Research Topics
Genomes and Genes | JAMES BRENNASummaryAffiliation: Cornell University Country: USA Publications
Research Grants
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Publications
Highly sensitive and selective analysis of urinary steroids by comprehensive two-dimensional gas chromatography combined with positive chemical ionization quadrupole mass spectrometryYing Zhang
Cornell University, Division of Nutritional Sciences, Ithaca, NY 14853, USA
Analyst 137:3102-10. 2012....
Plasma incorporation, apparent retroconversion and β-oxidation of 13C-docosahexaenoic acid in the elderlyMélanie Plourde
Research Center on Aging, Health and Social Sciences Center Sherbrooke University Geriatrics Institute, Department of Medicine, Universite de Sherbrooke, Canada
Nutr Metab (Lond) 8:5. 2011....- The influence of long chain polyunsaturate supplementation on docosahexaenoic acid and arachidonic acid in baboon neonate central nervous systemGuan Yeu Diau
Division of Nutritional Sciences, Cornell University, Ithaca, New York, USA
BMC Med 3:11. 2005..We quantitatively mapped fatty acids in 26 regions of the four-week-old breastfed baboon CNS, and studied the influence of dietary DHA and ARA supplementation and prematurity on CNS DHA and ARA concentrations... - Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy, lactation and early post-natal lifeJ Thomas Brenna
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
Matern Child Nutr 7:59-79. 2011..Inclusion of DHA in these diets is likely to further enhance visual and neural development... - Alternative transcripts of fatty acid desaturase (FADS) genesJ Thomas Brenna
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
Prostaglandins Leukot Essent Fatty Acids 82:281-5. 2010..AT may serve as templates to generate protein isoforms or as signaling molecules, and their widespread detection and expression patterns suggest that they play an important role in PUFA biosynthesis... - alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humansJ Thomas Brenna
Division of Nutritional Sciences, Cornell University, Savage Hall, Ithaca, NY 14853, USA
Prostaglandins Leukot Essent Fatty Acids 80:85-91. 2009..With no other changes in diet, improvement of blood DHA status can be achieved with dietary supplements of preformed DHA, but not with supplementation of ALA, EPA, or other precursors... - The influence of dietary docosahexaenoic acid and arachidonic acid on central nervous system polyunsaturated fatty acid compositionJ Thomas Brenna
Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA
Prostaglandins Leukot Essent Fatty Acids 77:247-50. 2007..DHA is a substrate for docosanoids, signaling compounds of intense current interest. The high concentration in tissues with high rates of oxidative metabolism may be explained by a critical role related to oxidative metabolism... 
Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwideJ Thomas Brenna
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14850, USA
Am J Clin Nutr 85:1457-64. 2007..This comprehensive analysis of breast-milk DHA and AA indicates a broad range of these nutrients worldwide and serves as a guide for infant feeding...- Use of stable isotopes to study fatty acid and lipoprotein metabolism in manJ T Brenna
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
Prostaglandins Leukot Essent Fatty Acids 57:467-72. 1997..Carnielli applied GCC-IRMS to 8:0 elongation in very-low-birth-weight infants. Significant conversion products of 8:0 were 14:0 (5%), 16:0 (8%) but not 10:0 or 12:0... - High-precision continuous-flow isotope ratio mass spectrometryJ T Brenna
Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA
Mass Spectrom Rev 16:227-58. 1997..Finally, IRMS notation and useful elementary isotopic relationships derived from the fundamental mass balance equation are presented... - Natural intramolecular isotope measurements in physiology: elements of the case for an effort toward high-precision position-specific isotope analysisJ T Brenna
Division of Nutritional Sciences, Savage Hall, Cornell University, Ithaca, New York 14853, USA
