer 124:2893-8. 2009
    ..In summary, the expression frequency and characteristics of CT45 expression are similar to other CT cancer vaccine targets currently in clinical trials, e.g., NY-ESO-1 and MAGE-A, suggesting CT45 as a potentially useful cancer target...
  7. ncbi request reprint Messenger RNA expression ratios among four genes predict subtypes of renal cell carcinoma and distinguish oncocytoma from carcinoma
    Yao Tseng Chen
    Department of Pathology and Laboratory Medicine, Weill Medical College, Cornell University, New York, NY 10021, USA
    Clin Cancer Res 11:6558-66. 2005
    ..Whether these renal tumors can be distinguished by their mRNA expression profile of a few selected genes was examined...
  8. pmc Identification of cancer/testis-antigen genes by massively parallel signature sequencing
    Yao Tseng Chen
    Weill Medical College of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:7940-5. 2005
    ..Thus, MPSS analysis has resulted in a significant extension of our knowledge of CT antigens, leading to the discovery of a distinctive X-linked CT-antigen gene family...
  9. ncbi request reprint Vaccine-induced CD4+ T cell responses to MAGE-3 protein in lung cancer patients
    Djordje Atanackovic
    Ludwig Institute for Cancer Research, and Department of Human Immunogenetics, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 172:3289-96. 2004
    ..This development provides the framework for further evaluating integrated immune responses in vaccine settings and for optimizing these responses for clinical benefit...
  10. pmc Survey of naturally occurring CD4+ T cell responses against NY-ESO-1 in cancer patients: correlation with antibody responses
    Sacha Gnjatic
    Ludwig Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:8862-7. 2003
    ....
  11. ncbi request reprint CT7 (MAGE-C1) antigen expression in normal and neoplastic tissues
    Achim A Jungbluth
    Ludwig Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Cancer 99:839-45. 2002
    ....
  12. ncbi request reprint Distinct but overlapping T helper epitopes in the 37-58 region of SSX-2
    Maha Ayyoub
    Ludwig Institute Clinical Trial Center, Division of Medical Oncology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Clin Immunol 114:70-8. 2005
    ..Retrieval of multiple overlapping epitopes in a defined region of SSX-2 protein suggests the presence of a "hot spot" for T cell recognition that may prove sufficient for the induction of immune responses...
  13. ncbi request reprint Identification of cancer/testis genes by database mining and mRNA expression analysis
    Matthew J Scanlan
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Cancer 98:485-92. 2002
    ..This study demonstrates the merits of database mining with respect to the identification of tissue-restricted gene products expressed in cancer...
  14. ncbi request reprint Cross-presentation of HLA class I epitopes from exogenous NY-ESO-1 polypeptides by nonprofessional APCs
    Sacha Gnjatic
    Ludwig Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 170:1191-6. 2003
    ..e., HLA eligibility criteria and knowledge of epitope, while allowing for facilitated immunogenicity in the presence of helper epitopes...
  15. ncbi request reprint CD4+ T cell responses to SSX-4 in melanoma patients
    Maha Ayyoub
    Ludwig Institute Clinical Trial Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Immunol 174:5092-9. 2005
    ....
  16. ncbi request reprint Identification of the gonad-specific anion transporter SLCO6A1 as a cancer/testis (CT) antigen expressed in human lung cancer
    Sang Yull Lee
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cancer Immun 4:13. 2004
    ..The analysis also permits us to estimate the eventual size of the SEREX-defined cancer immunome at around 4000 genes. This emphasizes the importance of continued SEREX screening to define the cancer immunome...
  17. pmc Immunomic analysis of human sarcoma
    Sang Yull Lee
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:2651-6. 2003
    ..NY-SAR-35 is therefore a potential target for cancer vaccines and monoclonal antibody-based immunotherapies...
  18. ncbi request reprint Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes
    Stephen Rohan
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    Clin Cancer Res 12:6937-45. 2006
    ..To compare gene expression profiles of chromophobe renal cell carcinoma (RCC) and benign oncocytoma, aiming at identifying differentially expressed genes...
  19. ncbi request reprint The SSX gene family: characterization of 9 complete genes
    Ali O Gure
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Int J Cancer 101:448-53. 2002
    ..These agents also induce SSX6, but not SSX3, 7, 8 or 9 in the tumor cell lines tested, indicating that mechanisms other than methylation or histone acetylation may be responsible for the repressed state of some SSX genes...
