M Altemus

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi Phenotypic differences between pregnancy-onset and postpartum-onset major depressive disorder
    Margaret Altemus
    Department of Psychiatry, Weill Medical College, Cornell University, NY, USA
    J Clin Psychiatry 73:e1485-91. 2012
  2. ncbi Immune function in PTSD
    Margaret Altemus
    Department of Psychiatry, Weill Medical College, Cornell University, Box 244, 1300 York Ave, New York, NY 10021, USA
    Ann N Y Acad Sci 1071:167-83. 2006
  3. ncbi Changes in cerebrospinal fluid neurochemistry during pregnancy
    Margaret Altemus
    Department of Psychiatry, Weill Medical College, Cornell University, New York, New York 10021, USA
    Biol Psychiatry 56:386-92. 2004
  4. ncbi Enhanced cellular immune response in women with PTSD related to childhood abuse
    Margaret Altemus
    Department of Psychiatry, Weill Medical College, Cornell University, 1300 York Avenue, Box 244, New York, NY 10021, USA
    Am J Psychiatry 160:1705-7. 2003
  5. ncbi Sex differences in depression and anxiety disorders: potential biological determinants
    Margaret Altemus
    Department of Psychiatry, Weill Medical College, Cornell University, New York, NY 10021, USA
    Horm Behav 50:534-8. 2006
  6. ncbi Responses to laboratory psychosocial stress in postpartum women
    M Altemus
    Department of Psychiatry, Weill Medical College, Cornell University, New York, NY 10021, USA
    Psychosom Med 63:814-21. 2001
  7. ncbi Growth hormone response to clonidine in adversely reared young adult primates: relationship to serial cerebrospinal fluid corticotropin-releasing factor concentrations
    J D Coplan
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, Unit 14, New York, NY 10032, USA
    Psychiatry Res 95:93-102. 2000
  8. ncbi Lymphocyte responses to stress in postpartum women: relationship to vagal tone
    L S Redwine
    Department of Psychiatry, University of California San Diego, CA 92161, USA
    Psychoneuroendocrinology 26:241-51. 2001
  9. ncbi Neuroendocrine and emotional changes in the post-partum period
    C S Carter
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Prog Brain Res 133:241-9. 2001
  10. ncbi Abnormalities in response to vasopressin infusion in chronic fatigue syndrome
    M Altemus
    Weill Medical College, Cornell University, Box 244, 1300 York Avenue, New York, NY 10021, USA
    Psychoneuroendocrinology 26:175-88. 2001

Research Grants

  1. ESTROGEN EFFECTS ON ANXIETY RELATED NEURAL SYSTEMS
    Margaret Altemus; Fiscal Year: 2004
  2. EFFECT OF SRIs ON GONADAL STEROIDS
    Margaret Altemus; Fiscal Year: 2006
  3. Androgen Hormones in PMDD
    Margaret Altemus; Fiscal Year: 2007
  4. Symptom Onset Antidepressant Treatment for PMDD
    Margaret Altemus; Fiscal Year: 2007
  5. Symptom Onset Antidepressant Treatment for PMDD
    Margaret Altemus; Fiscal Year: 2009
  6. Symptom Onset Antidepressant Treatment for PMDD
    Margaret Altemus; Fiscal Year: 2010
  7. Symptom Onset Antidepressant Treatment for PMDD
    Margaret Altemus; Fiscal Year: 2010

