Philip C Spinella

Summary

Affiliation: Connecticut Children's Medical Center
Country: USA

Publications

  1. doi Warm fresh whole blood transfusion for severe hemorrhage: U.S. military and potential civilian applications
    Philip C Spinella
    Connecticut Children s Medical Center, Hartford, CT, USA
    Crit Care Med 36:S340-5. 2008
  2. ncbi Risks associated with fresh whole blood and red blood cell transfusions in a combat support hospital
    Philip C Spinella
    U S Army Institute of Surgical Research, San Antonio, TX, USA
    Crit Care Med 35:2576-81. 2007
  3. doi The effect of recombinant activated factor VII on mortality in combat-related casualties with severe trauma and massive transfusion
    Philip C Spinella
    US Army Institute of Surgical Research, San Antonio, Texas, USA
    J Trauma 64:286-93; discussion 293-4. 2008
  4. ncbi Increased mortality associated with the early coagulopathy of trauma in combat casualties
    Sarah E Niles
    USA MEDDAC Bavaria S E N, Vilseck, Germany
    J Trauma 64:1459-63; discussion 1463-5. 2008
  5. doi Pediatric trauma in an austere combat environment
    Philip C Spinella
    Department of Pediatrics PCS, Connecticut Children s Medical Center, Hartford, CT, USA
    Crit Care Med 36:S293-6. 2008
  6. pmc Balanced massive transfusion ratios in multiple injury patients with traumatic brain injury
    Sigune Peiniger
    Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Centre, Ostmerheimerstrasse 200, D 51109 Cologne, Germany
    Crit Care 15:R68. 2011
  7. pmc Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study
    Oliver Karam
    Pediatric Critical Care Unit, CHU Sainte Justine, Universite de Montreal, 3175 chemin de la Cote Sainte Catherine, Montreal, Canada
    Crit Care 14:R57. 2010
  8. doi Effect of plasma and red blood cell transfusions on survival in patients with combat related traumatic injuries
    Philip C Spinella
    Connecticut Children s Medical Center, Hartford, CT 06106, USA
    J Trauma 64:S69-77; discussion S77-8. 2008
  9. pmc Resuscitation and transfusion principles for traumatic hemorrhagic shock
    Philip C Spinella
    University of Connecticut, Pediatric Intensivist, Department of Pediatrics, Department of Surgery, Connecticut Children s Medical Center, Hartford, CT 06106, USA
    Blood Rev 23:231-40. 2009
  10. pmc Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries
    Philip C Spinella
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 66:S69-76. 2009

Collaborators

Detail Information

Publications44

  1. doi Warm fresh whole blood transfusion for severe hemorrhage: U.S. military and potential civilian applications
    Philip C Spinella
    Connecticut Children s Medical Center, Hartford, CT, USA
    Crit Care Med 36:S340-5. 2008
    ..S. Army research from Afghanistan and Iraq. We also discuss current indications for its use as well as potential civilian applications for large-scale disasters...
  2. ncbi Risks associated with fresh whole blood and red blood cell transfusions in a combat support hospital
    Philip C Spinella
    U S Army Institute of Surgical Research, San Antonio, TX, USA
    Crit Care Med 35:2576-81. 2007
    ..Fresh whole blood (FWB) and red blood cells (RBCs) are transfused to injured casualties in combat support hospitals. We evaluated the risks of FWB and RBCs transfused to combat-related casualties...
  3. doi The effect of recombinant activated factor VII on mortality in combat-related casualties with severe trauma and massive transfusion
    Philip C Spinella
    US Army Institute of Surgical Research, San Antonio, Texas, USA
    J Trauma 64:286-93; discussion 293-4. 2008
    ....
  4. ncbi Increased mortality associated with the early coagulopathy of trauma in combat casualties
    Sarah E Niles
    USA MEDDAC Bavaria S E N, Vilseck, Germany
    J Trauma 64:1459-63; discussion 1463-5. 2008
    ..We hypothesized that acute coagulopathy (international normalized ratio >/=1.5) in combat casualties was associated with increased injury severity and mortality as is seen in civilian trauma patients...
