J S Hyams

Summary

Affiliation: Connecticut Children's Medical Center
Country: USA

Publications

  1. ncbi request reprint Diagnosis and management of inflammatory bowel disease in children
    Ryan Carvalho
    Children s Medical Center, Wright University and Boonshoft School of Medicine, Dayton, Ohio, USA
    Semin Pediatr Surg 16:164-71. 2007
  2. doi request reprint Outcome following infliximab therapy in children with ulcerative colitis
    Jeffrey S Hyams
    Connecticut Children s Medical Center, Hartford, Connecticut 06106, USA
    Am J Gastroenterol 105:1430-6. 2010
  3. doi request reprint Safety and efficacy of adalimumab for moderate to severe Crohn's disease in children
    Jeffrey S Hyams
    Connecticut Children s Medical Center, Hartford, CT, USA
    Gastroenterology 143:365-74.e2. 2012
  4. doi request reprint Induction and maintenance therapy with infliximab for children with moderate to severe ulcerative colitis
    Jeffrey Hyams
    Division of Digestive Diseases and Nutrition, Connecticut Children s Medical Center, 282 Washington Street, Hartford, Connecticut 06106, USA
    Clin Gastroenterol Hepatol 10:391-9.e1. 2012
  5. ncbi request reprint Functional gastrointestinal disorders
    J S Hyams
    Division of Digestive Diseases and Nutrition, Connecticut Children s Medical Center, Hartford 06106, USA
    Curr Opin Pediatr 11:375-8. 1999
  6. ncbi request reprint Natalizumab therapy for moderate to severe Crohn disease in adolescents
    Jeffrey S Hyams
    Division of Digestive Diseases and Nutrition, Connecticut Children s Medical Center, Hartford, CT 06106, USA
    J Pediatr Gastroenterol Nutr 44:185-91. 2007
  7. ncbi request reprint Induction and maintenance infliximab therapy for the treatment of moderate-to-severe Crohn's disease in children
    Jeffrey Hyams
    Connecticut Children s Medical Center, Hartford, Conneticut 06106, USA
    Gastroenterology 132:863-73; quiz 1165-6. 2007
  8. doi request reprint Long-term outcome of maintenance infliximab therapy in children with Crohn's disease
    Jeffrey S Hyams
    Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children s Medical Center, Hartford, CT 06106, USA
    Inflamm Bowel Dis 15:816-22. 2009
  9. doi request reprint Risk/benefit strategies must be employed in the management of pediatric Crohn's disease
    Jeffrey S Hyams
    Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children s Medical Center, University of Connecticut School of Medicine, Hartford, CT 06106, USA
    Dig Dis 27:291-6. 2009
  10. doi request reprint Outcome following thiopurine use in children with ulcerative colitis: a prospective multicenter registry study
    Jeffrey S Hyams
    Connecticut Children s Medical Center, Hartford, Connecticut 06106, USA
    Am J Gastroenterol 106:981-7. 2011

