Research Topics
| Marjory BrooksSummaryAffiliation: Cornell University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Evaluation of a chromogenic assay to measure the factor Xa inhibitory activity of unfractionated heparin in canine plasmaMarjory B Brooks
Comparative Coagulation Section, Animal Health Diagnostic Laboratory, Cornell University, Ithaca, NY 14850, USA
Vet Clin Pathol 33:208-14. 2004..Factor Xa inhibitory assays (to measure anti-Xa activity) are used to adjust UFH dosage and define safe and effective regimens for specific thrombotic disorders in humans...- A review of canine inherited bleeding disorders: biochemical and molecular strategies for disease characterization and carrier detectionM Brooks
Comparative Coagulation Section, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Hered 90:112-8. 1999..Molecular diagnostic techniques enhance the accuracy of carrier detection, providing their clinical application takes into account the molecular heterogeneity underlying naturally occurring hemostatic defects in dogs... - Cosegregation of a factor VIII microsatellite marker with mild hemophilia A in Golden Retriever dogsMarjory B Brooks
Department of Population Medicine and Diagnostic Sciences, Comparative Coagulation Section, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
J Vet Intern Med 19:205-10. 2005..We conclude that genotype analysis for the intragenic factor VIII marker can aid in control of canine hemophilia A through enhanced carrier detection... 
Equine coagulopathiesMarjory B Brooks
Comparative Coagulation Section, Animal Health Diagnostic Center, Upper Tower Road, Cornell University, Ithaca, NY 14853, USA
Vet Clin North Am Equine Pract 24:335-55, vi. 2008..This article provides an overview of preliminary screening and definitive tests to identify hemostatic defects in horses...- A Line 1 insertion in the Factor IX gene segregates with mild hemophilia B in dogsMarjory B Brooks
Department of Population Medicine and Diagnostic Sciences, Comparative Coagulation Section, College of Veterinary Medicine, Cornell University, Upper Tower Road, Ithaca, NY 14853, USA
Mamm Genome 14:788-95. 2003..This is the first description of a Factor IX mutation associated with mild hemophilia B in a non-human species and provides evidence for a recent Line-1 insertion event in the canine genome... - Evaluation of platelet function screening tests to detect platelet procoagulant deficiency in dogs with Scott syndromeMarjory B Brooks
Department of Population Medicine and Diagnostic Sciences, Cornell University, Ithaca, NY, USA
Vet Clin Pathol 38:306-15. 2009..While "global" hemostasis analyzers and whole blood assays have potential for testing platelet function, their ability to evaluate platelet procoagulant activity is ill-defined... 
A genome-wide linkage scan in German shepherd dogs localizes canine platelet procoagulant deficiency (Scott syndrome) to canine chromosome 27Marjory Brooks
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Gene 450:70-5. 2010..These results provide the basis for fine mapping studies to narrow the disease interval and target the evaluation of putative disease genes...- A hereditary bleeding disorder of dogs caused by a lack of platelet procoagulant activityMarjory B Brooks
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Upper Tower Road, Ithaca, NY 14853, USA
Blood 99:2434-41. 2002.... - Heritability of plasma von Willebrand factor antigen concentration in German Wirehaired pointersM B Brooks
Diagnostic Laboratory, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Vet Q 23:126-8. 2001..Our analyses indicate that phenotype, assigned on the basis of a single vWF:Ag determination, is heritable and can be applied for selective breeding in a von Willebrand disease test programme... - Indirect carrier detection of canine haemophilia A using factor VIII microsatellite markersM B Brooks
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Upper Tower Road, Ithaca, NY 14853, USA
Anim Genet 39:278-83. 2008..Our results demonstrate an apparent allelic heterogeneity in canine haemophilia A; however, an indirect method based on a three-marker panel is feasible to facilitate carrier detection and genetic counselling... - Evaluation of latex agglutination kits for detection of fibrin(ogen) degradation products and D-dimer in healthy horses and horses with severe colicTracy Stokol
Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
Vet Clin Pathol 34:375-82. 2005..To the authors' knowledge, latex-agglutination-based plasma FDP and D-dimer assays have not been validated for use in horses... - Influence of treatment with ultralow-dose aspirin on platelet aggregation as measured by whole blood impedance aggregometry and platelet P-selectin expression in clinically normal dogsKristopher S Sharpe
Department of Clinical Sciences, Cornell University, Ithaca, NY 14853, USA
Am J Vet Res 71:1294-304. 2010..To evaluate the influence of treatment with ultralow-dose aspirin (ULDAsp) on platelet aggregation, P-selectin (CD62P) expression, and formation of platelet-leukocyte aggregates in clinically normal dogs... - Pharmacokinetics of subcutaneous low molecular weight heparin (enoxaparin) in dogsKari V Lunsford
Department of Clinical Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, Mississippi 39762, USA
J Am Anim Hosp Assoc 45:261-7. 2009..Enoxaparin at 0.8 mg/kg SC q 6 hours consistently maintained target levels of anti-Xa activity in normal dogs without evidence of hemorrhagic complications... - Evaluation of plasma protein C activity for detection of hepatobiliary disease and portosystemic shunting in dogsOlivier Toulza
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Am Vet Med Assoc 229:1761-71. 2006..Protein C activity can help prioritize tests used to distinguish PSVA from MVD and sensitively reflects improved hepatic-portal perfusion after PSVA ligation... - Clinical and clinicopathologic features of dogs that consumed foodborne hepatotoxic aflatoxins: 72 cases (2005-2006)Diane M Dereszynski
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
J Am Vet Med Assoc 232:1329-37. 2008..To characterize clinical signs, clinicopathologic features, treatments, and survival in dogs with naturally acquired foodborne aflatoxicosis... - Effect of levothyroxine administration on hemostatic analytes in Doberman Pinschers with von Willebrand diseaseJohanna C Heseltine
Department of Veterinary Clinical Sciences, Oklahoma State University, Stillwater, OK 74078, USA
J Vet Intern Med 19:523-7. 2005..The results of this study failed to identify a direct action of levothyroxine supplementation on plasma vWf concentration or activity in euthyroid Doberman Pinschers with vWd... - Hereditary factor VII deficiency in the Alaskan Klee Kai dogJennifer A Kaae
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA
J Vet Intern Med 21:976-81. 2007..An Alaskan Klee Kai dog with severe bleeding after trauma was diagnosed with FVII deficiency based on coagulation testing. Molecular analyses were undertaken to identify the genetic basis of the defect in this breed... - Congenital factor XI deficiency in a domestic shorthair catMark T Troxel
Garden State Veterinary Specialists, Tinton Falls, New Jersey 07753, USA
J Am Anim Hosp Assoc 38:549-53. 2002..The signalment, lack of primary disease, and the finding of persistent factor XI deficiency in the absence of coagulation inhibitors were considered compatible with congenital factor XI deficiency in the cat of this report... - Type-3 von willebrand's disease in a rhesus monkey (Macaca mulatta)Mary M Patterson
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA
Comp Med 52:368-71. 2002..Fresh whole blood was transfused to control frequent bleeding episodes throughout the monkey's life. Although vWD is the most common inherited bleeding disorder in humans and dogs, this is the first report of vWD in a nonhuman primate... - Effect of a single plasma transfusion on thromboembolism in 13 dogs with primary immune-mediated hemolytic anemiaMary F Thompson
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, USA
J Am Anim Hosp Assoc 40:446-54. 2004..There was no significant difference in the incidence of thromboembolism between the current treatment group and a historical control group... - Anticoagulant effects of low-molecular-weight heparins in healthy catsAmy J Alwood
Department of Clinical Studies Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA
J Vet Intern Med 21:378-87. 2007..However, LMWH pharmacokinetics has not been characterized in the cat. Drug effect with LMWH may be evaluated with analysis of factor Xa inhibition (anti-Xa) or thromboelastography (TEG)...