A Bretscher

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. pmc Magazine or journal--what is the difference? The role of the monitoring editor
    Anthony Bretscher
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA
    Mol Biol Cell 24:887-9. 2013
  2. ncbi request reprint Regulation of cortical structure by the ezrin-radixin-moesin protein family
    A Bretscher
    Section of Biochemistry, Molecular and Cell Biology Biotechnology Building Cornell University Ithaca NY 14853 USA
    Curr Opin Cell Biol 11:109-16. 1999
  3. ncbi request reprint Polarization of cell growth in yeast
    D Pruyne
    Department of Molecular Biology, Cornell University, Ithaca, NY 14853, USA
    J Cell Sci 113:571-85. 2000
  4. ncbi request reprint ERM proteins and merlin: integrators at the cell cortex
    Anthony Bretscher
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nat Rev Mol Cell Biol 3:586-99. 2002
  5. pmc Polarized growth and organelle segregation in yeast: the tracks, motors, and receptors
    Anthony Bretscher
    Dept of Molecular Biology and Genetics, Biotechnology Bldg, Cornell University, Ithaca, NY 14853, USA
    J Cell Biol 160:811-6. 2003
  6. ncbi request reprint ERM-Merlin and EBP50 protein families in plasma membrane organization and function
    A Bretscher
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, New York 14853, USA
    Annu Rev Cell Dev Biol 16:113-43. 2000
  7. doi request reprint Epithelial polarity: dual Lkb1 pathways regulate apical microvilli
    Anthony Bretscher
    Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA
    Dev Cell 16:491-2. 2009
  8. pmc Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP
    D Reczek
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    J Cell Biol 153:191-206. 2001
  9. pmc Ras regulates the polarity of the yeast actin cytoskeleton through the stress response pathway
    J Ho
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Mol Biol Cell 12:1541-55. 2001
  10. pmc The COOH-terminal domain of Myo2p, a yeast myosin V, has a direct role in secretory vesicle targeting
    D Schott
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    J Cell Biol 147:791-808. 1999

Research Grants

  1. Microfilaments in Budding Yeast and the Nematode
    Anthony Bretscher; Fiscal Year: 2009
  2. MICROFILAMENT ORGANIZATION AND REGULATION
    Anthony Bretscher; Fiscal Year: 2002
  3. MICROFILAMENTS IN THE YEAST SACCHAROMYCES CEREVISIAE
    Anthony Bretscher; Fiscal Year: 2001
  4. MICROFILAMENTS IN THE YEAST SACCHAROMYCES CEREVISIAE
    Anthony Bretscher; Fiscal Year: 2005
  5. MICROFILAMENT ORGANIZATION AND REGULATION
    Anthony P Bretscher; Fiscal Year: 2010
  6. Microfilaments in Budding Yeast and the Nematode
    Anthony Bretscher; Fiscal Year: 2009
  7. MICROFILAMENT ORGANIZATION AND REGULATION
    Anthony Bretscher; Fiscal Year: 2007
  8. Microfilaments in Budding Yeast and the Nematode
    Anthony Bretscher; Fiscal Year: 2007
  9. MICROFILAMENT ORGANIZATION AND REGULATION
    Anthony Bretscher; Fiscal Year: 2006
  10. MICROFILAMENTS IN THE YEAST SACCHAROMYCES CEREVISIAE
    Anthony Bretscher; Fiscal Year: 1992

