Gregory Acland

Summary

Affiliation: Cornell University
Country: USA

Publications

  1. pmc An ADAM9 mutation in canine cone-rod dystrophy 3 establishes homology with human cone-rod dystrophy 9
    Orly Goldstein
    Baker Institute for Animal Health, Cornell University College of Veterinary Medicine, Ithaca, NY 14853 6401, USA
    Mol Vis 16:1549-69. 2010
  2. pmc Sequence comparison of prefrontal cortical brain transcriptome from a tame and an aggressive silver fox (Vulpes vulpes)
    Anna V Kukekova
    Baker Institute for Animal Health, Cornell University, Ithaca, NY 14853, USA
    BMC Genomics 12:482. 2011
  3. pmc Mouse H6 Homeobox 1 (Hmx1) mutations cause cranial abnormalities and reduced body mass
    Robert J Munroe
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    BMC Dev Biol 9:27. 2009
  4. ncbi request reprint The dog that came in from the cold
    G M Acland
    Center for Canine Genetics and Reproduction, James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Heredity (Edinb) 90:201-2. 2003
  5. pmc Linkage analysis and comparative mapping of canine progressive rod-cone degeneration (prcd) establishes potential locus homology with retinitis pigmentosa (RP17) in humans
    G M Acland
    James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca NY 14853, USA
    Proc Natl Acad Sci U S A 95:3048-53. 1998
  6. pmc Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness
    Gregory M Acland
    Baker Institute, Cornell University, Hungerford Hill Road, Ithaca, NY 14853, USA
    Mol Ther 12:1072-82. 2005
  7. ncbi request reprint A novel retinal degeneration locus identified by linkage and comparative mapping of canine early retinal degeneration
    G M Acland
    James A Baker Institute for Animal Health, College of Veterinary Medicine, Ithaca, New York, 14853 6401, USA
    Genomics 59:134-42. 1999
  8. ncbi request reprint Power of a Labrador Retriever-Greyhound pedigree for linkage analysis of hip dysplasia and osteoarthritis
    Rory J Todhunter
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 64:418-24. 2003
  9. pmc Cloning and characterization of canine PAX6 and evaluation as a candidate gene in a canine model of aniridia
    Linda S Hunter
    J A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Mol Vis 13:431-42. 2007
  10. pmc Linkage disequilibrium mapping in domestic dog breeds narrows the progressive rod-cone degeneration interval and identifies ancestral disease-transmitting chromosome
    Orly Goldstein
    James A Baker Institute, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Genomics 88:541-50. 2006

Research Grants

  1. Models for Therapy of Hereditary Retinal Degenerations
    Gregory M Acland; Fiscal Year: 2010
  2. Models of Hereditary Retinal Degenerations
    Gregory Acland; Fiscal Year: 2009
  3. Models of Hereditary Retinal Degenerations
    Gregory Acland; Fiscal Year: 2007
  4. Models of Hereditary Retinal Degenerations
    Gregory Acland; Fiscal Year: 2006
  5. Models of Hereditary Retinal Degenerations
    Gregory Acland; Fiscal Year: 2005
  6. MODELS OF HEREDITY RETINAL DEGENERATION
    Gregory Acland; Fiscal Year: 2004
  7. MODELS OF HEREDITY RETINAL DEGENERATION
    Gregory Acland; Fiscal Year: 2003
  8. MODELS OF HEREDITY RETINAL DEGENERATION
    Gregory Acland; Fiscal Year: 2002
  9. MODELS OF HEREDITY RETINAL DEGENERATION
    Gregory Acland; Fiscal Year: 2001
  10. MODELS OF HEREDITY RETINAL DEGENERATION
    Gregory Acland; Fiscal Year: 2000