Detail Information

Publications30

  1. ncbi request reprint Diagnosis and management of inflammatory bowel disease in children
    Ryan Carvalho
    Children s Medical Center, Wright University and Boonshoft School of Medicine, Dayton, Ohio, USA
    Semin Pediatr Surg 16:164-71. 2007
    ..As more aggressive therapy is being increasingly employed, rare complications such as lymphoma or opportunistic infection have developed...
  2. doi request reprint Outcome following infliximab therapy in children with ulcerative colitis
    Jeffrey S Hyams
    Connecticut Children s Medical Center, Hartford, Connecticut 06106, USA
    Am J Gastroenterol 105:1430-6. 2010
    ..Infliximab is effective in treating moderate/severe ulcerative colitis (UC) in adults. The aim of this study was to determine the outcome after treatment with infliximab in pediatric UC...
  3. doi request reprint Safety and efficacy of adalimumab for moderate to severe Crohn's disease in children
    Jeffrey S Hyams
    Connecticut Children s Medical Center, Hartford, CT, USA
    Gastroenterology 143:365-74.e2. 2012
    ..The IMAgINE 1 study (NCT00409682) evaluated the safety and efficacy of adalimumab double-blind maintenance dosing regimens following open-label induction for pediatric patients with moderate to severe Crohn's disease (CD)...
  4. doi request reprint Induction and maintenance therapy with infliximab for children with moderate to severe ulcerative colitis
    Jeffrey Hyams
    Division of Digestive Diseases and Nutrition, Connecticut Children s Medical Center, 282 Washington Street, Hartford, Connecticut 06106, USA
    Clin Gastroenterol Hepatol 10:391-9.e1. 2012
    ..We evaluated the efficacy and safety of infliximab for inducing and maintaining benefit in children with moderately to severely active ulcerative colitis (UC)...
  5. ncbi request reprint Functional gastrointestinal disorders
    J S Hyams
    Division of Digestive Diseases and Nutrition, Connecticut Children s Medical Center, Hartford 06106, USA
    Curr Opin Pediatr 11:375-8. 1999
    ..This paper presents a brief review of our current understanding of each diagnosis and gives suggestions for management...
  6. ncbi request reprint Natalizumab therapy for moderate to severe Crohn disease in adolescents
    Jeffrey S Hyams
    Division of Digestive Diseases and Nutrition, Connecticut Children s Medical Center, Hartford, CT 06106, USA
    J Pediatr Gastroenterol Nutr 44:185-91. 2007
    ..This study evaluated the safety, tolerability, and efficacy of natalizumab, a humanized monoclonal immunoglobulin-G4 antibody to [alpha]4 integrin, in adolescent patients with moderately to severely active Crohn disease (CD)...
  7. ncbi request reprint Induction and maintenance infliximab therapy for the treatment of moderate-to-severe Crohn's disease in children
    Jeffrey Hyams
    Connecticut Children s Medical Center, Hartford, Conneticut 06106, USA
    Gastroenterology 132:863-73; quiz 1165-6. 2007
    ..The REACH study evaluated the safety and efficacy of infliximab in children with moderately to severely active Crohn's disease...
  8. doi request reprint Long-term outcome of maintenance infliximab therapy in children with Crohn's disease
    Jeffrey S Hyams
    Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children s Medical Center, Hartford, CT 06106, USA
    Inflamm Bowel Dis 15:816-22. 2009
    ..Infliximab therapy has short-term benefits in children with moderate-to-severe Crohn's disease (CD). We assessed the long-term outcome of infliximab maintenance therapy in children with CD...
  9. doi request reprint Risk/benefit strategies must be employed in the management of pediatric Crohn's disease
    Jeffrey S Hyams
    Division of Digestive Diseases, Hepatology, and Nutrition, Connecticut Children s Medical Center, University of Connecticut School of Medicine, Hartford, CT 06106, USA
    Dig Dis 27:291-6. 2009
    ..Long-term observations will determine whether biologics will change natural history and demonstrate adequate safety...
  10. doi request reprint Outcome following thiopurine use in children with ulcerative colitis: a prospective multicenter registry study
    Jeffrey S Hyams
    Connecticut Children s Medical Center, Hartford, Connecticut 06106, USA
    Am J Gastroenterol 106:981-7. 2011
    ..Despite little supporting data, thiopurine use is common in pediatric ulcerative colitis (UC). Our aim was to determine outcome following thiopurine use in a multicenter inception cohort of children diagnosed with UC...
  11. doi request reprint Safety and efficacy of maintenance infliximab therapy for moderate-to-severe Crohn's disease in children: REACH open-label extension
    Jeffrey Hyams
    Division of Digestive Diseases and Nutrition, Connecticut Children s Medical Center, Hartford, CT 06106, USA
    Curr Med Res Opin 27:651-62. 2011
    ..Assess long-term effects of maintenance infliximab therapy in children with moderately-to-severely active Crohn's disease...
  12. ncbi request reprint The natural history of corticosteroid therapy for ulcerative colitis in children
    Jeffrey Hyams
    Connecticut Children s Medical Center, Hartford, Connecticut, USA
    Clin Gastroenterol Hepatol 4:1118-23. 2006
    ..The aim of this study was to determine the clinical outcome after corticosteroid therapy in children who are newly diagnosed with ulcerative colitis (UC)...
  13. ncbi request reprint Diet and gastrointestinal disease
    Jeffrey S Hyams
    Pediatrics, University of Connecticut School of Medicine and Division of Digestive Diseases and Nutrition, Connecticut Children s Medical Center, Hartford, 06106, USA
    Curr Opin Pediatr 14:567-9. 2002
    ..A thorough understanding of the role of diet is essential to the management of these disorders...
  14. ncbi request reprint Irritable bowel syndrome, functional dyspepsia, and functional abdominal pain syndrome
    Jeffrey S Hyams
    Department of Pediatrics, University of Connecticut School of Medicine, Farmington 06030, USA
    Adolesc Med Clin 15:1-15. 2004
