Mark I Evans

Summary

Affiliation: Comprehensive Genetics
Country: USA

Publications

  1. ncbi Update on selective reduction
    Mark I Evans
    Comprehensive Genetics, Mt Sinai School of Medicine, New York, NY 10021, USA
    Prenat Diagn 25:807-13. 2005
  2. ncbi Pregnancy loss rates after midtrimester amniocentesis
    Ronald J Wapner
    Obstet Gynecol 109:780; author reply 780-1. 2007
  3. doi Quality of nuchal translucency measurements correlates with broader aspects of program rigor and culture of excellence
    Mark I Evans
    Comprehensive Genetics and Department of Obstetrics and Gynecology, Mount Sinai School of Medicine, New York, NY, USA
    Fetal Diagn Ther 33:230-4. 2013
  4. doi Digital PCR for noninvasive detection of aneuploidy: power analysis equations for feasibility
    Mark I Evans
    Prenatal Diagnosis, Comprehensive Genetics, Columbia University, New York, NY 10065, USA
    Fetal Diagn Ther 31:244-7. 2012
  5. ncbi Invasive prenatal diagnostic procedures 2005
    Mark I Evans
    Institute for Genetics, Mt Sinai School of Medicine, New York, NY 10022, USA
    Semin Perinatol 29:215-8. 2005
  6. ncbi Fetal reduction
    Mark I Evans
    Fetal Medicine Foundation of America
    Semin Perinatol 29:321-9. 2005
  7. ncbi Principles of screening
    Mark I Evans
    Comprehensive Genetics, Mt Sinai School of Medicine, New York, NY 10021, USA
    Semin Perinatol 29:364-6. 2005
  8. ncbi Automated microscopy of amniotic fluid cells: detection of FISH signals using the FastFISH imaging system
    Mark I Evans
    Comprehensive Genetics, New York, NY 10021, USA
    Fetal Diagn Ther 21:523-7. 2006
  9. ncbi Nuchal translucency measurements for first-trimester screening: the 'price' of inaccuracy
    Mark I Evans
    Fetal Medicine Foundation of America, Comprehensive Genetics, Mt Sinai School of Medicine, New York, NY 10021, USA
    Fetal Diagn Ther 22:401-4. 2007
  10. doi Chorionic villus sampling and amniocentesis in 2008
    Mark I Evans
    Fetal Medicine Foundation of America, New York, New York, USA
    Curr Opin Obstet Gynecol 20:164-8. 2008

Collaborators

Detail Information

Publications55

  1. ncbi Update on selective reduction
    Mark I Evans
    Comprehensive Genetics, Mt Sinai School of Medicine, New York, NY 10021, USA
    Prenat Diagn 25:807-13. 2005
    ..For all starting numbers, including twins, reduction to a lower number of fetuses reduces fetal losses, prematurity, and infant mortality and morbidity...
  2. ncbi Pregnancy loss rates after midtrimester amniocentesis
    Ronald J Wapner
    Obstet Gynecol 109:780; author reply 780-1. 2007
  3. doi Quality of nuchal translucency measurements correlates with broader aspects of program rigor and culture of excellence
    Mark I Evans
    Comprehensive Genetics and Department of Obstetrics and Gynecology, Mount Sinai School of Medicine, New York, NY, USA
    Fetal Diagn Ther 33:230-4. 2013
    ..To determine if nuchal translucency (NT) quality correlates with the extent to which clinics vary in rigor and quality control...
  4. doi Digital PCR for noninvasive detection of aneuploidy: power analysis equations for feasibility
    Mark I Evans
    Prenatal Diagnosis, Comprehensive Genetics, Columbia University, New York, NY 10065, USA
    Fetal Diagn Ther 31:244-7. 2012
    ..To determine the feasibility of digital PCR analysis for noninvasive prenatal diagnosis of trisomy 21...
