R Phillip Dellinger

Summary

Affiliation: Cooper University Hospital
Country: USA

Publications

  1. pmc Ethics roundtable: Using new, expensive drugs
    Richard Burrows
    Intensive Care Unit, Addington Hospital, Durban, South Africa
    Crit Care 6:473-8. 2002
  2. pmc The International Sepsis Forum's controversies in sepsis: my initial vasopressor agent in septic shock is norepinephrine rather than dopamine
    Vinay K Sharma
    Critical Care Section, Cooper Health System, Camden, New Jersey, USA
    Crit Care 7:3-5. 2003
  3. ncbi request reprint Sepsis change bundles: converting guidelines into meaningful change in behavior and clinical outcome
    Mitchell M Levy
    Medical Intensive Care Unit Rhode Island Hospital Providence, RI, USA
    Crit Care Med 32:S595-7. 2004
  4. ncbi request reprint Inclusion criteria for clinical trials in sepsis: did the American College of Chest Physicians/Society of Critical Care Medicine consensus conference definitions of sepsis have an impact?
    Stephen Trzeciak
    Department of Emergency Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, NJ 08103, USA
    Chest 127:242-5. 2005
  5. ncbi request reprint Positive clinical impact of low tidal volume strategy
    R Phillip Dellinger
    Crit Care Med 33:1143-4. 2005
  6. doi request reprint Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012
    R Phillip Dellinger
    Cooper University Hospital, Camden, New Jersey, USA
    Crit Care Med 41:580-637. 2013
  7. doi request reprint Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012
    R P Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Intensive Care Med 39:165-228. 2013
  8. pmc Association between inhaled nitric oxide treatment and long-term pulmonary function in survivors of acute respiratory distress syndrome
    R Phillip Dellinger
    Division of Critical Care Medicine, Department of Medicine, Cooper University Hospital, 1 Cooper Plaza, Camden, NJ 08103, USA
    Crit Care 16:R36. 2012
  9. pmc Arterial pressure optimization in the treatment of septic shock: a complex puzzle
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Crit Care 14:102. 2010
  10. pmc Multinational, observational study of procalcitonin in ICU patients with pneumonia requiring mechanical ventilation: a multicenter observational study
    Frank Bloos
    Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany
    Crit Care 15:R88. 2011

Collaborators

Detail Information

Publications79

  1. pmc Ethics roundtable: Using new, expensive drugs
    Richard Burrows
    Intensive Care Unit, Addington Hospital, Durban, South Africa
    Crit Care 6:473-8. 2002
  2. pmc The International Sepsis Forum's controversies in sepsis: my initial vasopressor agent in septic shock is norepinephrine rather than dopamine
    Vinay K Sharma
    Critical Care Section, Cooper Health System, Camden, New Jersey, USA
    Crit Care 7:3-5. 2003
  3. ncbi request reprint Sepsis change bundles: converting guidelines into meaningful change in behavior and clinical outcome
    Mitchell M Levy
    Medical Intensive Care Unit Rhode Island Hospital Providence, RI, USA
    Crit Care Med 32:S595-7. 2004
  4. ncbi request reprint Inclusion criteria for clinical trials in sepsis: did the American College of Chest Physicians/Society of Critical Care Medicine consensus conference definitions of sepsis have an impact?
    Stephen Trzeciak
    Department of Emergency Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, NJ 08103, USA
    Chest 127:242-5. 2005
    ..To promote uniformity in inclusion criteria for patient enrollment, the American College of Chest Physicians and Society of Critical Care Medicine first published consensus conference definitions for sepsis in 1992...
  5. ncbi request reprint Positive clinical impact of low tidal volume strategy
    R Phillip Dellinger
    Crit Care Med 33:1143-4. 2005
  6. doi request reprint Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012
    R Phillip Dellinger
    Cooper University Hospital, Camden, New Jersey, USA
    Crit Care Med 41:580-637. 2013
    ..To provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," last published in 2008...
  7. doi request reprint Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012
    R P Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Intensive Care Med 39:165-228. 2013
    ..To provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," last published in 2008...
