George S Alexopoulos

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. doi request reprint Microstructural white matter abnormalities and remission of geriatric depression
    George S Alexopoulos
    Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medical College, New York, NY, USA
    Am J Psychiatry 165:238-44. 2008
  2. pmc BDNF val66met polymorphism, white matter abnormalities and remission of geriatric depression
    George S Alexopoulos
    Weill Cornell Medical College, Weill Cornell Institute of Geriatric Psychiatry, White Plains, NY, United States
    J Affect Disord 125:262-8. 2010
  3. pmc Functional connectivity in apathy of late-life depression: a preliminary study
    George S Alexopoulos
    Weill Cornell Medical College, Weill Cornell Institute of Geriatric Psychiatry, NY, USA
    J Affect Disord 149:398-405. 2013
  4. pmc The inflammation hypothesis in geriatric depression
    George S Alexopoulos
    Weill Cornell Institute of Geriatric Psychiatry, White Plains, New York, USA
    Int J Geriatr Psychiatry 26:1109-18. 2011
  5. pmc Personalised intervention for people with depression and severe COPD
    George S Alexopoulos
    Weill Cornell Medical Center, 21 Bloomingdale Road, White Plains, NY 10605, USA
    Br J Psychiatry 202:235-6. 2013
  6. pmc Ecosystem focused therapy in poststroke depression: a preliminary study
    George S Alexopoulos
    Weill Cornell Medical College, Weill Cornell Institute of Geriatric Psychiatry, New York, USA
    Int J Geriatr Psychiatry 27:1053-60. 2012
  7. pmc Functional connectivity in the cognitive control network and the default mode network in late-life depression
    George S Alexopoulos
    Weill Cornell Medical College, Weill Cornell Institute of Geriatric Psychiatry, USA
    J Affect Disord 139:56-65. 2012
  8. ncbi request reprint Frontostriatal and limbic dysfunction in late-life depression
    George S Alexopoulos
    Weill Medical College of Cornell University, White Plains, NY 10605, USA
    Am J Geriatr Psychiatry 10:687-95. 2002
  9. pmc Placebo-controlled study of relapse prevention with risperidone augmentation in older patients with resistant depression
    George S Alexopoulos
    Department of Psychiatry, Weill Medical College of Cornell University, 21 Bloomingdale Road, White Plains, NY, USA
    Am J Geriatr Psychiatry 16:21-30. 2008
  10. ncbi request reprint Role of executive function in late-life depression
    George S Alexopoulos
    Weill Cornell Institute of Geriatric Psychiatry, Weill Medical College of Cornell University, White Plains, NY 10605, USA
    J Clin Psychiatry 64:18-23. 2003

Detail Information

Publications89

  1. doi request reprint Microstructural white matter abnormalities and remission of geriatric depression
    George S Alexopoulos
    Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medical College, New York, NY, USA
    Am J Psychiatry 165:238-44. 2008
    ..The authors used diffusion tensor imaging to test the hypothesis that depressed elders who fail to achieve remission have microstructural white matter abnormalities in cortico-striato-limbic networks implicated in geriatric depression...
  2. pmc BDNF val66met polymorphism, white matter abnormalities and remission of geriatric depression
    George S Alexopoulos
    Weill Cornell Medical College, Weill Cornell Institute of Geriatric Psychiatry, White Plains, NY, United States
    J Affect Disord 125:262-8. 2010
    ....
  3. pmc Functional connectivity in apathy of late-life depression: a preliminary study
    George S Alexopoulos
    Weill Cornell Medical College, Weill Cornell Institute of Geriatric Psychiatry, NY, USA
    J Affect Disord 149:398-405. 2013
    ....
  4. pmc The inflammation hypothesis in geriatric depression
    George S Alexopoulos
    Weill Cornell Institute of Geriatric Psychiatry, White Plains, New York, USA
    Int J Geriatr Psychiatry 26:1109-18. 2011
    ..This paper examines whether age-related and comorbid disease-related immune deregulation is an etiologic contributor to geriatric depression...
  5. pmc Personalised intervention for people with depression and severe COPD
    George S Alexopoulos
    Weill Cornell Medical Center, 21 Bloomingdale Road, White Plains, NY 10605, USA
    Br J Psychiatry 202:235-6. 2013
    ..If replicated, PID-C may serve as a care model for patients with both depression and medical illnesses with a deteriorating course...
  6. pmc Ecosystem focused therapy in poststroke depression: a preliminary study
    George S Alexopoulos
    Weill Cornell Medical College, Weill Cornell Institute of Geriatric Psychiatry, New York, USA
    Int J Geriatr Psychiatry 27:1053-60. 2012
    ..This is a preliminary study of its efficacy...
  7. pmc Functional connectivity in the cognitive control network and the default mode network in late-life depression
    George S Alexopoulos
    Weill Cornell Medical College, Weill Cornell Institute of Geriatric Psychiatry, USA
    J Affect Disord 139:56-65. 2012
    ..This study examined whether functional connectivity at rest (FC) within these networks characterizes late-life depression and predicts antidepressant response...
