Juan C Salazar

Summary

Affiliation: Connecticut Children's Medical Center
Country: USA

Publications

  1. pmc Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta
    Juan C Salazar
    Connecticut Children s Medical Center, Division of Pediatric Infectious Diseases, Hartford, Connecticut, USA
    PLoS Pathog 5:e1000444. 2009
  2. pmc Role of tipranavir in treatment of patients with multidrug-resistant HIV
    Joshua D Courter
    University of Connecticut School of Pharmacy, Storrs
    Ther Clin Risk Manag 6:431-41. 2010
  3. pmc Immune evasion and recognition of the syphilis spirochete in blood and skin of secondary syphilis patients: two immunologically distinct compartments
    Adriana R Cruz
    Centro Internacional de Entrenamiento e Investigaciones Medicas, Cali, Colombia
    PLoS Negl Trop Dis 6:e1717. 2012
  4. ncbi request reprint The immune response to infection with Treponema pallidum, the stealth pathogen
    Juan C Salazar
    Center for Microbial Pathogenesis, MC 3710, University of Connecticut Medical School, 263 Farmington Avenue, Farmington, CT 06030, USA
    Microbes Infect 4:1133-40. 2002
  5. pmc Treponema pallidum elicits innate and adaptive cellular immune responses in skin and blood during secondary syphilis: a flow-cytometric analysis
    Juan C Salazar
    Department of Pediatrics, Connecticut Children s Medical Center, Division of Pediatric Infectious Diseases, Hartford, CT, 06106, USA
    J Infect Dis 195:879-87. 2007
  6. pmc Lipoprotein-dependent and -independent immune responses to spirochetal infection
    Juan C Salazar
    Division of Pediatric Infectious Diseases, Connecticut Children s Medical Center, 282 Washington Street, Hartford, Connecticut 06106, USA
    Clin Diagn Lab Immunol 12:949-58. 2005
  7. pmc Efficacy, safety and tolerability of tipranavir coadministered with ritonavir in HIV-1-infected children and adolescents
    Juan C Salazar
    Connecticut Children s Medical Center, University of Connecticut School of Medicine, Hartford, Connecticut 06106, USA
    AIDS 22:1789-98. 2008
  8. ncbi request reprint Pediatric clinical trial experience: government, child, parent and physician's perspective
    Juan C Salazar
    Department of Pediatrics, University of Connecticut Medical School, Hartford, USA
    Pediatr Infect Dis J 22:1124-7. 2003
  9. ncbi request reprint Coevolution of markers of innate and adaptive immunity in skin and peripheral blood of patients with erythema migrans
    Juan C Salazar
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Connecticut Children s Medical Center, 282 Washington Street, Hartford, CT 06106, USA
    J Immunol 171:2660-70. 2003
  10. pmc Phagocytosis of Borrelia burgdorferi, the Lyme disease spirochete, potentiates innate immune activation and induces apoptosis in human monocytes
    Adriana R Cruz
    Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3715, USA
    Infect Immun 76:56-70. 2008

