Juan C Salazar

Summary

Affiliation: Connecticut Children's Medical Center
Country: USA

Publications

  1. ncbi request reprint The immune response to infection with Treponema pallidum, the stealth pathogen
    Juan C Salazar
    Center for Microbial Pathogenesis, MC 3710, University of Connecticut Medical School, 263 Farmington Avenue, Farmington, CT 06030, USA
    Microbes Infect 4:1133-40. 2002
  2. pmc Treponema pallidum elicits innate and adaptive cellular immune responses in skin and blood during secondary syphilis: a flow-cytometric analysis
    Juan C Salazar
    Department of Pediatrics, Connecticut Children s Medical Center, Division of Pediatric Infectious Diseases, Hartford, CT, 06106, USA
    J Infect Dis 195:879-87. 2007
  3. pmc Efficacy, safety and tolerability of tipranavir coadministered with ritonavir in HIV-1-infected children and adolescents
    Juan C Salazar
    Connecticut Children s Medical Center, University of Connecticut School of Medicine, Hartford, Connecticut 06106, USA
    AIDS 22:1789-98. 2008
  4. pmc Lipoprotein-dependent and -independent immune responses to spirochetal infection
    Juan C Salazar
    Division of Pediatric Infectious Diseases, Connecticut Children s Medical Center, 282 Washington Street, Hartford, Connecticut 06106, USA
    Clin Diagn Lab Immunol 12:949-58. 2005
  5. ncbi request reprint Pediatric clinical trial experience: government, child, parent and physician's perspective
    Juan C Salazar
    Department of Pediatrics, University of Connecticut Medical School, Hartford, USA
    Pediatr Infect Dis J 22:1124-7. 2003
  6. ncbi request reprint Coevolution of markers of innate and adaptive immunity in skin and peripheral blood of patients with erythema migrans
    Juan C Salazar
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Connecticut Children s Medical Center, 282 Washington Street, Hartford, CT 06106, USA
    J Immunol 171:2660-70. 2003
  7. pmc Phagocytosis of Borrelia burgdorferi, the Lyme disease spirochete, potentiates innate immune activation and induces apoptosis in human monocytes
    Adriana R Cruz
    Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3715, USA
    Infect Immun 76:56-70. 2008
  8. pmc TprC/D (Tp0117/131), a trimeric, pore-forming rare outer membrane protein of Treponema pallidum, has a bipartite domain structure
    Arvind Anand
    Departments of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Bacteriol 194:2321-33. 2012
  9. pmc Phagocytosis of Borrelia burgdorferi and Treponema pallidum potentiates innate immune activation and induces gamma interferon production
    Meagan W Moore
    Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3715, USA
    Infect Immun 75:2046-62. 2007
  10. pmc Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta
    Juan C Salazar
    Connecticut Children s Medical Center, Division of Pediatric Infectious Diseases, Hartford, Connecticut, USA
    PLoS Pathog 5:e1000444. 2009