  5. ncbi Invasive prenatal diagnostic procedures 2005
    Mark I Evans
    Institute for Genetics, Mt Sinai School of Medicine, New York, NY 10022, USA
    Semin Perinatol 29:215-8. 2005
    ..There is no increased risks of limb reduction defects following CVS at 10 weeks or greater, but there is an increase in Talipes from "Early Amniocentesis." In the first trimester CVS is the safer procedure...
  6. ncbi Fetal reduction
    Mark I Evans
    Fetal Medicine Foundation of America
    Semin Perinatol 29:321-9. 2005
    ..Genetic diagnosis prior to reduction can improve the overall outcomes. Reduction of triplets or more clearly improves outcomes, and reduction of twins to a singleton is now a reasonable consideration...
  7. ncbi Principles of screening
    Mark I Evans
    Comprehensive Genetics, Mt Sinai School of Medicine, New York, NY 10021, USA
    Semin Perinatol 29:364-6. 2005
    ..Understanding the differences among four key measures of evaluation for tests (sensitivity, specificity, positive predictive value and negative predictive value) are necessary for proper utilization of screening tests...
  8. ncbi Automated microscopy of amniotic fluid cells: detection of FISH signals using the FastFISH imaging system
    Mark I Evans
    Comprehensive Genetics, New York, NY 10021, USA
    Fetal Diagn Ther 21:523-7. 2006
    ..However, FISH is expensive, labor-intensive, and requires a high skill level and subjective signal interpretation. A fully automated system for FISH analysis could improve laboratory efficiency and potentially reduce errors and costs...
  9. ncbi Nuchal translucency measurements for first-trimester screening: the 'price' of inaccuracy
    Mark I Evans
    Fetal Medicine Foundation of America, Comprehensive Genetics, Mt Sinai School of Medicine, New York, NY 10021, USA
    Fetal Diagn Ther 22:401-4. 2007
    ..Here we assess the impact of systematic under-measurement on abnormality detection...
  10. doi Chorionic villus sampling and amniocentesis in 2008
    Mark I Evans
    Fetal Medicine Foundation of America, New York, New York, USA
    Curr Opin Obstet Gynecol 20:164-8. 2008
    ..Here, we review the historical and current literature to determine realistic estimates...
  11. doi Fetal reduction 2008
    Mark I Evans
    Fetal Medicine Foundation of America, New York, New York, USA
    Curr Opin Obstet Gynecol 20:386-93. 2008
    ..Multifetal pregnancy reduction has lowered the complications considerably. Here, we review the historical and current literature to determine reasonable statistics upon which to counsel patients..
  12. doi Impact of quality of nuchal translucency measurements on detection rates of trisomies 13 and 18
    Mark I Evans
    Department of Obstetrics and Gynecology, Mt Sinai School of Medicine, New York, NY, USA
    Fetal Diagn Ther 27:68-71. 2010
    ....
  13. doi Screening and testing in multiples
    Mark I Evans
    Fetal Medicine Foundation of America, New York, NY, USA Comprehensive Genetics, 131 East 65th Street, New York, NY 10065, USA
    Clin Lab Med 30:643-54. 2010
    ..However, there can be significant differences in the safety and efficacy of all approaches with multiple gestations. This article deals with specific aspects of screening in multiple pregnancies...
  14. doi Noninvasive prenatal diagnosis: 2010
    Mark I Evans
    Fetal Medicine Foundation of America, New York, NY, USA
    Clin Lab Med 30:655-65. 2010
    ..The large number of approaches that have been used is testimony to the fact that none of them have been particularly successful. This article discusses the current status and challenges of noninvasive prenatal diagnosis...
  15. doi Multifetal pregnancy reduction: evolution of the ethical arguments
    Mark I Evans
    Comprehensive Genetics, Fetal Medicine Foundation of America, New York, New York 10065, USA
    Semin Reprod Med 28:295-302. 2010
    ..The ethical principle of proportionality takes precedence (i.e., trying to obtain the most good for the least harm while looking for areas of moral compromise to achieve the best outcomes)...