Collaborators

Detail Information

Publications33

  1. ncbi Phenotypic differences between pregnancy-onset and postpartum-onset major depressive disorder
    Margaret Altemus
    Department of Psychiatry, Weill Medical College, Cornell University, NY, USA
    J Clin Psychiatry 73:e1485-91. 2012
    ..The hormonal environments of pregnancy and postpartum periods are quite different and therefore may promote distinct subtypes of major depression...
  2. ncbi Immune function in PTSD
    Margaret Altemus
    Department of Psychiatry, Weill Medical College, Cornell University, Box 244, 1300 York Ave, New York, NY 10021, USA
    Ann N Y Acad Sci 1071:167-83. 2006
    ..These findings contrast with suppression of DTH and skin barrier function recovery in healthy volunteers in response to acute psychological stress...
  3. ncbi Changes in cerebrospinal fluid neurochemistry during pregnancy
    Margaret Altemus
    Department of Psychiatry, Weill Medical College, Cornell University, New York, New York 10021, USA
    Biol Psychiatry 56:386-92. 2004
    ..Little is known about changes in brain function that may occur during pregnancy. Studies in rodents and sheep suggest that several brain neurotransmitter and neurohormonal systems known to modulate anxiety may be altered during pregnancy...
  4. ncbi Enhanced cellular immune response in women with PTSD related to childhood abuse
    Margaret Altemus
    Department of Psychiatry, Weill Medical College, Cornell University, 1300 York Avenue, Box 244, New York, NY 10021, USA
    Am J Psychiatry 160:1705-7. 2003
    ....
  5. ncbi Sex differences in depression and anxiety disorders: potential biological determinants
    Margaret Altemus
    Department of Psychiatry, Weill Medical College, Cornell University, New York, NY 10021, USA
    Horm Behav 50:534-8. 2006
    ....
  6. ncbi Responses to laboratory psychosocial stress in postpartum women
    M Altemus
    Department of Psychiatry, Weill Medical College, Cornell University, New York, NY 10021, USA
    Psychosom Med 63:814-21. 2001
    ..This study was designed to determine the effect of lactation on hypothalamic-pituitary-adrenal axis, autonomic nervous system, and anxiety responses to psychological stress...
  7. ncbi Growth hormone response to clonidine in adversely reared young adult primates: relationship to serial cerebrospinal fluid corticotropin-releasing factor concentrations
    J D Coplan
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, Unit 14, New York, NY 10032, USA
    Psychiatry Res 95:93-102. 2000
    ..These data raise the possibility that a reduced GH response to clonidine may inversely reflect trait-like increases of central nervous system (CNS) CRF activity...
  8. ncbi Lymphocyte responses to stress in postpartum women: relationship to vagal tone
    L S Redwine
    Department of Psychiatry, University of California San Diego, CA 92161, USA
    Psychoneuroendocrinology 26:241-51. 2001
    ..To summarize, these findings suggest that lactation and parturition can influence lymphocyte proliferation and that activity in the vagal system may influence lymphocyte responses to stress...
  9. ncbi Neuroendocrine and emotional changes in the post-partum period
    C S Carter
    Department of Psychiatry, University of Illinois at Chicago, Chicago, IL 60612, USA
    Prog Brain Res 133:241-9. 2001
    ..The integrative function of neural systems that influence both reproduction and the hypothalamo-pituitary-adrenal axis suggests one central mechanism for mediating the effects of environmental challenges...
  10. ncbi Abnormalities in response to vasopressin infusion in chronic fatigue syndrome
    M Altemus
    Weill Medical College, Cornell University, Box 244, 1300 York Avenue, New York, NY 10021, USA
    Psychoneuroendocrinology 26:175-88. 2001
    ..These results provide further evidence of reduced hypothalamic CRH secretion in patients with chronic fatigue syndrome...
  11. ncbi Open trial of flutamide for treatment of obsessive-compulsive disorder
    M Altemus
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Clin Psychiatry 60:442-5. 1999
    ..In this study, we examined the effects of treatment with flutamide, a synthetic, nonsteroidal, competitive antagonist of the androgen receptor, on OCD symptoms...
  12. ncbi Orbitofrontal cortex activity related to emotional processing changes across the menstrual cycle
    Xenia Protopopescu
    Functional Neuroimaging Laboratory, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:16060-5. 2005
    ..The data also demonstrate that menstrual cycle phase is an important consideration in further studies attempting to elucidate the neural substrates of affective representation...
  13. ncbi Hippocampal structural changes across the menstrual cycle
    Xenia Protopopescu
    Functional Neuroimaging Laboratory, Weill Medical College of Cornell University, New York, New York 10021, USA
    Hippocampus 18:985-8. 2008
    ....
  14. ncbi Diurnal cortisol amplitude and fronto-limbic activity in response to stressful stimuli
    Amy C Cunningham-Bussel
    Functional Neuroimaging Laboratory, Department of Psychiatry, Box 140, Rm 1302, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, United States
    Psychoneuroendocrinology 34:694-704. 2009
    ....
  15. ncbi Toward a functional neuroanatomy of premenstrual dysphoric disorder
    Xenia Protopopescu
    Functional Neuroimaging Laboratory, Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, United States
    J Affect Disord 108:87-94. 2008
    ..The neurobiology of this underdiagnosed and undertreated illness is poorly understood. A functional magnetic resonance imaging (fMRI) probe of fronto-limbic function was used to advance understanding of PMDD pathophysiology...
  16. ncbi Frontolimbic function and cortisol reactivity in response to emotional stimuli
    James C Root
    Functional Neuroimaging Laboratory, Department of Psychiatry, PO Box 140, Weill Medical College of Cornell University, 1300 York Avenue, NY 10021, USA
    Neuroreport 20:429-34. 2009
    ..Cortisol reactivity to the paradigm was positively associated with amygdalar and hippocampal activity and negatively associated with ventromedial prefrontal cortex activity in conditions involving emotional imagery...
  17. ncbi Salivary cortisol and psychopathology in adults bereaved by the September 11, 2001 terror attacks
    Cynthia R Pfeffer
    Weill Cornell Medical College, New York Presbyterian Hospital, White Plains, NY 10605, USA
    Int J Psychiatry Med 39:215-26. 2009
    ..This prospective study aimed to describe the nature and time course of HPA axis dysregulation and psychopathology among terror-bereaved spouses...
  18. ncbi Salivary cortisol and psychopathology in children bereaved by the september 11, 2001 terror attacks
    Cynthia R Pfeffer
    Department of Psychiatry, Weill Medical College of Cornell University, New York, 10605 USA