  20. ncbi request reprint NY-ESO-1: review of an immunogenic tumor antigen
    Sacha Gnjatic
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York 10021, USA
    Adv Cancer Res 95:1-30. 2006
    ..An overview of immunological findings and immunotherapeutic approaches with NY-ESO-1, as well the role of regulation in NY-ESO-1 immunogenicity, is presented here...
  21. pmc CD8(+) T cell responses against a dominant cryptic HLA-A2 epitope after NY-ESO-1 peptide immunization of cancer patients
    Sacha Gnjatic
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 99:11813-8. 2002
    ....
  22. pmc PLAC1, a trophoblast-specific cell surface protein, is expressed in a range of human tumors and elicits spontaneous antibody responses
    Wilson A Silva
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Immun 7:18. 2007
    ..We found by ELISA that PLAC1 is immunogenic in a subset of cancer patients and healthy women. Its physical and expression characteristics render it a potential target for both active and passive cancer immunotherapeutic strategies...
  23. ncbi request reprint Cancer/testis antigens: an expanding family of targets for cancer immunotherapy
    Matthew J Scanlan
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, Department of Pathology, New York, NY 10021, USA
    Immunol Rev 188:22-32. 2002
    ..Since CT antigens are immunogenic and highly restricted to tumors, their discovery has led directly to the development of antigen-specific cancer vaccines, and clinical trials with MAGE-A and NY-ESO-1 are in progress...
  24. ncbi request reprint Assessment of CD4+ T cells specific for the tumor antigen SSX-1 in cancer-free individuals
    Emmanuelle Godefroy
    Ludwig Institute Clinical Trial Center, Division of Medical Oncology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Cancer Immunol Immunother 56:1183-92. 2007
    ....
  25. ncbi request reprint Identification and characterization of mouse SSX genes: a multigene family on the X chromosome with restricted cancer/testis expression
    Yao Tseng Chen
    Weill Medical College of Cornell University, 10021, New York, NY, USA
    Genomics 82:628-36. 2003
    ..All putative human and mouse SSX proteins share conserved KRAB and SSX-RD domains. Mouse tumors were found to express some, but not all, Ssxb genes, similar to the SSX activation in human tumors...
  26. pmc Effects of CT-Xp gene knock down in melanoma cell lines
    Otavia L Caballero
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, USA
    Oncotarget 4:531-41. 2013
    ..Our results suggest that GAGE, XAGE1 and SSX4 might each have a role in tumor progression and are possible therapeutic targets for the treatment of melanoma and other malignancies...
  27. ncbi request reprint Identification of CT46/HORMAD1, an immunogenic cancer/testis antigen encoding a putative meiosis-related protein
    Yao Tseng Chen
    Weill Medical College, Cornell University, New York, NY 10021, USA
    Cancer Immun 5:9. 2005
    ..The CT46/HORMAD1 protein was found to be homologous to the prototype HORMA domain-containing protein, Hop1, a yeast meiosis-specific protein, as well as to asy1, a meiotic synaptic mutant protein in Arabidopsis thaliana...
  28. ncbi request reprint A new member of the NY-ESO-1 gene family is ubiquitously expressed in somatic tissues and evolutionarily conserved
    Birgit Alpen
    Weill Medical College of Cornell University, New York, NY 10021, USA
    Gene 297:141-9. 2002
    ..In addition, an intronless and presumably non-coding, copy of the mESO3, psimESO3, was identified on mouse chromosome 15. No counterpart of the ESO1 or 2 genes was found in rodents...
  29. ncbi request reprint SSX antigens as tumor vaccine targets in human sarcoma
    Maha Ayyoub
    Ludwig Institute Clinical Trial Center, Division of Medical Oncology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Cancer Immun 3:13. 2003
    ..The results of this study indicate that SSX antigens are relevant targets for the development of vaccine-based immunotherapy of sarcoma and encourage the start of vaccination trials using SSX-derived immunogens in sarcoma patients...
