Affiliation: Connecticut Children's Medical Center
- Babesiosis: similar to malaria but differentPaul M Lantos
Division of Infectious Diseases, Connecticut Children s Medical Center, 282 Washington Street, Hartford, CT 06105, USA
Pediatr Ann 31:192-7. 2002
- Persistent and relapsing babesiosis in immunocompromised patientsPeter J Krause
Division of Infectious Diseases, Connecticut Children s Medical Center, and Department of Pediatrics, University of Connecticut School of Medicine, Farmington, Connecticut 06106, USA
Clin Infect Dis 46:370-6. 2008..Although patients experiencing babesiosis that is unresponsive to standard antimicrobial therapy have been described, the pathogenesis, clinical course, and optimal treatment regimen of such cases remain uncertain...
- Hypersensitivity to ticks and Lyme disease riskGeorgine Burke
Connecticut Children s Medical Center, Hartford, Connecticut, USA
Emerg Infect Dis 11:36-41. 2005..14, 95% CI 0.94-0.03, p = 0.01). Prior exposure to uninfected vector ticks protects residents of disease-endemic sites from Lyme disease...
- Reinfection and relapse in early Lyme diseasePeter J Krause
Department of Pediatrics, Connecticut Children s Medical Center and the University of Connecticut School of Medicine, Hartford, CT 06106, USA
Am J Trop Med Hyg 75:1090-4. 2006..People experiencing recurrent episodes tended to have frequent contact with vector ticks. Prompt administration of standard antibiotic therapy for early Lyme disease reliably eliminates persistent infection and prevents relapse...
- Increasing health burden of human babesiosis in endemic sitesPeter J Krause
Department of Pediatrics, University of Connecticut School of Medicine and Connecticut Children s Medical Center, Hartford, Connecticut 06106, USA
Am J Trop Med Hyg 68:431-6. 2003..Few Babesia-infected children were hospitalized. Babesial incidence at endemic sites in southern New England appears to have risen during the 1990s to a level approaching that due to borreliosis...
- Babesiosis diagnosis and treatmentPeter J Krause
Department of Pediatrics, University of Connecticut School of Medicine, Farmington, USA
Vector Borne Zoonotic Dis 3:45-51. 2003..Babesiosis may be prevented by avoiding areas such as tall grass and brush where ticks, deer, and mice are known to thrive...
- Ehrlichiosis in childrenPaul Lantos
University of Connecticut School of Medicine and the Connecticut Children s Medical Center, Hartford, CT 06106, USA
Semin Pediatr Infect Dis 13:249-56. 2002..Diagnosis is confirmed by identification of the microorganism on blood smear or polymerase chain reaction or by detection of anti-ehrlichial antibody. Doxycycline is the antibiotic of choice for treatment of ehrlichiosis...
- Shared features in the pathobiology of babesiosis and malariaPeter J Krause
University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030, USA
Trends Parasitol 23:605-10. 2007..Continued investigation of similarities and differences in the pathogenesis of babesiosis and malaria should lead to additional fundamental insights for both conditions...
- BabesiosisPeter J Krause
University of Connecticut School of Medicine, Department of Pediatrics, Connecticut Children s Medical Center, Hartford, Connecticut, USA
Med Clin North Am 86:361-73. 2002..Treatment consists of clindamycin and quinine or atovaquone and azithromycin and, in severe cases, exchange transfusion...
- Disease-specific diagnosis of coinfecting tickborne zoonoses: babesiosis, human granulocytic ehrlichiosis, and Lyme diseasePeter J Krause
Department of Pediatrics, Medicine, Clinical Microbiology, Genetics, and Developmental Biology, and The Center for Microbial Pathogenesis, University of Connecticut School of Medicine, Farmington, CT, USA
Clin Infect Dis 34:1184-91. 2002..Physicians should consider use of tests designed to diagnose babesiosis and HGE in patients with Lyme disease who experience a prolonged flulike illness that fails to respond to appropriate antiborrelial therapy...
- Atovaquone and azithromycin treatment for babesiosis in an infantMina Raju
Division of Infectious Diseases, Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA
Pediatr Infect Dis J 26:181-3. 2007..The infant was treated successfully with a combination of oral azithromycin and atovaquone. This combination is an alternative to clindamycin and quinine for the treatment of children with babesiosis...