  8. ncbi request reprint Frontostriatal and limbic dysfunction in late-life depression
    George S Alexopoulos
    Weill Medical College of Cornell University, White Plains, NY 10605, USA
    Am J Geriatr Psychiatry 10:687-95. 2002
    ....
  9. pmc Placebo-controlled study of relapse prevention with risperidone augmentation in older patients with resistant depression
    George S Alexopoulos
    Department of Psychiatry, Weill Medical College of Cornell University, 21 Bloomingdale Road, White Plains, NY, USA
    Am J Geriatr Psychiatry 16:21-30. 2008
    ..The effect of risperidone augmentation of citalopram for relapse prevention in older patients with antidepressant-resistant depression was evaluated...
  10. ncbi request reprint Role of executive function in late-life depression
    George S Alexopoulos
    Weill Cornell Institute of Geriatric Psychiatry, Weill Medical College of Cornell University, White Plains, NY 10605, USA
    J Clin Psychiatry 64:18-23. 2003
    ..There is early evidence that psychosocial interventions aimed at improving the behavioral deficits of DED patients may also be effective in increasing remission rates and reducing depressive symptoms and disability...
  11. ncbi request reprint Event-related potentials in an emotional go/no-go task and remission of geriatric depression
    George S Alexopoulos
    Weill Medical College of Cornell University, Weill Cornell Institute of Geriatric Psychiatry, White Plains, New York 10605, USA
    Neuroreport 18:217-21. 2007
    ..Thus, these findings suggest that two distinct conflict-processing functions of the anterior cingulate are important for antidepressant response of geriatric depression...
  12. ncbi request reprint Late-life depression: a model for medical classification
    George S Alexopoulos
    Weill Medical College of Cornell University, White Plains, New York 10605, USA
    Biol Psychiatry 58:283-9. 2005
    ....
  13. ncbi request reprint Executive dysfunction and the course of geriatric depression
    George S Alexopoulos
    Cornell Institute of Geriatric Psychiatry, Weill Medical College of Cornell University, 21 Bloomingdale Road, White Plains, NY 10605, USA
    Biol Psychiatry 58:204-10. 2005
    ..This study examined the relationship of executive impairment to the course of depressive symptoms among elderly patients with major depression...
  14. ncbi request reprint Executive dysfunction, heart disease burden, and remission of geriatric depression
    George S Alexopoulos
    Weill Cornell Institute of Geriatric Psychiatry, Weill Medical College of Cornell University, NY 10605, USA
    Neuropsychopharmacology 29:2278-84. 2004
    ..The findings of this study provide the rationale for investigation of the role of specific frontostriatal-limbic pathways in predisposing to geriatric depression or worsening its course...
  15. ncbi request reprint Depression in the elderly
    George S Alexopoulos
    Weill Medical College of Cornell University and Weill Cornell Institute of Geriatric Psychiatry, 21 Bloomingdale Road, White Plains, New York, NY 10605, USA
    Lancet 365:1961-70. 2005
    ..However, in North America at least, public insurance covers these services inadequately...
  16. ncbi request reprint Developing an intervention for depressed, chronically medically ill elders: a model from COPD
    George S Alexopoulos
    Department of Psychiatry, Weill Cornell Medical College, NY 10605, USA
    Int J Geriatr Psychiatry 23:447-53. 2008
    ..Disability, hopelessness, lack of acceptance of antidepressant treatment, and limited problem-solving skills contribute to poor treatment adherence, compromised outcomes, and chronically experienced adversity...
  17. ncbi request reprint Anterior cingulate dysfunction in geriatric depression
    George S Alexopoulos
    Weill Cornell Institute of Geriatric Psychiatry, Department of Psychiatry, Weill Cornell Medical College, New York, USA
    Int J Geriatr Psychiatry 23:347-55. 2008
    ..Although several brain abnormalities have been identified in geriatric depression, their relationship to the pathophysiological mechanisms leading to the development and perpetuation of this syndrome remain unclear...
  18. pmc Remission in depressed geriatric primary care patients: a report from the PROSPECT study
    George S Alexopoulos
    Department of Psychiatry, Weill Medical College of Cornell University, New York, USA
    Am J Psychiatry 162:718-24. 2005
    ..In addition, it sought to identify risk factors for nonremission that could guide treatment planning and referral to care managers or specialists...
  19. pmc Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction: effect on disability
    George S Alexopoulos
    Department of Psychiatry, Weill Cornell Medical College, White Plains, NY 10605, USA
    Arch Gen Psychiatry 68:33-41. 2011
    ..Older patients with depression and executive dysfunction represent a population with significant disability and a high likelihood of failing pharmacotherapy...