  5. doi Pediatric trauma in an austere combat environment
    Philip C Spinella
    Department of Pediatrics PCS, Connecticut Children s Medical Center, Hartford, CT, USA
    Crit Care Med 36:S293-6. 2008
    ..S. combat support hospitals and to provide insight into both critical care and noncritical care challenges this presents...
  6. pmc Balanced massive transfusion ratios in multiple injury patients with traumatic brain injury
    Sigune Peiniger
    Department of Trauma and Orthopedic Surgery, University of Witten Herdecke, Cologne Merheim Medical Centre, Ostmerheimerstrasse 200, D 51109 Cologne, Germany
    Crit Care 15:R68. 2011
    ....
  7. pmc Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study
    Oliver Karam
    Pediatric Critical Care Unit, CHU Sainte Justine, Universite de Montreal, 3175 chemin de la Cote Sainte Catherine, Montreal, Canada
    Crit Care 14:R57. 2010
    ..No prospective study has been conducted in children. Our objectives were to assess the clinical impact of the length of storage of red blood cell units on clinical outcome of critically ill children...
  8. doi Effect of plasma and red blood cell transfusions on survival in patients with combat related traumatic injuries
    Philip C Spinella
    Connecticut Children s Medical Center, Hartford, CT 06106, USA
    J Trauma 64:S69-77; discussion S77-8. 2008
    ..Our objective was to determine the independent effects of plasma and RBC transfusion on survival for patients with combat-related traumatic injuries receiving any blood products...
  9. pmc Resuscitation and transfusion principles for traumatic hemorrhagic shock
    Philip C Spinella
    University of Connecticut, Pediatric Intensivist, Department of Pediatrics, Department of Surgery, Connecticut Children s Medical Center, Hartford, CT 06106, USA
    Blood Rev 23:231-40. 2009
    ..Taken together, the preponderance of data suggests that these concepts may significantly decrease mortality in massively transfused trauma patients...
  10. pmc Warm fresh whole blood is independently associated with improved survival for patients with combat-related traumatic injuries
    Philip C Spinella
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 66:S69-76. 2009
    ..We hypothesized that warm fresh whole blood (WFWB) transfusion would be associated with improved survival in patients with trauma compared with those transfused only stored component therapy (CT)...
  11. doi Survey of transfusion policies at US and Canadian children's hospitals in 2008 and 2009
    Philip C Spinella
    Department of Pediatrics, Connecticut Children s Hospital, Hartford, Connecticut, USA
    Transfusion 50:2328-35. 2010
    ..Our objective was to determine the current transfusion policies in US and Canadian children's hospitals for both neonatal and pediatric general populations...
  12. ncbi The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital
    Matthew A Borgman
    Brooke Army Medical Center, Fort Sam Houston, TX, USA
    J Trauma 63:805-13. 2007
    ..The risk of death from hemorrhagic shock increases in this population. To treat the coagulopathy of trauma, some have suggested early, aggressive correction using a 1:1 ratio of plasma to red blood cell (RBC) units...
  13. doi Ten-year analysis of transfusion in Operation Iraqi Freedom and Operation Enduring Freedom: increased plasma and platelet use correlates with improved survival
    Heather F Pidcoke
    US Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma Acute Care Surg 73:S445-52. 2012
    ....
  14. doi Ten years of military pediatric care in Afghanistan and Iraq
    Matthew Borgman
    Department of Pediatrics, Brooke Army Medical Center, San Antonio, Texas, USA
    J Trauma Acute Care Surg 73:S509-13. 2012
    ..This study's objective was to evaluate the burden and epidemiology of pediatric medical care during the past decade of military operations in Iraq and Afghanistan...
  15. ncbi Fresh whole blood transfusions in coalition military, foreign national, and enemy combatant patients during Operation Iraqi Freedom at a U.S. combat support hospital
    Philip C Spinella
    U S Army Institute of Surgical Research, San Antonio, Texas, USA
    World J Surg 32:2-6. 2008
    ....
