Research Topics
Genomes and GenesSpecies | Marie A CaudillSummaryAffiliation: Cornell University Country: USA Publications
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Publications
Choline intake, plasma riboflavin, and the phosphatidylethanolamine N-methyltransferase G5465A genotype predict plasma homocysteine in folate-deplete Mexican-American men with the methylenetetrahydrofolate reductase 677TT genotypeMarie A Caudill
Division of Nutritional Sciences and Genomics, Cornell University, Ithaca, NY 14853, USA
J Nutr 139:727-33. 2009..001); an effect confined to the MTHFR 677TT genotype. Thus, in folate-deplete men, several factors with roles in 1-carbon metabolism interact with the MTHFR C677T genotype to affect plasma tHcy...
Folate bioavailability: implications for establishing dietary recommendations and optimizing statusMarie A Caudill
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
Am J Clin Nutr 91:1455S-1460S. 2010....
Pre- and postnatal health: evidence of increased choline needsMarie A Caudill
Cornell University, Division of Nutritional Sciences, 228 Savage Hall, Ithaca, NY, USA
J Am Diet Assoc 110:1198-206. 2010..Because choline is not found in most varieties of prenatal vitamins (or regular multivitamins), increased consumption of choline-rich foods may be needed to meet the high pre- and postnatal demands for choline...
Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfurationMartha S Field
Division of Nutritional Science, Cornell University, Ithaca, NY, USA
J Nutr 143:41-5. 2013....
Maternal choline intake alters the epigenetic state of fetal cortisol-regulating genes in humansXinyin Jiang
Division of Nutritional Sciences and Genomics, Cornell University, Ithaca, NY 14853, USA
FASEB J 26:3563-74. 2012..These data collectively suggest that maternal choline intake in humans modulates the epigenetic state of genes that regulate fetal HPA axis reactivity as well as the epigenomic status of fetal derived tissues...
Folate-status response to a controlled folate intake in nonpregnant, pregnant, and lactating womenAllyson A West
Division of Nutritional Science, Cornell University, Ithaca, NY, USA
Am J Clin Nutr 96:789-800. 2012..Folate dose-response studies in women of childbearing age who consumed a folic acid (FA)-containing multivitamin in the era of FA fortification are lacking...
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humansJian Yan
Division of Nutritional Science, Cornell University, Ithaca, NY 14583, USA
Am J Clin Nutr 95:1060-71. 2012..However, to our knowledge, no dose-response studies have been conducted to evaluate the effects of pregnancy or maternal choline intake on biomarkers of choline metabolism...
Pregnancy induces transcriptional activation of the peripheral innate immune system and increases oxidative DNA damage among healthy third trimester pregnant womenXinyin Jiang
Division of Nutritional Sciences, Cornell University, Ithaca, New York, United States of America
PLoS ONE 7:e46736. 2012..Nevertheless, the interplay between human pregnancy, choline and the human genome is largely unexplored...
A higher maternal choline intake among third-trimester pregnant women lowers placental and circulating concentrations of the antiangiogenic factor fms-like tyrosine kinase-1 (sFLT1)Xinyin Jiang
Division of Nutritional Sciences, Cornell University, 228 Savage Hall, Ithaca, NY 14853, USA
FASEB J 27:1245-53. 2013..These findings indicate that supplementing the maternal diet with extra choline may improve placental angiogenesis and mitigate some of the pathological antecedents of preeclampsia...
Genetic variation: impact on folate (and choline) bioefficacyAllyson A West
Division of Nutritional Sciences and Genomics, Cornell University, Ithaca, NY, USA
Int J Vitam Nutr Res 80:319-29. 2010..Nutrient-gene and gene-gene interactions will be considered along with the need to account for these genetic variants when updating dietary folate and choline recommendations...
MTHFR C677T genotype influences the isotopic enrichment of one-carbon metabolites in folate-compromised men consuming d9-cholineJian Yan
Division of Nutritional Sciences and Genomics, Cornell University, Ithaca, NY 14853, USA
Am J Clin Nutr 93:348-55. 2011..The choline adequate intake is 550 mg/d for men, although the metabolic consequences of consuming extra choline are unclear...
Choline intake influences phosphatidylcholine DHA enrichment in nonpregnant women but not in pregnant women in the third trimesterAllyson A West
Division of Nutritional Science, Cornell University, Ithaca, NY 14853, USA
Am J Clin Nutr 97:718-27. 2013..It is unknown whether choline, which can serve as a source of S-adenosylmethionine methyl groups, influences PC-DHA or the PC:PE ratio in pregnant and nonpregnant women...
A UV-responsive internal ribosome entry site enhances serine hydroxymethyltransferase 1 expression for DNA damage repairJennifer T Fox
Graduate Field of Biochemistry and Molecular and Cellular Biology, Cornell University, Ithaca, New York 14853, USA
J Biol Chem 284:31097-108. 2009....
Genetic and epigenetic contributions to human nutrition and health: managing genome-diet interactionsPatrick J Stover
Cornell University, Division of Nutritional Sciences, Ithaca, NY 14853, USA
J Am Diet Assoc 108:1480-7. 2008....