  16. doi Undermeasurement of nuchal translucencies: implications for screening
    Mark I Evans
    Comprehensive Genetics, Fetal Medicine Foundation of America, New York, New York, USA
    Obstet Gynecol 116:815-8. 2010
    ..5 mm or less (approximately 4% of nuchal translucency values should be 2.5 mm or higher)...
  17. doi Making decisions when no good choices exist: delivery of the survivor after intrauterine death of the co-twin in monochorionic twin pregnancies
    Mark I Evans
    Fetal Medicine Foundation of America, Comprehensive Genetics, and Mt Sinai School of Medicine, New York, NY 10065, USA
    Fetal Diagn Ther 28:191-5. 2010
    ..In utero death of one monozygotic twin predisposes the survivor to death and serious morbidity from hemodynamic collapse, thromboplastins, or microemboli. The optimal management of such cases, however, is unclear...
  18. doi Impact of nuchal translucency credentialing by the FMF, the NTQR or both on screening distributions and performance
    M I Evans
    Comprehensive Genetics and Department of Obstetrics and Gynecology, Mt Sinai School of Medicine, New York, NY 10065, USA
    Ultrasound Obstet Gynecol 39:181-4. 2012
    ..We sought to assess differences in the distribution of NT measurements based upon the system from which the operator obtained their education, review and credentialing...
  19. ncbi Meta-analysis of first trimester Down syndrome screening studies: free beta-human chorionic gonadotropin significantly outperforms intact human chorionic gonadotropin in a multimarker protocol
    Mark I Evans
    Comprehensive Genetics, and Mt Sinai School of Medicine, New York, NY 10021, USA
    Am J Obstet Gynecol 196:198-205. 2007
    ..The purpose of this study was to compare free beta and intact human chorionic gonadotropin in first trimester screening with pregnancy-associated plasma protein-A and nuchal translucency...
  20. doi Performance adjusted risks: a method to improve the quality of algorithm performance while allowing all to play
    Mark I Evans
    Comprehensive Genetics, Fetal Medicine Foundation of America, and Department of Obstetrics and Gynecology, Mt Sinai School of Medicine, New York, NY 10065, USA
    Prenat Diagn 31:797-801. 2011
    ..A new method, performance adjusted risks (PAR), is developed to allow for such differences and improve performance...
  21. ncbi Do reduced multiples do better?
    Mark I Evans
    Columbia University, Institute for Genetics and Fetal Medicine, New York, NY, USA
    Best Pract Res Clin Obstet Gynaecol 18:601-12. 2004
    ..Reduction to a singleton is becoming more common, particularly for women over 40. Combining MFPR with chorionic villus sampling in patients over 30 years of age has enabled couples to maximize the health of the resultant children...
  22. ncbi Fetal reduction from twins to a singleton: a reasonable consideration?
    Mark I Evans
    Department of Obstetrics and Gynecology, St Luke s Roosevelt Hospital Center, Columbia University, New York, NY, USA
    Obstet Gynecol 104:102-9. 2004
    ..With evidence of increased safety and more women (many aged 40 years or more) asking for counseling about reduction to a singleton, we reviewed our prior reasoning...
  23. ncbi Demographic factors for utilization of invasive genetic testing after multifetal pregnancy reduction
    Carol L Baker
    Department of Obstetrics and Gynecology, MCP Hahnemann University, Philadelphia, PA 19102, USA
    Fetal Diagn Ther 18:140-3. 2003
    ..We, therefore, sought to determine what demographic factors, including race and ethnic group, influenced patients' decisions to undergo genetic testing in addition to multifetal pregnancy reduction (MFPR)...
  24. ncbi Detection of genetic abnormalities by using CVS and FISH prior to fetal reduction in sonographically normal appearing fetuses
    Mara Rosner
    Department of Obstetrics and Gynecology, Montefiore Medical Center Albert Einstein College of Medicine, Bronx, NY, USA
    Prenat Diagn 33:940-4. 2013
    ..To examine the ability of chorionic villus sampling (CVS) and fluorescence in situ hybridization (FISH) to detect aneuploidy before first trimester fetal reduction (FR) in sonographically normal-appearing fetuses...