  20. pmc Reducing suicidal ideation and depression in older primary care patients: 24-month outcomes of the PROSPECT study
    George S Alexopoulos
    Department of Psychiatry, Weill Cornell Medical College, 21 Bloomingdale Rd, White Plains, NY 10605, USA
    Am J Psychiatry 166:882-90. 2009
    ..This is the first report of outcomes over a 2-year period...
  21. pmc A model for intervention research in late-life depression
    George S Alexopoulos
    Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medical College, 21 Bloomingdale Road, White Plains, NY, USA
    Int J Geriatr Psychiatry 24:1325-34. 2009
    ..To serve as a conceptual map of the role of new interventions designed to reduce the burden of late-life depression...
  22. pmc Serotonin transporter polymorphisms, microstructural white matter abnormalities and remission of geriatric depression
    George S Alexopoulos
    Weill Cornell Medical College, Weill Cornell Institute of Geriatric Psychiatry, United States
    J Affect Disord 119:132-41. 2009
    ..This study compared microstructural abnormalities in depressed elders and controls and studied the association of the serotonin transporter gene status to white matter abnormalities and to remission of depression...
  23. ncbi request reprint Frontal white matter microstructure and treatment response of late-life depression: a preliminary study
    George S Alexopoulos
    Department of Psychiatry, Weill Medical Colege, Cornell University, and the Nathan Kline Institute, Orangeburg, NY 10605, USA
    Am J Psychiatry 159:1929-32. 2002
    ..This study tested the hypothesis that microstructural abnormalities in white matter areas of the brain containing frontostriatal tracts are associated with a low rate of remission of geriatric depression...
  24. doi request reprint Problem solving therapy for the depression-executive dysfunction syndrome of late life
    George S Alexopoulos
    Department of Psychiatry, Weill Cornell Medical College, White Plains, NY 10605, USA
    Int J Geriatr Psychiatry 23:782-8. 2008
    ..Non-pharmacological approaches addressing their behavioral deficits may reduce disability and experienced stress and improve depression...
  25. pmc White-matter integrity predicts stroop performance in patients with geriatric depression
    Christopher F Murphy
    Weill Medical College of Cornell University, Neill Cornell Institute of Geriatric Psychiatry, White Plains, New York 10605, USA
    Biol Psychiatry 61:1007-10. 2007
    ..This study tested the hypothesis that microstructural white matter abnormalities in frontostriatal-limbic tracts are associated with poor response inhibition on the Stroop task in depressed elders...
  26. ncbi request reprint Reducing suicidal ideation and depressive symptoms in depressed older primary care patients: a randomized controlled trial
    Martha L Bruce
    Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA
    JAMA 291:1081-91. 2004
    ..Depression is the strongest risk factor for late-life suicide and for suicide's precursor, suicidal ideation...
  27. pmc Visual inspection of independent components: defining a procedure for artifact removal from fMRI data
    Robert E Kelly
    Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medical College, 21 Bloomingdale Road, White Plains, NY 10605, USA
    J Neurosci Methods 189:233-45. 2010
    ..Our hope is that continued scientific discussion of and testing of visual inspection methods will lead to the development of improved, cost-effective fMRI denoising procedures...
  28. pmc Impact of social support and self-efficacy on functioning in depressed older adults with chronic obstructive pulmonary disease
    Patricia Marino
    Department of Psychiatry, Weill Medical College of Cornell University, 21 Bloomingdale Road, White Plains, NY 10605, USA
    Int J Chron Obstruct Pulmon Dis 3:713-8. 2008
    ..The objective of this study was to examine the association between social support, self-efficacy, and functioning among a sample of depressed older adults with chronic obstructive pulmonary disease (COPD)...
  29. doi request reprint Executive dysfunction in elderly bipolar manic patients
    Faith M Gunning-Dixon
    Weill Cornell Institute of Geriatric Psychiatry, Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA
    Am J Geriatr Psychiatry 16:506-12. 2008
    ..This study used neuropsychological measures of executive skills to examine the functioning of frontostriatal networks in elderly bipolar patients...
  30. pmc Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction
    Patricia A Arean
    Department of Psychiatry, University of California, San Francisco, CA 94143, USA
    Am J Psychiatry 167:1391-8. 2010
    ..Problem-solving therapy was modified to be accessible to this population. Participants were randomly assigned to 12 weekly sessions of problem-solving therapy or supportive therapy and assessed at weeks 3, 6, 9, and 12...
  31. pmc Anterior cingulate cortical volumes and treatment remission of geriatric depression
    Faith M Gunning
    Weill Cornell Medical College, Weill Cornell Institute of Geriatric Psychiatry, White Plains, NY, USA
    Int J Geriatr Psychiatry 24:829-36. 2009
    ..We hypothesized that patients who failed to remit during a 12-week controlled treatment trial of escitalopram would exhibit smaller anterior cingulate gray matter volumes than patients who remitted...
  32. ncbi request reprint Evidence-based practices in geriatric mental health care: an overview of systematic reviews and meta-analyses
    Stephen J Bartels
    Department of Psychiatry, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Psychiatr Clin North Am 26:971-90, x-xi. 2003
    ..Cautions and limitations regarding the reliance on randomized, controlled trials, meta-analyses, and systematic reviews also are presented...
