B A Butcher

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Larvae-induced plasma membrane wounds and glycoprotein deposition are insufficient for Trichinella spiralis invasion of epithelial cells
    B A Butcher
    James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Mol Biochem Parasitol 107:207-18. 2000
  2. ncbi request reprint IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages
    Barbara A Butcher
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Immunol 174:3148-52. 2005
  3. pmc Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control
    Barbara A Butcher
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    PLoS Pathog 7:e1002236. 2011
  4. ncbi request reprint Toxoplasma gondii triggers myeloid differentiation factor 88-dependent IL-12 and chemokine ligand 2 (monocyte chemoattractant protein 1) responses using distinct parasite molecules and host receptors
    Laura Del Rio
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA
    J Immunol 172:6954-60. 2004
  5. ncbi request reprint p38 MAPK autophosphorylation drives macrophage IL-12 production during intracellular infection
    Leesun Kim
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 6401, USA
    J Immunol 174:4178-84. 2005
  6. ncbi request reprint Toxoplasma gondii interferes with lipopolysaccharide-induced mitogen-activated protein kinase activation by mechanisms distinct from endotoxin tolerance
    Leesun Kim
    Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA
    J Immunol 172:3003-10. 2004
  7. ncbi request reprint Toxoplasma gondii tachyzoites inhibit proinflammatory cytokine induction in infected macrophages by preventing nuclear translocation of the transcription factor NF-kappa B
    B A Butcher
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Immunol 167:2193-201. 2001
  8. pmc Mechanism of entry determines the ability of Toxoplasma gondii to inhibit macrophage proinflammatory cytokine production
    Barbara A Butcher
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853 6401, USA
    Infect Immun 70:5216-24. 2002
  9. pmc STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection
    L Cristina Gavrilescu
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Infect Immun 72:1257-64. 2004
  10. pmc Toxoplasma gondii prevents chromatin remodeling initiated by TLR-triggered macrophage activation
    Jin Leng
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Immunol 182:489-97. 2009