Research Grants

Detail Information

Publications34

  1. pmc Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta
    Juan C Salazar
    Connecticut Children s Medical Center, Division of Pediatric Infectious Diseases, Hartford, Connecticut, USA
    PLoS Pathog 5:e1000444. 2009
    ....
  2. pmc Role of tipranavir in treatment of patients with multidrug-resistant HIV
    Joshua D Courter
    University of Connecticut School of Pharmacy, Storrs
    Ther Clin Risk Manag 6:431-41. 2010
    ..We focus on the role of tipranavir, a recently approved nonpeptidic PI, for treating HIV-infected children, adolescents, and adults with a history of multidrug-resistant HIV...
  3. pmc Immune evasion and recognition of the syphilis spirochete in blood and skin of secondary syphilis patients: two immunologically distinct compartments
    Adriana R Cruz
    Centro Internacional de Entrenamiento e Investigaciones Medicas, Cali, Colombia
    PLoS Negl Trop Dis 6:e1717. 2012
    ..The clinical syndrome associated with secondary syphilis (SS) reflects the propensity of Treponema pallidum (Tp) to escape immune recognition while simultaneously inducing inflammation...
  4. ncbi request reprint The immune response to infection with Treponema pallidum, the stealth pathogen
    Juan C Salazar
    Center for Microbial Pathogenesis, MC 3710, University of Connecticut Medical School, 263 Farmington Avenue, Farmington, CT 06030, USA
    Microbes Infect 4:1133-40. 2002
    ..While some clinical manifestations can be attributed to humoral responses, most can be attributed to a combination of local innate and adaptive cellular immunity...
  5. pmc Treponema pallidum elicits innate and adaptive cellular immune responses in skin and blood during secondary syphilis: a flow-cytometric analysis
    Juan C Salazar
    Department of Pediatrics, Connecticut Children s Medical Center, Division of Pediatric Infectious Diseases, Hartford, CT, 06106, USA
    J Infect Dis 195:879-87. 2007
    ..Syphilis is caused by the spirochetal pathogen Treponema pallidum. The local and systemic cellular immune responses elicited by the bacterium have not been well studied in humans...
  6. pmc Lipoprotein-dependent and -independent immune responses to spirochetal infection
    Juan C Salazar
    Division of Pediatric Infectious Diseases, Connecticut Children s Medical Center, 282 Washington Street, Hartford, Connecticut 06106, USA
    Clin Diagn Lab Immunol 12:949-58. 2005
    ..These studies have provided in situ evidence for a prominent "lipoprotein effect" during human infection while at the same time helping to pinpoint aspects of the cutaneous response that are uniquely driven by spirochetal pathogens...
  7. pmc Efficacy, safety and tolerability of tipranavir coadministered with ritonavir in HIV-1-infected children and adolescents
    Juan C Salazar
    Connecticut Children s Medical Center, University of Connecticut School of Medicine, Hartford, Connecticut 06106, USA
    AIDS 22:1789-98. 2008
    ..To evaluate the efficacy, safety and tolerability of ritonavir-boosted tipranavir (TPV/r) in HIV-1-infected pediatric patients...
  8. ncbi request reprint Pediatric clinical trial experience: government, child, parent and physician's perspective
    Juan C Salazar
    Department of Pediatrics, University of Connecticut Medical School, Hartford, USA
    Pediatr Infect Dis J 22:1124-7. 2003
    ..Although children now have access to new medicines during the development process, their participation in clinical trials must still protect them from undue risk and secure their well being...
  9. ncbi request reprint Coevolution of markers of innate and adaptive immunity in skin and peripheral blood of patients with erythema migrans
    Juan C Salazar
    Department of Pediatrics, Division of Pediatric Infectious Diseases, Connecticut Children s Medical Center, 282 Washington Street, Hartford, CT 06106, USA
    J Immunol 171:2660-70. 2003
    ....
  10. pmc Phagocytosis of Borrelia burgdorferi, the Lyme disease spirochete, potentiates innate immune activation and induces apoptosis in human monocytes
    Adriana R Cruz
    Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3715, USA
    Infect Immun 76:56-70. 2008
    ..We propose that inflammation and apoptosis represent mutually reinforcing components of the immunologic arsenal that the host mobilizes to defend itself against infection with Lyme disease spirochetes...
  11. pmc TprC/D (Tp0117/131), a trimeric, pore-forming rare outer membrane protein of Treponema pallidum, has a bipartite domain structure
    Arvind Anand
    Departments of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Bacteriol 194:2321-33. 2012
    ....
  12. pmc Phagocytosis of Borrelia burgdorferi and Treponema pallidum potentiates innate immune activation and induces gamma interferon production
    Meagan W Moore
    Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 3715, USA
    Infect Immun 75:2046-62. 2007