  33. ncbi request reprint Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life
    Dennis S Charney
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 60:664-72. 2003
    ..To review progress made during the past decade in late-life mood disorders and to identify areas of unmet need in health care delivery and research...
  34. pmc Cognitive control in late-life depression: response inhibition deficits and dysfunction of the anterior cingulate cortex
    Richard Katz
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY, USA
    Am J Geriatr Psychiatry 18:1017-25. 2010
    ....
  35. ncbi request reprint Outcomes of depressed patients undergoing inpatient pulmonary rehabilitation
    George S Alexopoulos
    Department of Psychiatry, Weill Medical College of Cornell University, USA
    Am J Geriatr Psychiatry 14:466-75. 2006
    ..This study tested the hypothesis that brief inpatient pulmonary rehabilitation is followed by improvement in both depressive symptoms and function in patients with COPD with major depression...
  36. pmc Structural neuroimaging research methods in geriatric depression
    Matthew J Hoptman
    Division of Clinical Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    Am J Geriatr Psychiatry 14:812-22. 2006
    ..The authors argue that the available methods provide complementary information and that, when combined judiciously, can increase the knowledge gained from neuroimaging findings and conceptually advance the field of geriatric depression...
  37. ncbi request reprint A preliminary study of left frontal region error negativity and symptom improvement in geriatric depression
    Balu Kalayam
    Weill Medical College, Cornell University, 21 Bloomingdale Road, White Plains, NY 10605, USA
    Am J Psychiatry 160:2054-6. 2003
    ..This study tested the hypothesis that frontal error negative wave amplitude on EEG during Stroop test activation predict change in depressive symptoms in depressed elders...
  38. pmc Hippocampal volumes and the brain-derived neurotrophic factor val66met polymorphism in geriatric major depression
    Dora Kanellopoulos
    Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medical College, White Plains, NY, USA
    Am J Geriatr Psychiatry 19:13-22. 2011
    ..This study examined whether there is a relationship among BDNF genotype, hippocampal volumes, and MDD in older adults...
  39. ncbi request reprint Outcomes of minor and subsyndromal depression among elderly patients in primary care settings
    Jeffrey M Lyness
    Department of Psychiatry, University of Rochester Medical Center, Rochester, New York 14642, USA
    Ann Intern Med 144:496-504. 2006
    ..Although depressive conditions in later life are a major public health problem, the outcomes of minor and subsyndromal depression are largely unknown...
  40. ncbi request reprint Clinical presentation of the "depression-executive dysfunction syndrome" of late life
    George S Alexopoulos
    Joan and Sanford I Weill Medical College, Cornell University, White Plains, NY, USA
    Am J Geriatr Psychiatry 10:98-106. 2002
    ..These findings may aid clinicians in identifying patients needing vigilant follow-up, because depression with executive dysfunction was found to be associated with disability, poor treatment response, relapse, and recurrence...
  41. pmc MRI signal hyperintensities and treatment remission of geriatric depression
    Faith M Gunning-Dixon
    Weill Medical College of Cornell University, Weill Cornell Institute of Geriatric Psychiatry, White Plains, NY, United States
    J Affect Disord 126:395-401. 2010
    ..We hypothesized that patients who failed to remit during a 12-week controlled treatment trial of escitalopram would exhibit greater SH burden than patients who remitted...
  42. pmc Executive function and short-term remission of geriatric depression: the role of semantic strategy
    Sarah Shizuko Morimoto
    Weill Cornell Medical College, Department of Psychiatry, Institute of Geriatric Psychiatry, White Plains, NY 10605, USA
    Am J Geriatr Psychiatry 19:115-22. 2011
    ....
  43. doi request reprint Macromolecular white matter abnormalities in geriatric depression: a magnetization transfer imaging study
    Faith M Gunning-Dixon
    Institute of Geriatric Psychiatry and the Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA
    Am J Geriatr Psychiatry 16:255-62. 2008
    ..The objective of this study was to identify subtle white matter abnormalities in late-life depression...
  44. pmc Semantic organizational strategy predicts verbal memory and remission rate of geriatric depression
    Sarah Shizuko Morimoto
    Department of Psychiatry, Institute of Geriatric Psychiatry, Weill Cornell Medical College, White Plains, NY, USA
    Int J Geriatr Psychiatry 27:506-12. 2012
    ..This study tests the hypothesis that the use of semantic organizational strategy during the free-recall phase of a verbal memory task predicts remission of geriatric depression...
  45. pmc A home-delivered intervention for depressed, cognitively impaired, disabled elders
    Dimitris N Kiosses
    Weill Cornell Medical College, White Plains, NY, USA
    Int J Geriatr Psychiatry 26:256-62. 2011
    ..A new intervention is needed in this population as antidepressant treatment is effective in only a minority of these patients...
