Research Topics
| S TrzeciakSummaryAffiliation: Cooper University Hospital Country: USA Publications
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Detail Information
Publications
Outcome measures utilized in clinical trials of interventions for post-cardiac arrest syndrome: a systematic reviewStephen Trzeciak
Department of Medicine, Division of Critical Care Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, NJ 08103, United States
Resuscitation 80:617-23. 2009..We aimed to determine the current degree of uniformity of outcome measures in clinical trials of post-ROSC interventions...
The association of near-infrared spectroscopy-derived tissue oxygenation measurements with sepsis syndromes, organ dysfunction and mortality in emergency department patients with sepsisNathan I Shapiro
Department of Emergency Medicine and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
Crit Care 15:R223. 2011....- The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsisNathan I Shapiro
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Road CC2 W, Boston, MA 02215, USA
Crit Care 14:R182. 2010..We investigated the association between biomarkers of endothelial cell activation and sepsis severity, organ dysfunction sequential organ failure assessment (SOFA) score, and death... - Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trialsStephen Trzeciak
Department of Emergency Medicine, Division of Critical Care Medicine, University of Medicine and Dentistry of New Jersey UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, NJ, USA
Acad Emerg Med 15:399-413. 2008..We also present the scientific rationale for clinical trials of exogenous NO administration to treat microcirculatory dysfunction and augment microcirculatory blood flow in early sepsis therapy... - Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsisStephen Trzeciak
Department of Medicine, Divisions of Cardiovascular Disease and Critical Care Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, One Cooper Plaza D363, Camden, NJ 08103, USA
Intensive Care Med 34:2210-7. 2008..We hypothesized that changes in microcirculatory flow during resuscitation are associated with changes in organ failure over the first 24 h of sepsis therapy... - Clinical manifestations of disordered microcirculatory perfusion in severe sepsisStephen Trzeciak
Section of Critical Care Medicine and the Department of Emergency Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, New Jersey, USA
Crit Care 9:S20-6. 2005..Using new technologies to directly image microcirculatory blood flow will help define the role of microcirculatory dysfunction in oxygen transport and circulatory support in severe sepsis... - Emergency department overcrowding in the United States: an emerging threat to patient safety and public healthS Trzeciak
Department of Emergency Medicine, Section of Critical Care Medicine, Robert Wood Johnson Medical School at Camden, University of Medicine and Dentistry of New Jersey, Cooper Health System, Camden, USA
Emerg Med J 20:402-5. 2003..4) Potential solutions for ED overcrowding will require multidisciplinary system-wide support... 
Significance of arterial hypotension after resuscitation from cardiac arrestStephen Trzeciak
Division of Critical Care Medicine and Emergency Medicine, Robert Wood Johnson Medical School, Cooper University Hospital, Camden, NJ, USA
Crit Care Med 37:2895-903; quiz 2904. 2009..Our objective was to determine whether post-ROSC arterial hypotension predicts outcome among postcardiac arrest patients who survive to intensive care unit admission...- Translating research to clinical practice: a 1-year experience with implementing early goal-directed therapy for septic shock in the emergency departmentStephen Trzeciak
Division of Cardiovascular Disease and Critical Care Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, One Cooper Plaza, D363, Camden, NJ 08103, USA
Chest 129:225-32. 2006..We aimed to determine if EGDT end points could reliably be achieved in real-world clinical practice... - Infections and severe sepsis in solid-organ transplant patients admitted from a university-based EDStephen Trzeciak
Department of Emergency Medicine, University of Illinois at Chicago, Chicago, IL, USA
Am J Emerg Med 22:530-3. 2004..7% of these patients had severe sepsis. The emergency physician must have a high index of suspicion for infections when evaluating organ transplant recipients... - Inclusion criteria for clinical trials in sepsis: did the American College of Chest Physicians/Society of Critical Care Medicine consensus conference definitions of sepsis have an impact?Stephen Trzeciak
Department of Emergency Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, NJ 08103, USA
Chest 127:242-5. 2005..To promote uniformity in inclusion criteria for patient enrollment, the American College of Chest Physicians and Society of Critical Care Medicine first published consensus conference definitions for sepsis in 1992... - A prospective multicenter cohort study of the association between global tissue hypoxia and coagulation abnormalities during early sepsis resuscitationStephen Trzeciak
Department of Medicine, Division of Critical Care Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, NJ, USA
Crit Care Med 38:1092-100. 2010..We aimed to test the hypothesis that the quantity of exposure to global tissue hypoxia is associated with the degree of coagulation activation during early sepsis resuscitation... - Serum lactate as a predictor of mortality in patients with infectionStephen Trzeciak
UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Division of Cardiovascular Disease and Critical Care Medicine, One Cooper Plaza, Camden 08103, NJ, USA