  8. pmc Association between inhaled nitric oxide treatment and long-term pulmonary function in survivors of acute respiratory distress syndrome
    R Phillip Dellinger
    Division of Critical Care Medicine, Department of Medicine, Cooper University Hospital, 1 Cooper Plaza, Camden, NJ 08103, USA
    Crit Care 16:R36. 2012
    ..This analysis examined potential effects of iNO or placebo on pulmonary function six months post-treatment in ARDS survivors from that original study...
  9. pmc Arterial pressure optimization in the treatment of septic shock: a complex puzzle
    Alan E Jones
    Department of Emergency Medicine, Carolinas Medical Center, Charlotte, NC 28203, USA
    Crit Care 14:102. 2010
    ..Although these data add important new evidence to our understanding of arterial pressure management, there are still many unanswered questions upon which future investigations should focus...
  10. pmc Multinational, observational study of procalcitonin in ICU patients with pneumonia requiring mechanical ventilation: a multicenter observational study
    Frank Bloos
    Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Erlanger Allee 101, 07747 Jena, Germany
    Crit Care 15:R88. 2011
    ..The intent of this study was to determine whether serum procalcitonin (PCT) levels are associated with prognosis, measured as organ dysfunctions and 28-day mortality, in patients with severe pneumonia...
  11. ncbi request reprint Efficacy and safety of a phospholipid emulsion (GR270773) in Gram-negative severe sepsis: results of a phase II multicenter, randomized, placebo-controlled, dose-finding clinical trial
    R Phillip Dellinger
    Cooper University Hospital and University Medicine Dentistry New Jersey PD, Camden, NJ, USA
    Crit Care Med 37:2929-38. 2009
    ..Endotoxin neutralization correlates with the amount of phospholipid in the lipoprotein particles...
  12. pmc Recombinant activated protein C: the key is clinical assessment of risk of death, not subset analysis
    R Phillip Dellinger
    Section of Critical Care Medicine, Cooper University Hospital, One Cooper Plaza, Camden, NJ 08103, USA
    Crit Care 10:114. 2006
    ..Additional studies of recombinant activated protein C (rhAPC) have added to our understanding about this drug and to controversy as well. So how do we deal with rhAPC use in our clinical practice?..
  13. pmc The Surviving Sepsis Campaign sepsis change bundles and clinical practice
    R Phillip Dellinger
    Section of Critical Care Medicine, Cooper University Hospital, Robert Wood Johnson Medical School, Camden, New Jersey, USA
    Crit Care 9:653-4. 2005
    ..The next step will be to demonstrate that the use of education and feedback for performance improvement will increase compliance and decrease mortality in the patient population in general...
  14. ncbi request reprint Important issues in the design and reporting of clinical trials in severe sepsis and acute lung injury
    R Phillip Dellinger
    Cooper University Hospital, Robert Wood Johnson Medical School, Camden, NJ, USA
    J Crit Care 23:493-9. 2008
    ..This article reviews many of the problems encountered in clinical trial design and reporting and offers a perspective on dealing with them to the betterment of a clinical trial...
  15. doi request reprint Multicenter clinical trials in sepsis: understanding the big picture and building a successful operation at your hospital
    R Phillip Dellinger
    Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, USA
    Crit Care Nurs Clin North Am 23:215-25. 2011
    ..The most professional satisfaction comes from the knowledge of contributing to original science in the field of the sepsis...
  16. ncbi request reprint Multicenter clinical trials in sepsis: understanding the big picture and building a successful operation at your hospital
    R Phillip Dellinger
    Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Division of Critical Care Medicine, Cooper University Hospital, Camden, NJ 08103, USA
    Crit Care Clin 25:869-79, xi. 2009
    ..Because early enrollment into sepsis clinical trials is usually required, collaboration between emergency medicine and critical care is needed...
  17. pmc Regional distribution of acoustic-based lung vibration as a function of mechanical ventilation mode
    R Phillip Dellinger
    Division of Cardiovascular Disease and Critical Care Medicine, Robert Wood Johnson School of Medicine, University of Medicine and Dentistry of New Jersey, Cooper University Hospital, Camden, NJ 08103, USA
    Crit Care 11:R26. 2007
    ..In this study, we objectively evaluated the differences in regional lung vibration during different modes of mechanical ventilation by means of this new technology...
  18. ncbi request reprint Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 36:296-327. 2008
    ..To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," published in 2004...