  46. ncbi request reprint An intervention to improve depression care in older adults with COPD
    Jo Anne Sirey
    Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medical College, White Plains, New York, USA
    Int J Geriatr Psychiatry 22:154-9. 2007
    ..The intervention supplements antidepressant therapy for depression with an individualized care manager who targets psychological barriers that interfere with treatment participation...
  47. pmc Conceptual and methodological issues in designing a randomized, controlled treatment trial for geriatric bipolar disorder: GERI-BD
    Robert C Young
    Institute of Geriatric Psychiatry, Weill Cornell Medical College, White Plains, NY 10605, USA
    Bipolar Disord 12:56-67. 2010
    ..This report considers the conceptual and methodological concerns confronting clinical investigators seeking to generate knowledge regarding the tolerability and benefits of pharmacotherapy in geriatric bipolar disorder (BD) patients...
  48. ncbi request reprint Age and ratings of manic psychopathology
    Robert C Young
    Institute of Geriatric Psychiatry, Weill Medical College of Cornell University, New York, NY, USA
    Bipolar Disord 9:301-4. 2007
    ..e., Sexual Interest, Increased Activity-Energy, Speech--Rate and Amount, and Disruptive-Aggressive Behavior...
  49. ncbi request reprint Attention network dysfunction and treatment response of geriatric depression
    Christopher F Murphy
    Department of Psychology, Weill Medical College of Cornell University, White Plains, NY 10605, USA
    J Clin Exp Neuropsychol 28:96-100. 2006
    ....
  50. ncbi request reprint Placebo response and antidepressant response
    George S Alexopoulos
    Weill Cornell Institute of Geriatric Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA
    Am J Geriatr Psychiatry 15:149-58. 2007
    ..This study focused on the placebo lead-in phase and examines whether change in severity of depression during placebo lead-in predicts change in depressive symptoms during antidepressant treatment...
  51. pmc Treating depression in disabled, low-income elderly: a conceptual model and recommendations for care
    Patricia A Arean
    Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medical College, University of California, San Francisco, USA
    Int J Geriatr Psychiatry 25:765-9. 2010
    ..Interventions that not only address the depressive syndrome but also manage social adversity are sorely needed to help this patient population recover from depression...
  52. pmc Home-delivered problem adaptation therapy (PATH) for depressed, cognitively impaired, disabled elders: A preliminary study
    Dimitris N Kiosses
    Department of Psychiatry, Weill Cornell Institute of Geriatric Psychiatry, Weill Medical College of Cornell University, New York, NY, USA
    Am J Geriatr Psychiatry 18:988-98. 2010
    ....
  53. ncbi request reprint Identification of suicidal ideation and prevention of suicidal behaviour in the elderly
    Katalin Szanto
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Drugs Aging 19:11-24. 2002
    ..Prevention and treatment trials are underway to detect the effectiveness of improved treatment of depression by primary care physicians as a means of reducing the prevalence of depressive symptoms, hopelessness and suicidal ideation...
  54. ncbi request reprint Assessment of late life depression
    George S Alexopoulos
    Weil Medical College, Cornell University GSA, White Plains, New York 10605, USA
    Biol Psychiatry 52:164-74. 2002
    ..Care managers working together with primary care physicians can improve the recognition and treatment of depressed elderly patients by obtaining the training in using validated instruments and treatment algorithms...
  55. ncbi request reprint Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the Cardiovascular Health Study
    Deborah E Barnes
    Department of Psychiatry, University of California, San Francisco 94121, USA
    Arch Gen Psychiatry 63:273-9. 2006
    ..It has been hypothesized that depressive symptoms and dementia may be attributable to underlying vascular disease in some older persons...
  56. ncbi request reprint Response inhibition predicts poor antidepressant treatment response in very old depressed patients
    Joel R Sneed
    Department of Psychiatry, Columbia University and the New York State Psychiatric Institute, New York, NY 10032, USA
    Am J Geriatr Psychiatry 15:553-63. 2007
    ..There have been mixed findings regarding the prognostic significance of age of onset, executive dysfunction, and hyperintensity burden on treatment outcome in late-life depression...
  57. ncbi request reprint Frontal signal hyperintensities in mania in old age
    Jose M de Asis
    Department of Psychiatry, NY Presbyterian Hospital, Weill Medical College of Cornell University, Westchester Division, White Plains, NY 10605, USA
    Am J Geriatr Psychiatry 14:598-604. 2006
    ..The authors assessed frontal and subcortical SH in elderly bipolar manic patients and the comparison group, and hypothesized that SH scores would be greater in the patient group...
  58. pmc Neuroplasticity-based computerized cognitive remediation for geriatric depression
    Sarah Shizuko Morimoto
    Department of Psychiatry, Institute of Geriatric Psychiatry, Weill Cornell Medical College, White Plains, NY, USA
    Int J Geriatr Psychiatry 27:1239-47. 2012
    ..This article describes a novel treatment model designed to target specific neurocognitive deficits in geriatric depression with neuroplasticity-based computerized cognitive remediation (NBCCR)...