  30. ncbi request reprint A comprehensive study of nondysplastic and dysplastic serrated polyps of the vermiform appendix
    Rhonda K Yantiss
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA
    Am J Surg Pathol 31:1742-53. 2007
    ..These features, including BRAF mutations, may be more closely related to a serrated morphology in appendiceal polyps rather than biologically important changes...
  31. ncbi request reprint Serological analysis of expression cDNA libraries (SEREX): an immunoscreening technique for identifying immunogenic tumor antigens
    Yao Tseng Chen
    Weill Medical College of Cornell University and Ludwig Institute for Cancer Research, New York Branch, NY, USA
    Methods Mol Med 103:207-16. 2005
    ..Several tumor antigens identified by SEREX on various types of cancer indeed showed such characteristics and these antigens are being tested as targets for therapeutic cancer vaccines...
  32. ncbi request reprint The cancer-testis antigens CT7 (MAGE-C1) and MAGE-A3/6 are commonly expressed in multiple myeloma and correlate with plasma-cell proliferation
    Achim A Jungbluth
    New York Branch, Ludwig Institute for Cancer Research, New York, NY, USA
    Blood 106:167-74. 2005
    ..Furthermore, the common expression and correlation with proliferation suggest a possible pathogenic role for these proteins in myeloma...
  33. ncbi request reprint Diagnostic usefulness of HBME1, galectin-3, CK19, and CITED1 and evaluation of their expression in encapsulated lesions with questionable features of papillary thyroid carcinoma
    Theresa Scognamiglio
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Am J Clin Pathol 126:700-8. 2006
    ..These antibodies can have a confirmatory role in distinguishing the follicular variant of PTC and FA. For FL/QPTC, these antibodies are helpful in some cases, their limitation perhaps suggesting the biologic ambiguity of these lesions...
  34. ncbi request reprint Filiform serrated adenomas: a clinicopathologic and immunophenotypic study of 18 cases
    Rhonda K Yantiss
    Weill Medical College of Cornell University, Department of Pathology, New York, NY 10021, USA
    Am J Surg Pathol 31:1238-45. 2007
    ..We conclude that filiform SA potentially represents an unusual variant of SA with a predilection for the left colon, particularly the rectum...
  35. pmc Expression of cancer testis antigen CT45 in classical Hodgkin lymphoma and other B-cell lymphomas
    Yao Tseng Chen
    Department of Pathology, Weill Cornell Medical College, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 107:3093-8. 2010
    ....
  36. pmc MicroRNA expression aids the preoperative diagnosis of pancreatic ductal adenocarcinoma
    Nicole C Panarelli
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Pancreas 41:685-90. 2012
    ....
  37. pmc Seromic profiling of ovarian and pancreatic cancer
    Sacha Gnjatic
    Ludwig Institute for Cancer Research Ltd, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 107:5088-93. 2010
    ..Serological analysis of arrays displaying the complete human proteome (seromics) represents a new era in cancer immunology, opening the way to defining the repertoire of the humoral immune response to cancer...
  38. doi request reprint Identification of borderline thyroid tumors by gene expression array analysis
    Nimmi Arora
    Department of Surgery, New York Presbyterian Hospital Weill Cornell Medical Center, New York, New York 10065, USA
    Cancer 115:5421-31. 2009
    ..A subset of follicular lesions of the thyroid is encapsulated similar to follicular adenomas but with partial nuclear features suggestive of papillary thyroid carcinoma (PTC), raising the possibility of biologically borderline tumors...
  39. ncbi request reprint Cancer-related serological recognition of human colon cancer: identification of potential diagnostic and immunotherapeutic targets
    Matthew J Scanlan
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Cancer Res 62:4041-7. 2002
    ..In contrast, 9 of 9 colon cancer specimens showed overexpression of KNSL6 mRNA, ranging from 5 to 44 times the level detected in normal colon tissue, indicating that this antigen could also be a valuable therapeutic target...
  40. ncbi request reprint Gene fusions between TMPRSS2 and ETS family genes in prostate cancer: frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues
    Jiangling J Tu
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA
    Mod Pathol 20:921-8. 2007
    ..004). These morphological correlates, and more importantly the potential correlation of such fusions to clinical outcome and treatment responses, should be further explored...
