Edward J Cone

Summary

Country: USA

Publications

  1. ncbi Effects of high-dose intravenous buprenorphine in experienced opioid abusers
    Annie Umbricht
    National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA
    J Clin Psychopharmacol 24:479-87. 2004
  2. ncbi Passive cannabis smoke exposure and oral fluid testing. II. Two studies of extreme cannabis smoke exposure in a motor vehicle
    R Sam Niedbala
    Lehigh University, Department of Chemistry, Bethlehem, Pennsylvania 18015, USA
    J Anal Toxicol 29:607-15. 2005
  3. ncbi Effect of repeated cocaine administration on detection times in oral fluid and urine
    Rebecca Jufer
    Office of the Chief Medical Examiner, Baltimore, Maryland, USA
    J Anal Toxicol 30:458-62. 2006
  4. ncbi Oral fluid results compared to self reports of recent cocaine and heroin use by methadone maintenance patients
    Edward J Cone
    Johns Hopkins School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD 21224, United States
    Forensic Sci Int 215:88-91. 2012
  5. ncbi Urine drug testing of chronic pain patients: licit and illicit drug patterns
    Edward J Cone
    Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Anal Toxicol 32:530-43. 2008
  6. ncbi Prevalence and disposition of drugs of abuse and opioid treatment drugs in oral fluid
    Edward J Cone
    Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Anal Toxicol 31:424-33. 2007
  7. ncbi Urine toxicology testing in chronic pain management
    Edward J Cone
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Postgrad Med 121:91-102. 2009
  8. ncbi Urine testing for cocaine abuse: metabolic and excretion patterns following different routes of administration and methods for detection of false-negative results
    Edward J Cone
    ConeChem Research, LLC, Severna Park, Maryland 21146, USA
    J Anal Toxicol 27:386-401. 2003
  9. ncbi Urine testing for norcodeine, norhydrocodone, and noroxycodone facilitates interpretation and reduces false negatives
    Edward J Cone
    Johns Hopkins School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD 21224, USA
    Forensic Sci Int 198:58-61. 2010
  10. ncbi Interpretation of oral fluid tests for drugs of abuse
    Edward J Cone
    Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Ann N Y Acad Sci 1098:51-103. 2007