Collaborators

Detail Information

Publications56

  1. pmc An ADAM9 mutation in canine cone-rod dystrophy 3 establishes homology with human cone-rod dystrophy 9
    Orly Goldstein
    Baker Institute for Animal Health, Cornell University College of Veterinary Medicine, Ithaca, NY 14853 6401, USA
    Mol Vis 16:1549-69. 2010
    ..To identify the causative mutation in a canine cone-rod dystrophy (crd3) that segregates as an adult onset disorder in the Glen of Imaal Terrier breed of dog...
  2. pmc Sequence comparison of prefrontal cortical brain transcriptome from a tame and an aggressive silver fox (Vulpes vulpes)
    Anna V Kukekova
    Baker Institute for Animal Health, Cornell University, Ithaca, NY 14853, USA
    BMC Genomics 12:482. 2011
    ..To understand the genetic differences underlying these behavioral phenotypes fox-specific genomic resources are needed...
  3. pmc Mouse H6 Homeobox 1 (Hmx1) mutations cause cranial abnormalities and reduced body mass
    Robert J Munroe
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    BMC Dev Biol 9:27. 2009
    ..These tandemly duplicated genes have functional overlap as indicated by the loss of the entire vestibular system in double mutants. Mutants have not been described for Hmx1, the most divergent of the family...
  4. ncbi request reprint The dog that came in from the cold
    G M Acland
    Center for Canine Genetics and Reproduction, James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Heredity (Edinb) 90:201-2. 2003
  5. pmc Linkage analysis and comparative mapping of canine progressive rod-cone degeneration (prcd) establishes potential locus homology with retinitis pigmentosa (RP17) in humans
    G M Acland
    James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca NY 14853, USA
    Proc Natl Acad Sci U S A 95:3048-53. 1998
    ....
  6. pmc Long-term restoration of rod and cone vision by single dose rAAV-mediated gene transfer to the retina in a canine model of childhood blindness
    Gregory M Acland
    Baker Institute, Cornell University, Hungerford Hill Road, Ithaca, NY 14853, USA
    Mol Ther 12:1072-82. 2005
    ..Successful, stable restoration of rod and cone photoreceptor function in these dogs has important implications for treatment of human patients affected with Leber congenital amaurosis caused by RPE65 mutations...
  7. ncbi request reprint A novel retinal degeneration locus identified by linkage and comparative mapping of canine early retinal degeneration
    G M Acland
    James A Baker Institute for Animal Health, College of Veterinary Medicine, Ithaca, New York, 14853 6401, USA
    Genomics 59:134-42. 1999
    ..The rapid progress now occurring in canine genetics will expedite identification of the genes and molecular mechanisms underlying the inherited traits and diseases that make the dog a unique asset for study of mammalian traits...
  8. ncbi request reprint Power of a Labrador Retriever-Greyhound pedigree for linkage analysis of hip dysplasia and osteoarthritis
    Rory J Todhunter
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 64:418-24. 2003
    ..To estimate the number of dogs required to find linkage to heritable traits of hip dysplasia in dogs from an experimental pedigree...
  9. pmc Cloning and characterization of canine PAX6 and evaluation as a candidate gene in a canine model of aniridia
    Linda S Hunter
    J A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Mol Vis 13:431-42. 2007
    ..The small eye (sey) mouse represents an animal model for aniridia. However, no large animal model currently exists. We cloned and characterized canine PAX6, and evaluated PAX6 for causal associations with inherited aniridia in dogs...
  10. pmc Linkage disequilibrium mapping in domestic dog breeds narrows the progressive rod-cone degeneration interval and identifies ancestral disease-transmitting chromosome
    Orly Goldstein
    James A Baker Institute, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Genomics 88:541-50. 2006
    ..The findings strongly suggest that a common ancestor transmitted the prcd disease allele to many of the modern dog breeds and demonstrate the power of the LD approach in the canine model...
  11. ncbi request reprint Different RPGR exon ORF15 mutations in Canids provide insights into photoreceptor cell degeneration
    Qi Zhang
    A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Hum Mol Genet 11:993-1003. 2002
    ..The cellular and molecular results in the two canine RPGR exon ORF15 mutations have implications for understanding the phenotypic variability found in human RP3 families that carry similar mutations...
  12. ncbi request reprint Linkage mapping of canine rod cone dysplasia type 2 (rcd2) to CFA7, the canine orthologue of human 1q32
    Anna V Kukekova
    James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Invest Ophthalmol Vis Sci 47:1210-5. 2006
    ..Multiple genes have previously been evaluated as candidates for rcd2, but all have been excluded...
  13. ncbi request reprint Cloning of the canine ABCA4 gene and evaluation in canine cone-rod dystrophies and progressive retinal atrophies
    James W Kijas
    James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Mol Vis 10:223-32. 2004
    ..To characterize a novel early onset canine retinal disease, and evaluate the ATP-binding cassette transporter gene ABCA4 as a potential candidate gene in this and other canine retinal degenerations...
  14. ncbi request reprint Quantitative trait loci for hip dysplasia in a cross-breed canine pedigree
    Rory J Todhunter
    Department of Clinical Sciences, Box 32 College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Mamm Genome 16:720-30. 2005
