Research Topics
Genomes and Genes | BETTY CASEYSummaryAffiliation: Cornell University Country: USA Publications
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Publications
Neuroscience. Windows into the human brainB J Casey
Sackler Institute for Developmental Psychobiology, Department of Psychiatry, Weill Medical College, Cornell University, New York, NY 10021, USA
Science 296:1408-9. 2002- Early development of subcortical regions involved in non-cued attention switchingB J Casey
Sackler Institute, Weill Medical College of Cornell University, New York, NY 10021, USA
Dev Sci 7:534-42. 2004..These results suggest an important role of subcortical regions (i.e. caudate nucleus) in non-cued attention switching, with increasing recruitment of cortical regions with age... - MR quantitation of volume and diffusion changes in the developing brainLijuan Zhang
Department of Radiology, Weill Medical College of Cornell University, New York, NY 10021, USA
AJNR Am J Neuroradiol 26:45-9. 2005..The brain model used in this study provides a good estimate of the increasing brain volume... 
Special considerations for functional magnetic resonance imaging of pediatric populationsEleni Kotsoni
Sackler Institute for the Developmental Psychobiology, Weill Medical College of Cornell University, Ithaca, New York 10021, USA
J Magn Reson Imaging 23:877-86. 2006..Finally, we emphasize the importance of a converging methods approach in constraining and supporting interpretations of pediatric imaging results...
Treating the developing brain: implications from human imaging and mouse geneticsB J Casey
Sackler Institute for Developmental Psychology, Department of Psychiatry
Annu Rev Med 64:427-39. 2013..Based on these findings, we provide future directions for determining the efficacy of innovative therapies and preventive strategies for anxiety disorders as a function of age and potential genetic effects inferred from mice and humans...- Changes in cerebral functional organization during cognitive developmentB J Casey
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, 1300 York Avenue, Box 140, New York, NY 10021, USA
Curr Opin Neurobiol 15:239-44. 2005.... - Imaging the developing brain: what have we learned about cognitive development?B J Casey
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, 1300 York Avenue, Box 140, New York, NY 10021, USA
Trends Cogn Sci 9:104-10. 2005..Brain regions associated with more basic functions such as sensory and motor processes mature first, followed by association areas involved in top-down control of behavior... - Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across developmentB J Casey
Weill Cornell Medical College, New York, NY 10065, USA
Neuroscience 164:108-20. 2009..The findings illustrate the use of a genetic mouse model that mimics the human polymorphism, to constrain the interpretation of gene-environment interactions across development in humans... - The adolescent brainB J Casey
Sackler Institute, Weill Cornell Medical College of Cornell University, 1300 York Avenue, Box 140, New York, NY 10021, USA
Ann N Y Acad Sci 1124:111-26. 2008..This developmental pattern may be exacerbated in those adolescents prone to emotional reactivity, increasing the likelihood of poor outcomes... - Brain plasticity, learning, and developmental disabilitiesB J Casey
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York 10021, USA
Ment Retard Dev Disabil Res Rev 9:133-4. 2003..This issue reflects a sampling of current approaches to the study of brain plasticity, development and learning in typically and atypically developing humans and animals... - Imaging genetics and development: challenges and promisesB J Casey
Department of Psychiatry, Sackler Institute, Weill Cornell Medical College, New York, New York, USA
Hum Brain Mapp 31:838-51. 2010..Each of these approaches alone, provide limited information on gene function in complex human behavior, but together, they are forming bridges between animal models and human psychiatric disorders... - Dissociating striatal and hippocampal function developmentally with a stimulus-response compatibility taskB J Casey
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York 10021, USA
J Neurosci 22:8647-52. 2002.... - The storm and stress of adolescence: insights from human imaging and mouse geneticsB J Casey
Sackler Institute for Developmental Psychobiology, Weil Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA
Dev Psychobiol 52:225-35. 2010..Together, these studies provide a converging methods approach for understanding the highly variable stress and turmoil experienced in adolescence... - Adolescence: what do transmission, transition, and translation have to do with it?B J Casey
Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College, 1300 York Avenue, Box 140, New York, NY 10065, USA
Neuron 67:749-60. 2010..This review examines changes in explorative and emotive behaviors during the transition into and out of adolescence and the underlying neurobiological bases in the context of adaptive and maladaptive functions... - Behavioral and neural correlates of delay of gratification 40 years laterB J Casey
Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College, New York, NY 10065, USA
Proc Natl Acad Sci U S A 108:14998-5003. 2011.... - Transitional and translational studies of risk for anxietyB J Casey
Sackler Institute for Developmental Psychobiology, Weil Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA
Depress Anxiety 28:18-28. 2011..Together, they reflect an emerging field of translational developmental neuroscience in forming important bridges between animal models of neurodevelopmental and neuropsychiatric disorders... - Neurobiology of the adolescent brain and behavior: implications for substance use disordersB J Casey
Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College, New York, NY 10065, USA
J Am Acad Child Adolesc Psychiatry 49:1189-201; quiz 1285. 2010..Understanding how the brain is changing during this period relative to childhood and adulthood and how these changes vary across individuals are key in predicting risk for later substance abuse and dependence... - Biological substrates of emotional reactivity and regulation in adolescence during an emotional go-nogo taskTodd A Hare
The Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York, USA
Biol Psychiatry 63:927-34. 2008..Individual differences in emotional reactivity might put some teens at greater risk during this sensitive transition in development... - Processing emotional facial expressions influences performance on a Go/NoGo task in pediatric anxiety and depressionCecile D Ladouceur
Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213, USA
J Child Psychol Psychiatry 47:1107-15. 2006..This study investigated whether processing emotionally salient information such as emotional facial expressions influences the performance on a cognitive control task in pediatric anxiety and depression... - Prolonged institutional rearing is associated with atypically large amygdala volume and difficulties in emotion regulationNim Tottenham
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, USA
Dev Sci 13:46-61. 2010..These changes in limbic circuitry may underlie residual emotional and social problems experienced by children who have been internationally adopted... - Parametric manipulation of conflict and response competition using rapid mixed-trial event-related fMRIS Durston
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, NY 10021, USA
Neuroimage 20:2135-41. 2003.... - Intentional false responding shares neural substrates with response conflict and cognitive controlJennifer Maria Nuñez
Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY 10021, USA
Neuroimage 25:267-77. 2005.... - Contributions of the hippocampus and the striatum to simple association and frequency-based learningDima Amso
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, 1300 York Avenue, Box 140, New York, NY 10021, USA
Neuroimage 27:291-8. 2005..This work provides evidence of different neural mechanisms underlying learning based on simple frequencies versus associations within a single paradigm... - Risk-taking and the adolescent brain: who is at risk?Adriana Galvan
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, NY 10021, USA
Dev Sci 10:F8-F14. 2007.... - A time of change: behavioral and neural correlates of adolescent sensitivity to appetitive and aversive environmental cuesLeah H Somerville
Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College, New York, NY 10065, USA
Brain Cogn 72:124-33. 2010..Finally, we discuss other influences that may contribute to exaggerated reward and emotion processing associated with adolescence, including hormonal fluctuations and the role of the social environment... - Variant brain-derived neurotrophic factor Val66Met endophenotypes: implications for posttraumatic stress disorderHelena Frielingsdorf
The Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York 10065, USA
Ann N Y Acad Sci 1208:150-7. 2010..The aim of this paper is to review the available knowledge on the BDNF Val66Met SNP, with emphasis on anxiety- and fear-related endophenotypes and its potential implications for PTSD... - The aftermath of 9/11: effect of intensity and recency of trauma on outcomeBarbara Ganzel
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, Ithaca, NY 14853, USA
Emotion 7:227-38. 2007..These data are consistent with a model of heightened amygdala reactivity following high-intensity trauma exposure, with relatively slow recovery... - Neural and behavioral correlates of expectancy violations in attention-deficit hyperactivity disorderSarah Durston
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, USA
J Child Psychol Psychiatry 48:881-9. 2007..Therefore, we hypothesized that the ability to predict the occurrence of frequent events would be compromised in ADHD, as well as the ability to adapt behavior when expectancy was violated... - Frontostriatal connectivity and its role in cognitive control in parent-child dyads with ADHDB J Casey
Sackler Institute, Weill Cornell Medical College of Cornell University, 1300 York Ave, Box 140, New York, NY 10021, USA
Am J Psychiatry 164:1729-36. 2007..Few studies have examined the role of white matter tracts between these structures or the extent to which white matter tract myelination and regularity correlate in family members with the disorder... - Differential cingulate and caudate activation following unexpected nonrewarding stimuliM C Davidson
Sackler Institute for Devevelopmental Psychobiology, Weill Medical College of Cornell University, 1300 York Avenue, Box 140, New York, NY 10021, USA
Neuroimage 23:1039-45. 2004.... - Developmental neurobiology of cognitive control and motivational systemsLeah H Somerville
Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College, NY, USA