Research Grants

Detail Information

Publications26

  1. ncbi request reprint The immune response to infection with Treponema pallidum, the stealth pathogen
    Juan C Salazar
    Center for Microbial Pathogenesis, MC 3710, University of Connecticut Medical School, 263 Farmington Avenue, Farmington, CT 06030, USA
    Microbes Infect 4:1133-40. 2002
    ..While some clinical manifestations can be attributed to humoral responses, most can be attributed to a combination of local innate and adaptive cellular immunity...
  2. pmc Treponema pallidum elicits innate and adaptive cellular immune responses in skin and blood during secondary syphilis: a flow-cytometric analysis
    Juan C Salazar
    Department of Pediatrics, Connecticut Children s Medical Center, Division of Pediatric Infectious Diseases, Hartford, CT, 06106, USA
    J Infect Dis 195:879-87. 2007
    ..Syphilis is caused by the spirochetal pathogen Treponema pallidum. The local and systemic cellular immune responses elicited by the bacterium have not been well studied in humans...
  3. pmc Efficacy, safety and tolerability of tipranavir coadministered with ritonavir in HIV-1-infected children and adolescents
    Juan C Salazar
    Connecticut Children s Medical Center, University of Connecticut School of Medicine, Hartford, Connecticut 06106, USA
    AIDS 22:1789-98. 2008
    ..To evaluate the efficacy, safety and tolerability of ritonavir-boosted tipranavir (TPV/r) in HIV-1-infected pediatric patients...
  4. pmc Lipoprotein-dependent and -independent immune responses to spirochetal infection
    Juan C Salazar
    Division of Pediatric Infectious Diseases, Connecticut Children s Medical Center, 282 Washington Street, Hartford, Connecticut 06106, USA
    Clin Diagn Lab Immunol 12:949-58. 2005
    ..These studies have provided in situ evidence for a prominent "lipoprotein effect" during human infection while at the same time helping to pinpoint aspects of the cutaneous response that are uniquely driven by spirochetal pathogens...
  5. ncbi request reprint Pediatric clinical trial experience: government, child, parent and physician's perspective
    Juan C Salazar
    Department of Pediatrics, University of Connecticut Medical School, Hartford, USA
    Pediatr Infect Dis J 22:1124-7. 2003
    ..Although children now have access to new medicines during the development process, their participation in clinical trials must still protect them from undue risk and secure their well being...
  6. ncbi request reprint Coevolution of markers of innate and adaptive immunity in skin and peripheral blood of patients with erythema migrans
    Juan C Salazar
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Connecticut Children s Medical Center, 282 Washington Street, Hartford, CT 06106, USA
    J Immunol 171:2660-70. 2003
    ....
  7. pmc Phagocytosis of Borrelia burgdorferi, the Lyme disease spirochete, potentiates innate immune activation and induces apoptosis in human monocytes
    Adriana R Cruz
    Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3715, USA
    Infect Immun 76:56-70. 2008
    ..We propose that inflammation and apoptosis represent mutually reinforcing components of the immunologic arsenal that the host mobilizes to defend itself against infection with Lyme disease spirochetes...
  8. pmc TprC/D (Tp0117/131), a trimeric, pore-forming rare outer membrane protein of Treponema pallidum, has a bipartite domain structure
    Arvind Anand
    Departments of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Bacteriol 194:2321-33. 2012
    ....
  9. pmc Phagocytosis of Borrelia burgdorferi and Treponema pallidum potentiates innate immune activation and induces gamma interferon production
    Meagan W Moore
    Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3715, USA
    Infect Immun 75:2046-62. 2007
    ..burgdorferi by host cells and the ability of T. pallidum to avoid detection and uptake by virtue of its denuded outer membrane rather than by differences in surface lipoprotein expression...
  10. pmc Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta
    Juan C Salazar
    Connecticut Children s Medical Center, Division of Pediatric Infectious Diseases, Hartford, Connecticut, USA
    PLoS Pathog 5:e1000444. 2009
    ....
  11. ncbi request reprint Activation of Human Monocytes by Live Borrelia burgdorferi Generates TLR2-Dependent and -Independent Responses Which Include Induction of IFN-beta
    Juan C Salazar
    Connecticut Children s Medical Center, Division of Pediatric Infectious Diseases, Hartford, Connecticut, United States of America
    PLoS Pathog 5:e1000444. 2009
    ....
  12. pmc Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-beta
    Jorge L Cervantes
    Department of Pediatrics, University of Connecticut Health Center, Farmington, CT 06030, USA
    Proc Natl Acad Sci U S A 108:3683-8. 2011
    ....
  13. pmc TP0326, a Treponema pallidum β-barrel assembly machinery A (BamA) orthologue and rare outer membrane protein
    Daniel C Desrosiers
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06040, USA
    Mol Microbiol 80:1496-515. 2011
    ..The syphilis spirochaete appears to have devised a stratagem for harnessing the Bam pathway while satisfying its need to limit surface antigenicity...
  14. doi request reprint Tipranavir: a new protease inhibitor for the pediatric population
    Joshua D Courter
    University of Connecticut School of Pharmacy, Department of Pharmacy Practice, Storrs, CT, USA