  25. ncbi Screening
    Mark I Evans
    Columbia University College of Physicians and Surgeons, St Luke s Roosevelt Hospital Center, 1000 10th Avenue, New York, NY 10019, USA
    Best Pract Res Clin Obstet Gynaecol 16:645-57. 2002
    ..In fact, the real 'take-home message' is that one must use these principles when looking at new technologies to understand their role in emerging practice...
  26. ncbi Standardization of methods reduces variability: explanation for historical discrepancies in biochemical screening
    Mark I Evans
    Institute for Genetics and Fetal Medicine, Department of Obstetrics and Gynecology, St Luke s Roosevelt Hospital Center, Columbia University, New York, NY 10019, USA
    Genet Test 7:81-3. 2003
    ..With national standardization of all parameters, the widely divergent results seen in the literature should narrow, and regional medians will no longer be necessary...
  27. ncbi Impact of folic acid fortification in the United States: markedly diminished high maternal serum alpha-fetoprotein values
    Mark I Evans
    Department of Obstetrics and Gynecology, Institute for Genetics and Fetal Medicine, St Luke s Roosevelt Hospital Center, 1000 10th Avenue, Suite 11A, New York, NY 10019, USA
    Obstet Gynecol 103:474-9. 2004
    ..In this study, we ascertain if the impact of folic acid fortification is better seen at the time of midtrimester prenatal diagnosis by looking at incidence of high maternal serum alpha-fetoprotein (MSAFP) values...
  28. ncbi Procedural risks versus theology: chorionic villus sampling for Orthodox Jews at less than 8 weeks' gestation
    Ronald J Wapner
    Department of Obstetrics and Gynecology, MCP Hahnemann University, Philadelphia, PA 19102, USA
    Am J Obstet Gynecol 186:1133-6. 2002
    ..This evaluation was performed to determine the feasibility and safety of performing chorionic villus sampling (CVS) at 7 to 8 weeks' gestation so that genetic results would be useful for these patients...
  29. ncbi Maternal weight correction for alpha-fetoprotein: mathematical truncations revisited
    Mark I Evans
    Department of Obstetrics and Gynecology, MCP Hahnemann University, Philadelphia, PA 19102, USA
    Genet Test 6:221-3. 2002
    ..5 MOM). The same relationship is seen for "lows." Without correction, higher weight lowers AFP, correction to 250 lbs. overcompensates, and 200 lbs. gives the most even distribution, and, therefore, optimizes the distribution of highs...
  30. ncbi Paternity balancing
    Mark I Evans
    Comprehensive Genetics, New York, N Y, USA
    Fetal Diagn Ther 34:135-9. 2013
    ..All desired reductions to twins for the standard medical indications, but requested, if reasonably possible, to have twins with one fathered by each partner...
  31. ncbi Framing the decision: determinants of how women considering multifetal pregnancy reduction as a pregnancy-management strategy frame their moral dilemma
    David W Britt
    Institute for Genetics and Fetal Medicine, St Luke s Roosevelt Hospital, Columbia University, New York, NY 10019, USA
    Fetal Diagn Ther 19:232-40. 2004
    ..Our objective is to examine the biographical determinants of frame dominance in this contest as it applies to multigestation pregnancies where selective reduction is being considered as a pregnancy-management strategy...
  32. ncbi Principles of screening
    Mark I Evans
    Department of Obstetrics and Gynecology, MCP Hahnemann University, Philadelphia, Pennsylvania 19107, USA
    Clin Obstet Gynecol 45:657-60; discussion 730-2. 2002
  33. ncbi Matching risk and resources in high-risk pregnancies
    David W Britt
    Fetal Medicine Foundation of America, New York, NY 10021, USA
    J Matern Fetal Neonatal Med 19:645-50. 2006
    ..To evaluate the joint impact of pregnancy risk and the timing of referral of high-risk pregnancies from obstetricians to maternal fetal medicine (MFM) sub-specialists on gestational age (GA) at delivery...