Curr Opin Neurobiol 20:236-41. 2010.... - Neuroanatomical abnormalities in adolescents with attention-deficit/hyperactivity disorderAmy Garrett
Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry, Stanford University, CA 94305 5795, USA
J Am Acad Child Adolesc Psychiatry 47:1321-8. 2008..However, findings are not always consistent, perhaps because of heterogeneous subject samples. Studying youths with documented familial ADHD provides an opportunity to examine a more homogeneous population... - The bivalent side of the nucleus accumbensLiat Levita
Sackler Institute for Developmental Psychobiology, Institute of Psychiatry, Weill Cornell Medical College, New York, NY, USA
Neuroimage 44:1178-87. 2009..Our results support the expanded bivalent view of NAcc function and call for expansion of current models of NAcc function that are solely focused on reward... - A genetic variant BDNF polymorphism alters extinction learning in both mouse and humanFatima Soliman
The Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College, New York, NY 10065, USA
Science 327:863-6. 2010..Thus, this variant BDNF allele may play a role in anxiety disorders showing impaired learning of cues that signal safety versus threat and in the efficacy of treatments that rely on extinction mechanisms, such as exposure therapy... - The NimStim set of facial expressions: judgments from untrained research participantsNim Tottenham
Sackler Institute for Developmental Psychobiology, Weill Cornell Medical College, New York, NY 10021, USA
Psychiatry Res 168:242-9. 2009..The results lend empirical support for the validity and reliability of this set of facial expressions as determined by accurate identification of expressions and high intra-participant agreement across two testing sessions, respectively... - Psychosocial stress reversibly disrupts prefrontal processing and attentional controlC Liston
Department of Psychiatry, Weill Medical College of Cornell University, 1300 York Avenue, Box 140, New York, NY 10021, USA
Proc Natl Acad Sci U S A 106:912-7. 2009.... - Dissociation of response conflict, attentional selection, and expectancy with functional magnetic resonance imagingB J Casey
Sackler Institute, Weill Medical College of Cornell University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 97:8728-33. 2000..These data provide a systems-level approach in understanding integrated attentional networks... - Altered emotional processing in pediatric anxiety, depression, and comorbid anxiety-depressionCecile D Ladouceur
Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Abnorm Child Psychol 33:165-77. 2005..Further, research is needed to replicate this study and delineate underlying neural mechanisms... - Contributions of amygdala and striatal activity in emotion regulationTodd A Hare
Sackler Institute, Weill Medical College of Cornell University, NY 10021, USA
Biol Psychiatry 57:624-32. 2005..Emotional information can facilitate or interfere with cognitive processes. In this study, we examined the influence of emotional information in biasing performance and the biological basis underlying this influence... - Exploring genetic influences on cognition: emerging strategies for target validation and treatment optimizationJohn A Fossella
The Sackler Institute for Developmental Psychobiology, Weill Medical College Cornell University, 1300 York Ave, New York, NY 10021, USA
Curr Drug Targets CNS Neurol Disord 2:357-62. 2003..This review describes some well-known findings that are at the forefront of this interface. The progress already made indicates that the goals of the new initiative are well founded and achievable... - Imaging the developing brain with fMRIM C Davidson
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York 10021, USA
Ment Retard Dev Disabil Res Rev 9:161-7. 2003..These methodologies and their application to development and learning are discussed in the current paper... - Differential patterns of striatal activation in young children with and without ADHDSarah Durston
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York 10021, USA
Biol Psychiatry 53:871-8. 2003..ADHD children show a slightly different cognitive profile at 6 to 10 years of age that is paralleled by a relative lack of or delay in the maturation of ventral frontostriatal circuitry... - Amygdala response to fearful faces in anxious and depressed childrenK M Thomas
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, 1300 York Ave, Box 140, Suite F 1332, New York, NY 10021
Arch Gen Psychiatry 58:1057-63. 2001..We hypothesized that children with anxiety and depression may show atypical amygdala responses to emotional stimuli... - Sensitivity of prefrontal cortex to changes in target probability: a functional MRI studyB J Casey
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York 10021, USA
Hum Brain Mapp 13:26-33. 2001..Most importantly, these findings taken as a whole suggest that any simple theory of prefrontal cortex function must take into account the sensitivity of this region to changes in target probability... - Structural and functional brain development and its relation to cognitive developmentB J Casey
Department of Psychiatry, The Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, 525 East 68th Street, Box 171, New York, NY 10021, USA
Biol Psychol 54:241-57. 2000..It is clear that innovative methods like fMRI together with MRI-based morphometry and nonhuman primate studies will transform our current understanding of human brain development and its relation to behavioral development... - Frontostriatal microstructure modulates efficient recruitment of cognitive controlConor Liston