Collaborators

Detail Information

Publications41

  1. ncbi Effects of high-dose intravenous buprenorphine in experienced opioid abusers
    Annie Umbricht
    National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA
    J Clin Psychopharmacol 24:479-87. 2004
    ..v. dose. Buprenorphine appears to have a ceiling for cardiorespiratory and subjective effects and a high safety margin even when taken by the i.v. route...
  2. ncbi Passive cannabis smoke exposure and oral fluid testing. II. Two studies of extreme cannabis smoke exposure in a motor vehicle
    R Sam Niedbala
    Lehigh University, Department of Chemistry, Bethlehem, Pennsylvania 18015, USA
    J Anal Toxicol 29:607-15. 2005
    ..The risk of a positive test for THC was virtually eliminated when specimens were collected in the absence of THC smoke...
  3. ncbi Effect of repeated cocaine administration on detection times in oral fluid and urine
    Rebecca Jufer
    Office of the Chief Medical Examiner, Baltimore, Maryland, USA
    J Anal Toxicol 30:458-62. 2006
    ....
  4. ncbi Oral fluid results compared to self reports of recent cocaine and heroin use by methadone maintenance patients
    Edward J Cone
    Johns Hopkins School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD 21224, United States
    Forensic Sci Int 215:88-91. 2012
    ..The addition of oral fluid testing to these programs would provide objective information on recent drug use...
  5. ncbi Urine drug testing of chronic pain patients: licit and illicit drug patterns
    Edward J Cone
    Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Anal Toxicol 32:530-43. 2008
    ..8%. Being the first study of this type, these data present a large array of information on licit and illicit drug use, drug detection frequencies, drug/metabolite patterns, and multi-drug use combinations in pain patients...
  6. ncbi Prevalence and disposition of drugs of abuse and opioid treatment drugs in oral fluid
    Edward J Cone
    Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    J Anal Toxicol 31:424-33. 2007
    ..The results from analysis of this large oral fluid database offer a rich mixture of new information on detection frequency, drug and metabolite patterns, and concentration data on drugs of abuse...
  7. ncbi Urine toxicology testing in chronic pain management
    Edward J Cone
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA
    Postgrad Med 121:91-102. 2009
    ..Given its inherent complexities, effective urine testing requires close collaboration between the primary care physician and a reliable laboratory to develop an appropriate test protocol for each patient and to interpret test results...
  8. ncbi Urine testing for cocaine abuse: metabolic and excretion patterns following different routes of administration and methods for detection of false-negative results
    Edward J Cone
    ConeChem Research, LLC, Severna Park, Maryland 21146, USA
    J Anal Toxicol 27:386-401. 2003
    ....
  9. ncbi Urine testing for norcodeine, norhydrocodone, and noroxycodone facilitates interpretation and reduces false negatives
    Edward J Cone
    Johns Hopkins School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, MD 21224, USA
    Forensic Sci Int 198:58-61. 2010
    ....
  10. ncbi Interpretation of oral fluid tests for drugs of abuse
    Edward J Cone
    Johns Hopkins School of Medicine, Baltimore, Maryland, USA
    Ann N Y Acad Sci 1098:51-103. 2007
    ..Chemical, metabolic, kinetic, and analytic parameters are summarized for selected drugs of abuse, and general guidelines are offered for understanding the significance of oral fluid tests...
  11. ncbi Normalization of urinary drug concentrations with specific gravity and creatinine
    Edward J Cone
    Johns Hopkins School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, Maryland 21224, USA
    J Anal Toxicol 33:1-7. 2009
    ..Drug/metabolite concentration normalization by these procedures is recommended for urine testing programs, especially as a means of coping with dilute specimens...
  12. ncbi Ephemeral profiles of prescription drug and formulation tampering: evolving pseudoscience on the Internet
    Edward J Cone
    ConeChem Research, LLC, 441 Fairtree Drive, Severna Park, MD 21146, USA
    Drug Alcohol Depend 83:S31-9. 2006
    ....
  13. ncbi Evidence of morphine metabolism to hydromorphone in pain patients chronically treated with morphine
    Edward J Cone
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21224, USA
    J Anal Toxicol 30:1-5. 2006
    ....
  14. ncbi Evidence that morphine is metabolized to hydromorphone but not to oxymorphone
    Edward J Cone
    Johns Hopkins School of Medicine, Department of Psychiatry and Behavioral Sciences, Baltimore, Maryland 21224, USA
    J Anal Toxicol 32:319-23. 2008
    ..2 to 2.2%. Oxymorphone was not detected in any specimen from high-dose morphine or high-dose hydromorphone patients. The authors conclude, based on these data, that oxymorphone is not a metabolite of morphine or hydromorphone...
  15. ncbi Methamphetamine and amphetamine pharmacokinetics in oral fluid and plasma after controlled oral methamphetamine administration to human volunteers
    Raf J F Schepers
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, 5500 Nathan Shock Dr, Baltimore, MD 21224, USA
    Clin Chem 49:121-32. 2003
    ..Methamphetamine (METH) and amphetamine (AMP) concentrations in 200 plasma and 590 oral fluid specimens were used to evaluate METH pharmacokinetics and pharmacodynamics after oral administration of sustained-release METH...
