Affiliation: Connecticut Children's Medical Center
- Chronic pediatric inflammatory diseases: effects on boneAnuradha Viswanathan
University of Connecticut School of Medicine, Farmington, CT, USA
Rev Endocr Metab Disord 9:107-22. 2008..In this paper we will provide an overview of the effects of chronic inflammatory conditions on bone mass in children. We will also present relevant data from adult patients, when pediatric data are scant or not available...
- Fecal osteoprotegerin may guide the introduction of second-line therapy in hospitalized children with ulcerative colitisFrancisco A Sylvester
Division of Digestive Diseases, Hepatology and Nutrition, Connecticut Children s Medical Center, Hartford, Connecticut, USA
Inflamm Bowel Dis 17:1726-30. 2011..We aimed to determine whether fecal OPG predicts the need for second-line therapies in children hospitalized for UC...
- A two-year longitudinal study of persistent lean tissue deficits in children with Crohn's diseaseFrancisco A Sylvester
Connecticut Children s Medical Center, Hartford, Connecticut 06106, USA
Clin Gastroenterol Hepatol 7:452-5. 2009..We observed the effects of Crohn's disease on body composition and bone mineral content (BMC), beginning at diagnosis and followed prospectively for 2 years...
- IBD and skeletal health: children are not small adults!Francisco A Sylvester
Division of Digestive Diseases and Nutrition, University of Connecticut School of Medicine, Connecticut Children s Medical Center, Hartford, Connecticut 06106, USA
Inflamm Bowel Dis 11:1020-3. 2005..In this concise review, we aim to provide an update on this topic, with focus on how pediatric IBD affects bone health...
- Are activated T cells regulators of bone metabolism in children with Crohn disease?Francisco A Sylvester
Connecticut Children s Medical Center, Saint Francis Hospital and Medical Center, Hartford 06106, and University of Connecticut School of Medicine, Farmington, Connecticut, USA
J Pediatr 148:461-6. 2006..To test the hypothesis that circulating activated T cells may release cytokines that decrease bone turnover in children with Crohn disease...
- Natural history of bone metabolism and bone mineral density in children with inflammatory bowel diseaseFrancisco A Sylvester
Division of Gastroenterology and Nutrition, Connecticut Children s Medical Center, Hartford, Connecticut 06106, USA
Inflamm Bowel Dis 13:42-50. 2007..In children with inflammatory bowel disease (IBD) it is not known whether reductions in bone mineral density (BMD) are a consequence of bone turnover alterations and if BMD improves with treatment...
- Skeletal health of children and adolescents with inflammatory bowel diseaseHELEN PAPPA
Division of Gastroenterology and Nutrition, Children s Hospital Boston, Boston, MA 02115, USA
J Pediatr Gastroenterol Nutr 53:11-25. 2011..Finally, we summarize the existing numerous gaps in knowledge and potential subjects for future research endeavors...
- Effect of Crohn's disease on bone metabolism in vitro: a role for interleukin-6Francisco A Sylvester
Department of Pediatrics, Connecticut Children s Medical Center, University of Connecticut, Hartford 06106, USA
J Bone Miner Res 17:695-702. 2002..These results suggest that IL-6 is a mediator of the effects of Crohn's serum on in vitro mineralization and may be a contributing factor to the osteopenia associated with CD...
- Effects of activated T cells on osteoclastogenesis depend on how they are activatedNancy Wyzga
Connecticut Children s Medical Center, Hartford, CT, USA
Bone 35:614-20. 2004..Both pro- and anti-resorptive properties have been described. We reasoned that this reported variability of the effects of T cells on osteoclast formation depends on how T cells are activated in vitro...
- Effects of serum from children with newly diagnosed Crohn disease on primary cultures of rat osteoblastsSamuel Varghese
Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut, USA
J Pediatr Gastroenterol Nutr 35:641-8. 2002..We therefore examined the effects of serum from newly diagnosed, untreated children with CD on osteoblasts in culture and the role of interleukin-6 (IL-6), a cytokine present in excess in active CD that also has direct effects on bone...
- Hemophagocytic syndrome in an adolescent with Crohn disease receiving azathioprine and infliximabKaren A Francolla
Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, USA
J Pediatr Gastroenterol Nutr 47:193-5. 2008
- Cracking the risk of fractures in Crohn diseaseFrancisco A Sylvester
University of Connecticut School of Medicine, USA
J Pediatr Gastroenterol Nutr 38:113-4. 2004
- Do bones crack under the effects of inflammatory bowel disease in children?Francisco A Sylvester
J Pediatr Gastroenterol Nutr 43:563-5. 2006