    ..Successful detection of QTL was due to the cross-breed pedigree, multiple-trait measurements, control of environmental background, and marked advancement in canine mapping tools...
  15. pmc A meiotic linkage map of the silver fox, aligned and compared to the canine genome
    Anna V Kukekova
    James A Baker Institute for Animal Health, Cornell University, Ithaca, NY 14850, USA
    Genome Res 17:387-99. 2007
    ..The fox meiotic map provides a critical tool for genetic studies in foxes and identification of genetic loci and genes implicated in fox domestication...
  16. ncbi request reprint Comparative analysis and expression of CLUL1, a cone photoreceptor-specific gene
    Qi Zhang
    James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA
    Invest Ophthalmol Vis Sci 44:4542-9. 2003
    ..To characterize CLUL1, a cone photoreceptor-specific gene...
  17. pmc Radiation hybrid mapping of cataract genes in the dog
    Linda S Hunter
    J A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA
    Mol Vis 12:588-96. 2006
    ..These can be used for segregation testing of the candidate genes in canine cataract pedigrees...
  18. ncbi request reprint Canine CNGB3 mutations establish cone degeneration as orthologous to the human achromatopsia locus ACHM3
    Duska J Sidjanin
    Center for Canine Genetics and Reproduction, James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Hum Mol Genet 11:1823-33. 2002
    ....
  19. ncbi request reprint Quantitative genetics of traits associated with hip dysplasia in a canine pedigree constructed by mating dysplastic Labrador Retrievers with unaffected Greyhounds
    Stuart Bliss
    Department of Clinical Sciences, College of Agricultural and Life Sciences, Cornell University, Ithica, NY 14853, USA
    Am J Vet Res 63:1029-35. 2002
    ..To determine the genetic influence on expression of traits associated with canine hip dysplasia...
  20. pmc Chromosomal mapping of canine-derived BAC clones to the red fox and American mink genomes
    Anna V Kukekova
    James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Hered 100:S42-53. 2009
    ..Much lower success was obtained for this more distantly related farm-bred species, although a few BAC clones were mapped to the predicted chromosomal locations...
  21. pmc The long (and winding) road to gene discovery for canine hip dysplasia
    Lan Zhu
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Vet J 181:97-110. 2009
    ....
  22. ncbi request reprint Cloning and characterization of canine SHARP1 and its evaluation as a positional candidate for canine early retinal degeneration (erd)
    Anna V Kukekova
    James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Gene 312:335-43. 2003
    ....
  23. pmc Canine RD3 mutation establishes rod-cone dysplasia type 2 (rcd2) as ortholog of human and murine rd3
    Anna V Kukekova
    James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Hungerford Hill Road, Ithaca, New York 14853, USA
    Mamm Genome 20:109-23. 2009
    ..This should permit a similar approach to tackle other hereditary traits that segregate in single closed populations...
  24. pmc Development and use of DNA archives at veterinary teaching hospitals to investigate the genetic basis of disease in dogs
    Marta G P Castelhano
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    J Am Vet Med Assoc 234:75-80. 2009
    ..The most important feature of a DNA archive is accurate identification or exclusion of diseases in each animal. Such archives will be complimentary resources to tissue banks that are currently available...
  25. pmc COL9A2 and COL9A3 mutations in canine autosomal recessive oculoskeletal dysplasia
    Orly Goldstein
    Baker Institute for Animal Health, Cornell University, Ithaca, NY 14853, USA
    Mamm Genome 21:398-408. 2010
    ....
  26. ncbi request reprint Cloning and characterization of opticin cDNA: evaluation as a candidate for canine oculo-skeletal dysplasia
    Beth Pellegrini
    The James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 6401, USA
    Gene 282:121-31. 2002
    ..Based on linkage analysis using a newly identified intragenic single nucleotide polymorphism opticin has been excluded from having any causal association with the OSD loci in both Samoyeds and Labrador retrievers...
  27. ncbi request reprint A frameshift mutation in RPGR exon ORF15 causes photoreceptor degeneration and inner retina remodeling in a model of X-linked retinitis pigmentosa
    William A Beltran
    James A Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA
    Invest Ophthalmol Vis Sci 47:1669-81. 2006
    ..To characterize the course of retinal disease in X-linked progressive retinal atrophy 2 (XLPRA2), a canine model of early onset X-linked retinitis pigmentosa (XLRP) caused by a two-nucleotide microdeletion in RPGR ORF15...
  28. pmc Naturally occurring rhodopsin mutation in the dog causes retinal dysfunction and degeneration mimicking human dominant retinitis pigmentosa
    James W Kijas
    James A Baker Institute for Animal Health, Cornell University, 47 Hungerford Hill Road, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 99:6328-33. 2002
    ..The RHO mutant dog also becomes the large animal needed for preclinical trials of therapies for a major subset of human retinopathies...
  29. ncbi request reprint Evaluation of multiple radiographic predictors of cartilage lesions in the hip joints of eight-month-old dogs
    Rory J Todhunter
    Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
    Am J Vet Res 64:1472-8. 2003
    ..To determine the radiographic methods that best predict the development of osteoarthritis in the hip joints of a cohort of dogs with hip dysplasia and unaffected dogs...