  41. pmc CT-X antigen expression in human breast cancer
    Anita Grigoriadis
    Ludwig Institute for Cancer Research, 605 Third Avenue, New York, NY 10158, USA
    Proc Natl Acad Sci U S A 106:13493-8. 2009
    ..Because of the limited therapeutic options for ER-negative breast cancers, vaccines based on CT-X antigens might prove to be useful...
  42. ncbi request reprint Cancer/testis antigens, gametogenesis and cancer
    Andrew J G Simpson
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, New York 10021, USA
    Nat Rev Cancer 5:615-25. 2005
    ....
  43. doi request reprint Survivin as a useful adjunct marker for the grading of papillary urothelial carcinoma
    Ying bei Chen
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, 1300 York Ave, New York, NY 10065, USA
    Arch Pathol Lab Med 132:224-31. 2008
    ..Survivin, presumably an antiapoptotic protein, was previously proposed as a prognostic marker for urothelial carcinoma...
  44. ncbi request reprint Frequency of NY-ESO-1 and LAGE-1 expression in bladder cancer and evidence of a new NY-ESO-1 T-cell epitope in a patient with bladder cancer
    Padmanee Sharma
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Cancer Immun 3:19. 2003
    ..This patient's T-cell response was determined to be specific for a new NY-ESO-1 epitope, p94-102, in the context of HLA-B35...
  45. ncbi request reprint Identification of an SSX-2 epitope presented by dendritic cells to circulating autologous CD4+ T cells
    Maha Ayyoub
    Ludwig Institute Clinical Trial Center and Division of Medical Oncology, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Immunol 172:7206-11. 2004
    ..In contrast, it was efficiently presented by autologous dendritic cells, supporting the concept that processing by professional APC is the main pathway through which the CD4(+) T cell immunoresponse to tumor Ags occurs in vivo...
  46. doi request reprint Clonal relationship between closely approximated low-grade ductal and lobular lesions in the breast: a molecular study of 10 cases
    Patrick L Wagner
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY 10065, USA
    Am J Clin Pathol 132:871-6. 2009
    ..Instead, these traditionally segregated classes of breast cancer may, in fact, share common precursor lesions...
  47. ncbi request reprint Physical interaction of two cancer-testis antigens, MAGE-C1 (CT7) and NY-ESO-1 (CT6)
    Hearn J Cho
    Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Cancer Immun 6:12. 2006
    ..This is the first report of direct interaction between two CT antigens and may be pertinent in the light of the frequently coordinated expression of these proteins...
  48. ncbi request reprint Real-Time, label-free monitoring of tumor antigen and serum antibody interactions
    Christine Campagnolo
    Field of Microbiology, Cornell University, Ithaca, NY 14853, USA
    J Biochem Biophys Methods 61:283-98. 2004
    ..These results demonstrate the potential of SPR technology for the rapid diagnosis and monitoring immune responses...
  49. pmc Microarray analysis of thyroid nodule fine-needle aspirates accurately classifies benign and malignant lesions
    Carrie C Lubitz
    Department of Surgery, Weill Cornell Medical College, Room A 983, 510 East 70th St, New York, NY 10021, USA
    J Mol Diagn 8:490-8; quiz 528. 2006
    ..These results illustrate that microarray analysis of FNA is feasible and has the potential to improve the accuracy of FNA in categorizing benign from malignant lesions beyond routine cytological evaluation...
  50. doi request reprint Clinical, pathologic, and molecular features of early-onset colorectal carcinoma
    Rhonda K Yantiss
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA
    Am J Surg Pathol 33:572-82. 2009
    ..Posttranslational regulation of mRNA and subsequent protein expression may be particularly important to the development of colorectal carcinomas in young patients...
  51. pmc Intraepithelial CD8+ tumor-infiltrating lymphocytes and a high CD8+/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
    Eiichi Sato
    Ludwig Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:18538-43. 2005
    ..We conclude that intraepithelial CD8+ TILs and a high CD8+/Treg ratio are associated with favorable prognosis in epithelial ovarian cancer...
  52. doi request reprint Tissue-specific cadherin CDH17 is a useful marker of gastrointestinal adenocarcinomas with higher sensitivity than CDX2
    Nicole C Panarelli
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Am J Clin Pathol 138:211-22. 2012
    ..Thus, CDH17 is slightly more sensitive than CDX2 when detecting gastrointestinal adenocarcinomas...
