G S Alexopoulos

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Placebo response and antidepressant response
    George S Alexopoulos
    Weill Cornell Institute of Geriatric Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA
    Am J Geriatr Psychiatry 15:149-58. 2007
  2. ncbi request reprint Executive dysfunction and long-term outcomes of geriatric depression
    G S Alexopoulos
    Department of Psychiatry, Cornell University, White Plains, NY, USA
    Arch Gen Psychiatry 57:285-90. 2000
  3. ncbi request reprint Predictors of antidepressant prescription and early use among depressed outpatients
    J A Sirey
    Department of Psychiatry, New York Presbyterian Hospital, White Plains 10605, USA
    Am J Psychiatry 156:690-6. 1999
  4. ncbi request reprint Executive dysfunction and disability in elderly patients with major depression
    D N Kiosses
    Weil College of Medicine, Cornell University, Ithaca, NY, USA
    Am J Geriatr Psychiatry 9:269-74. 2001
  5. ncbi request reprint Perceived stigma as a predictor of treatment discontinuation in young and older outpatients with depression
    J A Sirey
    Outpatient Department, Westchester Division, New York Presbyterian Hospital, White Plains, NY, USA
    Am J Psychiatry 158:479-81. 2001
  6. ncbi request reprint Continuation treatment of delusional depression in older adults
    B S Meyers
    Department of Psychiatry, Westchester Division New York Presbyterian Hospital, Weill Medical College of Cornell University, 21 Bloomingdale Road, White Plains, NY 10605, USA
    Am J Geriatr Psychiatry 9:415-22. 2001
  7. pmc The prognostic significance of subsyndromal symptoms emerging after remission of late-life depression
    D N Kiosses
    Weill Cornell Institute of Geriatric Psychiatry, Weill Medical College of Cornell University, White Plains, NY 10605, USA
    Psychol Med 43:341-50. 2013
  8. ncbi request reprint The systematic assessment of depressed elderly primary care patients
    P J Raue
    Weill Medical College of Cornell University, White Plains, NY 10605, USA
    Int J Geriatr Psychiatry 16:560-9. 2001
  9. ncbi request reprint Hippocampal and anterior cingulate activation deficits in patients with geriatric depression
    J M de Asis
    Department of Psychiatry, Weill Medical College of Cornell University, 525 East 68th St, New York, NY 10021, USA
    Am J Psychiatry 158:1321-3. 2001
  10. ncbi request reprint Use of the Cornell scale in nondemented patients
    G S Alexopoulos
    Department of Psychiatry, Cornell University Medical College, White Plains, New York 10605
    J Am Geriatr Soc 36:230-6. 1988

Detail Information

Publications74

  1. ncbi request reprint Placebo response and antidepressant response
    George S Alexopoulos
    Weill Cornell Institute of Geriatric Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA
    Am J Geriatr Psychiatry 15:149-58. 2007
    ..This study focused on the placebo lead-in phase and examines whether change in severity of depression during placebo lead-in predicts change in depressive symptoms during antidepressant treatment...
  2. ncbi request reprint Executive dysfunction and long-term outcomes of geriatric depression
    G S Alexopoulos
    Department of Psychiatry, Cornell University, White Plains, NY, USA
    Arch Gen Psychiatry 57:285-90. 2000
    ..This study investigated the relationship of executive and memory impairment to relapse, recurrence, and course of residual depressive symptoms and signs after remission of geriatric major depression...
  3. ncbi request reprint Predictors of antidepressant prescription and early use among depressed outpatients
    J A Sirey
    Department of Psychiatry, New York Presbyterian Hospital, White Plains 10605, USA
    Am J Psychiatry 156:690-6. 1999
    ..Site of service and the patients' sociodemographic and clinical characteristics were investigated as possible predictors...
  4. ncbi request reprint Executive dysfunction and disability in elderly patients with major depression
    D N Kiosses
    Weil College of Medicine, Cornell University, Ithaca, NY, USA
    Am J Geriatr Psychiatry 9:269-74. 2001
    ..Attention to executive function and disability may guide clinical management and lead to development of innovative pharmacological and behavioral interventions...