    Biol Psychiatry 61:957-65. 2007
    ..This prospective longitudinal study evaluated relationships among severe psychosocial stress, psychiatric morbidity, and HPA axis function in children...
  19. ncbi Variable foraging demand rearing: sustained elevations in cisternal cerebrospinal fluid corticotropin-releasing factor concentrations in adult primates
    J D Coplan
    Department of Psychiatry, SUNY Health Science Center, Brooklyn, New York 11203, USA
    Biol Psychiatry 50:200-4. 2001
    ..CONCLUSIONS: Disturbances of maternal-infant attachment processes have an enduring impact on primate CRF function into young adulthood. The CRF elevations following unpredictable maternal foraging conditions appear traitlike in nature...
  20. ncbi Stress-induced changes in skin barrier function in healthy women
    M Altemus
    Department of Psychiatry, Weill Medical College, Cornell University, New York, New York 10021, USA
    J Invest Dermatol 117:309-17. 2001
    ..These results suggest that acute psychosocial and sleep deprivation stress disrupts skin barrier function homeostasis in women, and that this disruption may be related to stress-induced changes in cytokine secretion...
  21. ncbi HPA axis activation in major depression and response to fluoxetine: a pilot study
    Elizabeth A Young
    Department of Psychiatry, The Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0729, USA
    Psychoneuroendocrinology 29:1198-204. 2004
    ..This may reflect the greater severity of subjects with HPA axis dysregulation or the need to normalize the HPA axis with medications for optimal response...
  22. ncbi Brain-derived neurotrophic factor as a model system for examining gene by environment interactions across development
    B J Casey
    Weill Cornell Medical College, New York, NY 10065, USA
    Neuroscience 164:108-20. 2009
    ..The findings illustrate the use of a genetic mouse model that mimics the human polymorphism, to constrain the interpretation of gene-environment interactions across development in humans...
  23. ncbi Increased vasopressin and adrenocorticotropin responses to stress in the midluteal phase of the menstrual cycle
    M Altemus
    Department of Psychiatry, Weill Medical College, Cornell University, New York, New York 10021, USA
    J Clin Endocrinol Metab 86:2525-30. 2001
    ..01), and glucose (P < 0.001) secretion. These findings suggest that relatively low levels of gonadal steroids during the early follicular phase of the menstrual cycle provide protection from the impact of stress on the HPA axis...
  24. ncbi The effect of a contemplative self-healing program on quality of life in women with breast and gynecologic cancers
    Joseph J Loizzo
    Center for Complementary and Integrative Medicine, Weill Cornell Medical College, New York, New York, USA
    Altern Ther Health Med 16:30-7. 2010
    ..These findings suggest a contemplative self-healing program can be effective in significantly improving QOL and reducing distress and disability among female breast and gynecologic cancer survivors...
  25. ncbi Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder
    M Karayiorgou
    The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:4572-5. 1997
    ..The mechanism underlying this sex-selective association remains to be defined and may include a sexual dimorphism in COMT activity, although close linkage with a nearby disease susceptibility locus cannot be excluded at this point...
  26. ncbi Differing concentrations of corticotropin-releasing factor and oxytocin in the cerebrospinal fluid of bonnet and pigtail macaques
    Leonard A Rosenblum
    Department of Psychiatry, SUNY Health Science Center at Brooklyn, State University of New York, 450 Clarkson Avenue, Brooklyn 11203 2098, USA
    Psychoneuroendocrinology 27:651-60. 2002
    ....
  27. ncbi Sex-related differences in stimulated hypothalamic-pituitary-adrenal axis during induced gonadal suppression
    Catherine A Roca
    Office of Special Populations, National Institute of Mental Health, Rockville, Maryland 20857, USA
    J Clin Endocrinol Metab 90:4224-31. 2005
    ..e. in the absence of characteristic differences in reproductive steroids)...
  28. ncbi Differential menstrual cycle regulation of hypothalamic-pituitary-adrenal axis in women with premenstrual syndrome and controls
    Catherine A Roca
    Behavioral Endocrinology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Endocrinol Metab 88:3057-63. 2003
    ..These data demonstrate that women with PMS, when symptomatic, appear to have an abnormal response to progesterone and, furthermore, do not display the HPA axis abnormalities characteristic of major depression...
  29. ncbi Effects of emotion on oxytocin, prolactin, and ACTH in women
    Rebecca A Turner
    California School of Professional Psychology, Alliant International University, San Francisco 94109, USA
    Stress 5:269-76. 2002
    ..Overall, the degree of change in circulating hormones in response to happy and sad emotions was very small and possibly not functionally significant...
  30. ncbi Replication of a premenstrual decrease in right-ear advantage on language-related dichotic listening tests of cerebral laterality
    Gerianne M Alexander
    Yale University Child Study Center, 230 South Frontage Road, New Haven, CT 06520, USA
    Neuropsychologia 40:1293-9. 2002
    ..Future research manipulating task demands (e.g. memory load) or the affective valence of the stimuli may be useful in understanding the observed changes in hemispheric advantage...
  31. ncbi Puberty, ovarian steroids, and stress
    Elizabeth A Young
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Ann N Y Acad Sci 1021:124-33. 2004
    ..The onset of these reproductive hormonal changes modulating stress systems at puberty may sensitize girls to stressful life events, which become more frequent at the transition to puberty and young adulthood...
  32. ncbi Maternal-infant response to variable foraging demand in nonhuman primates: effects of timing of stressor on cerebrospinal fluid corticotropin-releasing factor and circulating glucocorticoid concentrations
    Jeremy D Coplan
    State University of New York SUNY, Downstate Medical Center Box 120, 450 Clarkson Ave, Brooklyn, NY 11203, USA
    Ann N Y Acad Sci 1071:525-33. 2006
    ..However, absolute cortisol change was greater in early versus late VFD. Timing of the VFD stressor differentially affects maternal neuroendocrine response, with potential implications for the offspring's developmental trajectory...
  33. ncbi Romantic love and sexual desire in close relationships
    Gian C Gonzaga
    Department of Psychology, University of California, Los Angeles, CA, USA
    Emotion 6:163-79. 2006
    ..In Study 2, the nonverbal display of romantic love was related to the release of oxytocin. Discussion focuses on the place of romantic love and sexual desire in the literature on emotion...

