Jonathan T Butcher

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. pmc Serotonin potentiates transforming growth factor-beta3 induced biomechanical remodeling in avian embryonic atrioventricular valves
    Philip R Buskohl
    Department of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York, United States of America
    PLoS ONE 7:e42527. 2012
  2. pmc Inflammatory regulation of valvular remodeling: the good(?), the bad, and the ugly
    Gretchen J Mahler
    Department of Biomedical Engineering, Cornell University, 304 Weill Hall, Ithaca, NY 14853, USA
    Int J Inflam 2011:721419. 2011
  3. pmc Multi-scale biomechanical remodeling in aging and genetic mutant murine mitral valve leaflets: insights into Marfan syndrome
    Russell A Gould
    Department of Biomedical Engineering, Cornell University, Ithaca, New York, United States of America
    PLoS ONE 7:e44639. 2012
  4. pmc Inflammatory cytokines promote mesenchymal transformation in embryonic and adult valve endothelial cells
    Gretchen J Mahler
    Department of Bioengineering, Binghamton University, Binghamton, NY, USA
    Arterioscler Thromb Vasc Biol 33:121-30. 2013
  5. pmc Valvular endothelial cells and the mechanoregulation of valvular pathology
    Jonathan T Butcher
    Department of Biomedical Engineering, 270 Olin Hall, Cornell University, Ithaca, NY 14850, USA
    Philos Trans R Soc Lond B Biol Sci 362:1445-57. 2007
  6. doi request reprint Aortic valve disease and treatment: the need for naturally engineered solutions
    Jonathan T Butcher
    Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA
    Adv Drug Deliv Rev 63:242-68. 2011
  7. pmc Valvulogenesis: the moving target
    Jonathan T Butcher
    Department of Biomedical Engineering, 270 Olin Hall, Cornell University, Ithaca, NY 14853, USA
    Philos Trans R Soc Lond B Biol Sci 362:1489-503. 2007
  8. ncbi request reprint Transitions in early embryonic atrioventricular valvular function correspond with changes in cushion biomechanics that are predictable by tissue composition
    Jonathan T Butcher
    Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Children s Research Institute, Medical University of South Carolina, Charleston, SC, USA
    Circ Res 100:1503-11. 2007
  9. pmc Stiffness and adhesivity control aortic valve interstitial cell behavior within hyaluronic acid based hydrogels
    Bin Duan
    Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA
    Acta Biomater 9:7640-50. 2013
  10. doi request reprint Quantitative three-dimensional analysis of embryonic chick morphogenesis via microcomputed tomography
    Jun Sup Kim
    Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA
    Anat Rec (Hoboken) 294:1-10. 2011

Collaborators

Detail Information

Publications41

  1. pmc Serotonin potentiates transforming growth factor-beta3 induced biomechanical remodeling in avian embryonic atrioventricular valves
    Philip R Buskohl
    Department of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York, United States of America
    PLoS ONE 7:e42527. 2012
    ..Collectively, these results highlight TGFβ/5-HT signaling as a potent mechanism for control of biomechanical remodeling of AV cushions during development...
  2. pmc Inflammatory regulation of valvular remodeling: the good(?), the bad, and the ugly
    Gretchen J Mahler
    Department of Biomedical Engineering, Cornell University, 304 Weill Hall, Ithaca, NY 14853, USA
    Int J Inflam 2011:721419. 2011
    ..This paper summarizes the current state of knowledge regarding inflammatory mediation of heart valve remodeling and suggests key questions moving forward...
  3. pmc Multi-scale biomechanical remodeling in aging and genetic mutant murine mitral valve leaflets: insights into Marfan syndrome
    Russell A Gould
    Department of Biomedical Engineering, Cornell University, Ithaca, New York, United States of America
    PLoS ONE 7:e44639. 2012
    ..Decoupling of local cell-matrix deformation kinematics with global tissue stretch may be an important mechanism of normal and pathological biomechanical remodeling in valves...
  4. pmc Inflammatory cytokines promote mesenchymal transformation in embryonic and adult valve endothelial cells
    Gretchen J Mahler
    Department of Bioengineering, Binghamton University, Binghamton, NY, USA
    Arterioscler Thromb Vasc Biol 33:121-30. 2013
    ..Here, we test whether and how inflammatory cytokines (tumor necrosis factor-α and interleukin-6) regulate EndMT in embryonic and adult valve endothelium...
