Armin Alaedini

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. ncbi request reprint Narrative review: celiac disease: understanding a complex autoimmune disorder
    Armin Alaedini
    Department of Neurology and Neuroscience, Cornell University, New York, New York 10021, USA
    Ann Intern Med 142:289-98. 2005
  2. ncbi request reprint Detection of anti-ganglioside antibodies in Guillain-Barré syndrome and its variants by the agglutination assay
    Armin Alaedini
    Department of Neurology and Neuroscience, Cornell University, 525 E 68th St, Room LC 807, New York, NY 10021, USA
    J Neurol Sci 196:41-4. 2002
  3. doi request reprint Up-regulation of apoptosis and regeneration genes in the dorsal root ganglia during cisplatin treatment
    Armin Alaedini
    Department of Neurology and Neuroscience, Cornell University, New York, NY 10065, USA
    Exp Neurol 210:368-74. 2008
  4. doi request reprint Autoantibodies in celiac disease
    Armin Alaedini
    Department of Neurology and Neuroscience, Cornell University, New York, NY 10021, USA
    Autoimmunity 41:19-26. 2008
  5. ncbi request reprint Immune cross-reactivity in celiac disease: anti-gliadin antibodies bind to neuronal synapsin I
    Armin Alaedini
    Department of Neurology and Neuroscience, Cornell University, and St Vincent s Hospital Manhattan, New York, NY 10021, USA
    J Immunol 178:6590-5. 2007
  6. ncbi request reprint Transglutaminase-independent binding of gliadin to intestinal brush border membrane and GM1 ganglioside
    Armin Alaedini
    Department of Neurology and Neuroscience, 1300 York Ave, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Neuroimmunol 177:167-72. 2006
  7. ncbi request reprint Antibodies against OspA epitopes of Borrelia burgdorferi cross-react with neural tissue
    Armin Alaedini
    Department of Neurology and Neuroscience, Cornell University, 1300 York Ave, New York, NY 10021, USA
    J Neuroimmunol 159:192-5. 2005
  8. ncbi request reprint Ganglioside reactive antibodies in the neuropathy associated with celiac disease
    Armin Alaedini
    Department of Neurology and Neuroscience, Cornell University, 525 E 68th St, LC 807, New York, NY 10021, USA
    J Neuroimmunol 127:145-8. 2002
  9. ncbi request reprint Antiganglioside antibodies in multifocal acquired sensory and motor neuropathy
    Armin Alaedini
    Department of Neurology and Neuroscience, Cornell University, New York, NY 10021, USA
    Arch Neurol 60:42-6. 2003
  10. pmc Novel immune response to gluten in individuals with schizophrenia
    Diana Samaroo
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY, United States
    Schizophr Res 118:248-55. 2010