  53. ncbi request reprint Diagnostic Accuracy of Cervical Low-Grade Squamous Intraepithelial Lesions Is Improved With MIB-1 Immunostaining
    Edyta C Pirog
    Department of Pathology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Am J Surg Pathol 26:70-5. 2002
    ..9) and the specificity (0.8) of HPV testing. In conclusion, MIB-1 is a highly sensitive and specific marker for identifying low-grade squamous intraepithelial lesion and is helpful in verifying the diagnosis of equivocal cases...
  54. doi request reprint Immunohistochemical and molecular features of sporadic and FAP-associated duodenal adenomas of the ampullary and nonampullary mucosa
    Patrick L Wagner
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10021, USA
    Am J Surg Pathol 32:1388-95. 2008
    ..Similar to colorectal adenomas, they harbor APC and KRAS mutations; but BRAF mutations, p53 alterations, and DNA mismatch repair abnormalities are rare...
  55. ncbi request reprint p53 in esophageal adenocarcinoma: a critical reassessment of mutation frequency and identification of 72Arg as the dominant allele
    Sun M Chung
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA
    Int J Oncol 31:1351-5. 2007
    ..We concluded that p53 is insufficient as a single marker for Barrett's esophagus monitoring but may be useful as part of a panel due to its high specificity...
  56. pmc IFN-gamma enables cross-presentation of exogenous protein antigen in human Langerhans cells by potentiating maturation
    Mitsutoshi Matsuo
    Ludwig Institute for Cancer Research, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:14467-72. 2004
    ..This model of conditional cross-presentation establishes an original level of action for IFN-gamma as an effective immune modulator and supports the use of IFN-gamma in protein vaccination strategies targeting LCs...
  57. doi request reprint Autoantibodies against cancer antigens
    Sacha Gnjatic
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Methods Mol Biol 520:11-9. 2009
    ..We describe in this chapter a simple implementation of a serological monitoring platform for autoantibody measurement in cancer patients, from production of recombinant antigens to ELISA testing and interpretation...
  58. ncbi request reprint Expression of cancer/testis (CT) antigens MAGE-A1, MAGE-A3, MAGE-A4, CT-7, and NY-ESO-1 in malignant gammopathies is heterogeneous and correlates with site, stage and risk status of disease
    Madhav V Dhodapkar
    Laboratory of Tumor Immunology and Immunotherapy, The Rockefeller University, New York, NY 10021, USA
    Cancer Immun 3:9. 2003
    ..These data suggest that CT antigens may have important biological implications in malignant gammopathies and that CT-7 may be a suitable target for T cell-based and possibly antibody-mediated immunotherapy of myeloma...
  59. doi request reprint Combined small cell lung carcinomas: genotypic and immunophenotypic analysis of the separate morphologic components
    Patrick L Wagner
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, NY, USA
    Am J Clin Pathol 131:376-82. 2009
    ..The prevalent expression of synaptophysin and CD56 and loss of 22q13 suggest that these tumors are biologically closer to SCLC...
  60. doi request reprint Expression of cancer/testis (CT) antigens in squamous cell carcinoma of the head and neck: evaluation as markers of squamous dysplasia
    Kathryn C Piotti
    Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA Electronic address
    Pathol Res Pract 209:721-6. 2013
    ..The usefulness of CT antigens as positive predictors for SCC in squamous dysplasia biopsies remains to be determined by long-term follow-up in larger cohorts. ..
  61. doi request reprint Serrated polyps with "intermediate features" of sessile serrated polyp and microvesicular hyperplastic polyp: a practical approach to the classification of nondysplastic serrated polyps
    Sun M Chung
    Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA
    Am J Surg Pathol 32:407-12. 2008
    ....
  62. ncbi request reprint Expression and immunogenicity of NY-ESO-1 in hepatocellular carcinoma
    Shinichiro Nakamura
    Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    J Gastroenterol Hepatol 21:1281-5. 2006
    ....
  63. ncbi request reprint Expression of cancer/testis (CT) antigens in lung cancer
    Kouhei Tajima
    Division of Immunology, Aichi Cancer Center Research Institute, 1 1, Kanokoden, Chikusa ku, Nagoya, Aichi 464 8681, Japan
    Lung Cancer 42:23-33. 2003
    ..In addition, in silico surveys of dbEST database were used for identification of new CT antigens. We identified a novel gene, TES101RP, expressed only in some small cell lung cancers (SCLC) and in testis, as confirmed by RT-PCR analysis...