    ..burgdorferi by host cells and the ability of T. pallidum to avoid detection and uptake by virtue of its denuded outer membrane rather than by differences in surface lipoprotein expression...
  13. pmc Phagosomal signaling by Borrelia burgdorferi in human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-beta
    Jorge L Cervantes
    Department of Pediatrics, University of Connecticut Health Center, Farmington, CT 06030, USA
    Proc Natl Acad Sci U S A 108:3683-8. 2011
    ....
  14. pmc Human TLR8 is activated upon recognition of Borrelia burgdorferi RNA in the phagosome of human monocytes
    Jorge L Cervantes
    1 Connecticut Children s Medical Center, Division of Infectious Diseases and Immunology, 282 Washington St, Hartford, CT 06106
    J Leukoc Biol 94:1231-41. 2013
    ..We demonstrate, for the first time, that Bb RNA is a TLR8 ligand in human monocytes and that transcription of IFN-β in response to the spirochete is induced from within the phagosomal vacuole through the TLR8-MyD88 pathway. ..
  15. ncbi request reprint Activation of Human Monocytes by Live Borrelia burgdorferi Generates TLR2-Dependent and -Independent Responses Which Include Induction of IFN-beta
    Juan C Salazar
    Connecticut Children s Medical Center, Division of Pediatric Infectious Diseases, Hartford, Connecticut, United States of America
    PLoS Pathog 5:e1000444. 2009
    ....
  16. ncbi request reprint Tipranavir: a new protease inhibitor for the pediatric population
    Joshua D Courter
    University of Connecticut School of Pharmacy, Department of Pharmacy Practice, Storrs, CT, USA
    Expert Rev Anti Infect Ther 6:797-803. 2008
    ..In this article, we summarize available pharmacokinetic, safety, tolerability and efficacy data obtained from children and adolescents treated with a pediatric tipranavir formulation...
  17. pmc Secondary syphilis in cali, Colombia: new concepts in disease pathogenesis
    Adriana R Cruz
    Centro Internacional de Entrenamiento e Investigaciones Medicas CIDEIM, Cali, Colombia
    PLoS Negl Trop Dis 4:e690. 2010
    ....
  18. ncbi request reprint Cushing syndrome and severe adrenal suppression caused by fluticasone and protease inhibitor combination in an HIV-infected adolescent
    Renee M St Germain
    University of Connecticut School of Pharmacy, Department of Pharmacy Practice, Storrs, Connecticut, USA
    AIDS Patient Care STDS 21:373-7. 2007
    ..Health care professionals should be conscious of this important drug-drug interaction in HIV-infected children and adolescents and be aware that rapid onset of hypercortisolism and adrenal suppression are possible...
  19. pmc TP0326, a Treponema pallidum β-barrel assembly machinery A (BamA) orthologue and rare outer membrane protein
    Daniel C Desrosiers
    Department of Medicine, University of Connecticut Health Center, Farmington, CT 06040, USA
    Mol Microbiol 80:1496-515. 2011
    ..The syphilis spirochaete appears to have devised a stratagem for harnessing the Bam pathway while satisfying its need to limit surface antigenicity...
  20. ncbi request reprint Gestational and congenital syphilis epidemic in the Colombian Pacific Coast
    Adriana R Cruz
    From the Centro Internacional de Entrenamiento e Investigaciones Médicas CIDEIM, Cali, Colombia Hospital Departamental de Buenaventura, Buenaventura, Colombia Secretaría de Salud Departamental del Valle, Cali, Colombia and Departments of Pediatrics and Immunology, University of Connecticut Health Center, Farmington, CT Division of Infectious Diseases, Connecticut Children s Medical Center, Hartford, CT
    Sex Transm Dis 40:813-8. 2013
    ....
  21. pmc Phagosomal TLR signaling upon Borrelia burgdorferi infection
    Jorge L Cervantes
    Department of Pediatrics, University of Connecticut Health Center Farmington, CT, USA Division of Infectious Diseases, Connecticut Children s Medical Center Hartford, CT, USA
    Front Cell Infect Microbiol 4:55. 2014
    ..Toll-like receptors (TLRs) are key players in the recognition of spirochetal ligands from whole viable organisms (i.e., vita-PAMPs). Herein we will review the role of endosomal TLRs in the response to the Lyme disease spirochete. ..
  22. doi request reprint Efficacy and safety of tipranavir coadministered with ritonavir in HIV-1-infected children and adolescents: 5 years of experience
    Juan C Salazar
    From the Connecticut Children s Medical Center, Division of Pediatric Infectious Diseases and Departments of Pediatrics and Immunology, University of Connecticut School of Medicine, Hartford, CT Fundación Huésped, Buenos Aires, Argentina Instituto de Infectologia Emílio Ribas Department of Pediatrics, University of Sao Paulo Medical School, Sao Paulo, Brazil and Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT
    Pediatr Infect Dis J 33:396-400. 2014
    ..Long-term follow up of patients enrolled in the randomized, open-label pediatric trial (1182.14/PACTG1051)...
  23. ncbi request reprint Maternal and congenital syphilis in rural Haiti
    Chaylah J Lomotey
