Research Topics
| Armin AlaediniSummaryAffiliation: Cornell University Country: USA Publications
Research Grants
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Detail Information
Publications
Narrative review: celiac disease: understanding a complex autoimmune disorderArmin Alaedini
Department of Neurology and Neuroscience, Cornell University, New York, New York 10021, USA
Ann Intern Med 142:289-98. 2005..A gluten-free diet is the mainstay of safe and effective treatment of celiac disease, although its effect on some of the extraintestinal manifestations of the disease remains to be determined...- Detection of anti-ganglioside antibodies in Guillain-Barré syndrome and its variants by the agglutination assayArmin Alaedini
Department of Neurology and Neuroscience, Cornell University, 525 E 68th St, Room LC 807, New York, NY 10021, USA
J Neurol Sci 196:41-4. 2002..Some of the sera reacted with more than one ganglioside. Antibodies were not found in the control sera that were studied. The agglutination assay may be useful for rapid screening of GBS sera for antibodies to multiple gangliosides... 
Up-regulation of apoptosis and regeneration genes in the dorsal root ganglia during cisplatin treatmentArmin Alaedini
Department of Neurology and Neuroscience, Cornell University, New York, NY 10065, USA
Exp Neurol 210:368-74. 2008..As such, the identified genes may represent candidate processes and pathways that should be considered as targets for therapeutic intervention in cisplatin-induced neuropathy...- Autoantibodies in celiac diseaseArmin Alaedini
Department of Neurology and Neuroscience, Cornell University, New York, NY 10021, USA
Autoimmunity 41:19-26. 2008.... - Immune cross-reactivity in celiac disease: anti-gliadin antibodies bind to neuronal synapsin IArmin Alaedini
Department of Neurology and Neuroscience, Cornell University, and St Vincent s Hospital Manhattan, New York, NY 10021, USA
J Immunol 178:6590-5. 2007..Anti-gliadin Abs from patients with celiac disease also bound to the protein. Such cross-reactivity may provide clues into the pathogenic mechanism of the neurologic deficits that are associated with gluten sensitivity... - Transglutaminase-independent binding of gliadin to intestinal brush border membrane and GM1 gangliosideArmin Alaedini
Department of Neurology and Neuroscience, 1300 York Ave, Weill Medical College of Cornell University, New York, NY 10021, USA
J Neuroimmunol 177:167-72. 2006..Furthermore, binding of gliadin to GM1 on the intestinal epithelium might have a role in the anti-gliadin immune response and contribute to the intestinal inflammatory reaction in celiac disease... - Antibodies against OspA epitopes of Borrelia burgdorferi cross-react with neural tissueArmin Alaedini
Department of Neurology and Neuroscience, Cornell University, 1300 York Ave, New York, NY 10021, USA
J Neuroimmunol 159:192-5. 2005..Antibodies against two of the homologous OspA peptides were found to react with neurons in human brain, spinal cord and dorsal root ganglia by immunohistochemistry... - Antiganglioside antibodies in multifocal acquired sensory and motor neuropathyArmin Alaedini
Department of Neurology and Neuroscience, Cornell University, New York, NY 10021, USA
Arch Neurol 60:42-6. 2003..Multifocal acquired demyelinating sensory and motor neuropathies are considered autoimmune and responsive to immunotherapy. In the absence of demyelination, however, they are considered idiopathic if no other cause is found... - Ganglioside reactive antibodies in the neuropathy associated with celiac diseaseArmin Alaedini
Department of Neurology and Neuroscience, Cornell University, 525 E 68th St, LC 807, New York, NY 10021, USA
J Neuroimmunol 127:145-8. 2002..The neuropathy of celiac disease may be autoimmune and associated with anti-ganglioside antibodies. The presence of IgG reactivity furthermore implicates a T cell-mediated response to ganglioside antigens... 