  30. ncbi request reprint Safety of recombinant adeno-associated virus type 2-RPE65 vector delivered by ocular subretinal injection
    Samuel G Jacobson
    Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Ther 13:1074-84. 2006
    ..5-log unit range of vector doses proved efficacious. The efficacy and toxicity limits defined in this study lead to suggestions for the design of a subretinal AAV-2/2.RPE65 human trial of RPE65-associated LCA...
  31. pmc Breed relationships facilitate fine-mapping studies: a 7.8-kb deletion cosegregates with Collie eye anomaly across multiple dog breeds
    Heidi G Parker
    Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genome Res 17:1562-71. 2007
    ..This work both establishes that the primary cea mutation arose as a single disease allele in a common ancestor of herding breeds as well as highlights the value of comparative population analysis for refining regions of linkage...
  32. pmc Clinical light exposure, photoreceptor degeneration, and AP-1 activation: a cell death or cell survival signal in the rhodopsin mutant retina?
    Danian Gu
    Section of Ophthalmology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Invest Ophthalmol Vis Sci 48:4907-18. 2007
    ....
  33. pmc Reversal of blindness in animal models of leber congenital amaurosis using optimized AAV2-mediated gene transfer
    Jeannette Bennicelli
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6069, USA
    Mol Ther 16:458-65. 2008
    ..The data demonstrate that AAV2.RPE65 delivers the RPE65 transgene efficiently and quickly to the appropriate target cells in vivo in animal models. This vector holds great promise for treatment of LCA due to RPE65 mutations...
  34. pmc Operating in the dark: a night-vision system for surgery in retinas susceptible to light damage
    Andras M Komaromy
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 3900 Delancey St, Philadelphia, PA 19104, USA
    Arch Ophthalmol 126:714-7. 2008
    ....
  35. ncbi request reprint Eye movement recordings as an effectiveness indicator of gene therapy in RPE65-deficient canines: implications for the ocular motor system
    Jonathan B Jacobs
    Daroff Dell Osso Ocular Motility Laboratory, Veterans Affairs Medical Center, Department of Neurology, Case Western Reserve University and University Hospital of Cleveland, OH 44106, USA
    Invest Ophthalmol Vis Sci 47:2865-75. 2006
    ..To perform ocular motility recordings of infantile nystagmus (IN) in RPE65-deficient canines and determine whether they can be used as a motor indicator of restored retinal function to investigate the effects of gene therapy...
  36. ncbi request reprint Mutations associated with neutropenia in dogs and humans disrupt intracellular transport of neutrophil elastase
    Kathleen F Benson
    Division of Medical Genetics Department of Medicine, University of Washington School of Medicine, Box 357720, 1705 NE Pacific Street, HSB K236B, Seattle, Washington 98195, USA
    Nat Genet 35:90-6. 2003
    ..Most mutations in ELA2 that cause human cyclic hematopoiesis prevent membrane localization of neutrophil elastase, whereas most mutations in ELA2 that cause SCN lead to exclusive membrane localization...
  37. ncbi request reprint Linkage mapping of the primary disease locus for collie eye anomaly
    Jennifer K Lowe
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D4 100, Seattle, WA 98109 1024, USA
    Genomics 82:86-95. 2003
    ..076), in a region corresponding to human chromosome 2q35. These results suggest the presence of a developmental regulatory gene important in ocular embryogenesis, with potential implications for other disorders of ocular vascularization...
  38. ncbi request reprint Encapsulated cell-based delivery of CNTF reduces photoreceptor degeneration in animal models of retinitis pigmentosa
    Weng Tao
    Neurotech USA, Lincoln, Rhode Island 02865, USA
    Invest Ophthalmol Vis Sci 43:3292-8. 2002
    ..The dose-range effect of the treatment was also investigated...
  39. ncbi request reprint Cloning and characterization of the canine photoreceptor specific cone-rod homeobox (CRX) gene and evaluation as a candidate for early onset photoreceptor diseases in the dog
    Novrouz B Akhmedov
    Jules Stein Eye Institute, UCLA School of Medicine, Los Angeles, CA, USA
    Mol Vis 8:79-84. 2002
    ..To clone the full length cDNA, characterize the genomic organization of canine CRX, map the gene in a radiation hybrid (RH) panel, and evaluate it as a candidate for canine inherited retinal degenerations...
  40. ncbi request reprint The extent and distribution of linkage disequilibrium in a multi-hierarchic outbred canine pedigree
    Xiang Yang Lou
    Department of Statistics, 533 McCarty Hall C, University of Florida, Gainesville, Florida 32611, USA
    Mamm Genome 14:555-64. 2003
    ..This study supports the appropriateness of linkage disequilibrium analysis to detect and map quantitative trait loci underlying complex traits in dogs...
  41. ncbi request reprint Independent origin and restricted distribution of RPGR deletions causing XLPRA
    Barbara Zangerl
    Section of Ophthalmology, Department of Clinical Studies Philadelphia, University of Pennsylvania, Philadelphia, USA
    J Hered 98:526-30. 2007
    ..Overall, these data suggest a limited distribution of the affected haplotypes and indicate that mutations in the ORF15 are likely to be limited to the described dog breeds...
  42. pmc Canine and human visual cortex intact and responsive despite early retinal blindness from RPE65 mutation
    Geoffrey K Aguirre
    Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS Med 4:e230. 2007
