Yves Boisclair

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi The acid-labile subunit (ALS) of the 150 kDa IGF-binding protein complex: an important but forgotten component of the circulating IGF system
    Y R Boisclair
    Department of Animal Science, Cornell University, Ithaca, New York 14853, USA
    J Endocrinol 170:63-70. 2001
  2. ncbi Isolation of the cDNA encoding the acid labile subunit (ALS) of the 150 kDa IGF-binding protein complex in cattle and ALS regulation during the transition from pregnancy to lactation
    Jin W Kim
    Department of Animal Science, 259 Morrison Hall, Cornell University, Ithaca, New York 14853 4801, USA
    J Endocrinol 189:583-93. 2006
  3. doi Adiponectin deficit during the precarious glucose economy of early lactation in dairy cows
    Sarah L Giesy
    Department of Animal Science, Ithaca, NY 14853, USA
    Endocrinology 153:5834-44. 2012
  4. doi Plasma FGF21 is elevated by the intense lipid mobilization of lactation
    Katie M Schoenberg
    Department of Animal Science, Cornell University, 259 Morrison Hall, Ithaca, New York 14853, USA
    Endocrinology 152:4652-61. 2011
  5. ncbi Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-1beta on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells
    Y R Boisclair
    Department of Animal Science, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 275:3841-7. 2000
  6. ncbi Regulation and role of the acid-labile subunit of the 150-kilodalton insulin-like growth factor complex in the mouse
    Y R Boisclair
    Department of Animal Science, Cornell University, Ithaca, NY 14853, USA
    Pediatr Nephrol 14:562-6. 2000
  7. pmc t10,c12-CLA decreases adiposity in peripubertal mice without dose-related detrimental effects on mammary development, inflammation status, and metabolism
    M R Foote
    Dept of Animal Science, Cornell Univ, 259 Morrison Hall, Ithaca, NY 14853, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1521-8. 2010
  8. pmc Circulating levels of IGF-1 directly regulate bone growth and density
    Shoshana Yakar
    Section on Cellular and Molecular Physiology, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 110:771-81. 2002
  9. ncbi Spatial and developmental regulation of leptin in fetal sheep
    Richard A Ehrhardt
    Department of Animal Science, Cornell University, Ithaca, New York 14853, USA
    Am J Physiol Regul Integr Comp Physiol 282:R1628-35. 2002
  10. pmc Protein tyrosine phosphatase 1B attenuates growth hormone-mediated JAK2-STAT signaling
    Feng Gu
    McGill Cancer Center and Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Mol Cell Biol 23:3753-62. 2003

Research Grants

  1. REGULATION OF ALS AND ITS ROLE IN THE IGF SYSTEM
    Yves Boisclair; Fiscal Year: 2002
  2. REGULATION OF ALS AND ITS ROLE IN THE IGF SYSTEM
    Yves Boisclair; Fiscal Year: 2006

Collaborators

Detail Information

Publications10

  1. ncbi The acid-labile subunit (ALS) of the 150 kDa IGF-binding protein complex: an important but forgotten component of the circulating IGF system
    Y R Boisclair
    Department of Animal Science, Cornell University, Ithaca, New York 14853, USA
    J Endocrinol 170:63-70. 2001
    ..This review provides an overview on the current knowledge of ALS protein and gene structure, organisation and regulation by hormones, and insights from novel animal models such as the ALS knockout mice...
  2. ncbi Isolation of the cDNA encoding the acid labile subunit (ALS) of the 150 kDa IGF-binding protein complex in cattle and ALS regulation during the transition from pregnancy to lactation
    Jin W Kim
    Department of Animal Science, 259 Morrison Hall, Cornell University, Ithaca, New York 14853 4801, USA
    J Endocrinol 189:583-93. 2006
    ..We conclude that the decline in plasma ALS after parturition is a consequence of hepatic GH resistance and contributes to the associated reduction of plasma IGF-I...
  3. doi Adiponectin deficit during the precarious glucose economy of early lactation in dairy cows
    Sarah L Giesy
    Department of Animal Science, Ithaca, NY 14853, USA
    Endocrinology 153:5834-44. 2012
    ..These data suggest that reduced plasma adiponectin belongs to the subset of hormonal adaptations in EL dairy cows facilitating mammary glucose uptake via promotion of insulin resistance...
  4. doi Plasma FGF21 is elevated by the intense lipid mobilization of lactation
    Katie M Schoenberg
    Department of Animal Science, Cornell University, 259 Morrison Hall, Ithaca, New York 14853, USA
    Endocrinology 152:4652-61. 2011
    ..Overall, these data suggest a model whereby liver-derived FGF21 regulates the use of lipid reserves during lactation via focal actions on liver and WAT...
  5. ncbi Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-1beta on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells
    Y R Boisclair
    Department of Animal Science, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 275:3841-7. 2000
    ..We conclude that the induction of SOCS3 by IL-1beta contributes to the development of GH resistance in liver, and represents a mechanism by which cytokines such as IL-1beta cross-talk with cytokines using the JAK-STAT pathway...
  6. ncbi Regulation and role of the acid-labile subunit of the 150-kilodalton insulin-like growth factor complex in the mouse
    Y R Boisclair
    Department of Animal Science, Cornell University, Ithaca, NY 14853, USA
    Pediatr Nephrol 14:562-6. 2000
    ..Studies of this model will lead to a better understanding of the circulating IGF system...
  7. pmc t10,c12-CLA decreases adiposity in peripubertal mice without dose-related detrimental effects on mammary development, inflammation status, and metabolism
    M R Foote
    Dept of Animal Science, Cornell Univ, 259 Morrison Hall, Ithaca, NY 14853, USA
    Am J Physiol Regul Integr Comp Physiol 299:R1521-8. 2010
    ....
  8. pmc Circulating levels of IGF-1 directly regulate bone growth and density
    Shoshana Yakar
    Section on Cellular and Molecular Physiology, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 110:771-81. 2002
    ....
  9. ncbi Spatial and developmental regulation of leptin in fetal sheep
    Richard A Ehrhardt
    Department of Animal Science, Cornell University, Ithaca, New York 14853, USA
    Am J Physiol Regul Integr Comp Physiol 282:R1628-35. 2002
    ..The role of fetal plasma leptin remains uncertain given the lack of nutritional regulation and association with fetal growth...
  10. pmc Protein tyrosine phosphatase 1B attenuates growth hormone-mediated JAK2-STAT signaling
    Feng Gu
    McGill Cancer Center and Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    Mol Cell Biol 23:3753-62. 2003
    ..These results indicate that PTP-1B regulates GH signaling by reducing the extent of JAK2 phosphorylation and suggest that PTP-1B is essential for limiting the action of GH during metabolic stress such as fasting...

Research Grants10

  1. REGULATION OF ALS AND ITS ROLE IN THE IGF SYSTEM
    Yves Boisclair; Fiscal Year: 2002
    ..3. To study the fuction of the ALS protein in vivo. This will be done by obtaineng and studying mice in which the ALS protein is absent. These mice iwll be created by the gene knockout approach. ..
  2. REGULATION OF ALS AND ITS ROLE IN THE IGF SYSTEM
    Yves Boisclair; Fiscal Year: 2006
    ..Overall, these studies will significantly advance our understanding of the roles played by ALS and the circulating IGF reservoir in diseases of postnatal life. ..