  5. ncbi request reprint Perceived stigma as a predictor of treatment discontinuation in young and older outpatients with depression
    J A Sirey
    Outpatient Department, Westchester Division, New York Presbyterian Hospital, White Plains, NY, USA
    Am J Psychiatry 158:479-81. 2001
    ..The authors' goal was to examine the extent to which perceived stigma affected treatment discontinuation in young and older adults with major depression...
  6. ncbi request reprint Continuation treatment of delusional depression in older adults
    B S Meyers
    Department of Psychiatry, Westchester Division New York Presbyterian Hospital, Weill Medical College of Cornell University, 21 Bloomingdale Road, White Plains, NY 10605, USA
    Am J Geriatr Psychiatry 9:415-22. 2001
    ..Continuation treatment with a conventional antipsychotic does not decrease relapse rates but is associated with significant untoward adverse events in older persons after recovery from a delusional depression...
  7. pmc The prognostic significance of subsyndromal symptoms emerging after remission of late-life depression
    D N Kiosses
    Weill Cornell Institute of Geriatric Psychiatry, Weill Medical College of Cornell University, White Plains, NY 10605, USA
    Psychol Med 43:341-50. 2013
    ..However, some patients experience subsyndromal symptoms after they achieve remission. This study examines the prognostic significance of subsyndromal symptoms occurring during the first 6 months after remission of late-life depression...
  8. ncbi request reprint The systematic assessment of depressed elderly primary care patients
    P J Raue
    Weill Medical College of Cornell University, White Plains, NY 10605, USA
    Int J Geriatr Psychiatry 16:560-9. 2001
    ..Strategies are discussed for ensuring that data are complete, valid and reliable...
  9. ncbi request reprint Hippocampal and anterior cingulate activation deficits in patients with geriatric depression
    J M de Asis
    Department of Psychiatry, Weill Medical College of Cornell University, 525 East 68th St, New York, NY 10021, USA
    Am J Psychiatry 158:1321-3. 2001
    ..They also suggest that hippocampal dysfunction is related to the memory dysfunction characteristic of this disorder...
  10. ncbi request reprint Use of the Cornell scale in nondemented patients
    G S Alexopoulos
    Department of Psychiatry, Cornell University Medical College, White Plains, New York 10605
    J Am Geriatr Soc 36:230-6. 1988
    ..To our knowledge, the Cornell scale is the only depression-rating instrument that has been validated in both demented and nondemented geriatric subjects...
  11. ncbi request reprint Executive functions and P300 latency in elderly depressed patients and control subjects
    S S Kindermann
    Department of Psychiatry, University of California, San Diego, USA
    Am J Geriatr Psychiatry 8:57-65. 2000
    ..Regardless of patients' depression status, increased P300 latency predicts poorer performance on executive function tasks requiring speeded performance...
  12. ncbi request reprint Brainstem evoked response abnormalities in late-life depression with vascular disease
    B Kalayam
    Department of Psychiatry, Cornell University Medical College, New York
    Am J Psychiatry 154:970-5. 1997
    ....
  13. ncbi request reprint Personality disorder symptoms predict declines in global functioning and quality of life in elderly depressed patients
    R C Abrams
    New York Hospital Cornell Medical Center, New York, NY, USA
    Am J Geriatr Psychiatry 9:67-71. 2001
    ..Personality disorder symptoms in elderly patients appear to operate as co-factors that amplify or exacerbate the impact of residual depression on long-term functioning and quality of life...
  14. ncbi request reprint Depression and service utilization in elderly primary care patients
    M P Luber
    Department of Psychiatry, University of Pennsylvania, USA
    Am J Geriatr Psychiatry 9:169-76. 2001
    ..The somatic presentation of depression may contribute to the increased services utilization...
  15. pmc The vascular depression hypothesis: mechanisms linking vascular disease with depression
    W D Taylor
    Center for Cognitive Medicine, Department of Psychiatry, Vanderbilt University, Nashville, TN 37212, USA
    Mol Psychiatry 18:963-74. 2013
    ..Testing such hypotheses will not only inform the relationship between vascular disease and depression, but also provide guidance on the potential repurposing of pharmacological agents that may improve LLD outcomes. ..
  16. ncbi request reprint Cognitive impairment in bipolar disorder in old age: literature review and findings in manic patients
    R C Young
    Department of Psychiatry, Institute of Geriatric Psychiatry, Weill Medical College of Cornell University, and Payne Whitney Westchester, USA
    J Affect Disord 92:125-31. 2006
    ..Descriptions of aged patients with bipolar (BP) disorder have commented on cognitive impairments. However, the literature regarding cognitive test performance in this population has apparently been scant...