Collaborators

Detail Information

Publications47

  1. pmc Magazine or journal--what is the difference? The role of the monitoring editor
    Anthony Bretscher
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA
    Mol Biol Cell 24:887-9. 2013
    ..I enumerate the decisions a monitoring editor has to make, and how he or she goes about making them. Finally, I indicate ways in which authors can help to make the process a smoother and more positive experience...
  2. ncbi request reprint Regulation of cortical structure by the ezrin-radixin-moesin protein family
    A Bretscher
    Section of Biochemistry, Molecular and Cell Biology Biotechnology Building Cornell University Ithaca NY 14853 USA
    Curr Opin Cell Biol 11:109-16. 1999
    ..ERM proteins also play a role in the Rho and Rac signaling pathways: activated ERM proteins can dissociate Rho-GDI (GDP dissociation inhibitor) from Rho and thereby activate Rho-dependent pathways...
  3. ncbi request reprint Polarization of cell growth in yeast
    D Pruyne
    Department of Molecular Biology, Cornell University, Ithaca, NY 14853, USA
    J Cell Sci 113:571-85. 2000
    ..The dynamic arrangement of targeting and recycling provides flexibility for the precise control of morphogenesis...
  4. ncbi request reprint ERM proteins and merlin: integrators at the cell cortex
    Anthony Bretscher
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nat Rev Mol Cell Biol 3:586-99. 2002
    ..The closely related tumour suppressor merlin shares many properties with ERM proteins, yet also provides a distinct and essential function...
  5. pmc Polarized growth and organelle segregation in yeast: the tracks, motors, and receptors
    Anthony Bretscher
    Dept of Molecular Biology and Genetics, Biotechnology Bldg, Cornell University, Ithaca, NY 14853, USA
    J Cell Biol 160:811-6. 2003
    ..A recent study implicates specific degradation in the bud of the vacuolar receptor, Vac17, as a mechanism for cell cycle-regulated segregation of this organelle...
  6. ncbi request reprint ERM-Merlin and EBP50 protein families in plasma membrane organization and function
    A Bretscher
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, New York 14853, USA
    Annu Rev Cell Dev Biol 16:113-43. 2000
    ..Finally, the function of these proteins in cortical structure, endocytic traffic, signal transduction, and growth control is discussed...
  7. doi request reprint Epithelial polarity: dual Lkb1 pathways regulate apical microvilli
    Anthony Bretscher
    Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA
    Dev Cell 16:491-2. 2009
    ..In this issue of Developmental Cell, ten Klooster et al. show that the Lkb1/Strad/Mo25 complex mediates two separate pathways, and that both are required for assembly of apical microvilli...
  8. pmc Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP
    D Reczek
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    J Cell Biol 153:191-206. 2001
    ..Nadrin binds EBP50 directly, probably through its COOH-terminal STAL sequence. Thus, EBP50 appears to bind membrane proteins as well as factors potentially involved in regulating membrane traffic...
  9. pmc Ras regulates the polarity of the yeast actin cytoskeleton through the stress response pathway
    J Ho
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Mol Biol Cell 12:1541-55. 2001
    ..Thus, Ras2p regulates cytoskeletal polarity in yeast under conditions of mild temperature stress through the stress response pathway...
  10. pmc The COOH-terminal domain of Myo2p, a yeast myosin V, has a direct role in secretory vesicle targeting
    D Schott
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    J Cell Biol 147:791-808. 1999
    ..The data support a model in which the Myo2p tail tethers secretory vesicles, and the motor transports them down polarized actin cables to the site of exocytosis...
  11. ncbi request reprint Myosin V orientates the mitotic spindle in yeast
    H Yin
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Nature 406:1013-5. 2000
    ..The tail domain of Myo2 that binds Kar9 also interacts with secretory vesicles and vacuolar elements, making it a pivotal component of yeast cell polarization...
  12. ncbi request reprint Tropomyosin-containing actin cables direct the Myo2p-dependent polarized delivery of secretory vesicles in budding yeast
    D W Pruyne
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    J Cell Biol 143:1931-45. 1998
    ..Therefore, actin cables respond to polarity cues independently of the overall distribution of cortical patches and are able to directly target the Myo2p-dependent delivery of secretory vesicles and polarization of growth...
  13. pmc Mutations synthetically lethal with tpm1delta lie in genes involved in morphogenesis
    T Wang
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Genetics 147:1595-607. 1997
    ..These results indicate that this synthetic lethality approach provides a sensitive screen for the isolation of mutations affecting morphogenesis, many of which are likely to be in nonessential genes, like BEM2 and SLT2...
  14. pmc Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family
    D Reczek
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    J Cell Biol 139:169-79. 1997
    ..Since PDZ domains are known to mediate associations with integral membrane proteins, one mode of membrane attachment of ezrin is likely to be mediated through EBP50...
  15. ncbi request reprint Hierarchy of merlin and ezrin N- and C-terminal domain interactions in homo- and heterotypic associations and their relationship to binding of scaffolding proteins EBP50 and E3KARP
    R Nguyen
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 276:7621-9. 2001
    ..E3KARP binds tightly to the ezrin N-ERMAD but has little affinity for the merlin N-ERMAD. The implications of these associations and the hierarchies of binding for the function and regulation of merlin and ERM proteins are discussed...
  16. ncbi request reprint Polarization of cell growth in yeast. I. Establishment and maintenance of polarity states
    D Pruyne
    Department of Molecular Biology, Cornell University, Ithaca, NY 14853, USA
    J Cell Sci 113:365-75. 2000