  16. doi Coagulopathy and shock on admission is associated with mortality for children with traumatic injuries at combat support hospitals
    Jason T Patregnani
    Connecticut Children s Medical Center, Hartford, CT, USA
    Pediatr Crit Care Med 13:273-7. 2012
    ..Our objective was to determine whether coagulopathy and shock on admission are independently associated with mortality in children with traumatic injuries...
  17. doi The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital
    Harry K Stinger
    Brooke Army Medical Center, U S Army Institute of Surgical Research, San Antonio, TX 78234 6200, USA
    J Trauma 64:S79-85; discussion S85. 2008
    ..Our objective was to determine whether increased ratios of fibrinogen to red blood cells (RBCs) decreased mortality in combat casualties requiring massive transfusion...
  18. doi The association of blood component use ratios with the survival of massively transfused trauma patients with and without severe brain injury
    K J Brasel
    Department of Pediatrics, St Louis Children s Hospital, St Louis, Missouri 63110, USA
    J Trauma 71:S343-52. 2011
    ..The effect of blood component ratios on the survival of patients with traumatic brain injury (TBI) has not been studied...
  19. ncbi Freeze-dried plasma at the point of injury: from concept to doctrine
    Elon Glassberg
    Surgeon General s Headquarters, Israel Defense Forces, and Department of Military Medicine, Hebrew University, Jerusalem, Israel Department of Pediatrics, Division of Critical Care, Washington University in St Louis, Missouri and US Army Institute of Surgical Research, Fort Sam Houston and Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, University of Texas Health Science Center at Houston, Houston, Texas
    Shock 40:444-50. 2013
    ..It is our hope that others will be able to learn from our experience, thus improving trauma casualty care around the world. ..
  20. doi Timing and location of blood product transfusion and outcomes in massively transfused combat casualties
    Andrew P Cap
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
    J Trauma Acute Care Surg 73:S89-94. 2012
    ..Mortality outcomes associated with early (first 6 hours) resuscitation incorporating platelets, for combat casualties requiring MT, have not been reported...
  21. pmc Duration of red blood cell storage is associated with increased incidence of deep vein thrombosis and in hospital mortality in patients with traumatic injuries
    Philip C Spinella
    Department of Pediatrics, Connecticut Children s Medical Center, 282 Washington Street, Hartford, CT 06106, USA
    Crit Care 13:R151. 2009
    ..To determine if duration of RBC storage is associated with adverse outcomes we studied critically ill trauma patients requiring transfusion...
  22. doi Increased mortality rates of young children with traumatic injuries at a US army combat support hospital in Baghdad, Iraq, 2004
    Renee I Matos
    Department of Pediatrics, Lackland Air Force Base, TX 78236, USA
    Pediatrics 122:e959-66. 2008
    ..The objective of this study was to determine whether age <or=8 y is an independent predictor of mortality in noncoalition trauma patients at a US combat support hospital...
  23. doi Remote damage control resuscitation and the Solstrand Conference: defining the need, the language, and a way forward
    Robert T Gerhardt
    US Army Institute of Surgical Research, Department of Emergency Medicine, San Antonio Military Medical Center, Fort Sam Houston, Texas 78234, USA
    Transfusion 53:9S-16S. 2013
    ....
  24. doi Association of shock, coagulopathy, and initial vital signs with massive transfusion in combat casualties
    Claire R Larson
    Department of Surgery, United States Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    J Trauma 69:S26-32. 2010
    ..The objective of this study was to compare the results of an MT prediction model and actual MT incidence in combat casualties...
  25. ncbi Thromboelastography to direct the administration of recombinant activated factor VII in a child with traumatic injury requiring massive transfusion
    Cade M Nylund
    Department of Pediatrics, Willford Hall Medical Center, San Antonio, TX, USA
    Pediatr Crit Care Med 10:e22-6. 2009
    ..To describe the use of thromboelastography (TEG) to direct hemostatic resuscitation in a child with traumatic injury requiring massive transfusion...