  17. ncbi request reprint Stigma as a barrier to recovery: Perceived stigma and patient-rated severity of illness as predictors of antidepressant drug adherence
    J A Sirey
    Department of Psychiatry, New York Presbyterian Hospital, Westchester Division, White Plains, NY 10605, USA
    Psychiatr Serv 52:1615-20. 2001
    ..The authors examined the impact of barriers that were present at the initiation of antidepressant drug therapy on medication adherence in a mixed-age sample of outpatients with major depression...
  18. ncbi request reprint Chronic depression in the elderly: approaches for prevention
    C F Reynolds
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Drugs Aging 18:507-14. 2001
    ..Depression in old age is a major contributor to the global burden of illness-related disability, but it is extremely treatable if appropriate pharmacotherapy is prescribed and accepted by patients and their caregivers...
  19. pmc A double-blind randomized controlled trial of olanzapine plus sertraline vs olanzapine plus placebo for psychotic depression: the study of pharmacotherapy of psychotic depression (STOP-PD)
    Barnett S Meyers
    Department of Psychiatry, Weill Medical College of Cornell University and New York Presbyterian Hospital, Westchester Division, White Plains, New York 10605, USA
    Arch Gen Psychiatry 66:838-47. 2009
    ..Evidence for the efficacy of combination pharmacotherapy has been limited and without positive trials in geriatric patients with major depression (MD) with psychotic features...
  20. ncbi request reprint A short-term inpatient program for agitated demented nursing home residents
    P K Wiener
    Weill Medical College of Cornell University, USA
    Int J Geriatr Psychiatry 16:866-72. 2001
    ....
  21. ncbi request reprint Comorbidity of depression and anxiety disorders in later life
    E J Lenze
    Intervention Research Centers in Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 14:86-93. 2001
    ..We also recommend directions for future research in the area of psychiatric comorbidity in late life...
  22. pmc White-matter integrity predicts stroop performance in patients with geriatric depression
    Christopher F Murphy
    Weill Medical College of Cornell University, Neill Cornell Institute of Geriatric Psychiatry, White Plains, New York 10605, USA
    Biol Psychiatry 61:1007-10. 2007
    ..This study tested the hypothesis that microstructural white matter abnormalities in frontostriatal-limbic tracts are associated with poor response inhibition on the Stroop task in depressed elders...
  23. pmc Structural neuroimaging research methods in geriatric depression
    Matthew J Hoptman
    Division of Clinical Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    Am J Geriatr Psychiatry 14:812-22. 2006
    ..The authors argue that the available methods provide complementary information and that, when combined judiciously, can increase the knowledge gained from neuroimaging findings and conceptually advance the field of geriatric depression...
  24. ncbi request reprint Frontal signal hyperintensities in mania in old age
    Jose M de Asis
    Department of Psychiatry, NY Presbyterian Hospital, Weill Medical College of Cornell University, Westchester Division, White Plains, NY 10605, USA
    Am J Geriatr Psychiatry 14:598-604. 2006
    ..The authors assessed frontal and subcortical SH in elderly bipolar manic patients and the comparison group, and hypothesized that SH scores would be greater in the patient group...
  25. ncbi request reprint Outcomes of depressed patients undergoing inpatient pulmonary rehabilitation
    George S Alexopoulos
    Department of Psychiatry, Weill Medical College of Cornell University, USA
    Am J Geriatr Psychiatry 14:466-75. 2006
    ..This study tested the hypothesis that brief inpatient pulmonary rehabilitation is followed by improvement in both depressive symptoms and function in patients with COPD with major depression...
  26. ncbi request reprint Outcomes of minor and subsyndromal depression among elderly patients in primary care settings
    Jeffrey M Lyness
    Department of Psychiatry, University of Rochester Medical Center, Rochester, New York 14642, USA
    Ann Intern Med 144:496-504. 2006
    ..Although depressive conditions in later life are a major public health problem, the outcomes of minor and subsyndromal depression are largely unknown...
  27. ncbi request reprint Depressive symptoms, vascular disease, and mild cognitive impairment: findings from the Cardiovascular Health Study
    Deborah E Barnes
    Department of Psychiatry, University of California, San Francisco 94121, USA
    Arch Gen Psychiatry 63:273-9. 2006
    ..It has been hypothesized that depressive symptoms and dementia may be attributable to underlying vascular disease in some older persons...