  19. ncbi request reprint Cardiovascular management of septic shock
    R Phillip Dellinger
    Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Section of Critical Care Medicine, Cooper Health System, Camden 08103, USA
    Crit Care Med 31:946-55. 2003
  20. ncbi request reprint Inflammation and coagulation: implications for the septic patient
    R Phillip Dellinger
    Critical Care Section, of Cardiovascular Diseases and Critical Care Medicine, Cooper Health System, Camden, New Jersey 08103, USA
    Clin Infect Dis 36:1259-65. 2003
    ..The pathophysiological and clinical significance of this evidence and the relationship of coagulation to inflammation are discussed, as are positive and negative results of clinical trials of antithrombotic therapy...
  21. pmc Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008
    R Phillip Dellinger
    Cooper University Hospital, One Cooper Plaza, 393 Dorrance, Camden 08103, NJ, USA
    Intensive Care Med 34:17-60. 2008
    ..To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock," published in 2004...
  22. ncbi request reprint Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
    R Phillip Dellinger
    Section of Critical Care Medicine, Cooper University Hospital, One Cooper Plaza, 393 Dorrance, Camden, NJ 08103, USA
    Intensive Care Med 30:536-55. 2004
    ....
  23. doi request reprint A prospective multicenter cohort study of the association between global tissue hypoxia and coagulation abnormalities during early sepsis resuscitation
    Stephen Trzeciak
    Department of Medicine, Division of Critical Care Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 38:1092-100. 2010
    ..We aimed to test the hypothesis that the quantity of exposure to global tissue hypoxia is associated with the degree of coagulation activation during early sepsis resuscitation...
  24. doi request reprint Location of patients before transfer to a tertiary care intensive care unit: impact on outcome
    David R Gerber
    Critical Care Medicine, Cooper University Hospital, Camden, NJ 08103, USA
    J Crit Care 24:108-13. 2009
    ..To evaluate the impact of the source of patients transferred to a tertiary care intensive care unit (ICU) (referring hospital ICU vs referring hospital emergency department [ED]) on outcomes of transferred patients...
  25. ncbi request reprint Translating research to clinical practice: a 1-year experience with implementing early goal-directed therapy for septic shock in the emergency department
    Stephen Trzeciak
    Division of Cardiovascular Disease and Critical Care Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, One Cooper Plaza, D363, Camden, NJ 08103, USA
    Chest 129:225-32. 2006
    ..We aimed to determine if EGDT end points could reliably be achieved in real-world clinical practice...
  26. doi request reprint Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest
    J Hope Kilgannon
    Department of Emergency Medicine, Cooper University Hospital, Camden, NJ 08103, USA
    Circulation 123:2717-22. 2011
    ..We aimed to define the relationship between supranormal oxygen tension and outcome in postresuscitation patients...
  27. pmc The next generation of sepsis clinical trial designs: what is next after the demise of recombinant human activated protein C?*
    Steven M Opal
    1Infectious Disease Division, The Alpert Medical School of Brown University, Providence, RI 2Critical Care Department, Robert Wood Johnson Medical School, Camden, NJ 3Critical Care Department, Erasme University Hospital, Brussels, Belgium 4Critical Care Department, National Institutes of Health, Bethesda, MD 5Critical Care Department, University of Pittsburgh School of Medicine, Pittsburgh, PA
    Crit Care Med 42:1714-21. 2014
    ..We must critically reevaluate our basic approach to the preclinical and clinical evaluation of new sepsis therapies...
  28. pmc Transfusion of packed red blood cells is not associated with improved central venous oxygen saturation or organ function in patients with septic shock
    Brian M Fuller
    Department of Anesthesiology, Division of Critical Care Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Emerg Med 43:593-8. 2012
    ..The exact role of packed red blood cell (PRBC) transfusion in the setting of early resuscitation in septic shock is unknown...
  29. doi request reprint Discordance between microcirculatory alterations and arterial pressure in patients with hemodynamic instability
    Ryan C Arnold
    Department of Emergency Medicine, Division of Critical Care Medicine, Cooper University Hospital, Camden, NJ 08103, USA
    J Crit Care 27:531.e1-7. 2012
    ..We selected cardiopulmonary bypass (CPB) patients with expected and rapidly reversible hemodynamic instability to test the hypothesis that microcirculatory alterations can occur independent of mean arterial pressure (MAP)...