Novel immune response to gluten in individuals with schizophreniaDiana Samaroo
Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY, United States
Schizophr Res 118:248-55. 2010..Further characterization and understanding of the immune response to gluten in schizophrenia may provide novel insights into the etiopathogenesis of specific disease phenotypes...- Neuropathy and cognitive impairment following vaccination with the OspA protein of Borrelia burgdorferiNorman Latov
Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, NY 10022, USA
J Peripher Nerv Syst 9:165-7. 2004.... - Epitope mapping of antibodies to VlsE protein of Borrelia burgdorferi in post-Lyme disease syndromeAbhishek Chandra
Department of Neurology and Neuroscience, Weill Cornell Medical College, Cornell University, New York, NY, USA
Clin Immunol 141:103-10. 2011..The crystal structure of VlsE indicated that the newly described epitopes form a contiguous region in the surface-exposed membrane-proximal part of the monomeric form of the protein... - Anti-neural antibody reactivity in patients with a history of Lyme borreliosis and persistent symptomsAbhishek Chandra
Department of Neurology and Neuroscience, Cornell University, New York, NY 10065, USA
Brain Behav Immun 24:1018-24. 2010..The results provide evidence for the existence of a differential immune system response in PLS, offering new clues about the etiopathogenesis of the disease that may prove useful in devising more effective treatment strategies... - Anti-Borrelia burgdorferi antibody profile in post-Lyme disease syndromeAbhishek Chandra
Department of Neurology and Neuroscience, Weill Cornell Medical College, Cornell University, New York, New York, USA
Clin Vaccine Immunol 18:767-71. 2011..005). The described antiborrelia antibody profile in PLDS offers clues about the course of the antecedent infection in affected patients, which may be useful for understanding the pathogenic mechanism of the disease... - High-dose cyclophosphamide without stem cell rescue for refractory multifocal motor neuropathyThomas H Brannagan
Weill Medical College of Cornell University, Department of Neurology and Neuroscience, Peripheral Neuropathy Center, 635 Madison Avenue, Suite 400, New York, New York 10022, USA
Muscle Nerve 34:246-50. 2006..At a 6-month examination, her strength had improved and she had regained the ability to write. High-dose cyclophosphamide may be a successful treatment for patients with MMN refractory to other therapies... - Increased IFNα activity and differential antibody response in patients with a history of Lyme disease and persistent cognitive deficitsElzbieta Jacek
Division of Rheumatology, Hospital for Special Surgery, New York, NY, USA
J Neuroimmunol 255:85-91. 2013..The increase in IFNα activity is suggestive of a mechanism contributing to the ongoing neuropsychiatric symptoms... - Anti-heparan sulfate antibodies in neurological diseaseChiara Briani
Department of Neurological and Psychiatric Sciences, University of Padova, Via Giustiniani 5, 35128 Padova, Italy
Muscle Nerve 26:713-5. 2002..Antibodies to HS appear not to be specific for neuropathy, as they occur in several inflammatory diseases. They might contribute to the associated breakdown of the blood-brain or blood-nerve barrier... - Anti-ganglioside antibodies in idiopathic and hereditary cerebellar degenerationHolly A Shill
Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1428, USA
Neurology 60:1672-3. 2003..The authors investigated the presence of antiganglioside antibodies in 22 patients with hereditary and nonhereditary ataxia and found 64% reactive in a novel agglutination test... - Neurological complications of celiac disease and autoimmune mechanisms: a prospective studyChiara Briani
Department of Neurosciences, University of Padova, Padova, Italy
J Neuroimmunol 195:171-5. 2008..Follow-up of 62 patients did not reveal change in electrophysiology or antibodies, regardless of diet. However, in 2 patients with neuropathy, symptoms improved or worsened depending on the diet...
Research Grants
- Immune reactivity to synapsin in the neuropathy and ataxia of celiac diseaseArmin Alaedini; Fiscal Year: 2007....
- OspA and autoimmunity in chronic Lyme diseaseArmin Alaedini; Fiscal Year: 2007..Identification of specific immune reactivity to an autoantigen might also be useful as a diagnostic marker and for monitoring of disease activity in affected patients. ..