Research Grants

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Narrative review: celiac disease: understanding a complex autoimmune disorder
    Armin Alaedini
    Department of Neurology and Neuroscience, Cornell University, New York, New York 10021, USA
    Ann Intern Med 142:289-98. 2005
    ..A gluten-free diet is the mainstay of safe and effective treatment of celiac disease, although its effect on some of the extraintestinal manifestations of the disease remains to be determined...
  2. ncbi request reprint Detection of anti-ganglioside antibodies in Guillain-Barré syndrome and its variants by the agglutination assay
    Armin Alaedini
    Department of Neurology and Neuroscience, Cornell University, 525 E 68th St, Room LC 807, New York, NY 10021, USA
    J Neurol Sci 196:41-4. 2002
    ..Some of the sera reacted with more than one ganglioside. Antibodies were not found in the control sera that were studied. The agglutination assay may be useful for rapid screening of GBS sera for antibodies to multiple gangliosides...
  3. doi request reprint Up-regulation of apoptosis and regeneration genes in the dorsal root ganglia during cisplatin treatment
    Armin Alaedini
    Department of Neurology and Neuroscience, Cornell University, New York, NY 10065, USA
    Exp Neurol 210:368-74. 2008
    ..As such, the identified genes may represent candidate processes and pathways that should be considered as targets for therapeutic intervention in cisplatin-induced neuropathy...
  4. doi request reprint Autoantibodies in celiac disease
    Armin Alaedini
    Department of Neurology and Neuroscience, Cornell University, New York, NY 10021, USA
    Autoimmunity 41:19-26. 2008
    ....
  5. ncbi request reprint Immune cross-reactivity in celiac disease: anti-gliadin antibodies bind to neuronal synapsin I
    Armin Alaedini
    Department of Neurology and Neuroscience, Cornell University, and St Vincent s Hospital Manhattan, New York, NY 10021, USA
    J Immunol 178:6590-5. 2007
    ..Anti-gliadin Abs from patients with celiac disease also bound to the protein. Such cross-reactivity may provide clues into the pathogenic mechanism of the neurologic deficits that are associated with gluten sensitivity...
  6. ncbi request reprint Transglutaminase-independent binding of gliadin to intestinal brush border membrane and GM1 ganglioside
    Armin Alaedini
    Department of Neurology and Neuroscience, 1300 York Ave, Weill Medical College of Cornell University, New York, NY 10021, USA
    J Neuroimmunol 177:167-72. 2006
    ..Furthermore, binding of gliadin to GM1 on the intestinal epithelium might have a role in the anti-gliadin immune response and contribute to the intestinal inflammatory reaction in celiac disease...
  7. ncbi request reprint Antibodies against OspA epitopes of Borrelia burgdorferi cross-react with neural tissue
    Armin Alaedini
    Department of Neurology and Neuroscience, Cornell University, 1300 York Ave, New York, NY 10021, USA
    J Neuroimmunol 159:192-5. 2005
    ..Antibodies against two of the homologous OspA peptides were found to react with neurons in human brain, spinal cord and dorsal root ganglia by immunohistochemistry...
  8. ncbi request reprint Ganglioside reactive antibodies in the neuropathy associated with celiac disease
    Armin Alaedini
    Department of Neurology and Neuroscience, Cornell University, 525 E 68th St, LC 807, New York, NY 10021, USA
    J Neuroimmunol 127:145-8. 2002
    ..The neuropathy of celiac disease may be autoimmune and associated with anti-ganglioside antibodies. The presence of IgG reactivity furthermore implicates a T cell-mediated response to ganglioside antigens...
  9. ncbi request reprint Antiganglioside antibodies in multifocal acquired sensory and motor neuropathy
    Armin Alaedini
    Department of Neurology and Neuroscience, Cornell University, New York, NY 10021, USA
    Arch Neurol 60:42-6. 2003
    ..Multifocal acquired demyelinating sensory and motor neuropathies are considered autoimmune and responsive to immunotherapy. In the absence of demyelination, however, they are considered idiopathic if no other cause is found...
  10. pmc Novel immune response to gluten in individuals with schizophrenia
    Diana Samaroo
    Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY, United States
    Schizophr Res 118:248-55. 2010
    ..Further characterization and understanding of the immune response to gluten in schizophrenia may provide novel insights into the etiopathogenesis of specific disease phenotypes...
  11. ncbi request reprint Neuropathy and cognitive impairment following vaccination with the OspA protein of Borrelia burgdorferi
    Norman Latov
    Department of Neurology and Neurosciences, Weill Medical College of Cornell University, New York, NY 10022, USA
    J Peripher Nerv Syst 9:165-7. 2004
    ....
  12. pmc Increased IFNα activity and differential antibody response in patients with a history of Lyme disease and persistent cognitive deficits