  5. pmc Valvular endothelial cells and the mechanoregulation of valvular pathology
    Jonathan T Butcher
    Department of Biomedical Engineering, 270 Olin Hall, Cornell University, Ithaca, NY 14850, USA
    Philos Trans R Soc Lond B Biol Sci 362:1445-57. 2007
    ..Further understanding of these mechanisms may help lead to earlier diagnostic tools and therapeutic strategies...
  6. doi request reprint Aortic valve disease and treatment: the need for naturally engineered solutions
    Jonathan T Butcher
    Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA
    Adv Drug Deliv Rev 63:242-68. 2011
    ..This review summarizes the latest advancements in aortic valve research and highlights important future directions...
  7. pmc Valvulogenesis: the moving target
    Jonathan T Butcher
    Department of Biomedical Engineering, 270 Olin Hall, Cornell University, Ithaca, NY 14853, USA
    Philos Trans R Soc Lond B Biol Sci 362:1489-503. 2007
    ..It is hoped that appropriate developmental cues and phenotypic endpoints could help engineers and clinicians in their efforts to regenerate living valve alternatives...
  8. ncbi request reprint Transitions in early embryonic atrioventricular valvular function correspond with changes in cushion biomechanics that are predictable by tissue composition
    Jonathan T Butcher
    Department of Cell Biology and Anatomy, Cardiovascular Developmental Biology Center, Children s Research Institute, Medical University of South Carolina, Charleston, SC, USA
    Circ Res 100:1503-11. 2007
    ..These results have important implications in valvular development, as biomechanics may play a larger role in stimulating valvulogenic events than previously thought...
  9. pmc Stiffness and adhesivity control aortic valve interstitial cell behavior within hyaluronic acid based hydrogels
    Bin Duan
    Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA
    Acta Biomater 9:7640-50. 2013
    ..The Me-HA/Me-Gel hybrid hydrogels accommodated with VIC are promising as valve tissue engineering scaffolds and 3-D models for understanding valvular pathobiology. ..
  10. doi request reprint Quantitative three-dimensional analysis of embryonic chick morphogenesis via microcomputed tomography
    Jun Sup Kim
    Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA
    Anat Rec (Hoboken) 294:1-10. 2011
    ..Quantifying subtle differences in morphogenesis is increasingly important as research focuses on localized and conditional effects...
  11. pmc Quantification of embryonic atrioventricular valve biomechanics during morphogenesis
    Philip R Buskohl
    Department of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA
    J Biomech 45:895-902. 2012
    ..Quantitative biomechanical analysis is an important and underserved complement to molecular and genetic experimentation of embryonic morphogenesis...
  12. pmc Transforming growth factor β, bone morphogenetic protein, and vascular endothelial growth factor mediate phenotype maturation and tissue remodeling by embryonic valve progenitor cells: relevance for heart valve tissue engineering
    Yung Nung Chiu
    Department of Biomedical Engineering, Cornell University, Ithaca New York 14853, USA
    Tissue Eng Part A 16:3375-83. 2010
    ....
  13. pmc Computational simulation of hemodynamic-driven growth and remodeling of embryonic atrioventricular valves
    Philip R Buskohl
    Department of Mechanical and Aerospace Engineering, Cornell University, 306 Weill Hall, Ithaca, NY 14853, USA
    Biomech Model Mechanobiol 11:1205-17. 2012
    ..This model offers insight into how natural and perturbed mechanical environments may direct AV valvulogenesis and provides an initial framework on which to incorporate more mechano-biological details...
  14. pmc The mechanobiology of mitral valve function, degeneration, and repair
    Jennifer M Richards
    Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA
    J Vet Cardiol 14:47-58. 2012
    ..There are a number of experimental strategies already available to pursue this significant opportunity, but success requires the collaboration between veterinary clinicians, scientists, and engineers...
  15. pmc Periostin promotes atrioventricular mesenchyme matrix invasion and remodeling mediated by integrin signaling through Rho/PI 3-kinase
    Jonathan T Butcher
    Cardiovascular Developmental Biology Center, Chair of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC 29425, USA
    Dev Biol 302:256-66. 2007
    ..Taken together, these results highlight periostin as a mediator of matrix remodeling by cushion mesenchyme towards a mature valve structure...
  16. pmc Side-specific endothelial-dependent regulation of aortic valve calcification: interplay of hemodynamics and nitric oxide signaling
    Jennifer Richards
    Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA
    Am J Pathol 182:1922-31. 2013
    ..Valve endothelial-derived NO is a natural inhibitor of the early phases of valve calcification and therefore may be an important regulator of valve homeostasis and pathology...