    University of Connecticut Graduate Program in Public Health, Farmington, Connecticut, United States of America
    Rev Panam Salud Publica 26:197-202. 2009
    ..A study was conducted to assess the prevalence of maternal syphilis and estimate the rate of congenital syphilis in five rural villages surrounding Jeremie, Haiti...
  24. pmc TLR8: the forgotten relative revindicated
    Jorge L Cervantes
    Department of Pediatrics, University of Connecticut Health Center, Farmington, CT 06030, USA
    Cell Mol Immunol 9:434-8. 2012
    ..The functions of TLR8 extend beyond the recognition of foreign pathogens and include cross-talk with other endosomal TLRs, a process that may also have a role in the generation of autoimmunity...
  25. pmc Znu is the predominant zinc importer in Yersinia pestis during in vitro growth but is not essential for virulence
    Daniel C Desrosiers
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA
    Infect Immun 78:5163-77. 2010
    ..Our studies also underscore the need for bacterial cells to balance binding and transporter specificities within the periplasm in order to maintain transition metal homeostasis...
  26. ncbi request reprint HACEK endocarditis in infants and children: two cases and a literature review
    Henry M Feder
    Division of Infectious Disease, Connecticut Children s Medical Center, Hartford, CT, USA
    Pediatr Infect Dis J 22:557-62. 2003
    ..Mortality with HACEK endocarditis was 14%. HACEK organisms may be resistant to penicillins but are susceptible to third generation cephalosporins...
  27. ncbi request reprint Adherence to antiretroviral therapy in HIV-infected pediatric patients improves with home-based intensive nursing intervention
    Virginia M Berrien
    Connecticut Children s Medical Center, Pediatric and Youth HIV Program, Hartford, Connecticut 06106, USA
    AIDS Patient Care STDS 18:355-63. 2004
    ..We conclude that our home-based nursing intervention helped HIV-positive children and their families in better adhering to prescribed medication regimens...
  28. pmc Incidence of noninfectious conditions in perinatally HIV-infected children and adolescents in the HAART era
    Sharon A Nachman
    Department of Pediatrics, Stony Brook University Medical Center, Stony Brook, NY 11794 8111, USA
    Arch Pediatr Adolesc Med 163:164-71. 2009
    ....
  29. pmc Long-term effects of highly active antiretroviral therapy on CD4+ cell evolution among children and adolescents infected with HIV: 5 years and counting
    Kunjal Patel
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Clin Infect Dis 46:1751-60. 2008
    ....
  30. pmc Association of hypercholesterolemia incidence with antiretroviral treatment, including protease inhibitors, among perinatally HIV-infected children
    Katherine Tassiopoulos
    Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA 02115, USA
    J Acquir Immune Defic Syndr 47:607-14. 2008
    ..Antiretroviral therapy has been associated with hypercholesterolemia in HIV-infected children. Few longitudinal studies have been conducted to examine this association, however...
  31. ncbi request reprint Shared random effects analysis of multi-state Markov models: application to a longitudinal study of transitions to dementia
    Juan C Salazar
    Universidad Nacional de Colombia at Medellín, Escuela de Estadistica, Medellin, Colombia
    Stat Med 26:568-80. 2007
    ....
  32. pmc Assessment of the kinetics of Treponema pallidum dissemination into blood and tissues in experimental syphilis by real-time quantitative PCR
    Juan C Salazar
    Walter Reed Army Institute of Research, 1600 East Gude Drive, Rockville, MD 20850, USA
    Infect Immun 75:2954-8. 2007
    ..Our findings highlight the remarkable capacity of T. pallidum to disseminate from the site of infection to blood and tissues, and they identify the spleen as a prime target for treponemal invasion...
  33. pmc Association of site-specific and participant-specific factors with retention of children in a long-term pediatric HIV cohort study
    Paige L Williams
    Center for Biostatistics in AIDS Research, Harvard School of Public Health, Boston, MA 02115 6017, USA
    Am J Epidemiol 167:1375-86. 2008
    ..Although participant characteristics are difficult to modify, the authors identified several potentially modifiable site practices that could be targeted to improve retention...
  34. ncbi request reprint Concomitant use of medications with anticholinergic properties and acetylcholinesterase inhibitors: impact on cognitive and physical functioning in Alzheimer disease
    Kara A Bottiggi
    Am J Geriatr Psychiatry 15:357-9. 2007

Research Grants1

  1. Immunity in Early Syphillis: Pathway to HIV Coinfection
    Juan Salazar; Fiscal Year: 2007
    ..In Aim 2 we will study the effect of secondary syphilis on viral load (VL) in HIV co-infected individuals. In this aim we will compare VL between HIV patients with and without syphilis and determine the effect of penicillin on VL. ..