    ..Given that many of these signaling pathways are present in both fungi and animals, they are probably ancient and conserved mechanisms for regulating polarity...
  17. pmc The rho-GAP encoded by BEM2 regulates cytoskeletal structure in budding yeast
    T Wang
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Mol Biol Cell 6:1011-24. 1995
    ..In addition, we show that bem2 mutations confer benomyl sensitivity and have abnormal microtubule arrays, suggesting that the BEM2 product may also be involved directly or indirectly in regulating microtubule function...
  18. pmc Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins
    R Gary
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853
    Proc Natl Acad Sci U S A 90:10846-50. 1993
    ..These results suggest mechanisms by which ezrin and moesin might participate in dynamic aspects of cortical cytoskeletal structure...
  19. ncbi request reprint Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain
    M A Pearson
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Cell 101:259-70. 2000
    ..This extended binding mode suggests a novel mechanism for how different signals could produce varying levels of activation. Sequence conservation suggests a similar regulation of the tumor suppressor merlin...
  20. ncbi request reprint Ezrin: a protein requiring conformational activation to link microfilaments to the plasma membrane in the assembly of cell surface structures
    A Bretscher
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853, USA
    J Cell Sci 110:3011-8. 1997
    ..Although the membrane-cytoskeletal linking function is clear, further studies are necessary to reveal how the activation of ezrin and its association with different binding partners is regulated...
  21. pmc Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site
    R Gary
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853, USA
    Mol Biol Cell 6:1061-75. 1995
    ..The conformationally inaccessible C-terminal region included the F-actin binding site, suggesting that this activity is likewise regulated by masking...
  22. pmc Polarized growth in budding yeast in the absence of a localized formin
    Lina Gao
    Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Weill Hall, Cornell University, Ithaca, NY 14853, USA
    Mol Biol Cell 20:2540-8. 2009
    ..Our results show that multiple mechanisms contribute to cable orientation and polarized growth, with localized formins and myosin II being two major contributors...
  23. pmc Tropomyosin is essential in yeast, yet the TPM1 and TPM2 products perform distinct functions
    B Drees
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, New York 14853
    J Cell Biol 128:383-92. 1995
    ..S. cerevisiae therefore provides a simple system for the study of two tropomyosins having distinct yet overlapping functions...
  24. ncbi request reprint Moesin, like ezrin, colocalizes with actin in the cortical cytoskeleton in cultured cells, but its expression is more variable
    Z Franck
    Section of Biochemistry, Molecular and Cell Biology, Cornell University, Ithaca, NY 14853
    J Cell Sci 105:219-31. 1993
    ..This study shows that ezrin and moesin have a similar subcellular distribution in cultured cells, yet are distinguishable in their expression, structure and ability to serve as a kinase substrate...
  25. ncbi request reprint Disruption of the single tropomyosin gene in yeast results in the disappearance of actin cables from the cytoskeleton
    H P Liu
    Section on Biochemistry Molecular, Cornell University, Ithaca, New York 14853
    Cell 57:233-42. 1989
    ..These results strongly suggest that tropomyosin interacts with F actin in vivo and may play an important role in assembling or stabilizing actin cables in yeast...
  26. pmc Purification of tropomyosin from Saccharomyces cerevisiae and identification of related proteins in Schizosaccharomyces and Physarum
    H P Liu
    Section of Biochemistry, Cornell University, Ithaca, NY 14853
    Proc Natl Acad Sci U S A 86:90-3. 1989
    ..Our detection of tropomyosin in lower eukaryotes suggests that they might have contractile systems very similar to those found in higher organisms...
  27. pmc Stable and dynamic axes of polarity use distinct formin isoforms in budding yeast
    David Pruyne
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853 2703, USA
    Mol Biol Cell 15:4971-89. 2004
    ..By coupling different formin isoforms to unique cortical landmarks, yeast uses common cytoskeletal elements to maintain stable and dynamic axes in the same cell...
  28. ncbi request reprint Distinct cell type-specific expression of scaffolding proteins EBP50 and E3KARP: EBP50 is generally expressed with ezrin in specific epithelia, whereas E3KARP is not
    Janet Ingraffea
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Eur J Cell Biol 81:61-8. 2002
    ..These results document a preference for co-expression of EBP50, but not E3KARP, with ezrin in polarized epithelia. These results place constraints on the physiological roles that can be proposed for these scaffolding molecules...
  29. pmc Analysis of unregulated formin activity reveals how yeast can balance F-actin assembly between different microfilament-based organizations
    Lina Gao
    Department of Molecular Biology and Genetics, Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA
    Mol Biol Cell 19:1474-84. 2008
    ..Thus, cells must have a way of ensuring a proper balance between actin assembly pathways...
  30. pmc EPI64 regulates microvillar subdomains and structure
    Abraham Hanono
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    J Cell Biol 175:803-13. 2006
    ..These data reveal that microvilli have distinct cytoskeletal subdomains and that EPI64 regulates microvillar structure...
  31. pmc The yeast formin Bnr1p has two localization regions that show spatially and temporally distinct association with septin structures
    Lina Gao
    Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA
    Mol Biol Cell 21:1253-62. 2010
    ..Overexpression of Bnr1p-L1, but not Bnr1p-L2, disrupts septin organization at the bud neck. Thus Bnr1p has two separable regions that each contribute to its bud neck localization...
  32. ncbi request reprint Role of formins in actin assembly: nucleation and barbed-end association
    David Pruyne