  59. pmc Coping with health stresses and remission from late-life depression in primary care: a two-year prospective study
    Meredith L Wallace
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Int J Geriatr Psychiatry 27:178-86. 2012
    ..Conversely, disengagement strategies involve the withdrawal of these resources from obsolete or unattainable health goals, combined with goal restructuring...
  60. pmc Immunity, aging, and geriatric depression
    Sarah Shizuko Morimoto
    Weill Cornell Institute of Geriatric Psychiatry, 21 Bloomingdale Road, White Plains, NY 10605, USA
    Psychiatr Clin North Am 34:437-49, ix. 2011
    ..The successful treatment of comorbid conditions that increase central nervous system inflammatory responses has general health benefits and should be part of clinical practice...
  61. ncbi request reprint Enhanced and bilateralized visual sensory processing in the ventral stream may be a feature of normal aging
    Pierfilippo De Sanctis
    The Cognitive Neurophysiology Laboratory, Nathan S Kline Institute for Psychiatric Research, Program in Cognitive Neuroscience and Schizophrenia, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neurobiol Aging 29:1576-86. 2008
    ..Our results suggest that such compensatory mechanisms are not restricted to later higher-order cognitive processes but may also be a feature of early sensory-perceptual processes...
  62. pmc Depressive symptoms and suicidal ideation among older adults receiving home delivered meals
    Jo Anne Sirey
    Department of Psychiatry, Weill Medical College of Cornell University, Whit Plains, NY 10605, USA
    Int J Geriatr Psychiatry 23:1306-11. 2008
    ..The objective of this study is to document the rates of depression and correlates among a population of homebound elders...
  63. ncbi request reprint Problem-solving therapy versus supportive therapy in geriatric major depression with executive dysfunction
    George S Alexopoulos
    Cornell Institute of Geriatric Psychiatry, White Plains, NY 10605, USA
    Am J Geriatr Psychiatry 11:46-52. 2003
    ..This group was targeted because it has been shown to be at the risk for poor response to pharmacotherapy...
  64. ncbi request reprint Executive dysfunction in geriatric depression
    Kathryn A Lockwood
    Joan and Sanford I Weill College of Medicine, Cornell University, New York, USA
    Am J Psychiatry 159:1119-26. 2002
    ..The purpose of this study was to characterize the neuropsychological presentation of geriatric depression and to determine whether depression-related executive dysfunction is more pronounced during advanced age...
  65. pmc Pharmacotherapy for late-life depression
    George S Alexopoulos
    Department of Psychiatry, Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, NY, USA
    J Clin Psychiatry 72:e04. 2011
    ..The few treatment studies that have been conducted in the geriatric population since the publication of the guidelines have had mixed results and high placebo response rates. More large controlled trials are needed...
  66. ncbi request reprint The Treatment Initiation Program: an intervention to improve depression outcomes in older adults
    Jo Anne Sirey
    Geriatric Outpatient Clinic, Westchester Division, Weill Medical College of Cornell University, White Plains, NY 10605, USA
    Am J Psychiatry 162:184-6. 2005
    ..The TIP is an individualized, early intervention to address older adults' attitudes (e.g., perceived need for care and stigma) about depression and treatment...
  67. ncbi request reprint Comorbidity of late life depression: an opportunity for research on mechanisms and treatment
    George S Alexopoulos
    Weill Medical College of Cornell University, Cornell Institute of Geriatric Psychiatry, White Plains, New York 10605, USA
    Biol Psychiatry 52:543-58. 2002
    ....
  68. ncbi request reprint IADL functions, cognitive deficits, and severity of depression: a preliminary study
    Dimitris N Kiosses
    New York Presbyterian Hospital, 21 Bloomingdale Road, White Plains, NY 10605, USA
    Am J Geriatr Psychiatry 13:244-9. 2005
    ..The authors examined the relationship of depression severity and the cognitive domains of attention, initiation/perseveration, construction, conceptualization, and memory to nine distinct IADLs...
  69. pmc Population projection of US adults with lifetime experience of depressive disorder by age and sex from year 2005 to 2050
    Moonseong Heo
    Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY 10605, USA
    Int J Geriatr Psychiatry 23:1266-70. 2008
    ..To estimate the projected population of US adults aged 18 years or older with lifetime experience of doctor-diagnosed depressive disorder from 2005-2050...
  70. ncbi request reprint Genotype-controlled analysis of plasma dopamine beta-hydroxylase activity in psychotic unipolar major depression
    Joseph F Cubells
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Biol Psychiatry 51:358-64. 2002
    ..Plasma DbetaH is under genetic control by the structural locus encoding DbetaH protein, DBH. This study tested the hypothesis that diagnosis-specific allelic variation at DBH accounts for lower plasma DbetaH in UDPF...