  64. ncbi request reprint NY-ESO-1 mRNA expression and immunogenicity in advanced prostate cancer
    Tetsuya Nakada
    Department of Immunology, Okayama University Graduate School of Medicine and Dentistry, Japan
    Cancer Immun 3:10. 2003
    ..CD8 T cell responses specific to NY-ESO-1 were detected in two of three patients with NY-ESO-1 antibodies...
  65. ncbi request reprint Quantitative real-time RT-PCR analysis of NY-ESO-1 and LAGE-1a mRNA expression in normal tissues and tumors, and correlation of the protein expression with the mRNA copy number
    Shuichiro Sato
    Department of Immunology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
    Int J Oncol 26:57-63. 2005
    ..B9.8-specific staining was observed weakly and focally in one liver cancer specimen expressing >10(5) copies of LAGE-1a mRNA...
  66. ncbi request reprint Identification of a naturally processed NY-ESO-1 peptide recognized by CD8+ T cells in the context of HLA-B51
    Elke Jager
    II Medizinische Klinik, Hämatologie Onkologie, Krankenhaus Nordwest, Frankfurt, Germany
    Cancer Immun 2:12. 2002
    ....
  67. ncbi request reprint Expression of cancer-testis genes in human hepatocellular carcinomas
    Guorong Luo
    Department of Embryology, Guangxi Medical University, China
    Cancer Immun 2:11. 2002
    ..However, the identification of additional tumor-specific antigens with a frequent expression in HCCs is warranted to develop widely applicable, polyvalent HCC vaccines...
  68. ncbi request reprint HLA-DP4 expression and immunity to NY-ESO-1: correlation and characterization of cytotoxic CD4+ CD25- CD8- T cell clones
    Eduardo Huarte
    II Medizinische Klinik, Hämatologie Onkologie, Krankenhaus Nordwest, Frankfurt, Germany
    Cancer Immun 4:15. 2004
    ..The Th1 phenotype and effector functions of the CD4+ T cell clones described here provide an important rationale for the activation of antigen-specific CD4+ T cells along with CD8+ T cells in cancer vaccination strategies...
  69. ncbi request reprint Urine antibody against human cancer antigen NY-ESO-1
    Dirk Jager
    II Medizinische Klinik, Hämatologie Onkologie, Krankenhaus Nordwest, Frankfurt, Germany
    Cancer Immun 2:10. 2002
    ..Urine antibody detection may also be of value in the monitoring of spontaneous and vaccine-induced immunity against other defined tumor antigens...
  70. ncbi request reprint Immunohistochemical and molecular analysis of human melanomas for expression of the human cancer-testis antigens NY-ESO-1 and LAGE-1
    Hilary A Vaughan
    Ludwig Institute for Cancer Research, Melbourne, Australia
    Clin Cancer Res 10:8396-404. 2004
    ..This study evaluates typing strategies used to distinguish these two homologous but distinct antigens and to characterize and quantitate expression of each in clinical samples...
  71. ncbi request reprint Identification of tumor-restricted antigens NY-BR-1, SCP-1, and a new cancer/testis-like antigen NW-BR-3 by serological screening of a testicular library with breast cancer serum
    Dirk Jager
    II Medizinische Klinik, Hämatologie Onkologie, Krankenhaus Nordwest, Frankfurt, Germany
    Cancer Immun 2:5. 2002
    ..This study provides further evidence that SEREX is a powerful tool to identify new tumor antigens potentially relevant for immunotherapy approaches...
  72. ncbi request reprint NY-ESO-1 and LAGE-1 cancer-testis antigens are potential targets for immunotherapy in epithelial ovarian cancer
    Kunle Odunsi
    Division of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 63:6076-83. 2003
    ..These findings indicate that NY-ESO-1 and LAGE-1 are attractive targets for antigen-specific immunotherapy in EOC...
  73. ncbi request reprint NY-ESO-1 expression and immunogenicity in malignant and benign breast tumors
    Yurika Sugita
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita City, Osaka 565 0871, Japan
    Cancer Res 64:2199-204. 2004
    ....