  26. doi Constant challenges and evolution of US military transfusion medicine and blood operations in combat
    Philip C Spinella
    United States Army Institute of Surgical Research, Ft Sam Houston, TX, USA
    Transfusion 52:1146-53. 2012
    ..Blood operations are constrained by many limitations in combat settings. As a result there are many challenges that require innovative solutions...
  27. ncbi The U.S. military wartime pediatric trauma mission: how surgeons and pediatricians are adapting the system to address the need
    Michael M Fuenfer
    Department of Surgery, Walter Reed Army Medical Center, Washington, DC, USA
    Mil Med 174:887-91. 2009
    ..This report details how the military medical system is adapting to create a data driven and comprehensive response to optimize the medical and surgical pediatric care being provided...
  28. ncbi Refrigerated platelets for the treatment of acute bleeding: a review of the literature and reexamination of current standards
    Heather F Pidcoke
    Blood Research Program, US Army Institute of Surgical Research, Fort Sam Houston, Texas Department of Critical Care, Department of Pediatrics, Washington University in St Louis, Missouri Department of Biomedical Engineering, The University of Texas at San Antonio, San Antonio, Texas Norwegian Naval Special Operation Commando and Department of Immunology and Transfusion Medicine, Haukeland University Hospital, Bergen, Norway and Division of Transfusion Medicine, Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland
    Shock 41:51-3. 2014
    ..In summary, a "one-size-fits-all" strategy for PLT storage may not be adequate, and a reexamination of whether cold-stored PLTs should be offered as a widely available therapeutic product may be indicated. ..
  29. pmc Incidence and acute complications of asymptomatic central venous catheter-related deep venous thrombosis in critically ill children
    Edward Vincent S Faustino
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    J Pediatr 162:387-91. 2013
    ..To determined the current incidence and acute complications of asymptomatic central venous catheter (CVC)-related deep venous thrombosis (DVT) in critically ill children...
  30. ncbi Fresh whole blood use for hemorrhagic shock: preserving benefit while avoiding complications
    Philip C Spinella
    Department of Pediatrics, Washington University in St Louis, St Louis, MO 63110, USA
    Anesth Analg 115:751-8. 2012
    ..We intend this review to stimulate hypothesis generation and clinical investigation in determining when FWB may be indicated and how to optimally process and store FWB to maximize its risk-benefit ratio...
  31. doi Early management of pediatric vascular injuries through humanitarian surgical care during U.S. military operations
    Anahita Dua
    Department of Surgery, Center for Translational Injury Research, University of Texas Medical Center, Houston, Tex, USA
    J Vasc Surg 58:695-700. 2013
    ..Physiologic data included presenting vital signs (rectal temperature, blood pressure, and heart rate), arterial pH, base deficit, hemoglobin (g/dL), and international normalized ratio...
  32. ncbi Emergent endotracheal intubations in children: be careful if it's late when you intubate
    Christopher L Carroll
    Department of Pediatrics, Connecticut Children s Medical Center, Hartford, CT, USA
    Pediatr Crit Care Med 11:343-8. 2010
    ..The purpose of this study was to delineate the risks of emergent endotracheal intubations in children...
  33. doi Use of a massive transfusion protocol with hemostatic resuscitation for severe intraoperative bleeding in a child
    Alex M Dressler
    Department of Critical Care, Connecticut Children s Medical Center, Hartford, CT 06106, USA
    J Pediatr Surg 45:1530-3. 2010
    ..The MT protocol principles, benefits, and postoperative course of the patient are described...
  34. doi Symposium on fresh whole blood for severe hemorrhagic shock: from in-hospital to far forward resuscitations
    Philip C Spinella
    Department of Pediatrics, Division of Critical Care, Washington University in St Louis, St Louis, MO 63110, USA
    Transfus Apher Sci 46:113-7. 2012
    ..The meeting concluded with a discussion of the THOR network's three-year research program...