  30. ncbi request reprint Serum lactate as a predictor of mortality in patients with infection
    Stephen Trzeciak
    UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Division of Cardiovascular Disease and Critical Care Medicine, One Cooper Plaza, Camden 08103, NJ, USA
    Intensive Care Med 33:970-7. 2007
    ..To determine the utility of an initial serum lactate measurement for identifying high risk of death in patients with infection...
  31. doi request reprint Ventricular dilation is associated with improved cardiovascular performance and survival in sepsis
    Sergio L Zanotti Cavazzoni
    Division of Critical Care Medicine, Cooper University Hospital, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Camden, NJ 08103, USA
    Chest 138:848-55. 2010
    ..The goal of this study was to evaluate the impact of myocardial dysfunction and changes in LV diameter on hemodynamics and survival in a murine model of sepsis...
  32. ncbi request reprint Endotoxin removal: how far from the evidence? From EUPHAS to EUPHRATES
    Jean Sebastien Rachoin
    Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Department of Medicine, Division of Critical Care Medicine, Cooper University Hospital, Camden, NJ 08103, USA
    Contrib Nephrol 167:111-8. 2010
    ....
  33. pmc Hemodynamic optimization of sepsis-induced tissue hypoperfusion
    Sergio L Zanotti Cavazzoni
    Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Camden, New Jersey, USA
    Crit Care 10:S2. 2006
    ..This review will cover the most important aspects of hemodynamic optimization for treatment of sepsis induced tissue-hypoperfusion...
  34. doi request reprint Use of a standardized order set for achieving target temperature in the implementation of therapeutic hypothermia after cardiac arrest: a feasibility study
    J Hope Kilgannon
    Department of Emergency Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School at Camden, NJ, USA
    Acad Emerg Med 15:499-505. 2008
    ..We hypothesized that using a standardized order set, clinicians could achieve HT target temperature in routine practice with equal or better efficiency than that observed in randomized trials...
  35. doi request reprint Continuous cardiac index monitoring: A prospective observational study of agreement between a pulmonary artery catheter and a calibrated minimally invasive technique
    Jonathan V McCoy
    Department of Emergency Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, NJ 08103, USA
    Resuscitation 80:893-7. 2009
    ..However, pulmonary artery catheters (PAC) pose logistic challenges in acute care settings. We hypothesized that CCI measured with a calibrated minimally invasive technique (LiDCO/PulseCO, UK) would have good agreement with the PAC...
  36. doi request reprint Assessment of asymmetric lung disease in intensive care unit patients using vibration response imaging
    Smith Jean
    Department of Medicine, Robert Wood Johnson School of Medicine, University of Medicine and Dentistry of New Jersey, Cooper University Hospital, Camden, NJ 08103, USA
    Anesth Analg 107:1243-7. 2008
    ..The filtered output signal frequencies are presented as a gray-scale coded dynamic image, consisting of a series of 0.17 s frames, and as a table featuring the percentage contribution of each lung to the total vibration signal...
  37. ncbi request reprint Case report: vibration response imaging findings following inadvertent esophageal intubation
    Ismail Cinel
    Department of Medicine, Division of Critical Care Medicine, Robert Wood Johnson School of Medicine, University of Medicine and Dentistry of New Jersey, Cooper University Hospital, Camden, New Jersey, USA
    Can J Anaesth 55:172-6. 2008
    ..We describe the effect that inadvertent esophageal intubation has on the images and on the vibration distribution of vibration response imaging (VRI)...
  38. pmc Early arterial hypotension is common in the post-cardiac arrest syndrome and associated with increased in-hospital mortality
    J Hope Kilgannon
    Department of Emergency Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, One Cooper Plaza, 114 Kelemen, Camden, NJ 08103, USA
    Resuscitation 79:410-6. 2008
    ..We tested the hypothesis that exposure to arterial hypotension after ROSC occurs commonly (>50%) and is an independent predictor of death...
  39. ncbi request reprint Multicenter study of early lactate clearance as a determinant of survival in patients with presumed sepsis
    Ryan C Arnold
    Department of Emergency Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, New Jersey 08103, USA
    Shock 32:35-9. 2009
    ..These data provide rationale for a clinical trial of lactate clearance as a distinct end point of early sepsis resuscitation...