  17. pmc Cyclic strain anisotropy regulates valvular interstitial cell phenotype and tissue remodeling in three-dimensional culture
    Russell A Gould
    Department of Biomedical Engineering, Cornell University, Ithaca, NY 14850, USA
    Acta Biomater 8:1710-9. 2012
    ..05). Collectively, these results suggest that strain field anisotropy is an independent regulator of fibroblast cell phenotype, turnover, and matrix reorganization, which may inform normal and pathological remodeling in soft tissues...
  18. pmc 3D bioprinting of heterogeneous aortic valve conduits with alginate/gelatin hydrogels
    Bin Duan
    Department of Biomedical Engineering, Cornell University, Ithaca, New York, USA
    J Biomed Mater Res A 101:1255-64. 2013
    ..These results demonstrate that anatomically complex, heterogeneously encapsulated aortic valve hydrogel conduits can be fabricated with 3D bioprinting...
  19. doi request reprint Two-photon microscopy-guided femtosecond-laser photoablation of avian cardiogenesis: noninvasive creation of localized heart defects
    Huseyin C Yalcin
    Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853, USA
    Am J Physiol Heart Circ Physiol 299:H1728-35. 2010
    ....
  20. doi request reprint Neonatal and adult cardiovascular pathophysiological remodeling and repair: developmental role of periostin
    Russell A Norris
    Cardiovascular Developmental Biology Center, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA
    Ann N Y Acad Sci 1123:30-40. 2008
    ....
  21. pmc Computational fluid dynamics of developing avian outflow tract heart valves
    Koonal N Bharadwaj
    Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853 7501, USA
    Ann Biomed Eng 40:2212-27. 2012
    ..This novel method to quantify local dynamic hemodynamics parameters affords insight into sculpting role of blood flow in the embryonic heart and provides a quantitative baseline dataset for future research...
  22. pmc Interactions between TGFβ1 and cyclic strain in modulation of myofibroblastic differentiation of canine mitral valve interstitial cells in 3D culture
    Andrew S Waxman
    Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Vet Cardiol 14:211-21. 2012
    ..In this paper, we test the hypothesis that cyclic strain and TGFβ1 interact to modify MVIC phenotype in 3D culture...
  23. doi request reprint Method for non-optical quantification of in situ local soft tissue biomechanics
    Grant M Tarsi
    Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA
    J Biomech 46:1938-42. 2013
    ..These results establish a promising new method for minimally invasive local soft tissue biomechanical measurement, which may be useful for applications such as disease diagnosis and health monitoring. ..
  24. pmc Hierarchical approaches for systems modeling in cardiac development
    Russell A Gould
    Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA
    Wiley Interdiscip Rev Syst Biol Med 5:289-305. 2013
    ..Finally, we conclude with some important future directions for cardiac systems modeling...
  25. pmc Hemodynamic patterning of the avian atrioventricular valve
    Huseyin C Yalcin
    Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853 7501, USA
    Dev Dyn 240:23-35. 2011
    ..11 dynes/cm(2) for HH30. Hemodynamic changes often preceded and correlated with morphological changes. These results establish a quantitative baseline supporting future hemodynamic analyses and interpretations...
  26. pmc Valvular heart diseases in the developing world: developmental biology takes center stage
    Emily J Farrar
    Department of Biomedical Engineering, Cornell University, Ithaca, New York 14850, USA
    J Heart Valve Dis 21:234-40. 2012
    ....
  27. pmc Quantitative three-dimensional imaging of live avian embryonic morphogenesis via micro-computed tomography
    Alyssa L Henning
    Department of Biomedical Engineering, Cornell University, Ithaca, New York 14853 7501, USA
    Dev Dyn 240:1949-57. 2011
    ..We further quantified longitudinal volumetric morphogenesis of the allantois over 30 hr. These results demonstrate the safety and efficacy of contrast enhanced quantitative micro-CT imaging for live embryos...
  28. doi request reprint Translational paradigms in scientific and clinical imaging of cardiac development
    Chelsea L Gregg
    Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA
    Birth Defects Res C Embryo Today 99:106-20. 2013
    ..We conclude with discussing the translational impact and future opportunities for cardiovascular development imaging research...