  34. ncbi Evolution of gender options in multiple pregnancy management
    Mark I Evans
    Comprehensive Genetics and Fetal Medicine Foundation of America, Mt Sinai School of Medicine, New York, NY, USA Departments of Obstetrics and Gynecology, Mt Sinai School of Medicine, New York, NY, USA
    Prenat Diagn 33:935-9. 2013
    ..Fetal reduction (FR) in multiples dramatically improves outcomes. We prioritize FR decisions for health and historically declined to factor gender. As male preferences apparently diminished, our bioethicist encouraged a re-evaluation...
  35. ncbi Intact fetal cells in maternal plasma: are they really there?
    Farideh Z Bischoff
    Department of Obstetrics and Gynecology, Baylor College of Medicine, 6550 Fannin Street Suite 885, Houston, TX 77030, USA
    Lancet 361:139-40. 2003
    ..Although apoptotic intact fetal cells could contribute to the detection of fetal DNA in maternal plasma, we believe that recovery of these cells is difficult and not clinically practical...
  36. ncbi Selective reduction
    Mark I Evans
    Institute for Genetics and Fetal Medicine, St Luke s Roosevelt Hospital Center, 1000 10th Avenue, Suite 11A 1, New York, NY 10019, USA
    Clin Perinatol 30:103-11. 2003
    ..Triplets and singletons do not do as well. We hope that MFPR will become obsolete as better control of ovulation agents and assisted reproductive technologies make multifetal pregnancies uncommon...
  37. ncbi Information-sharing among couples considering multifetal pregnancy reduction
    David W Britt
    Fetal Medicine Foundation of America, New York, USA
    Fertil Steril 87:490-5. 2007
    ..To determine the information-sharing strategies of couples considering fetal reduction, and the impact of these strategies on the chances of encountering hostility in their social networks...
  38. ncbi The Wayne State experience
    Mark I Evans
    Department of Obstetrics and Gynecology, MCP Hahnemann University, Philadelphia, PA 19102, USA
    Fetal Diagn Ther 17:321-30. 2002
  39. ncbi Future directions
    Mark I Evans
    Columbia University College of Physicians and Surgeons, St Luke s Roosevelt Hospital Center, 1000 10th Avenue, New York, NY 10019, USA
    Best Pract Res Clin Obstet Gynaecol 16:757-9. 2002
  40. doi Sex chromosome micromosaicism in infertile men with normal karyotypes
    Jonathan D Schiff
    Department of Urology, Mount Sinai Medical Center, New York, NY 10128, USA
    Fertil Steril 93:1903-6. 2010
    ..To define the prevalence of low-level sex chromosome mosaicism in a cohort of infertile men...
  41. doi Fetal reduction: 25 years' experience
    Mark I Evans
    Comprehensive Genetics, Fetal Medicine Foundation of America, New York, N Y, USA
    Fetal Diagn Ther 35:69-82. 2014
    ..Ethical arguments have also evolved; as with many technologies in which the start was for only 'life or death cases', FR has also moved into 'quality of life' issues. FR of twins to a singleton now compromise about 30% of our cases...
  42. ncbi Fetal therapy
    Mark I Evans
    Columbia University College of Physicians and Surgeons, St Luke s Roosevelt Hospital Center, 1000 10th Avenue, New York, NY 10019, USA
    Best Pract Res Clin Obstet Gynaecol 16:671-83. 2002
    ....
  43. doi Overcoming militant mediocrity
    Mark I Evans
    Fetal Medicine Foundation of America, Comprehensive Centers PLLC, and Department of Obstetrics and Gynecology, Mt Sinai, New York, NY, USA
    Am J Obstet Gynecol 198:656-61. 2008
  44. ncbi Correction for insulin-dependent diabetes in maternal serum alpha-fetoprotein testing has outlived its usefulness
    Mark I Evans
    Department of Obstetrics and Gynecology, MCP Hahnemann University, 245 N 15th Street, MS 495, Philadelphia, PA 19102, USA
    Am J Obstet Gynecol 187:1084-6. 2002
    ..With new laboratory methods and improved precision, we sought to re-evaluate the correctness of this approach...