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Science 297:612-5. 2002
    ..This combination of properties suggests a direct role for formins in regulating nucleation and polarization of unbranched filamentous actin structures...
  33. ncbi request reprint Ezrin mutants affecting dimerization and activation
    David N Chambers
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, New York 14853, USA
    Biochemistry 44:3926-32. 2005
    ..These results provide strong support for the conformational activation model of ezrin, elucidate the basis for dimer formation, and reveal that a mutant generally considered to be fully activated is not...
  34. pmc The UBX protein SAKS1 negatively regulates endoplasmic reticulum-associated degradation and p97-dependent degradation
    David P LaLonde
    Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 286:4892-901. 2011
    ..Thus, SAKS1 inhibits protein degradation mediated by p97 complexes in the cytosol with a component of the mechanism being the ability to shield polyubiquitin chains from ubiquitin-processing factors...
  35. ncbi request reprint Mechanisms of polarized growth and organelle segregation in yeast
    David Pruyne
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
    Annu Rev Cell Dev Biol 20:559-91. 2004
    ..Indeed, several parallels to cellular organization in animals are evident...
  36. pmc Formin-dependent actin assembly is regulated by distinct modes of Rho signaling in yeast
    Yuqing Dong
    Department of Molecular Biology and Genetics, Cornell University, 353 Biotechnology Building, Ithaca, NY 14853, USA
    J Cell Biol 161:1081-92. 2003
    ..These results show that formin function is under the control of three distinct, essential Rho signaling pathways...
  37. pmc Secretory vesicle transport velocity in living cells depends on the myosin-V lever arm length
    Daniel H Schott
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    J Cell Biol 156:35-9. 2002
    ..Thus, secretory vesicle polarization is achieved through active transport by a myosin-V, and the motor mechanism is consistent with the lever arm model...
  38. ncbi request reprint The EBP50-moesin interaction involves a binding site regulated by direct masking on the FERM domain
    Casey M Finnerty
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
    J Cell Sci 117:1547-52. 2004
    ..The contribution of each ligand to ERM function can now be dissected by making structure-based mutations that specifically affect the binding of each ligand...
  39. pmc A regulated complex of the scaffolding proteins PDZK1 and EBP50 with ezrin contribute to microvillar organization
    David P LaLonde
    Department of Molecular Biology and Genetics, Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853, USA
    Mol Biol Cell 21:1519-29. 2010
    ..By entering into the ternary complex, PDZK1 can both enhance the scaffolding at the apical membrane as well as augment EBP50's role in microvilli formation...
  40. ncbi request reprint Microfilaments and microtubules: the news from yeast
    Daniel Schott
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Curr Opin Microbiol 5:564-74. 2002
    ..Meanwhile, microtubule-binding proteins have been found in the kinetochore, and factors affecting microtubule dynamic instability have been identified...
  41. pmc Characterization of TPM1 disrupted yeast cells indicates an involvement of tropomyosin in directed vesicular transport
    H Liu
    Section of Biochemistry, Cornell University, Ithaca, New York 14853
    J Cell Biol 118:285-99. 1992
    ..We conclude that tropomyosin, and by inference actin cables, may facilitate directed vesicular transport of components to the correct location on the cell surface...
  42. pmc Regulated phosphorylation of budding yeast's essential myosin V heavy chain, Myo2p
    Aster Legesse-Miller
    Department of Molecular Biology and Genetics, Biotechnology Building, Cornell University, Ithaca, NY 14853, USA
    Mol Biol Cell 17:1812-21. 2006
    ..These results suggest that in yeast, Myo2p is subject to phosphoregulation involving a PKA-related signaling pathway...
  43. ncbi request reprint Structure of the active N-terminal domain of Ezrin. Conformational and mobility changes identify keystone interactions
    William James Smith
    Department of Chemistry, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 278:4949-56. 2003
    ..Such interactions are well suited for long-lived cytoskeletal protein interactions. The keystone interactions concept leads us to predict two specific docking sites within lobes F2 and F3 that are likely to bind target proteins...
  44. pmc Immune synapse formation requires ZAP-70 recruitment by ezrin and CD43 removal by moesin
    Tal Ilani
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    J Cell Biol 179:733-46. 2007
    ..In contrast, moesin dephosphorylation and removal, along with CD43, are necessary to prepare a region of the cell cortex for IS. Thus, ezrin and moesin have distinct and critical functions in the T cell cortex during IS formation...
  45. ncbi request reprint Microtubule tips redirect actin assembly
    Anthony Bretscher
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Dev Cell 8:458-9. 2005
    ..Martin et al. describe a direct molecular link between the microtubule tip complex and the formin for3p, the nucleator for assembly of actin cables, which is necessary for this regulatory switch...
  46. pmc The scaffold protein PDZK1 undergoes a head-to-tail intramolecular association that negatively regulates its interaction with EBP50
    David P LaLonde
    Weill Institute for Cell and Molecular Biology, Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    Biochemistry 48:2261-71. 2009
    ..Thus, we have uncovered a regulated association between the two PDZ-containing scaffolding molecules, PDZK1 and EBP50...
  47. ncbi request reprint A Zn-finger/FH2-domain containing protein, FOZI-1, acts redundantly with CeMyoD to specify striated body wall muscle fates in the Caenorhabditis elegans postembryonic mesoderm
    Nirav M Amin
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Development 134:19-29. 2007
    ..elegans postembryonic mesoderm, implicating a remarkable level of complexity for the production of a simple striated musculature in C. elegans...