  40. ncbi request reprint Advances in pathogenesis and management of sepsis
    Ismail Cinel
    Robert Wood Johnson School of Medicine, University of Medicine and Dentistry of New Jersey, Department of Critical Care Medicine, Cooper University Hospital, Camden, New Jersey, USA
    Curr Opin Infect Dis 20:345-52. 2007
    ..The rationale for therapeutic targets in sepsis has arisen from the concept of pathogenesis. This review focuses on recent advances in pathogenesis of sepsis that can aid in management of sepsis patients...
  41. doi request reprint Fluid resuscitation influences cardiovascular performance and mortality in a murine model of sepsis
    Sergio L Zanotti-Cavazzoni
    Division of Critical Care Medicine, Cooper University Hospital, Dorrance 360, Once Cooper Plaza, Camden, NJ 08103, USA
    Intensive Care Med 35:748-54. 2009
    ..Current murine models of sepsis do not account for the effects of aggressive fluid resuscitation on hemodynamics and mortality...
  42. ncbi request reprint Impact of delayed transfer of critically ill patients from the emergency department to the intensive care unit
    Donald B Chalfin
    Division of Critical Care Medicine, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Crit Care Med 35:1477-83. 2007
    ..We aimed to determine the association between emergency department "boarding" (holding admitted patients in the emergency department pending intensive care unit transfer) and outcomes for critically ill patients...
  43. ncbi request reprint Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival
    Stephen Trzeciak
    Division of Cardiovascular Disease and Critical Care Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, NJ 08103, USA
    Ann Emerg Med 49:88-98, 98.e1-2. 2007
    ....
  44. ncbi request reprint A phase 2 randomized, double-blind, placebo-controlled study of the safety and efficacy of talactoferrin in patients with severe sepsis
    Kalpalatha Guntupalli
    Department of Medicine, Baylor College of Medicine, Ben Taub General, Hospital Houston, TX, USA
    Crit Care Med 41:706-16. 2013
    ..Our objective was to determine if talactoferrin could reduce 28-day all-cause mortality in patients with severe sepsis and to assess its safety...
  45. pmc The association of prior statin use in septic shock treated with early goal directed therapy
    Brian M Fuller
    Department of Anesthesiology, Division of Critical Care Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Eur J Emerg Med 19:226-30. 2012
    ..Previous literature suggests statins may have a therapeutic role in sepsis. No data have examined if statin use may have a positive impact beyond that afforded by early goal directed therapy (EGDT)...
  46. ncbi request reprint Other supportive therapies in sepsis: an evidence-based review
    Stephen Trzeciak
    UMDNJ Robert Wood Johnson Medical School at Camden, Camden, NJ, USA
    Crit Care Med 32:S571-7. 2004
    ....
  47. ncbi request reprint Guidelines for severe infections: are they useful?
    Ismail Cinel
    Robert Wood Johnson School of Medicine, University of Medicine and Dentistry of New Jersey, Section of Critical Care Medicine, Cooper University Hospital, Camden, New Jersey 08103, USA
    Curr Opin Crit Care 12:483-8. 2006
    ..The evolution of guidelines and their impact on delivery of care in severe infection is reviewed...
  48. ncbi request reprint Sepsis severity score: an internationally derived scoring system from the surviving sepsis campaign database*
    Tiffany M Osborn
    1Division of Acute and Critical Care Surgery, Department of Emergency Medicine and Department of Surgery, Barnes Jewish Hospital Washington University, St Louis, MO 2The Ohio State University Center for Biostatistics, Columbus, OH 3The Ohio State University College of Public Health, Columbus, OH 4Division of Pulmonary and Critical Care, Department of Medicine, California Pacific Medical Center, San Francisco, CA 5Division of Critical Care Medicine, Department of Medicine, Cooper University Hospital, Camden, NJ 6Division of Pulmonary Critical Care Medicine, Brown University Rhode Island Hospital, Providence, RI
    Crit Care Med 42:1969-76. 2014
    ....