  28. ncbi request reprint Perspectives on depression, mild cognitive impairment, and cognitive decline
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
    Arch Gen Psychiatry 63:130-8. 2006
    ....
  29. ncbi request reprint Attention network dysfunction and treatment response of geriatric depression
    Christopher F Murphy
    Department of Psychology, Weill Medical College of Cornell University, White Plains, NY 10605, USA
    J Clin Exp Neuropsychol 28:96-100. 2006
    ....
  30. pmc The role of medical comorbidity in outcome of major depression in primary care: the PROSPECT study
    Hillary R Bogner
    Dept of Family Practice and Community Medicine, Univ of Pennsylvania, 3400 Spruce Street, 2 Gates Building, Philadelphia, PA 19104, USA
    Am J Geriatr Psychiatry 13:861-8. 2005
    ..The authors described the influence of specific medical conditions on clinical remission and response of major depression (MDD) in a clinical trial evaluating a care-management intervention among older primary-care patients...
  31. pmc An intervention to improve depression care in older adults with COPD
    Jo Anne Sirey
    Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medical College, White Plains, New York, USA
    Int J Geriatr Psychiatry 22:154-9. 2007
    ..The intervention supplements antidepressant therapy for depression with an individualized care manager who targets psychological barriers that interfere with treatment participation...
  32. ncbi request reprint The expert consensus guideline series. Treatment of dementia and its behavioral disturbances. Introduction: methods, commentary, and summary
    George S Alexopoulos
    Postgrad Med . 2005
    ..We therefore conducted a new survey study of expert opinion on the treatment of cognitive impairment and behavioral disturbances associated with dementia...
  33. ncbi request reprint Executive dysfunction in elderly bipolar manic patients
    Faith M Gunning-Dixon
    Weill Cornell Institute of Geriatric Psychiatry, Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA
    Am J Geriatr Psychiatry 16:506-12. 2008
    ..This study used neuropsychological measures of executive skills to examine the functioning of frontostriatal networks in elderly bipolar patients...
  34. doi request reprint Macromolecular white matter abnormalities in geriatric depression: a magnetization transfer imaging study
    Faith M Gunning-Dixon
    Institute of Geriatric Psychiatry and the Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA
    Am J Geriatr Psychiatry 16:255-62. 2008
    ..The objective of this study was to identify subtle white matter abnormalities in late-life depression...
  35. doi request reprint Microstructural white matter abnormalities and remission of geriatric depression
    George S Alexopoulos
    Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medical College, New York, NY, USA
    Am J Psychiatry 165:238-44. 2008
    ..The authors used diffusion tensor imaging to test the hypothesis that depressed elders who fail to achieve remission have microstructural white matter abnormalities in cortico-striato-limbic networks implicated in geriatric depression...
  36. pmc Placebo-controlled study of relapse prevention with risperidone augmentation in older patients with resistant depression
    George S Alexopoulos
    Department of Psychiatry, Weill Medical College of Cornell University, 21 Bloomingdale Road, White Plains, NY, USA
    Am J Geriatr Psychiatry 16:21-30. 2008
    ..The effect of risperidone augmentation of citalopram for relapse prevention in older patients with antidepressant-resistant depression was evaluated...
  37. ncbi request reprint Response inhibition predicts poor antidepressant treatment response in very old depressed patients
    Joel R Sneed
    Department of Psychiatry, Columbia University and the New York State Psychiatric Institute, New York, NY 10032, USA
    Am J Geriatr Psychiatry 15:553-63. 2007
    ..There have been mixed findings regarding the prognostic significance of age of onset, executive dysfunction, and hyperintensity burden on treatment outcome in late-life depression...
  38. ncbi request reprint Double-blind comparison of escitalopram and duloxetine in the acute treatment of major depressive disorder
    Arif Khan
    Northwest Clinical Research Center, Bellevue, WA 98004, USA
    Clin Drug Investig 27:481-92. 2007
    ..This study evaluated the efficacy and safety of escitalopram versus duloxetine in the acute treatment of patients with moderate to severe major depressive disorder...