  29. pmc Cadherin-11 Expression Patterns in Heart Valves Associate with Key Functions during Embryonic Cushion Formation, Valve Maturation and Calcification
    Jingjing Zhou
    Department of Biomedical Engineering, Cornell University, Ithaca, N Y, USA
    Cells Tissues Organs 198:300-10. 2013
    ..Collectively, our results suggest that cad-11 is important for proper embryonic cushion formation and remodeling, but may also participate in aortic valve pathogenesis if re-expressed in adulthood. © 2013 S. Karger AG, Basel. ..
  30. ncbi request reprint Mechanobiology of the aortic heart valve
    Jonathan T Butcher
    Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA
    J Heart Valve Dis 17:62-73. 2008
    ..Finally, the means by which organ culture systems are being utilized to study heart valve biology, thereby providing a complementary approach to in vivo experimentation, are described...
  31. ncbi request reprint Quantitative volumetric analysis of cardiac morphogenesis assessed through micro-computed tomography
    Jonathan T Butcher
    Cardiovascular Developmental Biology Center, Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC 29425, USA
    Dev Dyn 236:802-9. 2007
    ..These results demonstrate that Micro-CT can be used to image and quantify cardiovascular structures during development...
  32. doi request reprint Quantitative three-dimensional analysis of embryonic chick morphogenesis via microcomputed tomography
    Jun Sup Kim
    Department of Biomedical Engineering, Cornell University, Ithaca, New York, 14853, USA
    Anat Rec (Hoboken) 294:1-10. 2011
    ..Quantifying subtle differences in morphogenesis is increasingly important as research focuses on localized and conditional effects...
  33. pmc Heterogeneous susceptibility of valve endothelial cells to mesenchymal transformation in response to TNFα
    Emily J Farrar
    Department of Biomedical Engineering, Cornell University, 304 Weill Hall, Ithaca, NY, 14853, USA
    Ann Biomed Eng 42:149-61. 2014
    ..Discovery of the molecular signature of transformation-resistant endothelial cells could inform development of treatment strategies that promote survival of the valve endothelium. ..
  34. pmc Quantitative in vivo imaging of embryonic development: opportunities and challenges
    Chelsea L Gregg
    Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA
    Differentiation 84:149-62. 2012
    ..We describe the physics behind their function, identify some examples in which the modality has revealed new quantitative insights, and then conclude with a discussion of new research directions with live imaging...
  35. ncbi request reprint The next frontier in cardiovascular developmental biology--an integrated approach to adult disease?
    Roger R Markwald
    Department of Anatomy and Cell Biology, Medical University of South Carolina, 171 Ashley Avenue, Charleston, SC 29425, USA
    Nat Clin Pract Cardiovasc Med 4:60-1. 2007
  36. ncbi request reprint Valvular endothelial cells regulate the phenotype of interstitial cells in co-culture: effects of steady shear stress
    Jonathan T Butcher
    Petit Institute for Bioengineering and Bioscience, Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, 30332, USA
    Tissue Eng 12:905-15. 2006
    ..Additionally, we show that tissue-engineered models can be used to discover and understand complex biomechanical relationships between cells that interact in vivo...
  37. ncbi request reprint Equibiaxial strain stimulates fibroblastic phenotype shift in smooth muscle cells in an engineered tissue model of the aortic wall
    Jonathan T Butcher
    Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA
    Biomaterials 27:5252-8. 2006
    ..We conclude that this system is effective in stimulating cells with cyclic equibiaxial strain in 3D cultures, and can be applied to a variety of biomaterial and tissue engineering applications...
  38. ncbi request reprint Unique morphology and focal adhesion development of valvular endothelial cells in static and fluid flow environments
    Jonathan T Butcher
    Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Arterioscler Thromb Vasc Biol 24:1429-34. 2004
    ....
  39. ncbi request reprint Transcriptional profiles of valvular and vascular endothelial cells reveal phenotypic differences: influence of shear stress
    Jonathan T Butcher
    Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, USA
    Arterioscler Thromb Vasc Biol 26:69-77. 2006
    ..The similarities between valvular and vascular lesions suggest pathological initiation mediated through endothelium, but the role of hemodynamics in valvular endothelial biology is poorly understood...
  40. ncbi request reprint Porcine aortic valve interstitial cells in three-dimensional culture: comparison of phenotype with aortic smooth muscle cells
    Jonathan T Butcher
    Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 315 Ferst Drive, Atlanta, GA 30332, USA
    J Heart Valve Dis 13:478-85; discussion 485-6. 2004
    ..The study aim was to compare the phenotype of porcine aortic valve interstitial cells (PAVICs) and porcine aortic smooth muscle cells (PASMCs) in two-dimensional cultures and within three-dimensional (3D) collagen gels...