  45. ncbi Comparison of serum markers in first-trimester down syndrome screening
    Mark I Evans
    Obstet Gynecol 109:782; author reply783. 2007
  46. ncbi Sometimes doing the right thing sucks: frame combinations and multi-fetal pregnancy reduction decision difficulty
    David W Britt
    Department of Health and Sports Sciences, College of Education and Human Development, University of Louisville, USA
    Soc Sci Med 65:2342-56. 2007
    ....
  47. ncbi 2nd-trimester maternal serum human chorionic gonadotropin and alpha-fetoprotein levels in male and female fetuses with Down syndrome
    Ofer Lehavi
    Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv, Israel
    Fetal Diagn Ther 20:235-8. 2005
    ..The purpose of this study was to evaluate the gender impact on marker levels in DS pregnancies and its effect on DS screening...
  48. doi Screening advances and diagnostic choice: the problem of residual risk
    George P Henry
    Reproductive Genetics Center, Denver, CO, USA
    Fetal Diagn Ther 23:308-15. 2008
    ..Data on Down syndrome (DS) births for Colorado from 1989 to 2005 were used to examine the implications of a decreasing use of amniocentesis...
  49. ncbi Spontaneous abortions in couples declining multifetal pregnancy reduction
    Mark I Evans
    Department of Obstetrics and Gynecology and Human Genetics, MCP Hahnemann University, Philadelphia, PA 19102 1192, USA
    Fetal Diagn Ther 17:343-6. 2002
    ..Two patients delivering triplets had a loss of 1 fetus/neonate. These data suggest that the loss rates of nonreduced pregnancies may be higher than generally thought, making the improvements with MFPR even bigger than generally realized...
  50. ncbi Automated detection of rare fetal cells in maternal blood: eliminating the false-positive XY signals in XX pregnancies
    Michael W Kilpatrick
    Ikonisys Inc, New Haven, CT, USA
    Am J Obstet Gynecol 190:1571-8; discussion 1578-81. 2004
    ..The purpose of this study was to develop a new method to help differentiate XX from XY signals in maternal blood from women carrying XY fetuses...
  51. ncbi Natural history of twin gestation complicated by in utero fetal demise: associations of chorionicity, prematurity, and maternal morbidity
    Howard K Kaufman
    Maternal Fetal Medicine, Rockford Memorial Hospital, Rockford, IL 61103, USA
    Fetal Diagn Ther 18:442-6. 2003
    ..To assess previously reported risks for maternal disseminated intravascular coagulopathy, peripartal hemorrhage, retained placenta and infection, as well as the fetal risk of prematurity...
  52. ncbi Re-evaluating the role of the MFM specialist: lead, follow, or get out of the way
    Robert D Eden
    The Desert Perinatal Center, Palm Springs, CA 19475, USA
    J Matern Fetal Neonatal Med 18:253-8. 2005
    ....
  53. ncbi Stem Cell Therapy: moving towards reality
    Mark I Evans
    Am J Obstet Gynecol 194:662-3. 2006
  54. ncbi Interphase FISH for prenatal diagnosis of common aneuploidies
    Baruch Feldman
    Danek Gertner Institute of Human Genetics, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Aviv University, Tel Hashomer, Israel
    Methods Mol Biol 204:219-41. 2002
  55. ncbi Multifetal pregnancies: evolution of methods of initiation and impact of REI certification for patients seeking reduction
    Byron Calhoun
    Madigan Army Medical Center, Tacoma, WA 98431, USA
    Fetal Diagn Ther 18:132-6. 2003
    ..Multifetal pregnancy as a result of ovulation induction (OI) and assisted reproductive technologies (ART) correlate with Board certification in reproductive endocrinology and infertility (REI)...