- Coevolution of markers of innate and adaptive immunity in skin and peripheral blood of patients with erythema migransJuan C Salazar
Department of Pediatrics, Division of Pediatric Infectious Diseases, Connecticut Children s Medical Center, 282 Washington Street, Hartford, CT 06106, USA
J Immunol 171:2660-70. 2003....
- The clinical assessment, treatment, and prevention of lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of AmericaGary P Wormser
Division of Infectious Diseases, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
Clin Infect Dis 43:1089-134. 2006..Tables list the doses and durations of antimicrobial therapy recommended for treatment and prevention of Lyme disease and provide a partial list of therapies to be avoided. A definition of post-Lyme disease syndrome is proposed...
- Cellular immunity, but not gamma interferon, is essential for resolution of Babesia microti infection in BALB/c miceMichael L Clawson
Center for Microbial Pathogenesis, University of Connecticut Health Center, Farmington, Connecticut 06030 3710, USA
Infect Immun 70:5304-6. 2002..These data indicate that cellular immunity is critical for the clearance of B. microti in BALB/c mice but that disease resolution can occur even in the absence of IFN-gamma...
- Dermatologic changes induced by repeated Ixodes scapularis bites and implications for prevention of tick-borne infectionPeter J Krause
University of Connecticut School of Medicine, Farmington, Connecticut, USA
Vector Borne Zoonotic Dis 9:603-10. 2009..scapularis attachment are likely to allow for successful transmission of tick-borne pathogens in non-tick-immune hosts and to inhibit tick-borne pathogen transmission in hosts that have developed tick immunity...
- Successful treatment of human granulocytic ehrlichiosis in children using rifampinPeter J Krause
Department of Pediatrics, University of Connecticut School of Medicine and Connecticut Children s Medical Center, Hartford, USA
Pediatrics 112:e252-3. 2003..A course of rifampin for 5 to 7 days should be considered in children younger than 8 years of age who experience non-life-threatening A phagocytophilum infection...
- Confirmation of tick bite by detection of antibody to Ixodes calreticulin salivary proteinFrancisco Alarcon-Chaidez
Departments of Immunology, University of Connecticut School of Medicine, Farmington, Connecticut 06030, USA
Clin Vaccine Immunol 13:1217-22. 2006..People experiencing deer tick bite(s) developed Ixodes calreticulin-specific antibody responses that persisted for up to 17 months. This Ixodes recombinant calreticulin ELISA provides objective evidence of deer tick exposure in people...
- Babesiosis in pregnancyHenry M Feder
N Engl J Med 349:195-6. 2003
- Human babesiosisEdouard Vannier
Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street, Boston, MA 02111, USA
Infect Dis Clin North Am 22:469-88, viii-ix. 2008..The combination of atovaquone and azithromycin is the treatment of choice for mild-to-moderate illness, whereas clindamycin and quinine and exchange transfusion are indicated for severe disease...
- Entomologic and serologic evidence of zoonotic transmission of Babesia microti, eastern SwitzerlandIvo M Foppa
Harvard School of Public Health, Boston, Massachusetts, USA
Emerg Infect Dis 8:722-6. 2002..These observations constitute the first report demonstrating B. microti in a human-biting vector, associated with evidence of human exposure to this agent in a European site...
- Serum reactivity against Borrelia burgdorferi OspA in patients with rheumatoid arthritisYu Fan Hsieh
Institute of Immunology, Department of Medicine, Chung Shan Medical University, 110 Sec 1, Chien Kuo N Road, Taichung 402, Taiwan
Clin Vaccine Immunol 14:1437-41. 2007..05) whose sera were nonreactive. Serum reactivity against OspA antigen is associated with the pathogenesis of rheumatoid arthritis...
- Absence of erythrocyte sequestration in a case of babesiosis in a splenectomized human patientIan A Clark
School of Biochemistry and Molecular Biology Australian National University, Canberra, ACT 0200, Australia
Malar J 5:69. 2006..The importance of vascular occlusion in the pathogenesis of human haemoprotozoal disease is unresolved...
- HEALTH BURDERN OF COINFECTING DEER ASSOCIATED ZOONOSESPeter Krause; Fiscal Year: 2001..The density of deer will be estimated in each site. This proposed effort will help define the health burden imposed on people residing in proximity to deer and will contribute to diagnosis and case-management of apparent Lyme disease. ..