  16. ncbi Excretion of methamphetamine and amphetamine in human sweat following controlled oral methamphetamine administration
    Allan J Barnes
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Clin Chem 54:172-80. 2008
    ..Understanding methamphetamine (MAMP) and amphetamine (AMP) excretion in sweat is important for interpreting sweat and hair testing results in judicial, workplace, and drug treatment settings...
  17. ncbi Opioid disposition in human sweat after controlled oral codeine administration
    Eugene W Schwilke
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
    Clin Chem 52:1539-45. 2006
    ..These results are consistent, considering the complex processes of codeine deposition in sweat. Sweat testing is a useful alternative technique for qualitative monitoring of opioid use...
  18. ncbi Oxycodone involvement in drug abuse deaths. II. Evidence for toxic multiple drug-drug interactions
    Edward J Cone
    Pinney Associates, Bethesda, Maryland, USA
    J Anal Toxicol 28:616-24. 2004
    ..Rather, the unique combination of drugs, the pattern of drug use/abuse, and individual factors, such as tolerance to the respiratory depressant effects of opioids, must be taken into account in arriving at a valid COD statement...
  19. ncbi Oxycodone involvement in drug abuse deaths. II. Evidence for toxic multiple drug-drug interactions
    Edward J Cone
    Pinney Associates, Bethesda, Maryland, USA
    J Anal Toxicol 28:217-25. 2004
    ..Rather, the unique combination of drugs, the pattern of drug use/abuse, and individual factors, such as tolerance to the respiratory depressant effects of opioids, must be taken into account in arriving at a valid COD statement...
  20. ncbi Major and minor metabolites of cocaine in human plasma following controlled subcutaneous cocaine administration
    Erin A Kolbrich
    Chemistry and Drug Metabolism, IRP, NIDA, NIH, 5500 Nathan Shock Drive, Baltimore, Maryland 21224, USA
    J Anal Toxicol 30:501-10. 2006
    ..7 ng/mL). These data improve our knowledge of the pharmacokinetics of cocaine and its major and minor metabolites in plasma following controlled subcutaneous cocaine administration...
  21. ncbi Urinary elimination of cocaine metabolites in chronic cocaine users during cessation
    Kenzie L Preston
    Clinical Pharmacology and Therapeutics Research Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA
    J Anal Toxicol 26:393-400. 2002
    ....
  22. ncbi Urinary excretion of ecgonine and five other cocaine metabolites following controlled oral, intravenous, intranasal, and smoked administration of cocaine
    Michael L Smith
    Division of Forensic Toxicology, Armed Forces Medical Examiner System, Armed Forces Institute of Pathology, Rockville, Maryland, USA
    J Anal Toxicol 34:57-63. 2010
    ..EC is an analyte to consider for identifying cocaine use due to its stability in urine and long detection times...
  23. ncbi Pharmacokinetics of cocaine and metabolites in human oral fluid and correlation with plasma concentrations after controlled administration
    Karl B Scheidweiler
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Ther Drug Monit 32:628-37. 2010
    ..Oral fluid is an attractive alternative matrix for drug testing with a noninvasive and directly observed collection, but there are few controlled cocaine administration studies to guide interpretation...
  24. ncbi Duration of detectable methamphetamine and amphetamine excretion in urine after controlled oral administration of methamphetamine to humans
    Jonathan M Oyler
    Chemistry and Drug Metabolism Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Dr, Baltimore, MD 21224, USA
    Clin Chem 48:1703-14. 2002
    ..We determined the urinary excretion of MAMP after oral ingestion and examined the effect of using lower cutoffs on detection of exposure...
  25. ncbi Urinary pharmacokinetics of methamphetamine and its metabolite, amphetamine following controlled oral administration to humans
    Insook Kim
    Chemistry and Drug Metabolism Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
    Ther Drug Monit 26:664-72. 2004
    ..4 +/- 6.5% to 35.7 +/- 26.6%. Slow urinary excretion results in drug accumulation and increases in detection time windows. Our findings also support the presence of an active renal excretion mechanism for methamphetamine...
  26. ncbi Cocaine and metabolites urinary excretion after controlled smoked administration
    Marilyn A Huestis
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Anal Toxicol 31:462-8. 2007
    ..T(max) was not dose-dependent. All metabolites were detected in some subjects within 2 h. EC concentrations were significantly higher after smoked cocaine in a precise delivery coil compared to a glass "crack" pipe...
  27. ncbi Oral fluid testing for drugs of abuse: positive prevalence rates by Intercept immunoassay screening and GC-MS-MS confirmation and suggested cutoff concentrations
    Edward J Cone
    ConeChem Research, LLC, Severna Park, Maryland, USA
    J Anal Toxicol 26:541-6. 2002
    ....
  28. ncbi Dose-related distribution of codeine, cocaine, and metabolites into human hair following controlled oral codeine and subcutaneous cocaine administration
    Karl B Scheidweiler
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    J Pharmacol Exp Ther 313:909-15. 2005
    ..These data are the first demonstrating melanin-related incorporation of cocaine and metabolites into human hair following controlled cocaine administration...