Research Grants8

  1. ESTROGEN EFFECTS ON ANXIETY RELATED NEURAL SYSTEMS
    Margaret Altemus; Fiscal Year: 2004
    ..This field of investigation is likely to improve understanding and treatment of anxiety and affective disorders, both of which are widely prevalent, chronic public health problems. ..
  2. EFFECT OF SRIs ON GONADAL STEROIDS
    Margaret Altemus; Fiscal Year: 2006
    ..Currently, for the 30% of subjects with PMDD and OCD who do not respond to SRI treatment, there are few, if any, alternative pharmacologic strategies. ..
  3. Androgen Hormones in PMDD
    Margaret Altemus; Fiscal Year: 2007
    ..This study will also provide evidence as to whether androgen hormones, acting through androgen receptors, play a role in the pathophysiology of PMDD. ..
  4. Symptom Onset Antidepressant Treatment for PMDD
    Margaret Altemus; Fiscal Year: 2007
    ..The findings of this study, designed to reflect real-life implementation (i.e., symptom onset), will assist in developing practical treatment guidelines for women with PMDD. ..
  5. Symptom Onset Antidepressant Treatment for PMDD
    Margaret Altemus; Fiscal Year: 2009
    ..The findings of this study, designed to reflect real-life implementation (i.e., symptom onset), will assist in developing practical treatment guidelines for women with PMDD. ..
  6. Symptom Onset Antidepressant Treatment for PMDD
    Margaret Altemus; Fiscal Year: 2010
    ..The findings of this study, designed to reflect real-life implementation (i.e., symptom onset), will assist in developing practical treatment guidelines for women with PMDD. ..
  7. Symptom Onset Antidepressant Treatment for PMDD
    Margaret Altemus; Fiscal Year: 2010
    ..The findings of this study, designed to reflect real-life implementation (i.e., symptom onset), will assist in developing practical treatment guidelines for women with PMDD. ..