  39. ncbi request reprint Enhanced and bilateralized visual sensory processing in the ventral stream may be a feature of normal aging
    Pierfilippo De Sanctis
    The Cognitive Neurophysiology Laboratory, Nathan S Kline Institute for Psychiatric Research, Program in Cognitive Neuroscience and Schizophrenia, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neurobiol Aging 29:1576-86. 2008
    ..Our results suggest that such compensatory mechanisms are not restricted to later higher-order cognitive processes but may also be a feature of early sensory-perceptual processes...
  40. ncbi request reprint Age and ratings of manic psychopathology
    Robert C Young
    Institute of Geriatric Psychiatry, Weill Medical College of Cornell University, New York, NY, USA
    Bipolar Disord 9:301-4. 2007
    ..e., Sexual Interest, Increased Activity-Energy, Speech--Rate and Amount, and Disruptive-Aggressive Behavior...
  41. ncbi request reprint Event-related potentials in an emotional go/no-go task and remission of geriatric depression
    George S Alexopoulos
    Weill Medical College of Cornell University, Weill Cornell Institute of Geriatric Psychiatry, White Plains, New York 10605, USA
    Neuroreport 18:217-21. 2007
    ..Thus, these findings suggest that two distinct conflict-processing functions of the anterior cingulate are important for antidepressant response of geriatric depression...
  42. pmc The effects of memory, attention, and executive dysfunction on outcomes of depression in a primary care intervention trial: the PROSPECT study
    Hillary R Bogner
    Department of Family Medicine and Community Health, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int J Geriatr Psychiatry 22:922-9. 2007
    ..To describe the influence of domains of cognition on remission and response of depression in an intervention trial among older primary care patients...
  43. doi request reprint Personalizing the care of geriatric depression
    George S Alexopoulos
    Am J Psychiatry 165:790-2. 2008
  44. ncbi request reprint Late-life depression: a model for medical classification
    George S Alexopoulos
    Weill Medical College of Cornell University, White Plains, New York 10605, USA
    Biol Psychiatry 58:283-9. 2005
    ....
  45. ncbi request reprint Executive dysfunction and the course of geriatric depression
    George S Alexopoulos
    Cornell Institute of Geriatric Psychiatry, Weill Medical College of Cornell University, 21 Bloomingdale Road, White Plains, NY 10605, USA
    Biol Psychiatry 58:204-10. 2005
    ..This study examined the relationship of executive impairment to the course of depressive symptoms among elderly patients with major depression...
  46. ncbi request reprint Depression and Bipolar Support Alliance consensus statement on the unmet needs in diagnosis and treatment of mood disorders in late life
    Dennis S Charney
    National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 60:664-72. 2003
    ..To review progress made during the past decade in late-life mood disorders and to identify areas of unmet need in health care delivery and research...
  47. ncbi request reprint Clinical and biological interactions in affective and cognitive geriatric syndromes
    George S Alexopoulos
    Am J Psychiatry 160:811-4. 2003
  48. ncbi request reprint Frontostriatal and limbic dysfunction in late-life depression
    George S Alexopoulos
    Weill Medical College of Cornell University, White Plains, NY 10605, USA
    Am J Geriatr Psychiatry 10:687-95. 2002
    ....
  49. ncbi request reprint Frontal white matter microstructure and treatment response of late-life depression: a preliminary study
    George S Alexopoulos
    Department of Psychiatry, Weill Medical Colege, Cornell University, and the Nathan Kline Institute, Orangeburg, NY 10605, USA
    Am J Psychiatry 159:1929-32. 2002
    ..This study tested the hypothesis that microstructural abnormalities in white matter areas of the brain containing frontostriatal tracts are associated with a low rate of remission of geriatric depression...
  50. ncbi request reprint Comorbidity of late life depression: an opportunity for research on mechanisms and treatment
    George S Alexopoulos
    Weill Medical College of Cornell University, Cornell Institute of Geriatric Psychiatry, White Plains, New York 10605, USA
    Biol Psychiatry 52:543-58. 2002
    ....
  51. ncbi request reprint Assessment of late life depression
    George S Alexopoulos
    Weil Medical College, Cornell University GSA, White Plains, New York 10605, USA
    Biol Psychiatry 52:164-74. 2002
    ..Care managers working together with primary care physicians can improve the recognition and treatment of depressed elderly patients by obtaining the training in using validated instruments and treatment algorithms...