  49. doi request reprint Evaluating the efficacy and safety of two doses of the polyclonal anti-tumor necrosis factor-α fragment antibody AZD9773 in adult patients with severe sepsis and/or septic shock: randomized, double-blind, placebo-controlled phase IIb study*
    Gordon R Bernard
    1Division of Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN 2Service de Réanimation Polyvalente, CIC P 0801, CHU Dupuytren, Limoges, Cedex, France 3Hôpitaux Paris Centre, AP HP Universite Paris Descartes, Faculte de Medecine, Paris, France and Cochin Institute, INSERM U567, CNRS UMR 8104, Paris, France 4Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium 5Department of Medicine, Cooper University Hospital, Camden, NJ 6Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada 7Division of Infectious Diseases, Beverly Hospital, Beverly, MA 8Critical Care Department, St Luc University Hospital, Universite Catholique de Louvain, Brussels, Belgium 9Department of Medicine, Brown University, Providence, RI 10Worldwide Medical Services Department, PAREXEL International, Durham, NC 11AstraZeneca, Alderley Park, India
    Crit Care Med 42:504-11. 2014
    ..This trial compared the efficacy/safety of two IV doses of AZD9773, a polyclonal antibody to tumor necrosis factor-α, in adult patients with severe sepsis/septic shock...
  50. ncbi request reprint Infections and severe sepsis in solid-organ transplant patients admitted from a university-based ED
    Stephen Trzeciak
    Department of Emergency Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Am J Emerg Med 22:530-3. 2004
    ..7% of these patients had severe sepsis. The emergency physician must have a high index of suspicion for infections when evaluating organ transplant recipients...
  51. doi request reprint TAKEDA-143242 increased survival via reduced cytokines in porcine peritonitis
    Roy D Goldfarb
    Department of Medicine, Sections of Cardiology and Critical Care, Rush Medical College, Chicago, Illinois, USA
    J Surg Res 166:e165-73. 2011
    ..This study found that pretreatment with TAK-242 yielded significantly positive survival benefit in a lethal sepsis model that was associated with improved cardiovascular status and suppressed cytokine release...
  52. doi request reprint Targeting endotoxin in the treatment of sepsis
    Jean Sebastien Rachoin
    Critical Care Medicine, Cooper University Hospital, Camden, NJ 08103, USA
    Subcell Biochem 53:323-38. 2010
    ..Since both pre-clinical rationale and studies support the targeting of endotoxin to ameliorate the pro-inflammatory and pro-coagulation response of severe sepsis, this therapeutic intervention is being pursued...
  53. ncbi request reprint Drotrecogin alfa (activated) in an infant with gram-negative septic shock
    Imran Sajan
    Department of Pediatrics, Division of Pediatric Critical Care Medicine, Cooper Hospital University Medical Center, Camden, NJ 08103, USA
    J Intensive Care Med 19:51-5. 2004
    ..The authors believe that drotrecogin alfa (activated) should be considered in select children with life-threatening severe sepsis...
  54. ncbi request reprint Controversies in sepsis clinical trials: proceedings of a meeting of the International Sepsis Forum, Lausanne, Switzerland, September 29, 2001
    R Phillip Dellinger
    Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08854, USA
    J Crit Care 21:38-47. 2006
    ..Once a therapy is approved, adopting less stringent but still appropriate criteria for the use of that therapy in clinical practice may be appropriate...
  55. doi request reprint Inhaled nitric oxide does not reduce mortality in patients with acute respiratory distress syndrome regardless of severity: systematic review and meta-analysis
    Neill K J Adhikari
    1Department of Critical Care Medicine and Sunnybrook Research Institute, Sunnybrook Health Sciences Centre and University of Toronto, Toronto, ON, Canada 2Division of Critical Care Medicine, Department of Medicine, Cooper University Hospital, Camden, NJ 3Department of Anesthesia and Intensive Care, Sahlgrenska University Hospital, Gothenburg, Sweden 4Department of Critical Care and Anesthesiology and SAMU, Hopital Lariboisiere, Universite Paris 7 Denis Diderot, Paris, France 5Department of Anesthesiology and Intensive Care Medicine, University Hospital of Lille, Lille, France 6Departments for Anesthesia, Intensive Care Medicine, and Pain Management, Vivantes Klinikum Neukoelln, Berlin, Germany 7Department of Pulmonary and Critical Care Medicine, Ajou University School of Medicine, Suwon, South Korea 8Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto ON, Canada 9The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto ON, Canada 10Departments of Critical Care and Medicine, The Keenan Research Centre in the Li Ka Shing Knowledge Institute, St Michael s Hospital and University of Toronto, Toronto, ON, Canada
    Crit Care Med 42:404-12. 2014
    ....