Intensive Care Med 33:970-7. 2007..To determine the utility of an initial serum lactate measurement for identifying high risk of death in patients with infection... - Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trialAlan E Jones
Department of Emergency Medicine, 1000 Blythe Blvd, Carolinas Medical Center, Charlotte, NC 28203, USA
JAMA 303:739-46. 2010..Goal-directed resuscitation for severe sepsis and septic shock has been reported to reduce mortality when applied in the emergency department... - The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentationAlan E Jones
Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
Crit Care Med 37:1649-54. 2009..We examined the utility of the SOFA score for assessing outcome of patients with severe sepsis with evidence of hypoperfusion at the time of emergency department (ED) presentation... - Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortalityJ Hope Kilgannon
Department of Emergency Medicine, Cooper University Hospital, One Cooper Plaza, Camden, NJ 08103, USA
JAMA 303:2165-71. 2010..Laboratory investigations suggest that exposure to hyperoxia after resuscitation from cardiac arrest may worsen anoxic brain injury; however, clinical data are lacking... - Impact of delayed transfer of critically ill patients from the emergency department to the intensive care unitDonald B Chalfin
Division of Critical Care Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
Crit Care Med 35:1477-83. 2007..We aimed to determine the association between emergency department "boarding" (holding admitted patients in the emergency department pending intensive care unit transfer) and outcomes for critically ill patients... - A prospective, multicenter derivation of a biomarker panel to assess risk of organ dysfunction, shock, and death in emergency department patients with suspected sepsisNathan I Shapiro
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Crit Care Med 37:96-104. 2009..To define a biomarker panel to predict organ dysfunction, shock, and in-hospital mortality in emergency department (ED) patients with suspected sepsis... - Use of a standardized order set for achieving target temperature in the implementation of therapeutic hypothermia after cardiac arrest: a feasibility studyJ Hope Kilgannon
Department of Emergency Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School at Camden, NJ, USA
Acad Emerg Med 15:499-505. 2008..We hypothesized that using a standardized order set, clinicians could achieve HT target temperature in routine practice with equal or better efficiency than that observed in randomized trials... - Continuous cardiac index monitoring: A prospective observational study of agreement between a pulmonary artery catheter and a calibrated minimally invasive techniqueJonathan V McCoy
Department of Emergency Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, NJ 08103, USA
Resuscitation 80:893-7. 2009..However, pulmonary artery catheters (PAC) pose logistic challenges in acute care settings. We hypothesized that CCI measured with a calibrated minimally invasive technique (LiDCO/PulseCO, UK) would have good agreement with the PAC... - Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsisRyan C Arnold
Department of Emergency Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, New Jersey 08103, USA
Shock 32:35-9. 2009..These data provide rationale for a clinical trial of lactate clearance as a distinct end point of early sepsis resuscitation... - Point-of-care assessment of microvascular blood flow in critically ill patientsRyan C Arnold
Department of Emergency Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, One Cooper Plaza, Camden, NJ 08103, USA
Intensive Care Med 35:1761-6. 2009..We hypothesized that a real-time point-of-care (POC) determination of the microcirculatory flow index (MFI), an established metric for assessing microcirculatory perfusion, agrees well with the conventional off-line analysis... - The feasibility and accuracy of point-of-care lactate measurement in emergency department patients with suspected infectionNathan I Shapiro
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02116, USA
J Emerg Med 39:89-94. 2010..Prior studies show that lactate is a useful prognostic marker in sepsis... - Microcirculatory dysfunction in sepsisDavid J Lundy
Department of Surgery, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, NJ 08103, USA
Crit Care Clin 25:721-31, viii. 2009..Finally, potential novel therapies and challenges in treating microcirculatory dysfunction in septic patients are discussed... - Multicenter clinical trials in sepsis: understanding the big picture and building a successful operation at your hospitalR Phillip Dellinger
Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Division of Critical Care Medicine, Cooper University Hospital, Camden, NJ 08103, USA
Crit Care Clin 25:869-79, xi. 2009..Because early enrollment into sepsis clinical trials is usually required, collaboration between emergency medicine and critical care is needed... - Multicenter study of central venous oxygen saturation (ScvO(2)) as a predictor of mortality in patients with sepsisJennifer V Pope
Harvard Affiliated Emergency Medicine Residency, Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Ann Emerg Med 55:40-46.e1. 2010..Abnormal (both low and high) central venous saturation (ScvO(2)) is associated with increased mortality in emergency department (ED) patients with suspected sepsis... - The effect of a quantitative resuscitation strategy on mortality in patients with sepsis: a meta-analysisAlan E Jones
Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, USA
Crit Care Med 36:2734-9. 2008..Quantitative resuscitation consists of structured cardiovascular intervention targeting predefined hemodynamic end points. We sought to measure the treatment effect of quantitative resuscitation on mortality from sepsis... 