  52. ncbi request reprint Executive dysfunction in geriatric depression
    Kathryn A Lockwood
    Joan and Sanford I Weill College of Medicine, Cornell University, New York, USA
    Am J Psychiatry 159:1119-26. 2002
    ..The purpose of this study was to characterize the neuropsychological presentation of geriatric depression and to determine whether depression-related executive dysfunction is more pronounced during advanced age...
  53. ncbi request reprint Identification of suicidal ideation and prevention of suicidal behaviour in the elderly
    Katalin Szanto
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Drugs Aging 19:11-24. 2002
    ..Prevention and treatment trials are underway to detect the effectiveness of improved treatment of depression by primary care physicians as a means of reducing the prevalence of depressive symptoms, hopelessness and suicidal ideation...
  54. ncbi request reprint Clinical presentation of the "depression-executive dysfunction syndrome" of late life
    George S Alexopoulos
    Joan and Sanford I Weill Medical College, Cornell University, White Plains, NY, USA
    Am J Geriatr Psychiatry 10:98-106. 2002
    ..These findings may aid clinicians in identifying patients needing vigilant follow-up, because depression with executive dysfunction was found to be associated with disability, poor treatment response, relapse, and recurrence...
  55. ncbi request reprint A preliminary study of left frontal region error negativity and symptom improvement in geriatric depression
    Balu Kalayam
    Weill Medical College, Cornell University, 21 Bloomingdale Road, White Plains, NY 10605, USA
    Am J Psychiatry 160:2054-6. 2003
    ..This study tested the hypothesis that frontal error negative wave amplitude on EEG during Stroop test activation predict change in depressive symptoms in depressed elders...
  56. ncbi request reprint Role of executive function in late-life depression
    George S Alexopoulos
    Weill Cornell Institute of Geriatric Psychiatry, Weill Medical College of Cornell University, White Plains, NY 10605, USA
    J Clin Psychiatry 64:18-23. 2003
    ..There is early evidence that psychosocial interventions aimed at improving the behavioral deficits of DED patients may also be effective in increasing remission rates and reducing depressive symptoms and disability...
  57. ncbi request reprint Evidence-based practices in geriatric mental health care: an overview of systematic reviews and meta-analyses
    Stephen J Bartels
    Department of Psychiatry, Dartmouth Medical School, One Medical Center Drive, Lebanon, NH 03756, USA
    Psychiatr Clin North Am 26:971-90, x-xi. 2003
    ..Cautions and limitations regarding the reliance on randomized, controlled trials, meta-analyses, and systematic reviews also are presented...
  58. ncbi request reprint Depression in the elderly
    George S Alexopoulos
    Weill Medical College of Cornell University and Weill Cornell Institute of Geriatric Psychiatry, 21 Bloomingdale Road, White Plains, New York, NY 10605, USA
    Lancet 365:1961-70. 2005
    ..However, in North America at least, public insurance covers these services inadequately...
  59. pmc Remission in depressed geriatric primary care patients: a report from the PROSPECT study
    George S Alexopoulos
    Department of Psychiatry, Weill Medical College of Cornell University, New York, USA
    Am J Psychiatry 162:718-24. 2005
    ..In addition, it sought to identify risk factors for nonremission that could guide treatment planning and referral to care managers or specialists...
  60. ncbi request reprint The Treatment Initiation Program: an intervention to improve depression outcomes in older adults
    Jo Anne Sirey
    Geriatric Outpatient Clinic, Westchester Division, Weill Medical College of Cornell University, White Plains, NY 10605, USA
    Am J Psychiatry 162:184-6. 2005
    ..The TIP is an individualized, early intervention to address older adults' attitudes (e.g., perceived need for care and stigma) about depression and treatment...
  61. ncbi request reprint Executive dysfunction, heart disease burden, and remission of geriatric depression
    George S Alexopoulos
    Weill Cornell Institute of Geriatric Psychiatry, Weill Medical College of Cornell University, NY 10605, USA
    Neuropsychopharmacology 29:2278-84. 2004
    ..The findings of this study provide the rationale for investigation of the role of specific frontostriatal-limbic pathways in predisposing to geriatric depression or worsening its course...
  62. ncbi request reprint Reducing suicidal ideation and depressive symptoms in depressed older primary care patients: a randomized controlled trial
    Martha L Bruce
    Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA
    JAMA 291:1081-91. 2004
    ..Depression is the strongest risk factor for late-life suicide and for suicide's precursor, suicidal ideation...