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, 1300 York Avenue, Box 140, New York, NY 10021, USA
Cereb Cortex 16:553-60. 2006..These findings suggest that frontostriatal connectivity may contribute to developmental and individual differences in the efficient recruitment of cognitive control... - The role of ventral frontostriatal circuitry in reward-based learning in humansAdriana Galvan
Sackler Institute, Weill Medical College of Cornell University, New York, New York 10021, USA
J Neurosci 25:8650-6. 2005..Our findings suggest discrete functions of regions within basal ganglia thalamocortical circuitry in adjusting behavior to maximize reward... - Genes, brain, and behavior: bridging disciplinesJohn A Fossella
Sackler Institute, Weill Medical College of Cornell University, 1300 York Ave, Box 140, New York, NY 10021, USA
Cogn Affect Behav Neurosci 6:1-8. 2006..Alone, each of these approaches provides limited information on gene function in complex human behavior, but together, they are forming bridges between animal models and human psychiatric disorders... - Earlier development of the accumbens relative to orbitofrontal cortex might underlie risk-taking behavior in adolescentsAdriana Galvan
The Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York 10021, USA
J Neurosci 26:6885-92. 2006..These findings suggest that maturing subcortical systems become disproportionately activated relative to later maturing top-down control systems, biasing the adolescent's action toward immediate over long-term gains... - Anterior cingulate and posterior parietal cortices are sensitive to dissociable forms of conflict in a task-switching paradigmConor Liston
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, 1300 York Avenue, Box 140, New York, New York 10021, USA
Neuron 50:643-53. 2006..These findings suggest that ACC and PPC may act in concert to detect dissociable forms of conflict and signal to DLPFC the need for increased control... - The face behind the mask: a developmental studyNim Tottenham
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, USA
Dev Sci 9:288-94. 2006.... - A shift from diffuse to focal cortical activity with developmentSarah Durston
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, USA
Dev Sci 9:1-8. 2006..Our longitudinal findings, relative to our cross-sectional ones, show attenuated activation in dorsolateral prefrontal cortical areas, paralleled by increased focal activation in ventral prefrontal regions related to task performance... - What have we learned about cognitive development from neuroimaging?Sarah Durston
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, NY 10021, USA
Neuropsychologia 44:2149-57. 2006..Finally, the relevance of normative studies for understanding neural and cognitive changes in developmental disorders is discussed... - Clinical, imaging, lesion, and genetic approaches toward a model of cognitive controlB J Casey
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, NY 10021, USA
Dev Psychobiol 40:237-54. 2002.... - Amygdala response to facial expressions in children and adultsK M Thomas
Sackler Institute, Weill Medical College of Cornell University, New York, New York 10021, USA
Biol Psychiatry 49:309-16. 2001..CONCLUSIONS: This is the first study to examine developmental differences in the amygdala response to facial expressions using functional magnetic resonance imaging... - A shift from diffuse to focal cortical activity with development: the authors' replySarah Durston
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, USA
Dev Sci 9:18-20. 2006 - The effect of preceding context on inhibition: an event-related fMRI studyS Durston
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York, USA
Neuroimage 16:449-53. 2002..A model using the BOLD response in our data was used to verify that the effect of context was not an artifact of the randomization scheme used in the design... - New potential leads in the biology and treatment of attention deficit-hyperactivity disorderB J Casey
Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York 10021, USA
Curr Opin Neurol 20:119-24. 2007..This review highlights recent neuroimaging and genetic studies of attention deficit-hyperactivity disorder that may inform biologically targeted interventions and treatments...
Research Grants
- Development of Basic Components of Decision MakingBETTY CASEY; Fiscal Year: 2007..The proposed studies are in response to RFA # DA-04-009 Behavioral and Cognitive Processes Related to Adolescent Drug Abuse. ..
- Brain Development Following InstitutionalizationBETTY CASEY; Fiscal Year: 2007..We will recruit a typically developing population of children to assess deviations or delays in the development of amygdala and hippocampal volume and function. ..
- Frontostriatal Development and Cognitive ControlBETTY CASEY; Fiscal Year: 2005....
- Development of Prediction and Reward Related CircuitryBETTY CASEY; Fiscal Year: 2004..The proposed studies will lay the critical groundwork, both scientific and methodological, for subsequent studies on substance abuse in children. ..
- Functional neuroanatomical deficits in ADHD familiesBETTY CASEY; Fiscal Year: 2003..Imaging will be performed at corresponding imaging sites at DUMC, Weill Medical College of Cornell University, and Stanford University respectively. ..