    Expert Rev Anti Infect Ther 6:797-803. 2008
    ..In this article, we summarize available pharmacokinetic, safety, tolerability and efficacy data obtained from children and adolescents treated with a pediatric tipranavir formulation...
  15. pmc TLR8: the forgotten relative revindicated
    Jorge L Cervantes
    Department of Pediatrics, University of Connecticut Health Center, Farmington, CT 06030, USA
    Cell Mol Immunol 9:434-8. 2012
    ..The functions of TLR8 extend beyond the recognition of foreign pathogens and include cross-talk with other endosomal TLRs, a process that may also have a role in the generation of autoimmunity...
  16. ncbi request reprint HACEK endocarditis in infants and children: two cases and a literature review
    Henry M Feder
    Division of Infectious Disease, Connecticut Children s Medical Center, Hartford, CT, USA
    Pediatr Infect Dis J 22:557-62. 2003
    ..Mortality with HACEK endocarditis was 14%. HACEK organisms may be resistant to penicillins but are susceptible to third generation cephalosporins...
  17. ncbi request reprint Adherence to antiretroviral therapy in HIV-infected pediatric patients improves with home-based intensive nursing intervention
    Virginia M Berrien
    Connecticut Children s Medical Center, Pediatric and Youth HIV Program, Hartford, Connecticut 06106, USA
    AIDS Patient Care STDS 18:355-63. 2004
    ..We conclude that our home-based nursing intervention helped HIV-positive children and their families in better adhering to prescribed medication regimens...
  18. pmc Znu is the predominant zinc importer in Yersinia pestis during in vitro growth but is not essential for virulence
    Daniel C Desrosiers
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    Infect Immun 78:5163-77. 2010
    ..Our studies also underscore the need for bacterial cells to balance binding and transporter specificities within the periplasm in order to maintain transition metal homeostasis...
  19. pmc Incidence of noninfectious conditions in perinatally HIV-infected children and adolescents in the HAART era
    Sharon A Nachman
    Department of Pediatrics, Stony Brook University Medical Center, Stony Brook, NY 11794 8111, USA
    Arch Pediatr Adolesc Med 163:164-71. 2009
    ....
  20. pmc Association of hypercholesterolemia incidence with antiretroviral treatment, including protease inhibitors, among perinatally HIV-infected children
    Katherine Tassiopoulos
    Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA 02115, USA
    J Acquir Immune Defic Syndr 47:607-14. 2008
    ..Antiretroviral therapy has been associated with hypercholesterolemia in HIV-infected children. Few longitudinal studies have been conducted to examine this association, however...
  21. pmc Long-term effects of highly active antiretroviral therapy on CD4+ cell evolution among children and adolescents infected with HIV: 5 years and counting
    Kunjal Patel
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Clin Infect Dis 46:1751-60. 2008
    ....
  22. ncbi request reprint Cushing syndrome and severe adrenal suppression caused by fluticasone and protease inhibitor combination in an HIV-infected adolescent
    Renee M St Germain
    University of Connecticut School of Pharmacy, Department of Pharmacy Practice, Storrs, Connecticut, USA
    AIDS Patient Care STDS 21:373-7. 2007
    ..Health care professionals should be conscious of this important drug-drug interaction in HIV-infected children and adolescents and be aware that rapid onset of hypercortisolism and adrenal suppression are possible...
  23. ncbi request reprint Shared random effects analysis of multi-state Markov models: application to a longitudinal study of transitions to dementia
    Juan C Salazar
    Universidad Nacional de Colombia at Medellín, Escuela de Estadistica, Medellin, Colombia
    Stat Med 26:568-80. 2007
    ....
  24. ncbi request reprint Concomitant use of medications with anticholinergic properties and acetylcholinesterase inhibitors: impact on cognitive and physical functioning in Alzheimer disease
    Kara A Bottiggi
    Am J Geriatr Psychiatry 15:357-9. 2007
  25. pmc Assessment of the kinetics of Treponema pallidum dissemination into blood and tissues in experimental syphilis by real-time quantitative PCR
    Juan C Salazar
    Walter Reed Army Institute of Research, 1600 East Gude Drive, Rockville, MD 20850, USA
    Infect Immun 75:2954-8. 2007
    ..Our findings highlight the remarkable capacity of T. pallidum to disseminate from the site of infection to blood and tissues, and they identify the spleen as a prime target for treponemal invasion...
  26. pmc Association of site-specific and participant-specific factors with retention of children in a long-term pediatric HIV cohort study
    Paige L Williams
    Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA 02115 6017, USA
    Am J Epidemiol 167:1375-86. 2008
    ..Although participant characteristics are difficult to modify, the authors identified several potentially modifiable site practices that could be targeted to improve retention...

Research Grants1

  1. Immunity in Early Syphillis: Pathway to HIV Coinfection
    Juan Salazar; Fiscal Year: 2007
    ..In Aim 2 we will study the effect of secondary syphilis on viral load (VL) in HIV co-infected individuals. In this aim we will compare VL between HIV patients with and without syphilis and determine the effect of penicillin on VL. ..