  35. doi Severity of head injury is associated with increased risk of coagulopathy in combat casualties
    Andrew Peter Cap
    US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    J Trauma 71:S78-81. 2011
    ..This has not been reported in a large series of combat casualties in which penetrating injuries predominate...
  36. ncbi Simulation training for surgical residents in pediatric trauma scenarios
    Jill Popp
    University of Connecticut School of Medicine, Connecticut Children s Medical Center, Hartford, USA
    Conn Med 76:159-62. 2012
    ..The goal of this study was to evaluate whether high-fidelity simulation training improved surgery residents' knowledge and self-efficacy in relation to pediatric trauma scenarios...
  37. doi Care of pediatric neurosurgical patients in Iraq in 2007: clinical and ethical experience of a field hospital
    Jonathan E Martin
    Department of Surgery, Division of Neurosurgery, University of Connecticut School of Medicine, Connecticut Children s Medical Center, Hartford, Connecticut 06106, USA
    J Neurosurg Pediatr 6:250-6. 2010
    ..The authors reviewed their experience with pediatric neurosurgical patients at a field hospital in Iraq in 2007 to provide insight into the management of this patient population...
  38. doi Survival after prolonged pediatric extracorporeal membrane oxygenation support for adenoviral pneumonia
    Taslim F Allibhai
    Department of Pediatrics, Wilford Hall USAF Medical Center, Lackland AFB, San Antonio, TX 78236 5300, USA
    J Pediatr Surg 43:e9-e11. 2008
    ..Our experience suggests that there may be use for prolonged ECMO support in children despite severe adenoviral pneumonia...
  39. ncbi Damage control mechanical ventilation: ventilator induced lung injury and lung protective strategies in children
    Philip C Spinella
    Department of Pediatrics, Wilford Hall Medical Center, 2200 Bergquist Drive Suite 1, Lackland AFB TX, 78236 5300, USA
    J Trauma 62:S82-3. 2007
  40. ncbi Pediatric trauma: experience of a combat support hospital in Iraq
    Rebecca McGuigan
    Martin Army Community Hospital, Fort Benning, GA 31905, USA
    J Pediatr Surg 42:207-10. 2007
    ..The purpose of this article is to report the experience of the 31st CSH treating pediatric trauma patients...
  41. doi Pediatric care as part of the US Army medical mission in the global war on terrorism in Afghanistan and Iraq, December 2001 to December 2004
    Mark W Burnett
    Camp Taji, Iraq
    Pediatrics 121:261-5. 2008
    ..Our objective in this report was to describe the epidemiologic features of and workload associated with pediatric admissions to 12 US Army military hospitals deployed to Iraq and Afghanistan...
  42. ncbi S-100beta protein--serum levels in children with brain neoplasms and its potential as a tumor marker
    Anil Rajendra
    Department of Anesthesiology and Critical Care Medicine, The Children s Hospital of Philadelphia, PA 19104, USA
    J Neurooncol 67:345-9. 2004
    ..To determine if serum S-100beta levels are elevated in children with brain neoplasms and if it can be used as a tumor marker for children with brain neoplasms...
  43. ncbi Cerebrospinal fluid levels of S-100beta in children and its elevation in pediatric meningitis
    Philip C Spinella
    Department of Anesthesiology, The Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Pediatr Crit Care Med 5:53-7. 2004
    ..To describe normal cerebrospinal fluid (CSF) levels of S-100beta in children and determine whether CSF S-100beta levels are elevated in pediatric meningitis...
  44. ncbi S-100beta protein-serum levels in healthy children and its association with outcome in pediatric traumatic brain injury
    Philip C Spinella
    Department of Anesthesiology, The Children s Hospital of Philadelphia, PA, USA
    Crit Care Med 31:939-45. 2003
    ..To describe normal serum levels of S-100beta in healthy children and determine whether serum S-100beta levels after traumatic brain injury are associated with outcome...