Jeffrey T Borenstein

Summary

Affiliation: Control and Information Systems Division
Country: USA

Publications

  1. ncbi request reprint Microfabrication of three-dimensional engineered scaffolds
    Jeffrey T Borenstein
    Biomedical Engineering Center, Charles Stark Draper Laboratory, Cambridge, Massachusetts 02139, USA
    Tissue Eng 13:1837-44. 2007
  2. pmc Intracochlear drug delivery systems
    Jeffrey T Borenstein
    Biomedical Engineering Center, Draper Laboratory, Cambridge, MA 02139, United States
    Expert Opin Drug Deliv 8:1161-74. 2011
  3. doi request reprint Functional endothelialized microvascular networks with circular cross-sections in a tissue culture substrate
    Jeffrey T Borenstein
    MEMS Technology Group, Charles Stark Draper Laboratory, Cambridge, MA 02139, USA
    Biomed Microdevices 12:71-9. 2010
  4. pmc Engineering tissue with BioMEMS
    Jeffrey T Borenstein
    Biomedical Engineering Center, Draper Laboratory, Cambridge, Massachusetts, USA
    IEEE Pulse 2:28-34. 2011
  5. doi request reprint Liver-assist device with a microfluidics-based vascular bed in an animal model
    Wen Ming Hsu
    Department of Surgery and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA
    Ann Surg 252:351-7. 2010
  6. doi request reprint In vitro and in vivo degradation of poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate) elastomers
    Christopher J Bettinger
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room E25 342, Cambridge, Massachusetts 02139, USA
    J Biomed Mater Res A 91:1077-88. 2009
  7. pmc Fabrication of a hybrid microfluidic system incorporating both lithographically patterned microchannels and a 3D fiber-formed microfluidic network
    Leon M Bellan
    Massachusetts Institute of Technology, 77 Massachussetts Avenue, The David H Koch Institute, Cambridge, MA 02139, USA
    Adv Healthc Mater 1:164-7. 2012
  8. pmc Biodegradable microfluidic scaffolds for tissue engineering from amino alcohol-based poly(ester amide) elastomers
    Jane Wang
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    Organogenesis 6:212-6. 2010
  9. pmc Performance and scaling effects in a multilayer microfluidic extracorporeal lung oxygenation device
    Tatiana Kniazeva
    Draper Laboratory, 555 Technology Square, Cambridge, MA, USA
    Lab Chip 12:1686-95. 2012
  10. pmc Kinetics of reciprocating drug delivery to the inner ear
    Erin E Leary Pararas
    C S Draper Laboratory, Cambridge, MA 02139, USA
    J Control Release 152:270-7. 2011

Research Grants

  1. Micromechanical Device for Intracochlear Drug Delivery
    Jeffrey T Borenstein; Fiscal Year: 2010
  2. Micromechanical Device for Intracochlear Drug Delivery
    Jeffrey Borenstein; Fiscal Year: 2007