  71. ncbi request reprint Longitudinal association of initiation/perseveration and severity of geriatric depression
    Christopher F Murphy
    Weill Medical College of Cornell University, 21 Bloomingdale Road, White Plains, NY 10605, USA
    Am J Geriatr Psychiatry 12:50-6. 2004
    ..Many older adults with major depression (MDD) present with impairment in initiation and perseveration (IP) tests. However, it remains unclear how these abnormalities change during the course of depression...
  72. pmc Aging of cerebral white matter: a review of MRI findings
    Faith M Gunning-Dixon
    Institute of Geriatric Psychiatry, Department of Psychiatry, Weill Cornell Medical College, USA
    Int J Geriatr Psychiatry 24:109-17. 2009
    ..Structural magnetic resonance imaging (MRI) can be used to identify and quantify non-disease-related aging of the cerebral white matter...
  73. pmc Collaborative depression care management and disparities in depression treatment and outcomes
    Yuhua Bao
    Department of Public Health, Weill Cornell Medical College, New York, NY 10065, USA
    Arch Gen Psychiatry 68:627-36. 2011
    ..Collaborative depression care management (DCM), by addressing barriers disproportionately affecting patients of racial/ethnic minority and low education, may reduce disparities in depression treatment and outcomes...
  74. doi request reprint Psychotherapy for late-life depression
    George S Alexopoulos
    Department of Psychiatry, Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, USA
    J Clin Psychiatry 71:e13. 2010
    ....
  75. ncbi request reprint New postoperative depressive symptoms and long-term cardiac outcomes after coronary artery bypass surgery
    Janey C Peterson
    Department of Medicine, Cardiothoracic Surgery, Weill Medical College, Cornell University, New York, NY 10021, USA
    Am J Geriatr Psychiatry 10:192-8. 2002
    ..In this small sample of patients, increased depressive symptoms at 6 months after surgery appear to be associated with the occurrence of subsequent major cardiac morbidity/ mortality...
  76. ncbi request reprint Venlafaxine ER as a treatment for generalized anxiety disorder in older adults: pooled analysis of five randomized placebo-controlled clinical trials
    Ira R Katz
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Am Geriatr Soc 50:18-25. 2002
    ....
  77. ncbi request reprint The vascular depression hypothesis: 10 years later
    George S Alexopoulos
    Department of Psychiatry, Weill Cornell Institute of Geriatric Psychiatry, White Plains, New York, USA
    Biol Psychiatry 60:1304-5. 2006
  78. ncbi request reprint Evidence-based practices in geriatric mental health care
    Stephen J Bartels
    Department of Psychiatry, Dartmouth Medical School, Hannover, New Hampshire, USA
    Psychiatr Serv 53:1419-31. 2002
    ..The anticipated growth in the population of older persons with mental disorders underscores the need for a strategy to facilitate the systematic and effective implementation of evidence-based practices in geriatric mental health care...
  79. pmc The role of medical comorbidity in outcome of major depression in primary care: the PROSPECT study
    Hillary R Bogner
    Dept of Family Practice and Community Medicine, Univ of Pennsylvania, 3400 Spruce Street, 2 Gates Building, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 13:861-8. 2005
    ..The authors described the influence of specific medical conditions on clinical remission and response of major depression (MDD) in a clinical trial evaluating a care-management intervention among older primary-care patients...
  80. doi request reprint Personalizing the care of geriatric depression
    George S Alexopoulos
    Am J Psychiatry 165:790-2. 2008
  81. ncbi request reprint Perspectives on depression, mild cognitive impairment, and cognitive decline
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
    Arch Gen Psychiatry 63:130-8. 2006
    ....
  82. ncbi request reprint The expert consensus guideline series. Treatment of dementia and its behavioral disturbances. Introduction: methods, commentary, and summary
    George S Alexopoulos
    Postgrad Med . 2005
    ..We therefore conducted a new survey study of expert opinion on the treatment of cognitive impairment and behavioral disturbances associated with dementia...
  83. pmc The effects of memory, attention, and executive dysfunction on outcomes of depression in a primary care intervention trial: the PROSPECT study
    Hillary R Bogner
    Department of Family Medicine and Community Health, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int J Geriatr Psychiatry 22:922-9. 2007
    ..To describe the influence of domains of cognition on remission and response of depression in an intervention trial among older primary care patients...
  84. ncbi request reprint Double-blind comparison of escitalopram and duloxetine in the acute treatment of major depressive disorder
    Arif Khan
    Northwest Clinical Research Center, Bellevue, WA 98004, USA
    Clin Drug Investig 27:481-92. 2007
    ..This study evaluated the efficacy and safety of escitalopram versus duloxetine in the acute treatment of patients with moderate to severe major depressive disorder...
  85. ncbi request reprint Clinical and biological interactions in affective and cognitive geriatric syndromes
    George S Alexopoulos
    Am J Psychiatry 160:811-4. 2003
  86. ncbi request reprint The course of depression in elderly patients
    Timothy I Mueller
    Brown University Medical School, Department of Psychiatry and Human Behavior, c o Butler Hospital, 345 Blackstone Blvd, Providence, RI 02906, USA
    Am J Geriatr Psychiatry 12:22-9. 2004
    ..Studies on the course of major depressive disorder (MDD) among elderly persons are limited to short periods of follow-up, seldom provide comparisons with younger cohorts, and raise other methodological concerns...