  74. ncbi request reprint Distinct expression patterns of the immunogenic differentiation antigen NY-BR-1 in normal breast, testis and their malignant counterparts
    Jean Philippe Theurillat
    Institute of Surgical Pathology, Department Pathology, University Hospital of Zurich, Switzerland
    Int J Cancer 122:1585-91. 2008
    ..Accordingly, analysis of matching pairs of primary tumors with their recurrences showed a marked decrease of NY-BR-1 expression in recurrences after tamoxifen treatment (p < 0.0001)...
  75. doi request reprint ECSA/DPPA2 is an embryo-cancer antigen that is coexpressed with cancer-testis antigens in non-small cell lung cancer
    Thomas John
    Ludwig Institute for Cancer Research, Melbourne Centre for Clinical Sciences, Victoria, Australia
    Clin Cancer Res 14:3291-8. 2008
    ..We hypothesized that ECSA/DPPA2 would be quiescent in most normal tissues but expressed in cancers and may therefore be a useful target for immunotherapy...
  76. pmc Recombinant NY-ESO-1 protein with ISCOMATRIX adjuvant induces broad integrated antibody and CD4(+) and CD8(+) T cell responses in humans
    Ian D Davis
    Ludwig Institute for Cancer Research, Melbourne 3084, Australia
    Proc Natl Acad Sci U S A 101:10697-702. 2004
    ..In an unplanned analysis, vaccinated patients appeared to have superior clinical outcomes to those treated with placebo or protein alone. The vaccine is safe and highly potent immunologically...
  77. ncbi request reprint [Expression of multiple cancer-testis antigen genes in non-small cell lung cancer treated by chemotherapy prior surgery]
    Yu Wang
    Typing and Monitoring Laboratory, Beijing Cancer Hospital, Beijing 100083, China
    Zhonghua Yi Xue Za Zhi 84:464-8. 2004
    ..To investigate the possibility of utilizing cancer-testi (CT) antigens as targets for immunotherapy of non-small cell lung cancer (NSCLC) with vaccines...
  78. ncbi request reprint NY-ESO-1 expression and immunogenicity in esophageal cancer
    Shoichiro Fujita
    Department of Surgery and Clinical Oncology, Graduate School of Medicine, Osaka University, Osaka, Japan
    Clin Cancer Res 10:6551-8. 2004
    ..We report here the frequency of NY-ESO-1 mRNA and protein expression in esophageal cancer and the presence of NY-ESO-1-specific immune response in patients...
  79. ncbi request reprint Antigen-specific immunity in neuroblastoma patients: antibody and T-cell recognition of NY-ESO-1 tumor antigen
    Monica Rodolfo
    Units of Melanoma Genetics, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milan, Italy
    Cancer Res 63:6948-55. 2003
    ..We conclude that NY-ESO-1 is an immunogenic antigen in neuroblastoma patients and represents a candidate target for immune-based therapy...
  80. ncbi request reprint NY-ESO-1 protein expression in primary breast carcinoma and metastases: correlation with CD8+ T-cell and CD79a+ plasmacytic/B-cell infiltration
    Jean Philippe Theurillat
    Department Pathology, Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland
    Int J Cancer 120:2411-7. 2007
    ..These findings suggest that NY-ESO-1-positive breast cancers represent a small subset of poorly differentiated tumors with evidence of cellular and humoral immune response...
  81. ncbi request reprint Cancer/testis antigen expression and autologous humoral immunity to NY-ESO-1 in gastric cancer
    Yu Wang
    Typing and Monitoring Laboratory, Beijing Cancer Hospital, Beijing 100036, China
    Cancer Immun 4:11. 2004
    ..About 74% of the samples expressed at least one CT antigen, most frequently MAGE-3 (41.6%). NY-ESO-1 and MAGE-3 are thus potential targets for a multivalent CT antigen vaccine...
  82. ncbi request reprint NY-BR-1 protein expression in breast carcinoma: a mammary gland differentiation antigen as target for cancer immunotherapy
    Jean Philippe Theurillat
    Institute for Surgical Pathology, Department of Pathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091, Zurich, Switzerland
    Cancer Immunol Immunother 56:1723-31. 2007
    ....