    ..We therefore studied the cortex of RPE65-mutant dogs before and after retinal gene therapy. Then, we inquired whether there is visual pathway integrity and responsivity in adult humans with LCA due to RPE65 mutations (RPE65-LCA)...
  43. ncbi request reprint Development and characterization of a normalized canine retinal cDNA library for genomic and expression studies
    Barbara Zangerl
    Section of Medical Genetics, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Invest Ophthalmol Vis Sci 47:2632-8. 2006
    ..Because of the conserved syntenies between the dog and human, this approach would identify new potential disease candidate genes for both species...
  44. pmc Modeling extent and distribution of zygotic disequilibrium: implications for a multigenerational canine pedigree
    Tian Liu
    Department of Statistics, University of Florida, Gainesville, Florida 32611, USA
    Genetics 174:439-53. 2006
    ..The results from this study provide scientific guidance about the determination of the number of markers used for whole-genome association studies...
  45. pmc In vivo dynamics of retinal injury and repair in the rhodopsin mutant dog model of human retinitis pigmentosa
    Artur V Cideciyan
    Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 102:5233-8. 2005
    ..These experiments provide a platform to study mechanisms of neuronal injury, repair, compensation, and degeneration. The data also argue for a gene-specific clinical trial of light reduction in human rhodopsin disease...
  46. pmc Identical mutation in a novel retinal gene causes progressive rod-cone degeneration in dogs and retinitis pigmentosa in humans
    Barbara Zangerl
    Clinical Studies Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Genomics 88:551-63. 2006
    ..This study provides strong evidence that a mutation in the novel gene PRCD is the cause of autosomal recessive retinal degeneration in both dogs and humans...
  47. pmc Analysis of six candidate genes as potential modifiers of disease expression in canine XLPRA1, a model for human X-linked retinitis pigmentosa 3
    Richard Guyon
    Section of Ophthalmology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Vis 13:1094-105. 2007
    ....
  48. pmc A naturally occurring mutation of the opsin gene (T4R) in dogs affects glycosylation and stability of the G protein-coupled receptor
    Li Zhu
    Department of Ophthalmology, University of Washington, 1957 NE Pacific St, Seattle, WA 98195 6485, USA
    J Biol Chem 279:53828-39. 2004
    ..The T4R mutation may represent a novel molecular mechanism of degeneration where the unliganded form of the mutant opsin exerts a detrimental effect by losing its structural integrity...
  49. pmc Intravitreal injection of ciliary neurotrophic factor (CNTF) causes peripheral remodeling and does not prevent photoreceptor loss in canine RPGR mutant retina
    William A Beltran
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Eye Res 84:753-71. 2007
    ..Our findings suggest that some inherited forms of retinal degeneration may not respond to CNTF's neuroprotective effects...
  50. pmc Bestrophin gene mutations cause canine multifocal retinopathy: a novel animal model for best disease
    Karina E Guziewicz
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Invest Ophthalmol Vis Sci 48:1959-67. 2007
    ..The disease shares a number of clinical and pathologic similarities with Best macular dystrophy (BMD), and cmr is proposed as a new large animal model for Best disease...
  51. ncbi request reprint A random model for mapping imprinted quantitative trait loci in a structured pedigree: an implication for mapping canine hip dysplasia
    Tian Liu
    Department of Statistics, University of Florida, Gainesville, FL 32611, USA
    Genomics 90:276-84. 2007
    ..The detected iQTL provide important candidate regions for fine-mapping of imprinted genes and for studying their structure and function in the control of complex traits...
  52. doi request reprint Effects of the topically applied calcium-channel blocker flunarizine on intraocular pressure in clinically normal dogs
    Andrew L Greller
    Eye Care for Animals, 2316 W Northern Ave, Phoenix, AZ 85021, USA
    Am J Vet Res 69:273-8. 2008
    ..To determine effects of the topically applied calcium-channel blocker flunarizine on intraocular pressure (IOP) in clinically normal dogs...
  53. ncbi request reprint Characterization of gene expression profiles of normal canine retina and brain using a retinal cDNA microarray
    Gerardo L Paez
    Department of Clinical Studies Philadelphia, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Vis 12:1048-56. 2006
    ....
  54. doi request reprint Characterization of gene expression profiles of normal canine retina and brain using a retinal cDNA microarray
    Gerardo L Paez
    Department of Clinical Studies Philadelphia, School of Veterinary Medicine, University of Pennsylvania Philadelphia, PA 19104, USA
    Adv Exp Med Biol 613:179-84. 2008
  55. ncbi request reprint The proto-oncogene C-KIT maps to canid B-chromosomes
    Alexander S Graphodatsky
    Institute of Cytology and Genetics, SB RAS, Novosibirsk, 630090, Russia
    Chromosome Res 13:113-22. 2005
    ..Identification of C-KIT gene on all B-chromosomes of two canid species provides new insight into the origin and evolution of supernumeraries and their potential role in the genome...
  56. ncbi request reprint Application of a new subretinal injection device in the dog
    Andras M Komaromy
    Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Transplant 15:511-9. 2006
    ..In summary, the use of the RetinaJect can be recommended as an alternative to the CSID for subretinal injections in dogs...