Research Grants48

  1. Microfilaments in Budding Yeast and the Nematode
    Anthony Bretscher; Fiscal Year: 2009
    ..Thus, the proposed studies will provide insight into a basic cell biology question as well as have clinical relevance. ..
  2. MICROFILAMENT ORGANIZATION AND REGULATION
    Anthony Bretscher; Fiscal Year: 2002
    ..g. EBP50) as well as different conformational states of ezrin. These studies will provide a comprehensive analysis of ezrin and EBP50 and the role they play in the structure and function of the apical membrane. ..
  3. MICROFILAMENTS IN THE YEAST SACCHAROMYCES CEREVISIAE
    Anthony Bretscher; Fiscal Year: 2001
    ....
  4. MICROFILAMENTS IN THE YEAST SACCHAROMYCES CEREVISIAE
    Anthony Bretscher; Fiscal Year: 2005
    ..Since homologues of molecules critical for these processes in yeast have been associated with defects in mice and in human diseases, this work should be of general relevance. ..
  5. MICROFILAMENT ORGANIZATION AND REGULATION
    Anthony P Bretscher; Fiscal Year: 2010
    ..Moreover, ezrin is elevated in many tumors, and an elevated level of ezrin has been shown to be necessary for metastasis in some tumor cell lines. ..
  6. Microfilaments in Budding Yeast and the Nematode
    Anthony Bretscher; Fiscal Year: 2009
    ..Thus, the proposed studies will provide insight into a basic cell biology question as well as have clinical relevance. ..
  7. MICROFILAMENT ORGANIZATION AND REGULATION
    Anthony Bretscher; Fiscal Year: 2007
    ..Moreover, ezrin is elevated in many tumors, and an elevated level of ezrin has been shown to be necessary for metastasis in some tumor cell lines. ..
  8. Microfilaments in Budding Yeast and the Nematode
    Anthony Bretscher; Fiscal Year: 2007
    ..Thus, the proposed studies will provide insight into a basic cell biology question as well as have clinical relevance. ..
  9. MICROFILAMENT ORGANIZATION AND REGULATION
    Anthony Bretscher; Fiscal Year: 2006
    ..This work should provide an integrated approach to the structure and function of the apical aspect of polarized cells. ..
  10. MICROFILAMENTS IN THE YEAST SACCHAROMYCES CEREVISIAE
    Anthony Bretscher; Fiscal Year: 1992
    ..If so, it should set the stage for the thorough analysis of these important cytoskeletal elements...
  11. MICROFILAMENTS IN THE YEAST SACCHAROMYCES CEREVISIAE
    Anthony Bretscher; Fiscal Year: 1993
    ..These studies should greatly advance our goal of uncovering the function of actin and its associated proteins in yeast...
  12. MICROFILAMENT ORGANIZATION AND REGULATION
    Anthony Bretscher; Fiscal Year: 1993
    ..The work set out in this study focusses on three proteins that play key roles in microfilament organizations. The results should provide some important basic information about the regulation and molecular organization of microfilaments...