    ..Although the clinician still evaluates for biologic disease, he or she maintains an appreciation that psychosocial events may have a profound impact on physiology and symptom production...
  15. ncbi request reprint Can we alter the natural history of Crohn disease in children?
    Jeffrey S Hyams
    Division of Digestive Diseases and Nutrition, Connecticut Children s Medical Center, Hartford, CT 06106, USA
    J Pediatr Gastroenterol Nutr 40:262-72. 2005
    ..The collection of contemporary natural history data is crucial to facilitate the better integration of current and emerging therapies in an attempt to alter the natural history of Crohn disease in children...
  16. ncbi request reprint Use of 6-mercaptopurine/azathioprine as the immunomodulator of choice for moderately active Crohn's disease: pro
    Jeffrey S Hyams
    Digestive Diseases and Nutrition Division, Connecticut Children s Medical Center, Hartford, Connecticut 06106, USA
    Inflamm Bowel Dis 11:197-9. 2005
  17. ncbi request reprint Natural history of bone metabolism and bone mineral density in children with inflammatory bowel disease
    Francisco A Sylvester
    Division of Gastroenterology and Nutrition, Connecticut Children s Medical Center, Hartford, Connecticut 06106, USA
    Inflamm Bowel Dis 13:42-50. 2007
    ..In children with inflammatory bowel disease (IBD) it is not known whether reductions in bone mineral density (BMD) are a consequence of bone turnover alterations and if BMD improves with treatment...
  18. doi request reprint A two-year longitudinal study of persistent lean tissue deficits in children with Crohn's disease
    Francisco A Sylvester
    Connecticut Children s Medical Center, Hartford, Connecticut 06106, USA
    Clin Gastroenterol Hepatol 7:452-5. 2009
    ..We observed the effects of Crohn's disease on body composition and bone mineral content (BMC), beginning at diagnosis and followed prospectively for 2 years...
  19. doi request reprint Improvement in biomarkers of bone formation during infliximab therapy in pediatric Crohn's disease: results of the REACH study
    Meena Thayu
    Division of Gastroenterology, Hepatology, and Nutrition, The Children s Hospital of Philadelphia, Philadelphia, PA 19014, USA
    Clin Gastroenterol Hepatol 6:1378-84. 2008
    ....
  20. ncbi request reprint Are activated T cells regulators of bone metabolism in children with Crohn disease?
    Francisco A Sylvester
    Connecticut Children s Medical Center, Saint Francis Hospital and Medical Center, Hartford 06106, and University of Connecticut School of Medicine, Farmington, Connecticut, USA
    J Pediatr 148:461-6. 2006
    ..To test the hypothesis that circulating activated T cells may release cytokines that decrease bone turnover in children with Crohn disease...
  21. ncbi request reprint Effect of Crohn's disease on bone metabolism in vitro: a role for interleukin-6
    Francisco A Sylvester
    Department of Pediatrics, Connecticut Children s Medical Center, University of Connecticut, Hartford 06106, USA
    J Bone Miner Res 17:695-702. 2002
    ..These results suggest that IL-6 is a mediator of the effects of Crohn's serum on in vitro mineralization and may be a contributing factor to the osteopenia associated with CD...
  22. doi request reprint Factors that determine risk for surgery in pediatric patients with Crohn's disease
    Marc E Schaefer
    Pediatric Inflammatory Bowel Disease Collaborative Research Group, Hartford, Connecticut, USA
    Clin Gastroenterol Hepatol 8:789-94. 2010
    ..We examined the incidence of Crohn's disease (CD)-related surgery in a multi-center, inception cohort of pediatric patients with CD. We also examined the effect of starting immunomodulator therapy within 30 days of diagnosis...
  23. ncbi request reprint Inflammatory bowel disease
    Jeffrey S Hyams
    Division of Digestive Diseases and Nutrition, Connecticut Children s Medical Center, Hartford, Conn, USA
    Pediatr Rev 26:314-20. 2005
  24. ncbi request reprint Recurrent abdominal pain in children
    Donna K Zeiter
    Division of Digestive Diseases and Nutrition, Connecticut Children s Medical Center, Hartford, USA
    Pediatr Clin North Am 49:53-71. 2002
    ....
  25. ncbi request reprint Treatment of functional gastrointestinal disorders associated with abdominal pain
    Jeffrey S Hyams
    Division of Digestive Diseases and Nutrition, Connecticut Children s Medical Center, Hartford, Connecticut, USA
    J Pediatr Gastroenterol Nutr 41:S47-8. 2005
  26. ncbi request reprint Chronic Abdominal Pain In Children: a Technical Report of the American Academy of Pediatrics and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
    Carlo Di Lorenzo
    J Pediatr Gastroenterol Nutr 40:249-61. 2005
    ..Pediatric studies of therapeutic interventions were examined and found to be limited or inconclusive...
  27. ncbi request reprint Infliximab treatment of Crohn's disease in children: it's time to not go retro(spective)
    Jeffrey S Hyams
    Am J Gastroenterol 98:5-6. 2003
  28. ncbi request reprint Childhood functional gastrointestinal disorders: child/adolescent
    Andrée Rasquin
    Division of Pediatric Gastroenterology and Nutrition, CHU Ste Justine, University of Montreal, Montreal, Quebec, Canada
    Gastroenterology 130:1527-37. 2006
    ..The future availability of additional evidence-based data will likely continue to modify pediatric criteria for FGIDs...
  29. ncbi request reprint Chronic abdominal pain in children: a clinical report of the American Academy of Pediatrics and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
    Carlo Di Lorenzo
    J Pediatr Gastroenterol Nutr 40:245-8. 2005
    ..The conclusions are based on the evidence reviewed in the technical report and on consensus achieved among subcommittee members...
  30. ncbi request reprint Differentiating ulcerative colitis from Crohn disease in children and young adults: report of a working group of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Crohn's and Colitis Foundation of America
    Athos Bousvaros
    J Pediatr Gastroenterol Nutr 44:653-74. 2007
    ....