Research Grants19

  1. Models for Therapy of Hereditary Retinal Degenerations
    Gregory M Acland; Fiscal Year: 2010
    ..This research proposal focuses on the development and preclinical proof of principle testing of new gene therapies to restore retinal function and prevent degeneration in genetically affected retinas. ..
  2. Models of Hereditary Retinal Degenerations
    Gregory Acland; Fiscal Year: 2009
    ....
  3. Models of Hereditary Retinal Degenerations
    Gregory Acland; Fiscal Year: 2007
    ....
  4. Models of Hereditary Retinal Degenerations
    Gregory Acland; Fiscal Year: 2006
    ....
  5. Models of Hereditary Retinal Degenerations
    Gregory Acland; Fiscal Year: 2005
    ....
  6. MODELS OF HEREDITY RETINAL DEGENERATION
    Gregory Acland; Fiscal Year: 2004
    ....
  7. MODELS OF HEREDITY RETINAL DEGENERATION
    Gregory Acland; Fiscal Year: 2003
    ....
  8. MODELS OF HEREDITY RETINAL DEGENERATION
    Gregory Acland; Fiscal Year: 2002
    ....
  9. MODELS OF HEREDITY RETINAL DEGENERATION
    Gregory Acland; Fiscal Year: 2001
    ....
  10. MODELS OF HEREDITY RETINAL DEGENERATION
    Gregory Acland; Fiscal Year: 2000
    ....
  11. MODELS OF HEREDITARY RETINAL DEGENERATION
    Gregory Acland; Fiscal Year: 1999
    ....
  12. Models for Therapy of Hereditary Retinal Degenerations
    Gregory M Acland; Fiscal Year: 2011
    ..This research proposal focuses on the development and preclinical proof of principle testing of new gene therapies to restore retinal function and prevent degeneration in genetically affected retinas. ..