Rapid Commun Mass Spectrom 15:1252-62. 2001..This science of isotope physiology, or simply isotopics, should add an important tool for elucidation of early factors that effect later health, probably the most difficult class of biomedical issues... - Efficiency of conversion of alpha-linolenic acid to long chain n-3 fatty acids in manJ Thomas Brenna
Division of Nutritional Sciences, Savage Hall, Cornell University, Ithaca, New York 14853, USA
Curr Opin Clin Nutr Metab Care 5:127-32. 2002..Further studies are required to establish quantitatively the partitioning of dietary 18:3n-3 among metabolic pathways and the influence of other dietary components and of physiological states on these processes... - The influence of moderate and high dietary long chain polyunsaturated fatty acids (LCPUFA) on baboon neonate tissue fatty acidsAndrea T Hsieh
Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA
Pediatr Res 61:537-45. 2007..These results imply that higher levels of DHA are necessary to normalize cortex DHA to those found in breastfed animals... - Dietary docosahexaenoic acid but not arachidonic acid influences central nervous system fatty acid status in baboon neonatesAndrea T Hsieh
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
Prostaglandins Leukot Essent Fatty Acids 81:105-10. 2009..These data on structure-specific LCPUFA accretion may provide insight into neural mechanisms responsible for suboptimal functional outcomes in infants consuming diets that do not support the highest tissue DHA levels... - Mice lacking FABP9/PERF15 develop sperm head abnormalities but are fertileVimal Selvaraj
Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
Dev Biol 348:177-89. 2010..Therefore, we conclude that FABP9 plays only a minor role in providing the murine sperm head its characteristic shape and is not absolutely required for spermatogenesis or sperm function... - Novel fatty acid desaturase 3 (FADS3) transcripts generated by alternative splicingWoo Jung Park
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
Gene 446:28-34. 2009..FADS3 AT, conserved in primates and under metabolic control in human cells, are a putative mediator of LCPUFA biosynthesis and/or regulation... - Influence of dietary long-chain PUFA on premature baboon lung FA and dipalmitoyl PC compositionAngela Chueh Chao
Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA
Lipids 38:425-9. 2003..The shift in FA composition toward greater unsaturation in the groups consuming LCP supported improved surfactant lipid concentration in preterm neonate lungs... - Alternative splicing generates a novel FADS2 alternative transcript in baboonsWoo Jung Park
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
Mol Biol Rep 37:2403-6. 2010..These data suggest that FADS2 AT1 is a candidate for regulation of LCPUFA synthesis... - Efficacy of dietary arachidonic acid provided as triglyceride or phospholipid as substrates for brain arachidonic acid accretion in baboon neonatesVasuki Wijendran
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
Pediatr Res 51:265-72. 2002..0-fold greater from TG-AA than from PL-AA. We estimate that about half of postnatal brain AA accretion is derived from dietary preformed AA in term baboon neonates consuming a formula with lipid composition similar to that of human milk... - Differential cerebral cortex transcriptomes of baboon neonates consuming moderate and high docosahexaenoic acid formulasKumar S D Kothapalli
Division of Nutritional Sciences, Cornell University, Savage Hall, Ithaca, New York, United States of America
PLoS ONE 2:e370. 2007..There are no investigations in primates of the biological consequences of dietary DHA at levels above those present in formulas but within normal breastmilk levels... - Docosahexaenoic and arachidonic acid influence on preterm baboon retinal composition and functionGuan-Yeu Diau
Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA
Invest Ophthalmol Vis Sci 44:4559-66. 2003..Formula supplemented with 22:6n-3 prevents a decrease in retinal 22:6n-3 and improves preterm ERG parameters compared with unsupplemented formula. Retinal 22:6n-3 status is most closely associated with a-wave parameters... - Formula feeding potentiates docosahexaenoic and arachidonic acid biosynthesis in term and preterm baboon neonatesEszter Sarkadi-Nagy
Division of Nutritional Sciences, Savage Hall, Cornell University, Ithaca, NY 14853