    Elzbieta Jacek
    Division of Rheumatology, Hospital for Special Surgery, New York, NY, USA
    J Neuroimmunol 255:85-91. 2013
    ..The increase in IFNα activity is suggestive of a mechanism contributing to the ongoing neuropsychiatric symptoms...
  13. pmc Anti-neural antibody reactivity in patients with a history of Lyme borreliosis and persistent symptoms
    Abhishek Chandra
    Department of Neurology and Neuroscience, Cornell University, New York, NY 10065, USA
    Brain Behav Immun 24:1018-24. 2010
    ..The results provide evidence for the existence of a differential immune system response in PLS, offering new clues about the etiopathogenesis of the disease that may prove useful in devising more effective treatment strategies...
  14. pmc Epitope mapping of antibodies to VlsE protein of Borrelia burgdorferi in post-Lyme disease syndrome
    Abhishek Chandra
    Department of Neurology and Neuroscience, Weill Cornell Medical College, Cornell University, New York, NY, USA
    Clin Immunol 141:103-10. 2011
    ..The crystal structure of VlsE indicated that the newly described epitopes form a contiguous region in the surface-exposed membrane-proximal part of the monomeric form of the protein...
  15. pmc Anti-Borrelia burgdorferi antibody profile in post-Lyme disease syndrome
    Abhishek Chandra
    Department of Neurology and Neuroscience, Weill Cornell Medical College, Cornell University, New York, New York, USA
    Clin Vaccine Immunol 18:767-71. 2011
    ..005). The described antiborrelia antibody profile in PLDS offers clues about the course of the antecedent infection in affected patients, which may be useful for understanding the pathogenic mechanism of the disease...
  16. ncbi request reprint High-dose cyclophosphamide without stem cell rescue for refractory multifocal motor neuropathy
    Thomas H Brannagan
    Weill Medical College of Cornell University, Department of Neurology and Neuroscience, Peripheral Neuropathy Center, 635 Madison Avenue, Suite 400, New York, New York 10022, USA
    Muscle Nerve 34:246-50. 2006
    ..At a 6-month examination, her strength had improved and she had regained the ability to write. High-dose cyclophosphamide may be a successful treatment for patients with MMN refractory to other therapies...
  17. pmc Lack of association between autism and anti-GM1 ganglioside antibody
    Sina Moeller
    From the Department of Medicine S M, N M L, P H R G, A A, Columbia University Medical Center, New York, NY Center for Clinical Research D H, Uppsala University, Falun, Sweden and Departments of Pediatrics J J H, A M R and Neurology and Neuroscience A M R, Weill Cornell Medical College, New York, NY
    Neurology 81:1640-1. 2013
    ....
  18. pmc Lack of serologic evidence to link IgA nephropathy with celiac disease or immune reactivity to gluten
    Sina Moeller
    Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, New York, United States of America Celiac Disease Center, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 9:e94677. 2014
    ..The data from this case-control study do not reveal any evidence to suggest a significant role for celiac disease or immune reactivity to gluten in IgA nephropathy. ..
  19. doi request reprint Neurological complications of celiac disease and autoimmune mechanisms: a prospective study
    Chiara Briani
    Department of Neurosciences, University of Padova, Padova, Italy
    J Neuroimmunol 195:171-5. 2008
    ..Follow-up of 62 patients did not reveal change in electrophysiology or antibodies, regardless of diet. However, in 2 patients with neuropathy, symptoms improved or worsened depending on the diet...
  20. ncbi request reprint Anti-ganglioside antibodies in idiopathic and hereditary cerebellar degeneration
    Holly A Shill
    Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1428, USA
    Neurology 60:1672-3. 2003
    ..The authors investigated the presence of antiganglioside antibodies in 22 patients with hereditary and nonhereditary ataxia and found 64% reactive in a novel agglutination test...
  21. ncbi request reprint Anti-heparan sulfate antibodies in neurological disease
    Chiara Briani
    Department of Neurological and Psychiatric Sciences, University of Padova, Via Giustiniani 5, 35128 Padova, Italy
    Muscle Nerve 26:713-5. 2002
    ..Antibodies to HS appear not to be specific for neuropathy, as they occur in several inflammatory diseases. They might contribute to the associated breakdown of the blood-brain or blood-nerve barrier...

Research Grants3

  1. Immune reactivity to synapsin in the neuropathy and ataxia of celiac disease
    Armin Alaedini; Fiscal Year: 2007
    ....
  2. OspA and autoimmunity in chronic Lyme disease
    Armin Alaedini; Fiscal Year: 2007
    ..Identification of specific immune reactivity to an autoantigen might also be useful as a diagnostic marker and for monitoring of disease activity in affected patients. ..