  87. ncbi request reprint Provisional diagnostic criteria for depression of Alzheimer disease
    Jason T Olin
    Adult and Geriatric Treatment and Preventive Interventions Research Branch, National Institute of Mental Health, Bethesda, MD 20892 9635, USA
    Am J Geriatr Psychiatry 10:125-8. 2002
    ....
  88. ncbi request reprint Using antipsychotic agents in older patients
    George S Alexopoulos
    Cornell Institute of Geriatric Psychiatry and Weill Medical College of Cornell University, USA
    J Clin Psychiatry 65:5-99; discussion 100-102; quiz 103-4. 2004
    ..g., delirium, dementia, schizophrenia, delusional disorder, psychotic mood disorders) and for patients with comorbid conditions or history of side effects, dosing strategies, duration of treatment, and medication combinations...
  89. ncbi request reprint Vascular disease, depression, and dementia
    George S Alexopoulos
    J Am Geriatr Soc 51:1178-80. 2003

Research Grants32

  1. Case Management and PST for Depressed Homebound Low-Income Elders
    George S Alexopoulos; Fiscal Year: 2010
    ..If CM-PST were found efficacious, it may be offered by trained case-workers of social services to large numbers of depressed, homebound, low-income elders. ..
  2. Treatment Effectiveness in Depressed Patients with COPD
    George Alexopoulos; Fiscal Year: 2006
    ..Finally, we believe that our approach to the care of depressed, medically ill patients can generate a practice model that has the ability to rapidly incorporate advances made in clinical science. ..
  3. Research Fellowship in Geriatric Mood Disorders
    George Alexopoulos; Fiscal Year: 2007
    ..Beyond a Core Curriculum, we guide and support our trainees in conducting their own research studies, in preparing competitive funding applications, and in publishing data-based papers. ..
  4. Case Management and PST for Depressed Homebound Low-Income Elders
    George Alexopoulos; Fiscal Year: 2007
    ..If CM-PST were found efficacious, it may be offered by trained case-workers of social services to large numbers of depressed, homebound, low-income elders. ..
  5. Cornell ACISR for Late Life Depression
    George Alexopoulos; Fiscal Year: 2007
    ..We are confident that our work will both advance scientific knowledge and have a broad impact on the care of depressed, disabled elders. ..
  6. ERPs Cognitive Dysfunction and Treatment Response of Geriatric Depression
    George Alexopoulos; Fiscal Year: 2007
    ..Such patients could be targeted for a vigilant clinical follow-up and a comprehensive treatment plan including a plan for successive pharmacological trials. ..
  7. Treating Older Patients with Major Depression and Severe COPD
    George Alexopoulos; Fiscal Year: 2009
    ....
  8. Case Management and PST for Depressed Homebound Low-Income Elders
    George Alexopoulos; Fiscal Year: 2009
    ..If CM-PST were found efficacious, it may be offered by trained case-workers of social services to large numbers of depressed, homebound, low-income elders. ..
  9. ERPs Cognitive Dysfunction and Treatment Response of Geriatric Depression
    George Alexopoulos; Fiscal Year: 2009
    ..Such patients could be targeted for a vigilant clinical follow-up and a comprehensive treatment plan including a plan for successive pharmacological trials. ..
  10. Treating Older Patients with Major Depression and Severe COPD
    George S Alexopoulos; Fiscal Year: 2010
    ....
  11. Aging, WM Changes, Executive Dysfunction and Depression
    George Alexopoulos; Fiscal Year: 2006
    ..The clinical significance of the proposed study is that it can guide research leading to physiologically meaningful, novel antidepressant therapies aimed at aging-related frontal system dysfunction. ..
  12. PREVENTION OF SUICIDE IN THE ELDERLY
    George Alexopoulos; Fiscal Year: 2002
    ..Data will also be collected to document the impact of intervention on patient care, and on physician knowledge, attitudes, and satisfaction and test hypotheses derived from preliminary studies of the three IRCs. ..
  13. PREVENTION OF GERATRIC DEPRESSION
    George Alexopoulos; Fiscal Year: 2003
    ..Accordingly, we are well positioned to meet the challenges inherent in this difficult but important area of research. ..
  14. PST in Geriatric Depression with Executive Dysfunction
    George Alexopoulos; Fiscal Year: 2004
    ..Accordingly, we are well positioned to meet the challenges inherent in this difficult but important area of research. ..
  15. ERPs Cognitive Dysfunction and Treatment Response of Geriatric Depression
    George S Alexopoulos; Fiscal Year: 2010
    ..Such patients could be targeted for a vigilant clinical follow-up and a comprehensive treatment plan including a plan for successive pharmacological trials. ..