  29. ncbi Oral fluid testing: new technology enables drug testing without embarrassment
    Edward J Cone
    Johns Hopkins School of Medicine, Baltimore, MD, USA
    J Calif Dent Assoc 34:311-5. 2006
    ..Oral fluid testing is a reliable, new technology that overcomes many of the problems of older methods for drug detection...
  30. ncbi Relationship of Delta 9-tetrahydrocannabinol concentrations in oral fluid and plasma after controlled administration of smoked cannabis
    Marilyn A Huestis
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Anal Toxicol 28:394-9. 2004
    ..Consequently, when very recent passive exposure to cannabis smoke can be ruled out, it is concluded that a positive oral fluid test provides credible evidence of active cannabis use...
  31. ncbi Disposition of cocaine and its metabolites in human sweat after controlled cocaine administration
    Sherri L Kacinko
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Clin Chem 51:2085-94. 2005
    ..Over 70% of weekly patches worn during low doses were positive for cocaine (> or =25 ng/patch), increasing to 100% during high doses. CONCLUSION: Sweat testing is an effective and reliable method of monitoring cocaine exposure...
  32. ncbi Oxycodone involvement in drug abuse deaths: a DAWN-based classification scheme applied to an oxycodone postmortem database containing over 1000 cases
    Edward J Cone
    Pinney Associates, Bethesda, Maryland, USA
    J Anal Toxicol 27:57-67; discussion 67. 2003
    ..Use of this new system for reporting mortality data in future studies involving opioids is recommended...
  33. ncbi Plasma and oral fluid pharmacokinetics and pharmacodynamics after oral codeine administration
    Insook Kim
    Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse/NIH, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA
    Clin Chem 48:1486-96. 2002
    ..These controlled drug administration data should aid in the interpretation of oral fluid codeine results...
  34. ncbi Methamphetamine disposition in oral fluid, plasma, and urine
    Marilyn A Huestis
    Chemistry and Drug Metabolism Section, IRP, NIDA, NIH, 5500 Nathan Shock Drive, Baltimore, MD, USA
    Ann N Y Acad Sci 1098:104-21. 2007
    ..When contemplating selection of oral fluid as a test matrix, the advantages of oral fluid collection should be weighed against its shorter time of detection compared to that of urine...
  35. ncbi Toxicologic aspects of heroin substitution treatment
    Edward J Cone
    ConeChem Research, Baltimore, Maryland, USA
    Ther Drug Monit 24:193-8. 2002
    ..Overall, the many recent developments in testing methodology provide more effective means to assess patients in heroin substitution programs and should contribute to improvements in public health...
  36. ncbi Intravenous butyrylcholinesterase administration and plasma and brain levels of cocaine and metabolites in rats
    Gilberto N Carmona
    Intramural Research Programs, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Eur J Pharmacol 517:186-90. 2005
    ..These findings suggest that butyrylcholinesterase treatment may have benefits in enhancing cocaine metabolism and in increasing levels of ecgonine methylester, which may have a protective action against cocaine...
  37. ncbi Correlation between pharmacological effects and plasma cocaine concentrations after smoked administration
    Amanda J Jenkins
    Addiction Research Center, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, Maryland 21224, USA
    J Anal Toxicol 26:382-92. 2002
    ..Several subjective and cardiovascular measures returned to baseline levels in the presence of detectable concentrations of cocaine...
  38. ncbi High prevalence of 6-acetylmorphine in morphine-positive oral fluid specimens
    Lance Presley
    LabOne Inc, Lenexa, Kansas, USA
    Forensic Sci Int 133:22-5. 2003
    ..7% of morphine-positive oral fluid specimens indicates that oral fluid testing for opioids may offer advantages over urine in workplace drug testing programs and in testing drugged drivers for recent heroin use...
  39. ncbi Relationship between plasma and oral fluid nicotine concentrations in humans: a pilot study
    Amanda J Jenkins
    The Office of the Cuyahoga County Coroner, Cleveland, Ohio 44106, USA
    Ther Drug Monit 27:345-8. 2005
    ..Oral fluid/plasma were >1 for up to 60 minutes after the low dose and 120 minutes after the high dose. There was no correlation between plasma and oral fluid nicotine concentrations...
  40. ncbi Passive cannabis smoke exposure and oral fluid testing
    Sam Niedbala
    OraSure Technologies, 150 Webster Street, Bethlehem, Pennsylvania 18015, USA
    J Anal Toxicol 28:546-52. 2004
    ..It is concluded that the risk of positive oral fluid tests from passive cannabis smoke inhalation is limited to a period of approximately 30 min following exposure...
  41. ncbi Simultaneous quantification of methamphetamine, cocaine, codeine, and metabolites in skin by positive chemical ionization gas chromatography-mass spectrometry
    Wonkyung Yang
    National Institute of Scientific Investigation, 331-1 Shinwol 7-Dong, Yangcheon-gu, Seoul 158-707, Republic of Korea
    J Chromatogr B Analyt Technol Biomed Life Sci 833:210-8. 2006
    ..999 and concentrations +/-20% of target. Intra- and inter-run precisions were <10%. This procedure should be useful for postmortem analysis; data are included on drug concentrations in skin after controlled drug administration...