  56. ncbi request reprint Recombinant activated protein C: decisions for administration
    R Phillip Dellinger
    Section of Critical Care Medicine, Cooper University Hospital, Camden, NJ, USA
    Crit Care Med 34:530-1. 2006
  57. ncbi request reprint Targeting the lipopolysaccharides: still a matter of debate?
    Raquel Nahra
    Division of Critical Care Medicine, Department of Internal Medicine, Cooper University Hospital, Camden, New Jersey, USA
    Curr Opin Anaesthesiol 21:98-104. 2008
    ....
  58. ncbi request reprint Dynamic visualization of lung sounds with a vibration response device: a case series
    R Phillip Dellinger
    Division of Cardiovascular Disease and Critical Care Medicine, UMDNJ Robert Wood Johnson Medical School at Camden, Cooper University Hospital, Camden, NJ, USA
    Respiration 75:60-72. 2008
    ..The field of computer-assisted mapping of lung sounds is constantly evolving and several devices have been developed in this field...
  59. ncbi request reprint The surviving sepsis guidelines: not another "groundhog day"
    R Phillip Dellinger
    Cooper Health Systems, Critical Care Section, Camden, NJ, USA
    Crit Care Med 32:1601-2. 2004
  60. pmc The impact of packed red blood cell transfusion on clinical outcomes in patients with septic shock treated with early goal directed therapy
    Brian M Fuller
    Department of Anesthesiology, Division of Critical Care Medicine, and the Division of Emergency Medicine, Washington University School of Medicine, St Louis, MO, USA
    Indian J Crit Care Med 14:165-9. 2010
    ..The optimal hemoglobin level and transfusion threshold in patients with septic shock treated with an early, goal oriented approach to resuscitation remains unknown...
  61. ncbi request reprint Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program*
    Ricard Ferrer
    1Department of Intensive Care, Mútua Terrassa University Hospital, CIBER Enfermedades Respiratorias, Barcelona, Spain 2Critical Care Center, Sabadell Hospital, CIBER Enfermedades Respiratorias, Corporación Sanitaria Universitaria Parc Tauli, Autonomous University of Barcelona, Sabadell, Spain 3The Ohio State University Center for Biostatistics, Columbus, OH 4Department of Surgery and Emergency Medicine, Division of Acute Care Surgery, Surgical Trauma Critical Care, Barnes Jewish Hospital, Washington University, St Louis, MO 5California Pacific Medical Center, San Francisco, CA 6Brown University Rhode Island Hospital, Providence, RI 7Cooper University Hospital, Camden, NJ
    Crit Care Med 42:1749-55. 2014
    ..To perform a retrospective analysis on the Surviving Sepsis Campaign database to evaluate the relationship between timing of antibiotic administration and mortality...
  62. ncbi request reprint Critical care medicine as a distinct product line with substantial financial profitability: the role of business planning
    Carolyn E Bekes
    Robert Wood Johnson Medical School, Camden, NJ, USA
    Crit Care Med 32:1207-14. 2004
    ..We hypothesized that a critical care business plan can be developed and analyzed like other more typical product lines and that such a critical care product line can be profitable for an institution...
  63. pmc Inhaled nitric oxide: another weapon in our armamentarium in the battle against acute hypoxic respiratory failure in preterm infants
    Shonola S Da-Silva
    Pediatric Critical Care Medicine, The Children s Regional Hospital, Cooper University Medical Center, UMDNJ RWJ Medical School at Camden, New Jersey, USA
    Crit Care 8:77-8. 2004
    ..The recognition that AHRF is often the result of a multifactorial process makes it unlikely that one treatment modality will have a major beneficial effect on mortality and morbidity...
  64. ncbi request reprint Care of critically ill surgical patients using the 80-hour Accreditation Council of Graduate Medical Education work-week guidelines: a survey of current strategies
    Chad R Gordon
    Department of Surgery, Division of Trauma and Surgical Critical Care, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Cooper University Hospital, Camden 08103, USA
    Am Surg 72:497-9. 2006
    ..The overall outcome of these new strategies still needs to be assessed before any beneficial results can be demonstrated...
