Jonathan T Butcher


Affiliation: Cornell University
Country: USA


  1. Butcher J, Mahler G, Hockaday L. Aortic valve disease and treatment: the need for naturally engineered solutions. Adv Drug Deliv Rev. 2011;63:242-68 pubmed publisher
    ..This review summarizes the latest advancements in aortic valve research and highlights important future directions. ..
  2. Yu J, Sarathchandra P, Chester A, Yacoub M, Brand T, Butcher J. Cardiac regeneration following cryoinjury in the adult zebrafish targets a maturation-specific biomechanical remodeling program. Sci Rep. 2018;8:15661 pubmed publisher
    ..These findings identify a novel biomechanical control of heart regeneration that may orchestrate cellular and tissue level remodeling responses. ..
  3. Butcher J. The root problem of heart valve engineering. Sci Transl Med. 2018;10: pubmed publisher
    ..Acellular heart valve grafts optimized through computational modeling recellularize and function in sheep for up to 1 year (Emmert et al., this issue). ..
  4. Butcher J, Nerem R. Valvular endothelial cells and the mechanoregulation of valvular pathology. Philos Trans R Soc Lond B Biol Sci. 2007;362:1445-57 pubmed
    ..Further understanding of these mechanisms may help lead to earlier diagnostic tools and therapeutic strategies. ..
  5. Cheung D, Duan B, Butcher J. Current progress in tissue engineering of heart valves: multiscale problems, multiscale solutions. Expert Opin Biol Ther. 2015;15:1155-72 pubmed publisher
  6. Richards J, Kunitake J, Hunt H, Wnorowski A, Lin D, Boskey A, et al. Crystallinity of hydroxyapatite drives myofibroblastic activation and calcification in aortic valves. Acta Biomater. 2018;71:24-36 pubmed publisher
    ..This study additionally lays the groundwork to capture the diversity of mineral properties in calcified valves, and link these properties to progression of the disease. ..
  7. Gould R, Yalcin H, MacKay J, Sauls K, Norris R, Kumar S, et al. Cyclic Mechanical Loading Is Essential for Rac1-Mediated Elongation and Remodeling of the Embryonic Mitral Valve. Curr Biol. 2016;26:27-37 pubmed publisher
    ..Together, these results demonstrate that cyclic mechanical signaling coordinates the RhoA to Rac1 signaling transition essential for proper embryonic mitral valve remodeling. ..
  8. Duan B, Yin Z, Hockaday Kang L, Magin R, Butcher J. Active tissue stiffness modulation controls valve interstitial cell phenotype and osteogenic potential in 3D culture. Acta Biomater. 2016;36:42-54 pubmed publisher
  9. Wu B, Wang Y, Xiao F, Butcher J, Yutzey K, Zhou B. Developmental Mechanisms of Aortic Valve Malformation and Disease. Annu Rev Physiol. 2017;79:21-41 pubmed publisher

More Information


  1. Wu S, Duan B, Qin X, Butcher J. Living nano-micro fibrous woven fabric/hydrogel composite scaffolds for heart valve engineering. Acta Biomater. 2017;51:89-100 pubmed publisher
    ..This work marks the first report of a combination composite scaffold using 3D hydrogel enhanced by nano-micro fibrous woven fabric, and represents a promising tissue engineering strategy to treat heart valve injury. ..
  2. Bowen C, Zhou J, Sung D, Butcher J. Cadherin-11 coordinates cellular migration and extracellular matrix remodeling during aortic valve maturation. Dev Biol. 2015;407:145-57 pubmed publisher
    ..Transfection of Cad-11 depleted cells with constitutively active RhoA restored cell phenotypes. Together, these results identify cadherin-11 mediated adhesive signaling for proper remodeling of the embryonic semilunar valves. ..
  3. Sung D, Bowen C, Vaidya K, Zhou J, Chapurin N, Recknagel A, et al. Cadherin-11 Overexpression Induces Extracellular Matrix Remodeling and Calcification in Mature Aortic Valves. Arterioscler Thromb Vasc Biol. 2016;36:1627-37 pubmed publisher
    ..The findings provide a potential molecular target for clinical treatment. ..
  4. Farrar E, Pramil V, Richards J, Mosher C, Butcher J. Valve interstitial cell tensional homeostasis directs calcification and extracellular matrix remodeling processes via RhoA signaling. Biomaterials. 2016;105:25-37 pubmed publisher
    ..Osteogenesis disrupts interstitial cell mechanical phenotype and drives disorganization, nodule formation, and pro-calcific signaling via a RhoA-dependent mechanism. ..
  5. Wu S, Duan B, Qin X, Butcher J. Nanofiber-structured hydrogel yarns with pH-response capacity and cardiomyocyte-drivability for bio-microactuator application. Acta Biomater. 2017;60:144-153 pubmed publisher
    ..Our nanofibrous hydrogel yarn holds the potential to be developed into novel linear and biological microactuators for various biomedical applications. ..