J Lipid Res 45:71-80. 2004..Current formula DHA concentrations are inadequate to normalize long-chain polyunsaturated fatty acids synthesis to that of breast-fed levels... - The influence of prematurity and long chain polyunsaturate supplementation in 4-week adjusted age baboon neonate brain and related tissuesEszter Sarkadi-Nagy
Cornell University, Savage Hall, Ithaca, NY 14853, USA
Pediatr Res 54:244-52. 2003.... - Biochemical and white blood cell profiles of baboon neonates consuming formulas with moderate and high dietary long-chain polyunsaturated fatty acidsA T Hsieh
Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA
J Med Primatol 37:81-7. 2008..Clinical chemistry and complete blood count (CBC) values were determined in 14 term baboons (Papio species) consuming formula with moderate or high levels of dietary long-chain polyunsaturated fatty acids (LCPUFA) from 2-12 weeks of age... - An alternate pathway to long-chain polyunsaturates: the FADS2 gene product Delta8-desaturates 20:2n-6 and 20:3n-3Woo Jung Park
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
J Lipid Res 50:1195-202. 2009..These findings provide unequivocal molecular evidence for a novel alternative biosynthetic route to long-chain polyunsaturated fatty acids in mammals from substrates previously considered to be dead-end products... - Double bond localization in minor homoallylic fatty acid methyl esters using acetonitrile chemical ionization tandem mass spectrometryAnthony L Michaud
Cornell University, Savage Hall, Ithaca, NY 14853, USA
Anal Biochem 307:348-60. 2002..The primate brain 22:3n-7 and algae 18:4n-5 are novel fatty acids. These results demonstrate the usefulness of the technique for analysis of real samples. Tables are presented to aid in interpretation of acetonitrile CIMS/MS spectra... - Acetonitrile covalent adduct chemical ionization mass spectrometry for double bond localization in non-methylene-interrupted polyene fatty acid methyl estersPeter Lawrence
Division of Nutritional Sciences, Savage Hall, Cornell University, Ithaca, NY 14853, USA
Anal Chem 78:1312-7. 2006..These data extend the principle of double bond localization by acetonitrile CACI-MS/MS to double bond structure in complex FAME found in nature... - Fast gas chromatography combustion isotope ratio mass spectrometryGavin L Sacks
Cornell University, Division of Nutritional Sciences, Savage Hall, Ithaca, New York 14853, USA
Anal Chem 79:6348-58. 2007.... - Disruption of FADS2 gene in mice impairs male reproduction and causes dermal and intestinal ulcerationChad K Stroud
Division of Nutritional Sciences, Department of Food Science and Human Nutrition, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
J Lipid Res 50:1870-80. 2009.... - Atmospheric pressure covalent adduct chemical ionization tandem mass spectrometry for double bond localization in monoene- and diene-containing triacylglycerolsYichuan Xu
Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA
Anal Chem 79:2525-36. 2007..With the exception of geometries about the double bonds, racemic TAG isomers containing two monoenes or dienes and a saturate can be fully characterized by APCACI-MS/MS/MS... - Individual trans octadecenoic acids and partially hydrogenated vegetable oil differentially affect hepatic lipid and lipoprotein metabolism in golden Syrian hamstersCynthia Tyburczy
Department of Animal Science and 5Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
J Nutr 139:257-63. 2009..Overall, results demonstrate that the hypercholesterolemic effects of PHVO are not dependent on the presence of EA or VA and that other bioactive components in PHVO must be responsible for its associated adverse health effects... - Branched chain fatty acids are constituents of the normal healthy newborn gastrointestinal tractRinat R Ran-Ressler
Division of Nutritional Sciences, Cornell University, Ithaca, New York 14853, USA
Pediatr Res 64:605-9. 2008..BCFA are candidates for agents that play a role in gut colonization and should be considered a nutritional component for the fetus/newborn... - The influence of maternal early to mid-gestation nutrient restriction on long chain polyunsaturated fatty acids in fetal sheepYunhua Zhou
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