  65. ncbi request reprint Porcine models of severe sepsis: emphasis on porcine peritonitis
    Roy D Goldfarb
    Robert Wood Johnson School of Medicine South University of Medicine and Dentistry, Camden, NJ 08103, USA
    Shock 24:75-81. 2005
  66. ncbi request reprint The Surviving Sepsis Campaign: past, present and future
    Christa A Schorr
    Division of Critical Care Medicine, Department of Medicine, Cooper University Hospital, Camden, NJ 08103, USA Electronic address
    Trends Mol Med 20:192-4. 2014
    ....
  67. pmc Lactate as a hemodynamic marker in the critically ill
    Brian M Fuller
    Division of Critical Care, Department of Anesthesiology, Washington University in St Louis, St Louis, Missouri, USA
    Curr Opin Crit Care 18:267-72. 2012
    ..This review focuses on the use of lactate as a marker for risk stratification, lactate clearance as a hemodynamic endpoint, and its use compared to mixed venous oxygenation as a resuscitation goal...
  68. ncbi request reprint Recent developments in the treatment of sepsis
    Vinay K Sharma
    Critical Care Section, Cooper Health System, 459 Kelleman, 1 Cooper Plaza, Camden, NJ 08103, USA
    Expert Opin Investig Drugs 12:139-52. 2003
    ..Attempts to reduce apoptosis have been a new focus in the treatment of sepsis. There have also been recent developments in supportive care suggesting a role for vasopressin and replacement corticosteroid therapy...
  69. ncbi request reprint Low-dose inhaled nitric oxide in patients with acute lung injury: a randomized controlled trial
    Robert W Taylor
    Critical Care Medicine, St Louis University St John s Mercy Medical Center, St Louis, MO, USA
    JAMA 291:1603-9. 2004
    ..Inhaled nitric oxide has been shown to improve oxygenation in acute lung injury...
  70. pmc The International Sepsis Forum's frontiers in sepsis: High cardiac output should not be maintained in severe sepsis
    Vinay K Sharma
    Pulmonary and Critical Care Division, Graduate Hospital, Philadelphia, Pennsylvania, USA
    Crit Care 7:272-5. 2003
  71. ncbi request reprint Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock
    R Phillip Dellinger
    Crit Care Med 32:858-73. 2004
    ....
  72. ncbi request reprint Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study
    John C Marshall
    University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Infect Dis 190:527-34. 2004
    ..Stepwise logistic regression analysis showed that elevated Acute Physiology and Chronic Health Evaluation II score, gram-negative infection, and emergency admission status were independent predictors of EA...
  73. doi request reprint Steroid therapy of septic shock: the decision is in the eye of the beholder
    R Phillip Dellinger
    Crit Care Med 36:1987-9. 2008
  74. ncbi request reprint 2008 update of international guidelines for the management of severe sepsis and septic shock: should we change our current clinical practice?
    Roman Z Jaeschke
    Pol Arch Med Wewn 118:92-5. 2008
  75. ncbi request reprint Severe sepsis in an emergency department: prevalence, rapid identification, and appropriate treatment
    R Phillip Dellinger
    Crit Care Med 35:2461-2. 2007
  76. ncbi request reprint Inhaled nitric oxide: should it be used in acute respiratory distress syndrome?
    R Phillip Dellinger
    Crit Care Med 34:3035-6. 2006
  77. ncbi request reprint Treatment options for severe sepsis and septic shock
    Vinay K Sharma
    Medical Intensive Care Unit, The Graduate Hospital and Clinical Assistant Professor of Medicine, Drexel University College of Medicine, Pepper Pavilion, Suite 607, 1800 Lombard Street, Philadelphia, PA 19144, USA
    Expert Rev Anti Infect Ther 4:395-403. 2006
    ..There is also some evidence to suggest that tight glucose control may improve outcome in these patients...
  78. ncbi request reprint Critical care medicine training and certification for emergency physicians
    David T Huang
    The CRISMA Laboratory Clinical Research, Investigation, and Systems Modeling of Acute Illness, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 33:2104-9. 2005
    ..We therefore propose that all accreditation bodies work cooperatively to create a route to CCM certification for emergency physicians who complete a critical care fellowship...
  79. ncbi request reprint Critical care medicine training and certification for emergency physicians
    David T Huang
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Ann Emerg Med 46:217-23. 2005
    ..We therefore propose that all accreditation bodies work cooperatively to create a route to critical care medicine certification for emergency physicians who complete a critical care fellowship...