Detail Information

Publications20

  1. ncbi request reprint Larvae-induced plasma membrane wounds and glycoprotein deposition are insufficient for Trichinella spiralis invasion of epithelial cells
    B A Butcher
    James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Mol Biochem Parasitol 107:207-18. 2000
    ....
  2. ncbi request reprint IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages
    Barbara A Butcher
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Immunol 174:3148-52. 2005
    ..gondii exploits host STAT3 to prevent LPS-triggered IL-12 and TNF-alpha production, revealing for the first time a molecular mechanism underlying the parasite's suppressive effect on macrophage proinflammatory cytokine production...
  3. pmc Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control
    Barbara A Butcher
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    PLoS Pathog 7:e1002236. 2011
    ..We conclude that encounter between Toxoplasma ROP16 and the host cell STAT signaling cascade has pleiotropic downstream effects that act in multiple and complex ways to direct the course of infection...
  4. ncbi request reprint Toxoplasma gondii triggers myeloid differentiation factor 88-dependent IL-12 and chemokine ligand 2 (monocyte chemoattractant protein 1) responses using distinct parasite molecules and host receptors
    Laura Del Rio
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14850, USA
    J Immunol 172:6954-60. 2004
    ..gondii possesses multiple molecules triggering distinct MyD88-dependent signaling cascades, that these pathways are independently regulated, and that they lead to distinct profiles of cytokine production...
  5. ncbi request reprint p38 MAPK autophosphorylation drives macrophage IL-12 production during intracellular infection
    Leesun Kim
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 6401, USA
    J Immunol 174:4178-84. 2005
    ..Furthermore, a synthetic p38 catalytic-site inhibitor blocked tachyzoite-induced p38alpha MAPK phosphorylation. These data are the first to demonstrate p38 MAPK autophosphorylation triggered by intracellular infection...
  6. ncbi request reprint Toxoplasma gondii interferes with lipopolysaccharide-induced mitogen-activated protein kinase activation by mechanisms distinct from endotoxin tolerance
    Leesun Kim
    Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY 14853, USA
    J Immunol 172:3003-10. 2004
    ..Our results show that T. gondii blocks LPS-triggered cytokine production in part through MAPK inactivation, and that this occurs through pathways distinct from endotoxin-induced tolerance...
  7. ncbi request reprint Toxoplasma gondii tachyzoites inhibit proinflammatory cytokine induction in infected macrophages by preventing nuclear translocation of the transcription factor NF-kappa B
    B A Butcher
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Immunol 167:2193-201. 2001
    ..Our results are the first to demonstrate the ability of an intracellular protozoan to actively interfere with the NF-kappaB activation pathway in macrophages, an activity that may enable parasite survival within the host...
  8. pmc Mechanism of entry determines the ability of Toxoplasma gondii to inhibit macrophage proinflammatory cytokine production
    Barbara A Butcher
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853 6401, USA
    Infect Immun 70:5216-24. 2002
    ..They also show that the effects of Toxoplasma on IL-12 and TNF-alpha production are nonidentical, with the parasite exerting a longer-lasting suppression of the latter...
  9. pmc STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection
    L Cristina Gavrilescu
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Infect Immun 72:1257-64. 2004
    ....
  10. pmc Toxoplasma gondii prevents chromatin remodeling initiated by TLR-triggered macrophage activation
    Jin Leng
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Immunol 182:489-97. 2009
    ....
  11. ncbi request reprint Toxoplasma gondii genotype determines MyD88-dependent signaling in infected macrophages
    Leesun Kim
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Immunol 177:2584-91. 2006
    ..Differences in host signaling pathways triggered by RH vs ME49 may contribute to the high and low virulence characteristics displayed by these parasite strains...
  12. pmc Dysregulation of macrophage signal transduction by Toxoplasma gondii: past progress and recent advances
    J Leng
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 6401, USA
    Parasite Immunol 31:717-28. 2009
    ..These studies reveal insight into the profound suppression of proinflammatory cytokine responses that occurs when the parasite infects macrophages and other cells of innate immunity...
  13. ncbi request reprint Neutrophils, dendritic cells and Toxoplasma
    Eric Y Denkers
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 6401, USA
    Int J Parasitol 34:411-21. 2004
    ..Neutrophil-empowered dendritic cells possess properties expected of highly potent antigen presenting cells that drive T helper 1 generation...
  14. ncbi request reprint In the belly of the beast: subversion of macrophage proinflammatory signalling cascades during Toxoplasma gondii infection
    Eric Y Denkers
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 6401, USA
    Cell Microbiol 5:75-83. 2003
    ..The balance of cytokine subversion and stimulation during infection probably results from the parasite's need to simultaneously avoid immune elimination and trigger immunity to prevent host death...
  15. ncbi request reprint Sabotage and exploitation in macrophages parasitized by intracellular protozoans
    Eric Y Denkers
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 6401, USA
    Trends Parasitol 21:35-41. 2005
    ..The molecular details of how intracellular protozoans manipulate macrophage signal transduction pathways for their own ends are beginning to emerge...
  16. ncbi request reprint Manipulation of mitogen-activated protein kinase/nuclear factor-kappaB-signaling cascades during intracellular Toxoplasma gondii infection
    Eric Y Denkers
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Immunol Rev 201:191-205. 2004
    ..The balance between activation and interference with proinflammatory signaling is likely to reflect the need to achieve an appropriate level of immunity that allows the host and parasite to maintain a stable interaction...
  17. pmc p47 GTPases regulate Toxoplasma gondii survival in activated macrophages
    Barbara A Butcher
    Dept of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Infect Immun 73:3278-86. 2005
    ..gondii. These results suggest that IGTP and LRG-47 are able to regulate host resistance to acute T. gondii infections through their ability to inhibit parasite growth within the macrophage...
  18. pmc Functional aspects of Toll-like receptor/MyD88 signalling during protozoan infection: focus on Toxoplasma gondii
    C E Egan
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Clin Exp Immunol 156:17-24. 2009
    ..We also speculate how TLR/MyD88 signalling might be exploited to provide protection against Toxoplasma, as well as other protozoa and infection in general...
  19. ncbi request reprint Cell wall lipids from Mycobacterium bovis BCG are inflammatory when inoculated within a gel matrix: characterization of a new model of the granulomatous response to mycobacterial components
    Elizabeth R Rhoades
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Tuberculosis (Edinb) 85:159-76. 2005
    ..We submit that the matrix model presents pertinent features of the murine granulomatous response that will prove to be an adaptable method for study of this complex response...
  20. ncbi request reprint Kinetics of phosphatidylinositol-3-phosphate acquisition differ between IgG bead-containing phagosomes and Mycobacterium tuberculosis-containing phagosomes
    Georgiana E Purdy
    Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Cell Microbiol 7:1627-34. 2005
    ..Given the role these lipids play in the regulation of phagosome maturation these findings have implications with respect to the mechanisms behind the arrest of phagosome maturation...