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Microfabrication of three-dimensional engineered scaffolds
    Jeffrey T Borenstein
    Biomedical Engineering Center, Charles Stark Draper Laboratory, Cambridge, Massachusetts 02139, USA
    Tissue Eng 13:1837-44. 2007
    ..Here a brief overview of the fundamental microfabrication technologies used for tissue engineering will be presented, along with a summary of progress in a number of applications, including the liver and kidney...
  2. pmc Intracochlear drug delivery systems
    Jeffrey T Borenstein
    Biomedical Engineering Center, Draper Laboratory, Cambridge, MA 02139, United States
    Expert Opin Drug Deliv 8:1161-74. 2011
    ..Ultimately, these systems may serve as a means for extended delivery of regenerative compounds to restore hearing in patients suffering from a host of auditory diseases...
  3. doi request reprint Functional endothelialized microvascular networks with circular cross-sections in a tissue culture substrate
    Jeffrey T Borenstein
    MEMS Technology Group, Charles Stark Draper Laboratory, Cambridge, MA 02139, USA
    Biomed Microdevices 12:71-9. 2010
    ..Endothelial cell viability was assessed, documenting nearly confluent monolayers within 3D microfabricated channel networks with rounded cross-sections...
  4. pmc Engineering tissue with BioMEMS
    Jeffrey T Borenstein
    Biomedical Engineering Center, Draper Laboratory, Cambridge, Massachusetts, USA
    IEEE Pulse 2:28-34. 2011
    ....
  5. doi request reprint Liver-assist device with a microfluidics-based vascular bed in an animal model
    Wen Ming Hsu
    Department of Surgery and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA
    Ann Surg 252:351-7. 2010
    ..This study evaluates a novel liver-assist device platform with a microfluidics-modeled vascular network in a femoral arteriovenous shunt in rats...
  6. doi request reprint In vitro and in vivo degradation of poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate) elastomers
    Christopher J Bettinger
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room E25 342, Cambridge, Massachusetts 02139, USA
    J Biomed Mater Res A 91:1077-88. 2009
    ..On the basis of the observed in vitro and in vivo biodegradation phenomena, we also propose that the primary modes of degradation are composition dependent...
  7. pmc Fabrication of a hybrid microfluidic system incorporating both lithographically patterned microchannels and a 3D fiber-formed microfluidic network
    Leon M Bellan
    Massachusetts Institute of Technology, 77 Massachussetts Avenue, The David H Koch Institute, Cambridge, MA 02139, USA
    Adv Healthc Mater 1:164-7. 2012
    ..With this improved delivery ability comes an increased fluidic resistance due to the tortuous network of small-diameter channels...
  8. pmc Biodegradable microfluidic scaffolds for tissue engineering from amino alcohol-based poly(ester amide) elastomers
    Jane Wang
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA
    Organogenesis 6:212-6. 2010
    ..The device is fabricated using a modified replica-molding technique, which is rapid, inexpensive, reproducible, and scalable, making the approach ideal for both rapid prototyping and manufacturing of tissue engineering scaffolds...
  9. pmc Performance and scaling effects in a multilayer microfluidic extracorporeal lung oxygenation device
    Tatiana Kniazeva
    Draper Laboratory, 555 Technology Square, Cambridge, MA, USA
    Lab Chip 12:1686-95. 2012
    ..These results contribute to our understanding of the complexity involved in designing three-dimensional microfluidic oxygenators for clinical applications...
  10. pmc Kinetics of reciprocating drug delivery to the inner ear
    Erin E Leary Pararas
    C S Draper Laboratory, Cambridge, MA 02139, USA
    J Control Release 152:270-7. 2011
    ....
  11. doi request reprint In vitro analysis of a hepatic device with intrinsic microvascular-based channels
    Amedeo Carraro
    Department of Surgery, Massachusetts General Hospital, Boston, MA, USA
    Biomed Microdevices 10:795-805. 2008
    ..The design and fabrication processes are scalable, enabling the device concept to serve as both a platform technology for drug discovery and toxicity, and for the continuing development of an improved liver-assist device...
  12. pmc Accordion-like honeycombs for tissue engineering of cardiac anisotropy
    George C Engelmayr
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E25 330 Cambridge, Massachusetts 02139, USA
    Nat Mater 7:1003-10. 2008
    ....
  13. pmc Nanofabricated collagen-inspired synthetic elastomers for primary rat hepatocyte culture
    Christopher J Bettinger
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Tissue Eng Part A 15:1321-9. 2009
    ..These results suggest that these engineered substrates can function as synthetic collagen analogs for in vitro cell culture...
  14. pmc Microsystems technologies for drug delivery to the inner ear
    Erin E Leary Pararas
    Charles Stark Draper Laboratory, 555 Technology Square, Cambridge, MA 02139, USA
    Adv Drug Deliv Rev 64:1650-60. 2012
    ..These advances also have the potential for broader clinical applications that share similar requirements and challenges with the inner ear, such as drug delivery to the central nervous system...
  15. pmc Drug delivery for treatment of inner ear disease: current state of knowledge
    Andrew A McCall
    Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts, USA
    Ear Hear 31:156-65. 2010
    ..The historical, current, and future delivery techniques and uses of drug delivery for treatment of inner ear disease serve as the basis for this review...
  16. pmc Engineering substrate topography at the micro- and nanoscale to control cell function
    Christopher J Bettinger
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Angew Chem Int Ed Engl 48:5406-15. 2009
    ..Future challenges and opportunities in cell-nanotopography engineering are also discussed, including the elucidation of mechanisms and applications in tissue engineering...
  17. doi request reprint Microfluidic cell culture models for tissue engineering
    Niraj K Inamdar
    Department of Mechanical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Curr Opin Biotechnol 22:681-9. 2011
    ....
  18. pmc Inner ear drug delivery for auditory applications
    Erin E Leary Swan
    Charles Stark Draper Laboratory, 555 Technology Square, Cambridge, MA 02139, USA
    Adv Drug Deliv Rev 60:1583-99. 2008
    ..Innovative drug delivery systems to treat various inner ear ailments such as ototoxicity, sudden sensorineural hearing loss, autoimmune inner ear disease, and for preserving neurons and regenerating sensory cells are being explored...
  19. pmc Amino alcohol-based degradable poly(ester amide) elastomers
    Christopher J Bettinger
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room E25 342, Cambridge, MA 02139, USA
    Biomaterials 29:2315-25. 2008
    ..These polymers exhibit in vitro and in vivo biocompatibility. These polymers have projected degradation half-lives up to 20 months in vivo...
  20. doi request reprint A microfluidic respiratory assist device with high gas permeance for artificial lung applications
    Tatiana Kniazeva
    Charles Stark Draper Laboratory, Cambridge, MA, USA
    Biomed Microdevices 13:315-23. 2011
    ....
  21. ncbi request reprint Microfabrication of poly (glycerol-sebacate) for contact guidance applications
    Christopher J Bettinger
    MEMS Technology Group, Charles Stark Draper Laboratory, 555 Technology Square, Cambridge, MA 02139, USA
    Biomaterials 27:2558-65. 2006
    ..Furthermore, these results may lead to further elucidation of the mechanism of cell alignment and contact guidance on microfabricated substrates...

Research Grants4

  1. Micromechanical Device for Intracochlear Drug Delivery
    Jeffrey T Borenstein; Fiscal Year: 2010
    ....
  2. Micromechanical Device for Intracochlear Drug Delivery
    Jeffrey Borenstein; Fiscal Year: 2007
    ....