Lipids 43:525-31. 2008.... - Identification and characterization of conjugated fatty acid methyl esters of mixed double bond geometry by acetonitrile chemical ionization tandem mass spectrometryAnthony L Michaud
Division of Nutritional Sciences, Cornell University, Savage Hall, Ithaca, New York 14853, USA
Anal Chem 75:4925-30. 2003.... - Differential tissue dose responses of (n-3) and (n-6) PUFA in neonatal piglets fed docosahexaenoate and arachidonoateMeng Chuan Huang
Department of Public Health, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80705, Taiwan
J Nutr 137:2049-55. 2007.... - Long chain polyunsaturate supplementation does not induce excess lipid peroxidation of piglet tissuesEszter Sarkadi-Nagy
Semmelweis University, Faculty of Medicine, Institute of Pathophysiology, Budapest, Hungary
Eur J Nutr 42:293-6. 2003..CONCLUSION: The results show that dietary vitamin E effectively prevented lipid peroxidation at the LCP concentrations investigated and suggest that levels presently in infant formulas are sufficient... - Dietary fat intakes for pregnant and lactating womenBerthold Koletzko
Dr von Hauner Children s Hospital, University of Munich, Germany
Br J Nutr 98:873-7. 2007.... - Effects of conjugated linoleic acid on linoleic and linolenic acid metabolism in manAnu M Turpeinen
Department of Applied Chemistry and Microbiology Nutrition, University of Helsinki, PO Box 66, 00014 University of Helsinki, Finland
Br J Nutr 95:727-33. 2006..This suggests that, in healthy human subjects consuming a diet with adequate intake of essential fatty acids, CLA does not affect metabolism of LA or LNA... - Straight-chain acyl-CoA oxidase knockout mouse accumulates extremely long chain fatty acids from alpha-linolenic acid: evidence for runaway carousel-type enzyme kinetics in peroxisomal beta-oxidation diseasesJuan P Infante
Institute for Theoretical Biochemistry and Molecular Biology, Ithaca, New York, 14852
Mol Genet Metab 75:108-19. 2002.... - Omega-3 fatty acids, energy substrates, and brain function during agingErika Freemantle
Research Centre on Aging, 1036 Belvedere Street South, , Sherbrooke, Qu, Canada J1H 4C4
Prostaglandins Leukot Essent Fatty Acids 75:213-20. 2006..Hence, it may be time to consider whether the main omega-3 fatty acids have distinct but complementary roles in brain function...
Research Grants
- DIETARY ESSENTIAL FATTY ACID ACCUMULATION IN RETINAJAMES BRENNA; Fiscal Year: 2002..Sub-normal development will be directly revealed via functional tests to assess the impact of low omega-3 fatty acid status on develop of vision acid status on development of vision and related health parameters. ..
- PRECISE ISOTOPE RATIO CHROMATOGRAPHY AND STABLE TRACERSJAMES BRENNA; Fiscal Year: 2004..The successful accomplishment of these plans will yield new tools and experimental approaches for investigation of the impact of developmental factors and recent physiological history on development of chronic disease. ..
- Lipidomics Session ISSFAL 2006JAMES BRENNA; Fiscal Year: 2006..ISSFAL 2006 is expected to be among the most important international lipid metabolism conferences of the year, and a lipidomics symposium is timely given the increasing progress in this area. ..
- LCPUFA Status and Birth Outcome in IndiaJAMES BRENNA; Fiscal Year: 2007..Positive results would justify an intervention studies to include LCPUFA in the diets of pregnant women in developed and developing countries. ..
- Gas phase derivatization for lipidomic MS analysisJAMES BRENNA; Fiscal Year: 2007....
- PRECISE ISOTOPE RATIO CHROMATOGRAPHY AND STABLE TRACERSJAMES BRENNA; Fiscal Year: 1993..The computer program CONSAAM will be used for biokinetic modeling of fatty acid transport and transformation as components of specific lipid classes in lipoproteins and plasma borne cell types...
- PRECISE ISOTOPE RATIO CHROMATOGRAPHY AND STABLE TRACERSJAMES BRENNA; Fiscal Year: 2000..Finally, continued studies of fatty acid metabolism in humans, particularly transformations of fatty acids into other bioactive molecules, allows timely evaluation and refinement of developed instruments and methods. ..
- GCx(py)GCC-IRMS for Isotope MetabolomicsJAMES T BRENNA; Fiscal Year: 2010..Applications to polyunsaturated fatty acid and lactic acid metabolism are pro- posed. ..