  63. ncbi request reprint Longitudinal association of initiation/perseveration and severity of geriatric depression
    Christopher F Murphy
    Weill Medical College of Cornell University, 21 Bloomingdale Road, White Plains, NY 10605, USA
    Am J Geriatr Psychiatry 12:50-6. 2004
    ..Many older adults with major depression (MDD) present with impairment in initiation and perseveration (IP) tests. However, it remains unclear how these abnormalities change during the course of depression...
  64. ncbi request reprint Using antipsychotic agents in older patients
    George S Alexopoulos
    Cornell Institute of Geriatric Psychiatry and Weill Medical College of Cornell University, USA
    J Clin Psychiatry 65:5-99; discussion 100-102; quiz 103-4. 2004
    ..g., delirium, dementia, schizophrenia, delusional disorder, psychotic mood disorders) and for patients with comorbid conditions or history of side effects, dosing strategies, duration of treatment, and medication combinations...
  65. ncbi request reprint Vascular disease, depression, and dementia
    George S Alexopoulos
    J Am Geriatr Soc 51:1178-80. 2003
  66. ncbi request reprint Genotype-controlled analysis of plasma dopamine beta-hydroxylase activity in psychotic unipolar major depression
    Joseph F Cubells
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Biol Psychiatry 51:358-64. 2002
    ..Plasma DbetaH is under genetic control by the structural locus encoding DbetaH protein, DBH. This study tested the hypothesis that diagnosis-specific allelic variation at DBH accounts for lower plasma DbetaH in UDPF...
  67. ncbi request reprint Provisional diagnostic criteria for depression of Alzheimer disease
    Jason T Olin
    Adult and Geriatric Treatment and Preventive Interventions Research Branch, National Institute of Mental Health, Bethesda, MD 20892 9635, USA
    Am J Geriatr Psychiatry 10:125-8. 2002
    ....
  68. ncbi request reprint New postoperative depressive symptoms and long-term cardiac outcomes after coronary artery bypass surgery
    Janey C Peterson
    Department of Medicine, Cardiothoracic Surgery, Weill Medical College, Cornell University, New York, NY 10021, USA
    Am J Geriatr Psychiatry 10:192-8. 2002
    ..In this small sample of patients, increased depressive symptoms at 6 months after surgery appear to be associated with the occurrence of subsequent major cardiac morbidity/ mortality...
  69. ncbi request reprint The course of depression in elderly patients
    Timothy I Mueller
    Brown University Medical School, Department of Psychiatry and Human Behavior, c o Butler Hospital, 345 Blackstone Blvd, Providence, RI 02906, USA
    Am J Geriatr Psychiatry 12:22-9. 2004
    ..Studies on the course of major depressive disorder (MDD) among elderly persons are limited to short periods of follow-up, seldom provide comparisons with younger cohorts, and raise other methodological concerns...
  70. ncbi request reprint Venlafaxine ER as a treatment for generalized anxiety disorder in older adults: pooled analysis of five randomized placebo-controlled clinical trials
    Ira R Katz
    Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Am Geriatr Soc 50:18-25. 2002
    ....
  71. ncbi request reprint IADL functions, cognitive deficits, and severity of depression: a preliminary study
    Dimitris N Kiosses
    New York Presbyterian Hospital, 21 Bloomingdale Road, White Plains, NY 10605, USA
    Am J Geriatr Psychiatry 13:244-9. 2005
    ..The authors examined the relationship of depression severity and the cognitive domains of attention, initiation/perseveration, construction, conceptualization, and memory to nine distinct IADLs...
  72. ncbi request reprint Problem-solving therapy versus supportive therapy in geriatric major depression with executive dysfunction
    George S Alexopoulos
    Cornell Institute of Geriatric Psychiatry, White Plains, NY 10605, USA
    Am J Geriatr Psychiatry 11:46-52. 2003
    ..This group was targeted because it has been shown to be at the risk for poor response to pharmacotherapy...
  73. ncbi request reprint The vascular depression hypothesis: 10 years later
    George S Alexopoulos
    Department of Psychiatry, Weill Cornell Institute of Geriatric Psychiatry, White Plains, New York, USA
    Biol Psychiatry 60:1304-5. 2006