Clinical review: Emergency department overcrowding and the potential impact on the critically illRobert M Cowan
Department of Emergency Medicine, UMDNJ Robert Wood Johnson Medical School, Camden, New Jersey, USA
Crit Care 9:291-5. 2005..This review describes the causes and effects of ED overcrowding; explores the potential impact that ED overcrowding has on care of the critically ill ED patient; and identifies possible solutions, focusing on ED based critical care...- Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survivalStephen Trzeciak
Division of Cardiovascular Disease and Critical Care Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, NJ 08103, USA
Ann Emerg Med 49:88-98, 98.e1-2. 2007.... - Multicenter clinical trials in sepsis: understanding the big picture and building a successful operation at your hospitalR Phillip Dellinger
Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, USA
Crit Care Nurs Clin North Am 23:215-25. 2011..The most professional satisfaction comes from the knowledge of contributing to original science in the field of the sepsis... - Microcirculatory dysfunction in sepsisDavid J Lundy
Department of Surgery, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School at Camden, Cooper University Hospital, NJ 08103, USA
Crit Care Nurs Clin North Am 23:67-77. 2011..With the advent of these techniques, the microcirculation may represent a new frontier for developing novel therapies for sepsis... - Early arterial hypotension is common in the post-cardiac arrest syndrome and associated with increased in-hospital mortalityJ Hope Kilgannon
Department of Emergency Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, One Cooper Plaza, 114 Kelemen, Camden, NJ 08103, USA
Resuscitation 79:410-6. 2008..We tested the hypothesis that exposure to arterial hypotension after ROSC occurs commonly (>50%) and is an independent predictor of death... - Goal-directed hemodynamic optimization in the post-cardiac arrest syndrome: a systematic reviewAlan E Jones
Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC, United States
Resuscitation 77:26-9. 2008.... - Early goal-directed therapy in severe sepsis and septic shock revisited: concepts, controversies, and contemporary findingsRonny M Otero
Department of Emergency Medicine, Henry Ford Hospital, Detroit, MI 48202, USA
Chest 130:1579-95. 2006..Although EGDT is faced with challenges, a coordinated approach to sepsis management is necessary to duplicate the progress in outcomes seen in patients with conditions such as acute myocardial infarction, stroke, and trauma... - Effect of glucose-insulin-potassium infusion on mortality in critical care settings: a systematic review and meta-analysisMichael A Puskarich
Department of Emergency Medicine, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232 2861, USA
J Clin Pharmacol 49:758-67. 2009..No studies are identified using GIK in patients with septic shock or other forms of circulatory shock, providing an absence of evidence regarding the effect of GIK as a therapy in patients with shock... - Other supportive therapies in sepsis: an evidence-based reviewStephen Trzeciak
UMDNJ-Robert Wood Johnson Medical School at Camden, Camden, NJ, USA
Crit Care Med 32:S571-7. 2004..Proton pump inhibitors have not been assessed in a direct comparison with histamine-2 receptor antagonists but do demonstrate equivalency and ability to increase gastric pH... - Modulation of the sepsis inflammatory response by resuscitation: The missing link between cytopathic and hypoxic hypoxia?Stephen Trzeciak
Crit Care Med 35:2206-7. 2007 - Lac-time?Stephen Trzeciak
Crit Care Med 32:1785-6. 2004 - Is impaired capillary perfusion a marker of tissue hypoxia and a hallmark of incipient circulatory shock?Nicole L Abate
Crit Care Med 34:566-7. 2006 - Severe sepsis and septic shock: review of the literature and emergency department management guidelinesH Bryant Nguyen
Loma Linda University, Loma Linda, CA, USA
Ann Emerg Med 48:28-54. 2006.... - "Vital" sign?Stephen Trzeciak
Chest 130:933-4. 2006 - Critical care medicine training and certification for emergency physiciansDavid T Huang
The CRISMA Laboratory (Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 33:2104-9. 2005..We therefore propose that all accreditation bodies work cooperatively to create a route to CCM certification for emergency physicians who complete a critical care fellowship... - Critical care medicine training and certification for emergency physiciansDavid T Huang
Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
Ann Emerg Med 46:217-23. 2005..We therefore propose that all accreditation bodies work cooperatively to create a route to critical care medicine certification for emergency physicians who complete a critical care fellowship...